LOCUS       NM_172069               6994 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pleckstrin homology, MyTH4 and FERM domain containing
            H2 (PLEKHH2), mRNA.
ACCESSION   NM_172069 XM_059415
VERSION     NM_172069.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6994)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 6994)
  AUTHORS   Perisic,L., Lal,M., Hulkko,J., Hultenby,K., Onfelt,B., Sun,Y.,
            Duner,F., Patrakka,J., Betsholtz,C., Uhlen,M., Brismar,H.,
            Tryggvason,K., Wernerson,A. and Pikkarainen,T.
  TITLE     Plekhh2, a novel podocyte protein downregulated in human focal
            segmental glomerulosclerosis, is involved in matrix adhesion and
            actin dynamics
  JOURNAL   Kidney Int 82 (10), 1071-1083 (2012)
   PUBMED   22832517
  REMARK    GeneRIF: Suggest a structural and functional role for Plekhh2 in
            the podocyte foot processes.
REFERENCE   5  (bases 1 to 6994)
  AUTHORS   Greene,C.N., Keong,L.M., Cordovado,S.K. and Mueller,P.W.
  TITLE     Sequence variants in the PLEKHH2 region are associated with
            diabetic nephropathy in the GoKinD study population
  JOURNAL   Hum Genet 124 (3), 255-262 (2008)
   PUBMED   18752002
  REMARK    GeneRIF: PLEKHH2, which has mRNA and protein expression exclusively
            in the glomerulus, may be a genetic risk factor for susceptibility
            to diabetic nephropathy in the diabetic population
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6994)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011242.8, BC063310.1, AL833400.1 and BC031914.1.
            
            On Nov 22, 2018 this sequence version replaced NM_172069.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832207.1, SRR1660803.120582.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282406.9/ ENSP00000282406.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC011242.8         184516-184555       c
            41-2424             BC063310.1         28-2411
            2425-4980           AL833400.1         688-3243
            4981-6994           BC031914.1         156-2169
FEATURES             Location/Qualifiers
     source          1..6994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..6994
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /note="pleckstrin homology, MyTH4 and FERM domain
                     containing H2"
                     /db_xref="GeneID:130271"
                     /db_xref="HGNC:HGNC:30506"
                     /db_xref="MIM:612723"
     exon            1..120
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            121..246
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4605
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /note="pleckstrin homology domain containing, family H
                     (with MyTH4 domain) member 2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family H
                     member 2"
                     /protein_id="NP_742066.2"
                     /db_xref="CCDS:CCDS1812.1"
                     /db_xref="GeneID:130271"
                     /db_xref="HGNC:HGNC:30506"
                     /db_xref="MIM:612723"
                     /translation="MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQ
                     LERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVI
                     QNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIR
                     TMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSK
                     EPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGIS
                     QNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSS
                     IFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKFQS
                     QRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPPPKLRIPNVFSIS
                     VALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDSTEVLENMDTSCD
                     DGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESRIYAVAKSGIRMSE
