LOCUS       NM_001308147           10526 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pleckstrin homology and RhoGEF domain containing G3
            (PLEKHG3), mRNA.
ACCESSION   NM_001308147 XM_005267513
VERSION     NM_001308147.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10526)
  AUTHORS   Nguyen,T.T., Park,W.S., Park,B.O., Kim,C.Y., Oh,Y., Kim,J.M.,
            Choi,H., Kyung,T., Kim,C.H., Lee,G., Hahn,K.M., Meyer,T. and
            Heo,W.D.
  TITLE     PLEKHG3 enhances polarized cell migration by activating actin
            filaments at the cell front
  JOURNAL   Proc Natl Acad Sci U S A 113 (36), 10091-10096 (2016)
   PUBMED   27555588
  REMARK    GeneRIF: PLEKHG3 enhances polarized cell migration by activating
            actin filaments at the cell front.
REFERENCE   2  (bases 1 to 10526)
  AUTHORS   Griswold,A.J., Ma,D., Sacharow,S.J., Robinson,J.L., Jaworski,J.M.,
            Wright,H.H., Abramson,R.K., Lybaek,H., Oyen,N., Cuccaro,M.L.,
            Gilbert,J.R. and Pericak-Vance,M.A.
  TITLE     A de novo 1.5 Mb microdeletion on chromosome 14q23.2-23.3 in a
            patient with autism and spherocytosis
  JOURNAL   Autism Res 4 (3), 221-227 (2011)
   PUBMED   21360829
  REMARK    GeneRIF: This is the first implication of chr14q23.2-23.3 in the
            etiology of autism and points to MTHFD1, PLEKHG3, and CHURC1 as
            potential candidate genes contributing to autism risk.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY057390.1, BC129953.1, CN284264.1, BX248779.1, BC129952.1,
            BU681724.1 and AL121774.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001308147.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.150426.1,
                                           SRR1803617.72740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247226.13/ ENSP00000247226.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               HY057390.1         17-189
            174-751             BC129953.1         1-578
            752-752             CN284264.1         501-501
            753-1048            BC129953.1         580-875
            1049-1049           BX248779.1         869-869
            1050-2110           BC129953.1         877-1937
            2111-2111           BC129952.1         1619-1619
            2112-4569           BC129953.1         1939-4396
            4570-4623           BU681724.1         17-70               c
            4624-10526          AL121774.5         83717-89619         c
FEATURES             Location/Qualifiers
     source          1..10526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..10526
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /note="pleckstrin homology and RhoGEF domain containing
                     G3"
                     /db_xref="GeneID:26030"
                     /db_xref="HGNC:HGNC:20364"
                     /db_xref="MIM:617940"
     exon            1..281
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            282..671
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..3980
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /note="pleckstrin homology domain containing, family G,
                     member 3; PH domain-containing family G member 3;
                     pleckstrin homology domain containing, family G (with
