LOCUS       NM_020631               3580 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens pleckstrin homology and RhoGEF domain containing G5
            (PLEKHG5), transcript variant 1, mRNA.
ACCESSION   NM_020631
VERSION     NM_020631.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3580)
  AUTHORS   Boyd,R.J., Olson,T.L., Zook,J.D., Stein,D., Aceves,M., Lin,W.H.,
            Craciunescu,F.M., Hansen,D.T., Anastasiadis,P.Z., Singharoy,A. and
            Fromme,P.
  TITLE     Characterization and computational simulation of human Syx, a
            RhoGEF implicated in glioblastoma
  JOURNAL   FASEB J 36 (7), e22378 (2022)
   PUBMED   35639414
  REMARK    GeneRIF: Characterization and computational simulation of human
            Syx, a RhoGEF implicated in glioblastoma.
REFERENCE   2  (bases 1 to 3580)
  AUTHORS   Chen,Z., Maroofian,R., Basak,A.N., Shingavi,L., Karakaya,M.,
            Efthymiou,S., Gustavsson,E.K., Meier,L., Polavarapu,K.,
            Vengalil,S., Preethish-Kumar,V., Nandeesh,B.N., Gokce Gunes,N.,
            Akan,O., Candan,F., Schrank,B., Zuchner,S., Murphy,D., Kapoor,M.,
            Ryten,M., Wirth,B., Reilly,M.M., Nalini,A., Houlden,H. and
            Sarraf,P.
  TITLE     Novel variants broaden the phenotypic spectrum of
            PLEKHG5-associated neuropathies
  JOURNAL   Eur J Neurol 28 (4), 1344-1355 (2021)
   PUBMED   33220101
  REMARK    GeneRIF: Novel variants broaden the phenotypic spectrum of
            PLEKHG5-associated neuropathies.
REFERENCE   3  (bases 1 to 3580)
  AUTHORS   Witte,K.E., Slotta,C., Lutkemeyer,M., Kitke,A., Coras,R., Simon,M.,
            Kaltschmidt,C. and Kaltschmidt,B.
  TITLE     PLEKHG5 regulates autophagy, survival and MGMT expression in
            U251-MG glioblastoma cells
  JOURNAL   Sci Rep 10 (1), 21858 (2020)
   PUBMED   33318498
  REMARK    GeneRIF: PLEKHG5 regulates autophagy, survival and MGMT expression
            in U251-MG glioblastoma cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3580)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3580)
  AUTHORS   Qian,M., Chen,Z., Wang,S., Guo,X., Zhang,Z., Qiu,W., Gao,X., Xu,J.,
            Zhao,R., Xue,H. and Li,G.
  TITLE     PLEKHG5 is a novel prognostic biomarker in glioma patients
  JOURNAL   Int J Clin Oncol 24 (11), 1350-1358 (2019)
   PUBMED   31309383
  REMARK    GeneRIF: PLEKHG5 promoted glioma cell migration and invasion.The
            expression patterns of PLEKHG5 are related to the glioma patients'
            survival.
REFERENCE   6  (bases 1 to 3580)
  AUTHORS   Rabizadeh,S. and Bredesen,D.E.
  TITLE     Ten years on: mediation of cell death by the common neurotrophin
            receptor p75(NTR)
  JOURNAL   Cytokine Growth Factor Rev 14 (3-4), 225-239 (2003)
   PUBMED   12787561
  REMARK    Review article
REFERENCE   7  (bases 1 to 3580)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   8  (bases 1 to 3580)
  AUTHORS   Salehi,A.H., Xanthoudakis,S. and Barker,P.A.
  TITLE     NRAGE, a p75 neurotrophin receptor-interacting protein, induces
            caspase activation and cell death through a JNK-dependent
            mitochondrial pathway
  JOURNAL   J Biol Chem 277 (50), 48043-48050 (2002)
   PUBMED   12376548
REFERENCE   9  (bases 1 to 3580)
  AUTHORS   Harrington,A.W., Kim,J.Y. and Yoon,S.O.
  TITLE     Activation of Rac GTPase by p75 is necessary for c-jun N-terminal
            kinase-mediated apoptosis
  JOURNAL   J Neurosci 22 (1), 156-166 (2002)
   PUBMED   11756498
REFERENCE   10 (bases 1 to 3580)
  AUTHORS   De Toledo,M., Coulon,V., Schmidt,S., Fort,P. and Blangy,A.
  TITLE     The gene for a new brain specific RhoA exchange factor maps to the
            highly unstable chromosomal region 1p36.2-1p36.3
  JOURNAL   Oncogene 20 (50), 7307-7317 (2001)
   PUBMED   11704860
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024676.1 and AL158217.25.