                     AFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDDSSGS
                     EEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYS
                     QPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSD
                     VIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRV
                     QAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFRSQEDKFPLGQIKLW
                     EAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHL
                     TVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGIISPLTTLPSEAL
                     QTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRR
                     RQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQRCV
                     ERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEF
                     LNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGK
                     CEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMAAL
                     LSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL
                     STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGL
                     SLLEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEI
                     TLLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL"
     exon            247..309
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            310..459
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            460..543
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            544..625
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            626..811
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1773
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1849
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1944
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2089
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2226
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2337
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2424
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2583
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2664
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2844
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2953
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3066
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3246
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3344
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3522
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3678
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3776
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3918
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4064
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4194
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4281
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4419
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..6994
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6973..6978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /note="hexamer: AATAAA"
     polyA_site      6994
                     /gene="PLEKHH2"
                     /gene_synonym="PLEKHH1L"
                     /note="major polyA site"
ORIGIN      
        1 ccccgccctc tccgagctcg gcttgaggcg ggcgcgggct gagagtccgg ggatcccggg
       61 ggccagtcgc ggccgggaca tcgggcgctg cggccgggga cccgctgctg agatagacag
      121 aatatggcag agctttctga gccagaggga ccagtagatt ggaaggaacg atgtgtagct
      181 ctggagtccc aactcatgaa atttagagtt caagcaagca agatacgaga gcttttagca
      241 gagaagatgc aacagcttga gagacaagtt attgatgctg aacgtcaagc agaaaaagct
      301 tttcaacagg tacaagttat ggaagataaa ttaaaagcag ctaatattca aaccagtgaa
      361 tcagagacaa gattatataa taagtgtcaa gatctggagt cgctaataca ggaaaaagat
      421 gacgtcattc aaaacttgga attgcaactt gaagagcaga aacaaataag aatacaagaa
      481 gctaaaataa tagaagagaa agcagctaag ataaaagaat gggtaacagt taagttaaat
      541 gagctggaat tggagaatca gaatcttcgt ttgatcaacc aaaaccaaac tgaagagata