                     RhoGef domain) member 3"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 3"
                     /protein_id="NP_001295076.1"
                     /db_xref="CCDS:CCDS76690.1"
                     /db_xref="GeneID:26030"
                     /db_xref="HGNC:HGNC:20364"
                     /db_xref="MIM:617940"
                     /translation="MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEA
                     PAKNGAGSLRSRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIV
                     ETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIENIYALNSQLLRDLDSCN
                     SDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSL
                     PLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRH
                     EHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRG
                     DHFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRL
                     ILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEP
                     TKHLLRQLNEKARAAGMKGKGRRESESSRSSRRPSGRSPTSTEKRMSFESISSLPEVE
                     PDPEAGSEQEVFSAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAA
                     ESTEDLKALSSEEEEEMGGAAQEPESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDS
                     KSSGFGSPRLVSRSSSVLSLEGSEKGLARHGSATDSLSCQLSPEVDISVGVATEDSPS
                     VNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRE
                     SLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQVGSRPTSWALFELPGPSQAVKG
                     DPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQANGFDLHEPLFILEEHELGA
                     ITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQGELVAPLHPRIVQLSHVM
                     DSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEA
                     GEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFFFNPSAVSQRTTSPG
                     GRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSHSVPENMVE
                     PPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADLTLEDNRRVIV
                     MEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDPADPSQQGR
                     VRNLREKFQALNSVG"
     exon            672..769
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            770..839
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            840..886
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1037
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1169
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1352
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1445
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1532
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1566
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1665
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1704
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1724
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1838
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..3258
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..10526
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4622
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /note="major polyA site"
     regulatory      10506..10511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
                     /note="hexamer: ATTAAA"
     polyA_site      10526