            
            On Jan 31, 2020 this sequence version replaced NM_020631.5.
            
            Summary: This gene encodes a protein that activates the nuclear
            factor kappa B (NFKB1) signaling pathway. Mutations in this gene
            are associated with autosomal recessive distal spinal muscular
            atrophy. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, May 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024676.1, SRR18074969.3065402.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377728.8/ ENSP00000366957.3
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3575              AK024676.1         34-3608
            3576-3580           AL158217.25        16295-16299         c
FEATURES             Location/Qualifiers
     source          1..3580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..3580
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /note="pleckstrin homology and RhoGEF domain containing
                     G5"
                     /db_xref="GeneID:57449"
                     /db_xref="HGNC:HGNC:29105"
                     /db_xref="MIM:611101"
     exon            1..31
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            32..161
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3139
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /note="isoform a is encoded by transcript variant 1;
                     pleckstrin homology domain-containing family G member 5;
                     NFkB activating protein; novel PH domain-containing
                     protein; PH domain-containing family G member 5;
                     pleckstrin homology domain containing, family G (with
                     RhoGef domain) member 5; guanine nucleotide exchange
                     factor 720; synectin-binding guanine exchange factor"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 5 isoform a"
                     /protein_id="NP_065682.2"
                     /db_xref="CCDS:CCDS79.1"
                     /db_xref="GeneID:57449"
                     /db_xref="HGNC:HGNC:29105"
                     /db_xref="MIM:611101"
                     /translation="MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEES
                     SVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGE
                     VLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQG
                     MKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQ
                     EPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGK
                     LHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQ
                     CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQ
                     LHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMR
                     GLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAK
                     EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFL
                     HLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERT
                     RVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNA
                     QNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSGTSAASSPTIMRK
                     SSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETSLSTTASSATP
                     TSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPMAELVPRAPESPRVPSPPPSP
                     RLRRRTPVQLLSCPPHLLKSKSEASLLQLLAGAGTHGTPSAPSRSLSELCLAVPAPGI
                     RTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLPSGASPRVQPEP
                     PPGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV"
     exon            162..267
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            268..328
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            329..420
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            421..557
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            558..709
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            710..913
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1102
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1198
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1249
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1399
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1510
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1660
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1798
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1918
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2051
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2167
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2367
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..3129
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3580