      601 agaacaatgc agtcaaaact acaagaagtt caaggaaaga agtcatccac tgtctctaca
      661 ctaaagcttt cggaaggcca gcgcctgagc agtttgacct ttgggtgctt tttatctcga
      721 gcaaggagtc ctcctcaagt agtaaaatct gaggaaatga gcaagatatc atcgaaagaa
      781 cctgagttca ctgaaggaaa agacatggaa gaaatggaaa ttccagaaaa gtctgttgat
      841 aaccaagttc tagaaaacaa cagaggccag agaacattgc atcaaacccc ttgtggctca
      901 gaacagaatc ggaaaacaag aacaagcttt gccacagatg gtggcatctc ccagaattct
      961 ggggctcctg tgagtgactg gagctctgat gaggaagacg ggagcaaagg aagatccaag
     1021 tccagatgca catccaccct ctccagtcac acatctgagg aaggggtcca gtgtagcagg
     1081 atgggaagtg aaatgtatct gacagcatct gatgacagca gctctatatt tgaggaagag
     1141 acttttggca taaagagacc agaacacaag aagctatatt cttggcagca ggaggcacag
     1201 tggaaagctc taaatagtcc tcttggaaag ggaaattctg aattaagtaa aaaggaacaa
     1261 gatagttcct cggatgaact gaataaaaaa tttcaatccc agagactcga ttattcatct
     1321 tcatcgagtg aagccaacac cccaagccct attttgaccc cagctttaat gccaaagcat
     1381 cctaactcac tctctggaaa aggaacacaa ttagtgcctt catcacacct gccaccccca
     1441 aagttaagga ttcctaatgt tttcagtata agtgtagcac tagccaaaag gcacttaagc
     1501 cagccacagt taagctctga caggatgttt ggtacaaata gaaacgctat aagcatgata
     1561 cgaccactga gacctcagga aactgatctt gatctagttg atggagacag tacagaagtt
     1621 ttagagaata tggacacgag ttgtgatgat ggattatttt cctatgactc cttggactct
     1681 ccaaattcag atgaccagga acactgtgac tcagcaaaga aggtggcata cagcaaacct
     1741 ccaactcctc ccctgcaccg ttttccttct tgggaaagca gaatttatgc tgtagccaaa
     1801 tcaggtattc gaatgtctga ggccttcaat atggagagtg ttaataaaaa ttctgctgca
     1861 accctttcct atactacatc aggactttat acatctctga tatacaagaa catgaccacc
     1921 ccagtgtata caactttgaa ggggaaggcg acccaaataa gtagcagccc tttcctggat
     1981 gactcatctg ggtcagagga agaagacagc tccagatcca gctcccggac gtcagagtca
     2041 gactcacgca gtaggagtgg gccaggcagc cccagagcca tgaaacgagg tgtgtctctc
     2101 tcctctgtgg cttctgaaag tgattatgct attcctcctg atgcttactc cacagacacg
     2161 gagtactcac agccagagca gaagctccca aaaacttgct catcttccag tgataatggg
     2221 aaaaatgaac cactggaaaa atctggttat ttattaaaaa tgagtggtaa agtcaagtct
     2281 tggaagcggc ggtggtttgt tcttaaaggt ggtgaattac tttactacaa atctccgagt
     2341 gatgtaatta gaaaacccca gggccatatt gaacttagtg catcctgtag tattttaaga
     2401 ggagataaca aacaaacagt tcagttgacc actgaaaaac acacatacta tctgactgca
     2461 gattctccca atatattgga agagtggatt aaagtgttac agaatgttct tcgagtacaa
     2521 gctgccaacc cactttccct gcagcctgag ggcaaaccca ccatgaaggg attgctcact
     2581 aaggtaaaac atggatattc caagagagtc tggtgtacac taataggaaa gacattatat
     2641 tattttcgga gtcaagaaga taagtttcct ttaggtcaga tcaaactctg ggaggctaaa
     2701 gtggaagagg ttgacagatc ttgtgattca gatgaagatt atgaagccag tggacgaagt
     2761 ctgttatcca cacattatac tatcgttatc catcccaaag accaaggtcc aacttacctc
     2821 ctaattggat ccaagcatga aaaggacact tggctttatc atctgactgt tgcagctgga
     2881 agcaacaatg taaacgttgg atctgaattt gaacaactgg tttgcaaatt gctaaatata
     2941 gacggggagc cttcctctca gatatggaga caccccactt tgtgtcacag taaagaagga
     3001 atcatttccc ctctgacaac tctaccttcc gaagccctgc agacagaagc tattaaatta
     3061 tttaagacct gccagctttt tataaatgct gcagttgact ctcctgcaat tgattaccac
     3121 atatctttag cccagagtgc tttgcaaatc tgcctgacac atcctgagct gcagaatgaa
     3181 atttgctgtc agcttattaa acagacaaga cgaagacagc cacagaatca accaggacca
     3241 ttgcagggct ggcagctctt ggcactctgc gttgggctct tccttcccca tcatcctttc
     3301 ctgtggctcc tcaggcttca cctaaagagg aatgcagatt ccaggacaga atttggaaaa
     3361 tatgccattt actgccagcg ttgtgtagaa agaacgcaac aaaatggtga cagagaagca
     3421 agaccctcaa ggatggaaat tctttcaact cttctccgaa acccttatca ccattctttg
     3481 ccctttagta tacctgtgca cttcatgaat gggatatacc aggtagttgg ttttgacgca
     3541 tctaccacag tggaagaatt tttgaatact ttgaaccagg acacaggaat gaggaaacca
     3601 gcgcagtctg gatttgcgtt gttcactgac gatccttctg gcagagattt agagcattgt
     3661 cttcaaggaa acatcaagat ttgtgacatt atttccaaat gggaacaggc ttccaaagaa
     3721 cagcagcctg gaaaatgtga aggtacaagg actgttcgtc tgacatacaa aaacagacta
     3781 tatttctcag tgcaagctcg tggagagact gatagagaaa agttgctgtt aatgtatcag