                     /gene="PLEKHG3"
                     /gene_synonym="ARHGEF43; KIAA0599"
ORIGIN      
        1 gctccctcgc tccctcgctc cctcctgccc tcccgctgca gctccggctc cgctcgactt
       61 cctgccgggc gctggcaagc cgcgcgctgc ctggggtctc cgggggccgc gcttgcagct
      121 ggccgagtcc gggccagctg aggggctggc ggtgggcggg agcggtcggc ggcctcagcc
      181 ccttcagaga gcgactttca aactcgcgcc cgcgtcgcgg cagcacctgg gcagccccgc
      241 acgccgtgcg cgtcccgagc ccgcggggca gctaccgctc gaatctccct ggggtgccct
      301 ccccaggcag caatgccagg atgcctgtgt ccacctccct ccaccaggat ggcagccagg
      361 agcggccggt gagcctgacc tctaccacct cctcgtcggg ctcctcctgt gacagtcgca
      421 gtgccatgga ggagcccagc agctccgagg ctcccgccaa gaatggggca ggctccctga
      481 gaagccggca tctgcccaac agcaacaaca actccagcag ctggttgaac gtgaaggggc
      541 ccctctcccc gttcaacagc cgggcagcgg cagggcctgc acaccacaag ctcagctacc
      601 tgggccgagt ggtgcgggag atcgtggaga cagagcgcat gtacgtacag gacctgcgca
      661 gcatcgtgga ggactacctc ttgaagatca ttgacacacc cgggctgctg aagccagaac
      721 aggtcagcgc cctctttggg aacatagaaa atatctacgc gctgaacagc cagctcctca
      781 gagacctgga cagctgcaat agtgaccccg tggctgtggc cagctgcttt gtggaaagga
      841 gccaagagtt tgatatctac actcagtatt gcaacaatta ccccaactcc gtggccgccc
      901 tgacggaatg catgcgggac aagcagcagg ccaagttctt tcgggaccgg caggagctgc
      961 tacagcactc gctgcccttg ggctcctacc tgctgaagcc agtccagcgc atcctcaagt
     1021 accacctgct gctccaggaa attgccaagc attttgatga agaagaggat ggctttgagg
     1081 tggtggagga tgccattgac accatgacct gtgtggcctg gtacatcaac gacatgaaga
     1141 ggaggcatga gcacgcggtc cggctccagg agattcagtc actcctcatc aactggaagg
     1201 ggcccgacct gaccacctac ggggagcttg tcctggaggg cacattccgc gtgcatcgcg
     1261 tgcgcaatga aaggaccttt ttcctctttg acaaaacact gcttatcacc aagaagcggg
     1321 gcgatcactt tgtctacaag ggcaacatcc cgtgctcctc cctgatgctg atcgaaagca
     1381 ccagagactc cctgtgcttc actgtcaccc actacaagca cagcaagcag cagtacagca
     1441 tccaggccaa gacagtggag gagaaacgga actggactca ccacatcaag aggctcatcc
     1501 tagagaacca ccatgccacc attccccaga aggccaagga agccatcttg gaaatggatt
     1561 cctattatcc caatcggtac cgctgcagcc cagagcggct gaagaaggct tggtcctccc
     1621 aggatgaggt gtccaccaat gtgcgccagg ggcgccggca atctgagcca accaaacacc
     1681 tgctcaggca actcaacgag aaagcccgag cagcaggaat gaagggaaag gggcgcaggg
     1741 agtctgaaag ctccaggagc agcagaaggc ccagtggccg gtctccaacc agtactgaga
     1801 agcgcatgag cttcgagtcc atttcttccc tgccagaggt tgagccggac cctgaggctg
     1861 ggagtgagca agaggtattt tctgctgtgg aagggcccag tgccgaggag acgccttcag
     1921 acacagaatc tccagaagtc ctggagacac agcttgatgc ccaccagggc cttctgggga
     1981 tggacccccc aggtgacatg gtggacttcg tggcagctga gagcactgag gaccttaagg
     2041 ccctgagcag cgaggaggaa gaagaaatgg gaggtgccgc ccaggagcct gagagccttc
     2101 tgccaccctc tgtgctggac caggccagcg tcattgcgga gcgatttgtc agcagcttct
     2161 ctcggcggag cagcgtggca caggaggaca gcaagtccag tggctttggg agcccgcggc
     2221 tggtcagccg gagcagcagc gtgctcagcc tggagggcag cgagaagggc ctggcccggc
     2281 atggcagtgc cacagactcc ctcagctgtc agctctcccc agaagtggac atcagtgtgg
     2341 gggtggccac agaggacagc ccttctgtca atgggatgga gcccccaagc ccaggctgcc
     2401 cagtggagcc tgaccggtct tcctgcaaga agaaggaatc agcactctcc acccgagacc
     2461 ggctgttgct agacaagatt aagagctatt atgaaaatgc agaacaccat gatgcaggct
     2521 tcagcgtccg tcgccgggag agcctctcct acatccccaa aggactggta agaaactcca
