LOCUS       NM_024927               3026 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pleckstrin homology, MyTH4 and FERM domain containing
            H3 (PLEKHH3), transcript variant 1, mRNA.
ACCESSION   NM_024927
VERSION     NM_024927.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC067852.23.
            
            On Nov 23, 2018 this sequence version replaced NM_024927.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052978.1, SRR9304719.523578.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591022.6/ ENSP00000468678.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               AC067852.23        1034-1626
            594-649             AC067852.23        3619-3674
            650-729             AC067852.23        4015-4094
            730-921             AC067852.23        4194-4385
            922-1079            AC067852.23        4472-4629
            1080-1200           AC067852.23        4732-4852
            1201-1507           AC067852.23        5636-5942
            1508-1715           AC067852.23        6470-6677
            1716-1852           AC067852.23        6898-7034
            1853-1985           AC067852.23        7323-7455
            1986-2444           AC067852.23        7652-8110
            2445-2636           AC067852.23        8407-8598
            2637-3026           AC067852.23        9725-10114
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..3026
                     /gene="PLEKHH3"
                     /note="pleckstrin homology, MyTH4 and FERM domain
                     containing H3"
                     /db_xref="GeneID:79990"
                     /db_xref="HGNC:HGNC:26105"
     exon            1..593
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..2813
                     /gene="PLEKHH3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pleckstrin homology domain-containing family H
                     member 3; PH domain-containing family H member 3;
                     pleckstrin homology domain containing, family H (with
                     MyTH4 domain) member 3"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family H
                     member 3 isoform 1 precursor"
                     /protein_id="NP_079203.4"
                     /db_xref="CCDS:CCDS11434.1"
                     /db_xref="GeneID:79990"
                     /db_xref="HGNC:HGNC:26105"
                     /translation="MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFEL
                     RTPSPAGGGRGPLEVTLTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWL
                     YREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRR
                     KETGLWSVTVSGRKHSVRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQES
                     CGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQA
                     LEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQ
                     LLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSL
                     AEISALSQRQELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYE
                     QRGAQERALAGGTLVADVLTRFENLAAEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPD
                     GHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLQRDFSPRVPLPRLDRLLPPP
                     APPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGA
                     GTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLELSTEPGRGAPQKLC
                     LGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTLALRVGESQLLLQSPQVEEIM
                     QLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDEPQGQSGCLGQLQD"
     exon            594..649
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..729
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            730..921
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1079
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1200
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1507
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1715
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1852
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1985