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3558..3563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /note="hexamer: TATAAA"
     polyA_site      3580
                     /gene="PLEKHG5"
                     /gene_synonym="ARHGEF45; CMTRIC; DSMA4; GEF720; HMNR4;
                     Syx; Tech"
                     /note="major polyA site"
ORIGIN      
        1 gaggccccca tggagaaggg acgggcagga tgtatgtcac cacgccgact gccagcagct
       61 gcaccgccgg gggcccctca acctctgcga ggcctgtgac agcaagttcc acagcaccat
      121 gcattatgat gggcatgtcc gcttcgacct tcccccacaa ggctctgtgc tggcccggaa
      181 cgtgtccacc cggtcatgcc cgccgcgcac cagccccgca gtggacttgg aggaggagga
      241 ggaggagagc tctgtggatg gcaaagggga ccggaagagc acaggcctga aactctccaa
      301 gaagaaagca aggaggagac acacggatga cccaagcaag gaatgcttca ctctgaaatt
      361 tgacctgaat gtggacattg agacagagat cgtcccagcc atgaagaaga agtcactggg
      421 ggaggtgctg ctgcctgtat ttgaaaggaa gggcattgcg ctgggcaaag tggacatcta
      481 cctggaccag tccaacacac ccctgtccct caccttcgag gcctacaggt tcgggggaca
      541 ctaccttcgt gtcaaagccc cagccaagcc tggagatgag ggcaaggtgg agcagggcat
      601 gaaggactcc aagtccctga gtttgccgat tctgcggcca gctgggaccg ggccccccgc
      661 cctggagcgt gtggacgccc agagccgccg ggagagcctg gacatcttgg cccctggccg
      721 ccgccgcaag aacatgtcgg agttcctggg ggaggcgagc atccccgggc aggagccccc
      781 cacgccctcc agctgctctc tgcccagcgg cagcagtggc agcaccaaca ctggcgacag
      841 ctggaagaac cgggcggcca gtcgcttcag cggctttttc agctccggcc ccagcaccag
      901 cgcctttggc cgggaggtag acaagatgga gcagctggag ggcaagctgc acacctacag
      961 cctcttcggg ctgcccaggc tgccccgggg gctgcgcttc gaccatgact cctgggagga
     1021 ggagtacgat gaagacgagg atgaggacaa tgcctgcctg aggctggagg acagctggcg
     1081 ggagctcatt gatgggcatg agaagctgac ccggcggcag tgccaccagc aggaggcggt
     1141 gtgggagctg ctgcacacgg aggcctccta catcaggaaa ctgcgggtga tcatcaacct
     1201 gttcctgtgc tgcctcctga acctgcaaga gtcagggctg ctgtgtgagg tggaggcgga
     1261 gcgcctgttc agcaacatcc cggagatcgc gcagctgcac cgcaggctgt gggctagcgt
     1321 gatggcgccg gtgctggaga aggcgcggcg cacgcgagcg ctgctacagc ccggggactt
     1381 cctcaaaggc ttcaagatgt tcggctcgct cttcaagccc tacatccgct actgcatgga
     1441 ggaggagggc tgcatggagt acatgcgcgg cctgctgcgc gacaacgacc tcttccgggc
     1501 ctacatcacg tgggcggaga agcacccaca gtgccagagg ctgaagctga gcgacatgct
     1561 ggccaaaccc caccagcggc tcaccaagta cccgctgctg ctcaagtcgg tgctgaggaa
     1621 gaccgaggag ccgcgcgcca aggaggccgt cgtcgccatg atcggctccg tggagcgctt
     1681 catccaccac gtgaacgcgt gcatgcggca gcggcaggag cggcagcggc tggcggccgt
     1741 ggtgagccgc atcgacgcct acgaggtggt ggaaagcagc agcgacgaag tggacaagct
     1801 cctgaaggaa tttctgcacc tggacttgac agcgcccatc cctggcgcct ccccggagga
     1861 gacgcggcag ctgctgctgg aggggagcct gaggatgaag gaggggaagg acagcaagat
     1921 ggatgtgtac tgcttcctct tcacggatct gctgttggtg accaaagcag tgaagaaggc
     1981 agagaggacc agggtcatca ggccacccct gctcgtggac aagattgtgt gccgggagct
     2041 acgggaccct gggtccttcc tccttatcta cctgaatgag tttcacagtg ctgtaggggc
     2101 ctacacgttc caggccagtg gccaggcctt gtgccgtggc tgggtggaca ccatttacaa
     2161 tgcccagaac cagctgcaac agctgcgtgc acaggagccc ccaggcagtc agcagcccct
     2221 gcagagcctg gaagaggagg aggatgagca ggaggaggaa gaggaggagg aggaggagga
     2281 ggaggaaggc gaggacagtg gcacttcagc tgccagctcc cctaccatca tgcggaaaag
     2341 cagcggcagc cccgactctc agcactgtgc ctcagatggc tccacggaga ccctggccat
     2401 ggttgtggta gagcctgggg acacgctgtc ctcccccgag ttcgacagcg gtcctttcag
     2461 ctcccagtct gatgagacct ctctcagcac cactgcctca tctgccacgc ccaccagtga
     2521 gctgctgccc ctgggtccgg tggacggccg ctcctgctcc atggactctg cctacggcac
     2581 cctctcccca acctccttac aagactttgt ggccccaggc ccaatggcag agctagtgcc
     2641 tcgggcccca gagtccccac gagttccttc ccctccaccc tcgccccgtc tccgccgccg
     2701 cacccctgtc cagctgttga gctgcccgcc ccacctgctc aagtctaagt ccgaggccag
     2761 cctcctccag ctgctggcag gggctggcac ccatgggaca ccctctgccc ccagccgcag
     2821 cctgtcagag ctctgcctgg ctgttccagc cccaggtatt aggactcagg gctcccctca
     2881 ggaagctggg cccagctggg attgccgagg ggcccctagc cctggcagcg gtcctgggct
     2941 agtcggctgc ctggccgggg aacctgcagg ctcccacagg aagaggtgtg gagacctgcc
     3001 ctcgggggcc tctcccaggg tccagcctga gcccccacca ggggtctctg cccagcacag
     3061 gaagctgacc ctggcccagc tctaccgaat caggaccacc ctgctgctta actccacgct
     3121 cactgcctcg gaggtctgag cagagggagg cccccaagag tgccattgac caagagacag
     3181 cagacagcct gcctcctggg gcgtgccggc acctgcttca gctactgcct cctgtatgca
     3241 tgagccggat gctgggcagg atccctgcct acgcccgggc ccgatttgcg ctttgccgga
     3301 ctggatggag tggaggaggc ccaggccaca gtaccacccc acctgcccag gcagcccctc
     3361 gtcacctact ccccgaagtt accagctcag ctcgagtctt cagggctggg ctcctaggct
     3421 gcccatccta cttctaccct cactggcctc cagtgggatt cactcctgcc ctgcccccac
     3481 cttcccagtc ccacaggcca cccctggctt gggctgggtt ctgtgaagtt acgtatttat
     3541 tgagcttttg gttcttttat aaagacttgt ctagactcca
//