     2581 tctccaggtt caacagcctt ccccggccag acccagagcc agtacctcca gtggggagca
     2641 agagacaggt gggctcccgg ccgacttcgt gggccctgtt tgagctccca ggaccaagcc
     2701 aggcagtcaa aggggaccca cctcccatct cagatgctga gttccgccca tcttcagaaa
     2761 ttgtgaagat ctgggaggga atggagtctt ccggagggag ccctgggaag gggccaggcc
     2821 agggccaggc caatggcttt gacctgcatg agccactctt catcctggag gagcatgagc
     2881 tgggagccat cacagaggag tcggccactg cctccccgga aagctcctct cccactgagg
     2941 ggcgcagccc ggcccacctg gcccgggagc tgaaagagct ggtgaaggag ctgagcagca
     3001 gtacccaggg ggagctggtg gccccactgc acccccgcat cgtgcagctc tcccacgtaa
     3061 tggacagcca cgtgagcgag cgcgtcaaga acaaggtcta ccagctggcc cgccagtaca
     3121 gcctccggat caagagcaac aagccagtga tggccaggcc accactgcag tgggaaaagg
     3181 tggcccctga gagggatggg aagagcccca ctgtgccctg tctacaggaa gaggctggag
     3241 agccattagg tggcaaaggt aagaggaagc cggtgctgtc tctatttgac tatgagcagc
     3301 tgatggccca ggagcacagc cctcccaagc cctcctcggc tggggagatg tcaccacagc
     3361 gtttcttctt caacccgtct gctgtcagcc agaggaccac ctcgcctggg ggccggccct
     3421 ccgcccggag ccccctcagc cccacagaga ccttcagctg gcccgacgtc cgtgagctct
     3481 gctccaagta tgcctcccgc gatgaggcac gccgagcagg gggcggccgg ccccgcggcc
     3541 cacccgtcaa caggagccac tcggtgccgg agaacatggt agagccacct ctgtcgggca
     3601 gggtgggccg ctgccgcagc ctgagcacca agaggggccg gggaggcgga gaggctgccc
     3661 aatcccctgg gcctctgccc cagagcaagc cggatggagg cgagaccctg tatgtcactg
     3721 cagacctcac cctggaggac aaccggcggg tgattgtcat ggagaaggga ccccttccca
     3781 gccccactgc agggctggag gagagcagtg gccagggacc aagctcaccg gtggccctgc
     3841 tggggcaggt tcaggacttc cagcagtctg cagagtgcca gccgaaggaa gagggttcca
     3901 gggacccggc agacccgagc cagcagggca gagtgagaaa ccttagagag aagttccagg
     3961 ccttgaactc tgtcggttga tgctgactcc tgggggaggg aggagtcatg ttggaggttg
     4021 gggaagaacc tgggcatcct tcccctcaag cctgggctca tggagcccct gcccagggcc
     4081 ctcaggtggg cggaaagtcc atcccctccg cccttcagga aggatgctcc cgtgtgcagg
     4141 ggtctcctgc ctgtgccatc cactggggct cgagacaatt tcccactcac ctgtgaggcc
     4201 ggtgtggctg cttcccttgt aaatagttgt tctctggtaa gaagccaaat atttaagctc
     4261 acttcttccc agagagagga agctctgctc aggcctccag cgttggctgg ccatggccac
     4321 agccagatgg aggagcccat ccccaggaga ctcaggcagt ggcctggaga ggctttgttc
     4381 tgtaacggtg ccttttctta gggtccaggc aggaatgaag ccaataattt attgctttcc
     4441 attctgtggt atgatgtgcg tgtgcgtgag tgtgtggccc ctgtttattc ccctcctgtc
     4501 aagaatgaag tggattcagt tcaggtactt ttgagggttg ttgtgctgac cctgtggttg
     4561 tcgctgatgt acacacattt cattatttgc caatggtgca ataaccactg ctgaccaacc
     4621 cactatgtgt gaactccttc ctaggcttgg ctggggtagg gaaggttatt catgggccag
     4681 ggatgtctta gggagatgga gacatggagg ttgttccttc cacactcaat tgtcacttgg
     4741 gcttatgaaa cataaggcac ccgggtactg gtgggggagg tggggcagga ggatgtgagg
     4801 gcgggctttt tctttctgct gcctagactc ccatgggctt ctctgtctag cagcagcctg
     4861 ctgtcctgtc tagggtaggg ggtcccgcat gccagccttt tgctcttttc cccaagggcc
     4921 agagttggac caagaaaaag ggaggtggtg aggtggatag actgtttttc tcataagcag
     4981 atgctcccag tatctggtgc cttttgcgtt tctctccggt ccccaggaaa catcctagaa
     5041 gacaaggatt tttttttttt ttttttttga gacagagtct tattctgtca cccaggctgg
     5101 agtgcaatgg cgtgatcttg gcttactgca acctccgcct cccaggttca agcaattctc
     5161 gttgtctcag cctcccaggt cgctgggact acaggcatga gccaccacac ccagctaatt