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2444
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2636
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..3026
                     /gene="PLEKHH3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3026
                     /gene="PLEKHH3"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgggg ctgcagggag cgcagcgcgc gcggcccggg ccccggccac cggacgccct
       61 accggacacg accctccctg gagcttggac aactgcccac ctcggacgct gcaccggaca
      121 ctgcccccca cagggctgga cactccaacg gacactactt cccagctccg gacattgctc
      181 cctcctctcc cggggccctg gacgcttttc cccctccccc ctccgggggc ccagacactg
      241 agcccccctc agcgtctggc tagcgtcccc ttgcacccca gcccaggaca ctgcctcctc
      301 cctgtcctct tctcccttct gctcctccca cctcatcttt cccctgctcg ggtcggagcc
      361 ccgccagttc ctccgacccc ctactgctcg gccgcggctg cccgcgcccc catccgcagc
      421 tcctcgcccg gatgcctctc cccgggggac tatggtggct tctctgctgc cgtcgaggct
      481 tcactcttct gcaccgggac tacggggacg gcgagcttag cggggacggg gacgaggacg
      541 aggacgagga aacctttgag ctgcggaccc cgagtccagc gggcggcggg aggggtcccc
      601 tggaagtgac gctgactcag ccagtgagga gcgggcctgt ctccaacagg ctgcagagct
      661 gggaggagac ttggagcctc atcccggaga aagggctgcc ggaggacgac ccggacatcg
      721 ttgtgaaagg ttggctgtac cgggagcccc gcggaggagg ggcgcggccc tggctgcccc
      781 cgcgccgagc ctggtttgtg ctcacgcggg actccctgga tcagttcagc agcagcggga
      841 aaggggcgcg gcgtctcggg agcctcgtgc tcaccagcct gtgctcggtg accggcccag
      901 agcgcaggcg taaggagaca ggtctgtggt cagtgactgt gtctggtcgg aaacacagtg
      961 tccgcctctg ctccccacgc caggcagagg ctgagcgctg gggggtggca ttgcgggaag
     1021 tgatcgcctc caaggcaccc ctggagaccc ccacccagct actgctcagg gacatacagg
     1081 aaagttgcgg ggacccagag gccgttgccc tcatttacct gaggaacccg attctgagac
     1141 acactagtgg agccttgtat gccccactcc tgcccctgcc ctatggagtc agcgccccag
     1201 gtccgggcta tgcacccctg cgcgaggagg cggtgcggct gttcttggcg ctgcaggcgc
     1261 tggagggggc gcggcgcccc gggcccttga tgcagggtgt gctccaaacc tgccgggact
     1321 tgcccgcgct ccgggatgaa ctcttcctgc agctggctaa gcagacctcg ggccctgcag
     1381 gtccccccgg gctcccggct acccaagacc ctgcggccct gcggtactgg caactcctca
     1441 cctgcatgag ctgcaccttc cgacctgggg gagctgtgcg ggggcacctc ctggggcact
     1501 tggagaggac cgagcaggca ctcccggact cggaactggc ggaatatgcg cgcttcatcc
     1561 ggaaagcgct gggccggacg cgcggcagag agctggtgcc ctcgctggcg gagatttccg
     1621 cgttgagcca acggcaggag ctgctgtgta ccgtgcactg tccgggggct ggtgcctgtg
     1681 ctgtggccat cgactcccac accacggcgg gggaggtggc tcgagagctg gtggggcggc
     1741 tgggcttggc ccggagccgc aacgcattcg cgctgtacga gcagcgaggg gcccaggagc
     1801 gagccctggc tggggggacc ctcgtggccg acgtgctcac caggtttgag aacttggccg
     1861 cggaggaagc tgggttggag gactcgcccg actccgggtg gagactatgt ctgcgtcttc
     1921 acggacctct gcaccctgag gggctgtccc cagacggtca cgaactgcct ttcctctttg
     1981 agcaggctca cgctctgctg ctgcggggcc ggccgccccc acccgacgac acgctgcgcg
     2041 ccctggcggc gctgcgcctg cagagcctgc agcgggactt ctctccgcgg gtgcccctgc
     2101 cccgcctgga ccgcctgctc ccgcccccgg ccccgccgcg cgaagacccg ccccgcccga
     2161 cccccaggcc gcccccttcc gctgccctgc tggccggggc gctctggagc ccgggcctgg
     2221 ccaagaggcg ggcggagcgg gcccggcgcg gcggggccgg ccgcactgcg ggaagcattg
     2281 cccgcgaggg aggaggcggc gccggcacgg cagctgccgt gctgggcggc tggaagcggc
     2341 tacggggcat gggccgagct gaggccatgg ccgcctacct ggccctggcg gcgcagtgtc
     2401 cggggttcgg cgctgctcgg tatgacgttc tggagctgag cacggagcct ggtcggggtg
     2461 ctccacagaa gctgtgcctg ggcttgggag ccaaggccat gtccctctcc cggccagggg
     2521 agacggagcc catccacagt gtcagctatg gccatgtggc cgcctgccag ctaatgggcc
     2581 cccacaccct ggccttgagg gtgggagaga gccagctcct cctgcagagc ccccaggtgg
     2641 aagagatcat gcagctggtg aatgcctact tggccaaccc ctcccccgag aggccctgca
     2701 gcagctcttc tcctccatgc caagacctgc cagacacctc ccctcccagc cagcgcccgg
     2761 gcctggacga gccccaggga cagtctggct gcttggggca gctgcaggac tgagcctgcc
     2821 aagaggtcac gacttccctc ctgcctgcag cctgggccag gactgctctg agatttgagg
     2881 gaaacatgga cccttttggc cctgcaggga cagggcacat cccacaccca agggctacaa
     2941 tgggtgtggg taattttcta gtttgtttct taatttattt gtagaagaga agcaaaaaaa
     3001 aaaaaaaagt ttcttattta cacaaa
//