     3841 acaaatgatc aaatcataaa tggacttttt cctctgaaca aagatctggc attagaaatg
     3901 gcagctcttt tatctcaggt agagattgga gattttgaaa gacctttctc aactccagca
     3961 gggcatgtta ccaatcagtg caaagtgaat caaactctaa agcaagtcat agagaaattt
     4021 tatcctaaaa ggtatagaga tggctgttct gaagagcagt taaggcagct ttgccagcga
     4081 ctttcaacca gatggatggc cctccgggga cacagtgctg ctgactgtgt gcgcatttat
     4141 ttgacagtag ccaggaagtg gccattcttt ggtgccaagt tgtttcttgc aaaacccata
     4201 actccatcat cacttggaag tactttcttg tggctggctg tacatgagga tggtttaagc
     4261 ctcttagaat acaactccat gaggttaata gtcagctatg tgtacaagag tctaatgacc
     4321 tttggaggct atcaagatga ttttatggta gtcattaaca atacacattc aaaggacaaa
     4381 ccaacagaga aattactttt tgccatggca aaacccaaga ttcttgaaat cactcttttg
     4441 atcgccagtt acataaacaa cttccatcag caaaaggcag catttcacca cctctctgct
     4501 ccagcactgc tctcagccca gacccgggga ccccaagcca gaatgatggg aagccagcct
     4561 cttctgtcaa gcagcagacc gaccaaaggc cccaccttac tctgaaagct ggggagcctg
     4621 aacattcact ccttgtcctc catgctgtgg ctgtatcagc tccctacaag ttcgtttaca
     4681 cctggcagca cggcagccac acaccggtat tccaaacctt aacaatgaag ggggttagtc
     4741 tcttttattt gattcttaaa tattcaaata aatattaaca gtaaaacata aacacaaaat
     4801 ttgccaacac actaattttc ttatagagta aatgagtaag aattcatcat tttttccatc
     4861 tcccttctcc cttgtcatca gacacattgt gcaatgtggc ttttcttttc ttttcttttt
     4921 ttcccctttt taatattctg gcaatcttta gaaagggaga ttccaaactc ccatttggta
     4981 aaccagttga ttatttggaa atgttcactg ccaaaatagt aagtgctata actaaatgcg
     5041 cttttaatta atgatatagt gtttggaaag gagtagaaca tgcagcataa gaaactgctg
     5101 cagagtggtg cgaggagtac attttcagag caggtgcagt acatcttccg gctctatgaa
     5161 tcattatgtg agaaagcagg ataacattag gtaacctgag cctcctgtgt ggtattagaa
     5221 agtataccgt caccttttca catcactgga gtgtaaaatt taaaacaaga tggtgattcc
     5281 tgacattcct tggctgtcag tgctgcccag attcagaaga atattgccca catttcactg
     5341 tatttggtgc tgggtcattt tgaccttgct ttgttaataa tatctttaaa aacaaagaca
     5401 atccttaaag ctttgctcct cacacattac cttctaatta tagtttgaaa atagattccc
     5461 tacacataca tacatatgta tgcacagata gggtcttgct atgttgccca ggctggtctt
     5521 gaactcctgg cctcaagcaa tcctctctcc tcagcctccc aaagtgctgg gattacaagt
     5581 gtgagccacc acacctggct ccagaaattt tattttattt ttttgaggca gggtctcact
     5641 ctggttgccc aggctggagt gcagtggtgc catcatagct cactgtagcc tcgaccttcc
     5701 gggatcaagc aatcccactt cagcctcttg aatagctggg actagaagca tgcaccacca
     5761 tgcccatcta atatttgtat ttttagtaga gacaggatct ccctatgttg tccagcctag
     5821 tctcaaactc ctgggttcaa gcaatcctcc cacctcggcc tcccaaagtg ctgggattgc
     5881 aggcatgagc caccgtgccc agcctcaaaa atatttttta aaagaaaaga gaaaataatt
     5941 cttctgtcaa aggaggttaa attttagttg atagagtact taaatgcatt actttattag
     6001 gttatgtaag tggtcagtgc attccagtat gtgtcacaac agtgtagttc atattcatga
     6061 taaaaatgaa actgtgataa gacatgaaaa ttatattatt aaaatgttca attgtaatgg
     6121 taatcatgag tatacttaat tttatttatg tatagaatat ttgtatttat tttttggaca
     6181 tatatttatc actttgtcat tttttttaac caatttgaga aatgttagct gctgaattaa
     6241 tttgttgccc gagccttcat attttcttct ttgctgcctt ctccctgtgg caatgtactg
     6301 ttctcacatt aagcctttta aaaatgttcc atactgtatt agcatcctta gaagggacag
     6361 aactaagaaa tacattgctc aaataatatt ttactttatt gataatgaca aaaagaatat
     6421 tttttaaacc ccatcaaaat agatttcaat tgactgtttc ccctacatct tttgagccac
     6481 agtcgcccat cgaataagca aatttgtttt tgagaataaa ctggtaacca gtttgtgatg
     6541 actctcagaa gccttttggc tgggttacag aagagtttct aagttcctag agagccattt
     6601 aataattagt tggtgagcca gaggcttgac agagctgtta cttatgtgtg agggctttat
     6661 tctcaggcag tagtttattc atcatttggt aagcccctcc ccacactcct ctaatttaaa
     6721 caagtagtga aggcttatct taaactgtgt agtaccttag acttggcatt tatttttgat
     6781 agagcagaga taaaatattt tgatggaagg aaatcaattt tctgtaactg atgatgtgaa
     6841 aattttattt tctgggaaat tatatagcca ttcaaaaatt caaagtatgt tattatgatt
     6901 ggttacaaga gaataatgtt acatgtttaa ttgtaatatt tgtctcctat cattttcttc
     6961 cctttcagtc ataataaatg atttacaaaa ccca
//
