LOCUS       NM_001377329            4641 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens pleckstrin homology and RhoGEF domain containing G7
            (PLEKHG7), transcript variant 3, mRNA.
ACCESSION   NM_001377329
VERSION     NM_001377329.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
            Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
  TITLE     GWAS for discovery and replication of genetic loci associated with
            sudden cardiac arrest in patients with coronary artery disease
  JOURNAL   BMC Cardiovasc Disord 11, 29 (2011)
   PUBMED   21658281
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016136.21.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA2144335 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344636.6/ ENSP00000344961.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC016136.21        34405-34548
            145-812             AC016136.21        37887-38554
            813-835             AC016136.21        39066-39088
            836-963             AC016136.21        60409-60536
            964-1004            AC016136.21        63649-63689
            1005-1100           AC016136.21        67898-67993
            1101-1244           AC016136.21        68794-68937
            1245-1340           AC016136.21        72269-72364
            1341-1442           AC016136.21        72907-73008
            1443-1556           AC016136.21        76894-77007
            1557-1731           AC016136.21        85506-85680
            1732-1847           AC016136.21        87241-87356
            1848-1941           AC016136.21        87714-87807
            1942-2021           AC016136.21        93168-93247
            2022-2175           AC016136.21        95457-95610
            2176-2273           AC016136.21        100399-100496
            2274-4641           AC016136.21        101504-103871
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..4641
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /note="pleckstrin homology and RhoGEF domain containing
                     G7"
                     /db_xref="GeneID:440107"
                     /db_xref="HGNC:HGNC:33829"
     exon            1..144
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            145..812
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2381
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /note="isoform 3 is encoded by transcript variant 3;
                     pleckstrin homology domain-containing family G member 7;
                     PH domain-containing family G member 7; pleckstrin
                     homology domain containing, family G (with RhoGef domain)
                     member 7; uncharacterized protein C12orf74"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 7 isoform 3"
                     /protein_id="NP_001364258.1"
                     /db_xref="CCDS:CCDS91737.1"
                     /db_xref="GeneID:440107"
                     /db_xref="HGNC:HGNC:33829"
                     /translation="MEKTESFCPEVPPQDCGASPRPSLRSLPKNQGSLLQFDRQAPGR
                     ISTSPTLRRLRTRGCGTRQDAWQVTTWGSWGAPVGFPCYLSKSLPGSPKDSSHLLSPL
                     RLHSRLTSEPERALNAADSLEPQTRPTDKYLPPELQPVNEGSLHQASLRQQEGHFLPS
                     PTLRHPSPQGEELHPSRFYEHRRSSVVLNLPGLEVFPGDLLVSDGAADYLCHPLLLLN
                     SESKKPRWPFSKRGVGKDKHKHISDLENCLSSVKITSFRGYDFYGLKDKTWDEVLETH
                     HKLPTDQLDLKKQQEAVWELFTSECTYFLDHLLVLKMIFMNTLRYLQTHEYLLDVDLW
                     RLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQTY
                     CLNYSAAIFYLESLRQRDDFGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPLLLKN
                     IWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDK
                     RFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTRFLDVYLFLFNDFLLVTK
                     TKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHVSV
                     FGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTKSQETKKISLF
                     TLPAESSEI"
     exon            813..835
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            836..963
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1004
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1100
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1244
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1340
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1442
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1556
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1731
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1847
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1941
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2021
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2175
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2273
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..4641
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2764..2769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /note="hexamer: CATAAA"
     polyA_site      2782
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /note="major polyA site"
     regulatory      4618..4623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /note="hexamer: AATAAA"
     polyA_site      4641
                     /gene="PLEKHG7"
                     /gene_synonym="C12orf74"
                     /note="major polyA site"
ORIGIN      
        1 actcagccag gaggacgcat tgttacaggt gtggaacttg ttgctccgag ccctcgcctg
       61 gcagctcact ctggatctgc gggttctgag gagcctcggg acccacctgg gtgcagttgc
      121 cttcagggac agaccatctt acagatgcaa taacctgctt gacattctcc tctggaaaag
      181 gaaaagaact acgagaggaa gcatggcact tggatgcaga aattgagcac cctccatgtg
      241 atccagagaa cagcaactca tacgtcttct ggaaccttct accaacagta gaacctctta
      301 gctttatgga gaaaacagag tcattctgtc cagaggtgcc accccaagac tgtggagcct
      361 ctcctcggcc ctcgctgagg agcctgccaa agaaccaggg gagtctcctc cagtttgacc
      421 ggcaagcccc aggccgcatc tccacctcgc ccactttgag gagattaagg acccgtggct
      481 gtgggacaag gcaggatgcc tggcaggtga ccacctgggg aagctgggga gctcctgtgg
      541 gcttcccatg ttacctttcg aagagcctgc caggaagccc aaaggattct tcacacttgc
      601 tgtcaccctt gagactccac tcaagattga cctctgaacc tgaaagggcc ctgaatgcag
      661 ctgactcact ggagccccaa acccggccca ctgacaagta tctccctcct gagcttcagc
      721 ctgtcaatga agggtccctt caccaggcct ctcttcggca gcaagaaggc cacttcctgc
      781 ccagccccac cctacgacac cctagtcctc agggagaaga attgcaccca tccaggttct
      841 acgagcacag gcggagttct gtggtgctga acttacctgg acttgaggtg ttccccgggg
      901 accttctggt gtcagatgga gctgctgatt acctatgcca tccacttctg ctgctgaatt
      961 cagaatccaa aaagccaaga tggcctttct ccaaaagagg agtgggcaaa gacaaacaca
     1021 agcacatatc tgatctggaa aactgcctgt cctctgtgaa aattaccagc ttcaggggct
     1081 atgacttcta cggtcttaag gataagacct gggatgaagt cttggaaaca catcacaaac
     1141 tcccgaccga tcaattagac ctgaaaaagc agcaagaggc cgtgtgggaa cttttcacaa
     1201 gtgaatgcac ctattttttg gaccatttat tagttcttaa gatgatcttt atgaatacac
     1261 taagatatct gcaaactcat gaatatctcc tagatgtgga tttatggaga ctttttgcaa
     1321 acctggagga gttaactcag acaagccttg gttttgtgaa cagtctcttt ggcatcatca
     1381 aggactatgt agacgcttct gagatttcct catcactgga ttttatttcc gtgctcacaa
     1441 agtatttccg agggagtctc tgtcagagcc accagaccta ctgcctgaac tattcagctg
     1501 ctatctttta tcttgagagc ctgaggcaga gagatgactt tggaatttat ttaaaatggt
     1561 gtgagcagaa tgaacaatgc agacggctcc acgtgccaga gctgctagtg gccccactac
     1621 agaggctcac tcgatatccg ttgttgctga agaatatctg gaaaaggagc atggactctg