     5221 ttttgtattt ttagtagaga cggggtttcg ccgtgttgac caggctggtc tcgaacttct
     5281 gacctcaggt gatccaccca cctcggcctc ccaaagtgct gggattacag gggtgagcca
     5341 ctgcatgcgg ctgaaggtaa ggattctaaa ctcggagact agaaatgtcc taaaggtgtc
     5401 tgcaacattg gatgaggagt acaagtgcat ttttctggga tgattcctcc ctttttatca
     5461 cattctcaga agtatctttg attcagaaga gttaggaatg cctccctatt tcagttgggt
     5521 tttctgccct ttctccacag aggtccagac tcattttgct taattttttt tctagctggg
     5581 gcctgggagg tagaggcttc agggcctggg tggtagagct gcctgacaag tgttcagcag
     5641 ggctgctggg tcagggccct gtgggccttc tgacccaacc tgaagatggg tctgctaagt
     5701 ctaacaaggt caagggaaga tcagagggac ccagattctt ttttatcccc cacttgaaac
     5761 ggagtcttgc tctgtcgccc aggctggagc gcagtggtgc aatcttggct cactgcaacc
     5821 tccgcctccc tgaccctcac actgtccagt gcccttgtgg ttactcagca tcatatcttg
     5881 agactggcct ggcaggagcc agtgactgtg gaatgaccac agaagattca gggcagctgc
     5941 cagaccaggg gctatctctg ccctgcgctg cttctgctca agagaggttg tcactagcct
     6001 ctgatcttcc cttgaagaac ccgactgggg ctcttcagag ggtggggccc aggaagttgt
     6061 agttaacccc ttccccaggc agtccttaca cggccatcta ggtatgcctg ggaaccttgc
     6121 accaggtcgg tggttctcac tggctgccca ttggaattat ctggggagcc ttctggaaac
     6181 gcagtgctta cattccatct ccctagacca acagaaactg ccctctggag gtgaatccca
     6241 ggcttagaga ttctgatgat tctgcggtcc agtgagtgct gagatctgtc ctgagctctg
     6301 tggggagggg cctggactga tcactgcttg gaaatgattt tgccctacag taggccttca
     6361 agttgatcaa atgcatgaat gagcaagctt ttcttggagt ttgtgatgaa gcccaggaac
     6421 cgggtgcttg cagtcgtccc ataaggctcc cagggacaag ctagagaatc tggctgtccc
     6481 tctgtctcca tggtgccagc cctcttaggc tcagttcaaa gggagaggag gctagttaaa
     6541 taagaaactg agagaaacat ggagcattat tgatttatta gaaaaactag taaatgggtt
     6601 tcctctggtt ggtggaagca cggttgagca ggtggaggac aggacccagc tggccccagg
     6661 gccagcccca gattgcatgg tctgtgccca acagggttgc attcctctgc agccgccgcc
     6721 tcctcatttc ctccctgagc ttgtttgtcc aagccaccaa gccatgtggt cccgctggct
     6781 tcatcctcct ctggattcct gcccccctcc catgaaggga ggaagaggat tcagggtcag
     6841 cctaggggac cctggctccc tccgataggc aggaaggagg agggatgcgg aggagaggct
     6901 gagccttcca cgggcctcct gttaggggtg ttggtggagg ccaggttggg gagggaagcc
     6961 taaggaccct ccacacctcc cacagccaga gtcagttgag gctgggacaa aggggaagga
     7021 gagagggaag gaggaccgcc tgaccttgcc cagaaggagc ttcctctaaa ctgccctggg
     7081 aaggaagcct ggtatgctgg tgtggactgg agctgtgtca acctcgtttg ggaatactgt
     7141 caaaagactg tagagtagaa taaggagaga aaaaaaaaaa aagaccttgc tagggcactg
     7201 ggagagctta gccctggtgt ggcacacaca gggtctccca aagctggatg cctgcatttt
     7261 cagtctagtt ggtcgaatgt cttggagcct gggtgacagg agggatgtgt ggggagctgg
     7321 caacagaatg gtcacatgca gctggctgcc ctggaccagg ccaggggacc tggggtggtg
     7381 agatgctagc tcttccacta gagcccttcc tttctcgggt ctgtggagtt gcttgctgga
     7441 aatgcctcac ttcaggtgct gatttggcac acgtggaagg gggagggtgg gcccttgtcc
     7501 ctaggctccc taaagactgg cccagggaaa cagttgaggg agatgtttgc caccatctgc
     7561 ccttcagcaa ggaacctgct ctctgcccca gaggaggaca tgcctgcaag tgcaccaaag
     7621 gcctacttta ttgctaggtg agtgcagtca cctcactgcc ttggtttccc cagatacaga
     7681 aagaggctgg tgagtgatac acactaggtt ccctgtatag ggtcatatgt accaaagcca
     7741 aatgaagacc ttgctcacca gggcgggaac ctggggatgt caggctccat cggatgacgt
     7801 cttccttcct gtggctcctg cctgctgcag ttggtgtcac cctgacatat agtgtcaggg