     1681 ctgagaaaat catgatctac tccatcaagg aaaaggtgga aaagtccatc cgggaccttg
     1741 aaggaaaagt gaagtggctg gacaatttcc aaaaatttag atatctacag gagattatag
     1801 tgtggccacc gctttgggat agagataaaa ggtttttcat tccagagtgt ttgaaacaca
     1861 tttttaaaga acacatggca gaaaacatct tgtcaccaac cagcagacac cttctctatg
     1921 aaggaaaatt aactcttgca gaaagcacga gattcctaga tgtttatctg tttctcttca
     1981 atgatttcct cttagttacg aaaactaagt gcaacaaaaa gaaacttgga ggctcagacc
     2041 ctggtttaat gtgtccttct cttactcctg agttgcaagc agtaataaaa gagggtggtt
     2101 cgtgtacagt actcgatcag cctattccac tagatagatt ggtagtcaaa agtattgaac
     2161 cactccatgt gtcagtcttt gggctgagaa atgcttttct tatacaacac gaaaacagat
     2221 atcgacagtg tatagcagca ttcttattac aagcccaaac ggaaaacatc aaaaaaacat
     2281 ggatggcaca aataacaact gcaatttctt gctttaccaa gagtcaggaa accaagaaaa
     2341 tatctttatt cacattgccc gcagaatcct ctgaaattta gggacctaaa acaagtggca
     2401 tgtcttttta gaagattatg gtttaaggta taatttcatt caaagttttg taacacttag
     2461 ctagtgataa gctagaagga aatttgcatt ttaaagaagt ttcagaattt gaaattttga
     2521 gctaggaaaa tcctcagtat agaggaataa tgactgcaac aaatttgaac tctgaggaat
     2581 ttcttgacaa atatatactg acatccagat taccttctaa tgcttccgtc aggtttgtaa
     2641 gaggtgtgag tgaagaaagg tgctaatttg taaagggtga atgatcagat aaatggagta
     2701 tcagaaggaa aacaatgtcc actgcttatg tccaatatga actccagcat cttactctgt
     2761 atccataaaa taatgaaacc aattttcctt catggcctgt caatcagtct taaccgcttt
     2821 atagtcctac ctcaaacata atgataaatc tttagataca aagcttgatt gttcttttaa
     2881 tatacaaagc aataaatagg gactacattt aagtagcagt tttaaaattc ctattctcaa
     2941 actcatctca ggtatatagt actctaacgt ggaagtagaa aatcccaaag actaaattcc
     3001 attactttaa gataggaaga aaaaaaaaat ctggctttca ccagttaaca cttttgcatg
     3061 gcttttcttg gcctgttgtg aagtgtacag attttcatag acatagtaag gtatctgtct
     3121 cttaacttta ttttttgaag aatgatggtg tttgccataa aaatactttc tggttttgat
     3181 tggtgtgtgt gtgtgtgtgt gtgtgtgtta gcacagtaca gtcacttaat tttatttggc
     3241 aggacttcaa atttcttcag aatttttatc atgaaaggca gtttgaataa ttattatcat
     3301 ggcaggatat atactattaa ctacattcaa ggaactagtt cttagggtca gattattgca
     3361 tcaaagggaa gtccacaaac ttccatttca gaatcgtacc ttttgcaatt tgcaaagtga
     3421 aagtagtaaa tttatcaaat ttggctgcaa gacaactgaa gccttagctg attttgttaa
     3481 gctgaagaat ggggtagaga ggataatgtt tgggcaagtc atgtgcccag taattccttg
     3541 aggaaggtga aatttcacta tgcaaacaaa gcagtaaaga caagtgcagc agaaaggctt
     3601 ttgtacaagg caagcactat tagaatggag actaataacc tctttataat aatgtcagaa
     3661 atttaataga agaaaaaaag gaaaatctgg aggacagtaa ctattgttaa tagctaagaa
     3721 taaatgaggt ggaggggaga aaaaggggag aatagacttc aagcttcaag tgaattccta
     3781 gagatggcat ctggatggga ctgaaagcag ttatgtccag gagaatacaa tatagattat
     3841 gcaagagaag attttataaa gaaatttctg gttaaaaaaa atttttacat taacaatcat
     3901 cttgcaaatg tttagatata aactaacctc ggaggtgagc agtggactag gatgaggtgg
     3961 cctctcaaat tcctttagtc ccatgaatcc agcaaccaca gacttacatg tataaaggta
     4021 gttttctccc tctgaatctc attaaaggga gagacagact gactaaatta acaaaatata
     4081 taaaacagct caagaatatg ctgtacataa actggaattc tataaagctc acaaagtaac
     4141 atgtctaata tacaatatat tagatgtttg aggatatgca cattaaactc tttggagggt
     4201 ttagaatgaa gcacattcga atgaagggat cacgggggtc agaacaaaaa ccattctaga
     4261 accgtggctc ccaggaagaa aaaatagcaa aaaacaatgg cacattgggc cttccaaaaa
     4321 gtatctttgg ggaggggagg gagaaaaata aataaataaa taaataaata atgttttaag
     4381 tatctttaaa tggtcatctg ggtattaaat gcagacacac aatgaaataa ggggttaatt
     4441 acatattttt tatatttgtt tttagttttg ttaattctct acaatattaa atggaatgtc
     4501 taaggcaaaa tggcattaat aatttctctt gagatcagga atttaattac tattcgaaat
     4561 tgaacaacat taaaacacca ctgtctatat ccaagtgcaa agtcctaata ttctgtaaat
     4621 aaattaatgc aaaatggtta a
//