     7861 ccacagggtg gaactgattt ctgccggcac tggtcagcac tcagggttcc tcagggggcc
     7921 tcattctgga tgcctgcccc tgtggcttct acctgaacct cacccacttc atctccatgg
     7981 aactaaggtc cttctcacgg ggaaggtgat agaaacttga ctgcaggccc tggggacttt
     8041 catggtttcc ttgggggaaa atgcctgctg ccctccgccc tcccccccac ccccgacccg
     8101 cttgactgct ctcttggacc taaccctagt ttgatactgg gccagaactg tgttgctttc
     8161 ggagtagagt ggtggggaaa atatggaatg agctttctct tcctccagaa gtatgacctg
     8221 agcagcaagg ggaaggccat tcctggggac gttggttgca gagcttctgg tgctcagggc
     8281 tggagggtgg tagatatttg acctctgtac tcatgtgacc ccctccccgc caagacctgg
     8341 ggccaggacg tggagaagct gatcaagggg taccacacct tcatggctct ggccctgaca
     8401 tttgtcccag ttgtgcagga gtagctgtca catgggtggt gataccaaga catggctgcg
     8461 tctgccaccc cgagaaaaca gatgatcaac tttactgtct gcccagccat taccctccaa
     8521 agtcccagct gcagacagga tgcaattgag catttggctt tgggatgctt tactgcaggt
     8581 gcggggggta tccatcttat atctgggggc ccacactgtc ccgtaggggg cctatgtctg
     8641 ttggatattg ctggtttggc tgccactggg agtggggcga gggtcccagc attgagaggg
     8701 agagccttag gcagtgttgt gacgcacctg tcactccttc agatcagagc cctgtgccct
     8761 agccacggtt ttcaatgagg aatggtctga ccttgctgcc cttcctggga ccgcctgtgg
     8821 tggcacaaag ggtgctagag gcactcagcc aggccctgcc aaccgtggga gggtaccctt
     8881 tgatctgggg ggagaagcag agaggaggga tgtggtggcc cctgaagtga gagtcccagt
     8941 tctgcggaag cccagtggga aggaggctgg cagctcccaa ggccctgcac ccagtctggt
     9001 cccctcagcc ccccagagcc cctggcccag agctagggct ttgtgggcca cctgaaggct
     9061 ccttcctcat gcccctaggg ggctggccat gcatttccag tgtcttcttc ctttcccctt
     9121 tccctggctg ccaccaggtg ggaggtgacc cgaagcaaga cttgctttag gaacgggcag
     9181 cgtttgaaga accccatcag ccttctccag ctcttttttt tttttttttt tggttggggg
     9241 taaggggcct gtgccccctc ggctcaggag gagggtggga gaggagggcg tgtgcctcag
     9301 agaaccgttt cctgccccca ggcctggagg ccccaaaggc gccagaggag ctgggagccc
     9361 ctgtccctgg agcggagcca gcgcgggcga gggcatggag ggggcgtcgg cccaggacac
     9421 gcgggcgaag gcagcttttg cagtgcagcg tggggcccgg gggcccggcc cgcgactcga
     9481 ctcatctcga ttcgaccggc gggcggcggc gagaggaggc caaggcctgg gctgcccggt
     9541 ctctgcgcgt cccgactccg ccgcgcccgc cagccccacc tgctacttct ttttggggaa
     9601 gaagctgaat ctcttctcct tgtctttctt gccgaggctg gcgtcggggc cggagaggga
     9661 aggcaggggc aggctctgcg ccttgacgcg gatgctctgg gactcgttga tggcggtgct
     9721 cacgccctgc agccaggaca gcatctcctc ctgcggggcg gagggtcacg gtggagtctg
     9781 gaggcccaca gccccccacc tcccgggcca ggcaacaatg gtgggggctc ttgggactgc
     9841 cccttctgag ggggcctcca gggcaagcgg cctggggtcc tccacctacc cccttcttag
     9901 ccaggtctgg gctaggctgc ccgcgcttac ctcatccttg ccatggaaga gccactcgct
     9961 gccattactc agcctaggag gacaaagggt ttcctgtcat ggagacacct ctggaggggg
    10021 cgctgggcag agggctggct ctgatcccac aataccctga gccgaacatc cagacccctc
    10081 tcaggcagcc cagcactttc tgagaggtca aagtctggac catcagcctc tttgatttga
    10141 aaaacccctg aggagcagct caggcctggc actggtcccc tacagagggc ctctgccctg
    10201 ccactaatgc caaatcaagc catcaacccg agctttcaaa ggccaggaag gcctcacctc
    10261 agcttaaaga cgtgcttctt cttcttgtag ttggcagcaa tctcacagat ggcatgtctc
    10321 agggccaggg gttcctcccc atggtagggc atccccaggg ccaggttctt ggcatccttg
    10381 tagaaggtta gctcactgtt cctgagcaca cagtacaggt tgttccagga cctgcaaaga
    10441 tgcagacagg caggtcaccc acatcctgat atggtatctc tagagtcaat tcctatagct
    10501 tcaccattaa aaaaaattac accatg
//
