LOCUS       NM_001029884            7217 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens pleckstrin homology and RhoGEF domain containing G1
            (PLEKHG1), transcript variant 3, mRNA.
ACCESSION   NM_001029884 XM_027307
VERSION     NM_001029884.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7217)
  AUTHORS   Traylor,M., Tozer,D.J., Croall,I.D., Lisiecka-Ford,D.M.,
            Olorunda,A.O., Boncoraglio,G., Dichgans,M., Lemmens,R., Rosand,J.,
            Rost,N.S., Rothwell,P.M., Sudlow,C.L.M., Thijs,V., Rutten-Jacobs,L.
            and Markus,H.S.
  CONSRTM   International Stroke Genetics Consortium
  TITLE     Genetic variation in PLEKHG1 is associated with white matter
            hyperintensities (n = 11,226)
  JOURNAL   Neurology 92 (8), e749-e757 (2019)
   PUBMED   30659137
  REMARK    GeneRIF: Genetic variation in PLEKHG1 is associated with white
            matter hyperintensities and ischemic stroke, most strongly with the
            small vessel subtype, suggesting it acts by promoting small vessel
            arteriopathy.
            Erratum:[Neurology. 2019 Sep 24;93(13):608. doi:
            10.1212/WNL.0000000000007914.. PMID: 31551276]
REFERENCE   2  (bases 1 to 7217)
  AUTHORS   Gray,K.J., Kovacheva,V.P., Mirzakhani,H., Bjonnes,A.C.,
            Almoguera,B., DeWan,A.T., Triche,E.W., Saftlas,A.F., Hoh,J.,
            Bodian,D.L., Klein,E., Huddleston,K.C., Ingles,S.A., Lockwood,C.J.,
            Hakonarson,H., McElrath,T.F., Murray,J.C., Wilson,M.L.,
            Norwitz,E.R., Karumanchi,S.A., Bateman,B.T., Keating,B.J. and
            Saxena,R.
  TITLE     Gene-Centric Analysis of Preeclampsia Identifies Maternal
            Association at PLEKHG1
  JOURNAL   Hypertension 72 (2), 408-416 (2018)
   PUBMED   29967039
  REMARK    GeneRIF: PLEKHG1 rs9478812 variant substantially increases risk of
            preeclampsia.
REFERENCE   3  (bases 1 to 7217)
  AUTHORS   Lei,S.F., Papasian,C.J. and Deng,H.W.
  TITLE     Polymorphisms in predicted miRNA binding sites and osteoporosis
  JOURNAL   J Bone Miner Res 26 (1), 72-78 (2011)
   PUBMED   20641033
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450344.4, AL450339.5 and AL035086.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001029884.2.
            
            Transcript Variant: This variant (3), as well as variants 4 and 5,
            encodes isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.225585.1,
                                           SRR1660809.72221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696526.1/ ENSP00000512689.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL450344.4         54258-54390
            134-192             AL450344.4         105101-105159
            193-701             AL450339.5         38052-38560
            702-802             AL035086.12        155677-155777       c
            803-872             AL035086.12        137956-138025       c
            873-919             AL035086.12        128513-128559       c
            920-1070            AL035086.12        123546-123696       c
            1071-1202           AL035086.12        119674-119805       c
            1203-1385           AL035086.12        115128-115310       c
            1386-1481           AL035086.12        114939-115034       c
            1482-1568           AL035086.12        114681-114767       c
            1569-1602           AL035086.12        106199-106232       c
            1603-1698           AL035086.12        104641-104736       c
            1699-1737           AL035086.12        103182-103220       c
            1738-1760           AL035086.12        100739-100761       c
            1761-3384           AL035086.12        92210-93833         c
            3385-7217           AL035086.12        80750-84582         c
FEATURES             Location/Qualifiers
     source          1..7217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..7217
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /note="pleckstrin homology and RhoGEF domain containing
                     G1"
                     /db_xref="GeneID:57480"
                     /db_xref="HGNC:HGNC:20884"
                     /db_xref="MIM:620134"
     exon            1..133
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            134..192
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            193..701
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..4448
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /note="isoform c is encoded by transcript variant 3;
                     pleckstrin homology domain containing, family G (with
                     RhoGef domain) member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 1 isoform c"
                     /protein_id="NP_001025055.1"
                     /db_xref="CCDS:CCDS34552.1"
                     /db_xref="GeneID:57480"
                     /db_xref="HGNC:HGNC:20884"
                     /db_xref="MIM:620134"
                     /translation="MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFN
                     QDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTI
                     ADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALF
                     GNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTEC
                     MRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVV
                     LDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQR
                     AKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKL
                     QHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGT
                     KALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPA
                     QRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSF
                     SSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGT
                     SDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAEST
                     PSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEEN
                     IYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAP
                     YHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDR
                     LLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRAN
                     CPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKT
                     KSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPA
                     IGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHST
                     YSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPGSVQRCS
                     VVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGK
                     QQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIA
                     TQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT
                     LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQC
                     LSSSSFA"
     exon            702..802
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            803..872
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            873..919
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1070
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1202
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1385
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1481
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1568
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1602
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1698
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1737
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1760
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..3384
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..7217
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4535..4540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /note="hexamer: ATTAAA"
     polyA_site      4555
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
     regulatory      7192..7197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /note="hexamer: AATAAA"
     polyA_site      7217
                     /gene="PLEKHG1"
                     /gene_synonym="ARHGEF41"
                     /note="major polyA site"
ORIGIN      
        1 gagcctgagc ccgagcccga gcccgacggc ggctgcaggg cgctccggca gcccgagccg
       61 gcgcagcgca gcccgcaccc tccccgcccg acctgcgagc gccgcccggg catgcgaagc
      121 cgtccctccc cgggtgaaga ctgatgagaa gagtctgtgg gtgaagacat tgaaaaggtt
      181 tcaactataa aaatgggcac cagttgcgtc ttgaagtgcc atcagctgta accaaagttc
      241 cacatcccaa gacgacagcc aggcgttcct gccctcaaga actgaagaca atggagctct
      301 ctgatagtga ccgacccgtc agcttcggtt ccacatcatc ctcggcctct tcccgcgaca
      361 gccatggttc cttcggcagc agaatgacct tagtttcaaa tagccacatg ggcttgttta
      421 accaggataa ggaggtaggg gccataaaac tggagctgat tcctgccagg ccgttttcca
      481 gcagcgagct gcagagggac aaccccgcca cggggcaaca gaacgcggat gagggcagcg
      541 aaaggccacc cagagcgcag tggagagtgg actcaaacgg ggcacccaag acgatcgcag
      601 actcggccac gagccccaag ctcctctatg tggatagagt tgttcaggaa attctggaaa
      661 ccgaaaggac ttatgtacaa gatttaaaaa gcatcgtaga ggattacctt gactgcatca
      721 gggaccaaac aaaacttccc ctggggaccg aagaaagatc agcccttttt ggaaacatac
      781 aggatatcta ccacttcaat agtgaacttc tgcaagattt ggaaaactgt gaaaatgatc
      841 ctgtggccat agcagagtgt tttgtgtcca agagtgaaga gttccacatt tatacccagt
      901 attgcactaa ctatccaagg tccgtggctg tgctaacaga gtgtatgagg aacaagatac
      961 tggccaaatt cttcagggag cgtcaggaaa ctctgaaaca ctcgctgcct ctggggtcct
     1021 atctcttgaa accagttcag cggattctca agtatcatct ccttctgcat gaaatagaaa
     1081 accaccttga taaggacaca gaaggctatg atgtggtgct tgatgctata gacacaatgc
     1141 agcgagtcgc ctggcatatc aatgacatga agcggaaaca cgagcacgcg gtccggttac
     1201 aggagataca gagtttgctc actaactgga aggggccaga cctgaccagc tacggggaac
     1261 tggtgcttga gggaaccttc cgcatccagc gagccaagaa tgagcggacg ctcttcctct
     1321 tcgacaagct gctgctcatc acgaagaaga gagatgacac gtttacatac aaagctcaca
     1381 tcctgtgtgg caacctcatg cttgtggagg tgattccaaa agagccgctc agcttcagcg
     1441 tcttccacta caagaatccc aagctgcagc acacagtcca ggccaaatcc cagcaagaca
     1501 aacgcctctg ggttctgcac ctaaagagac tgattctgga gaaccatgca gccaagattc
     1561 cagctaaggc caagcaagca atccttgaaa tggatgccat tcatcatcca ggcttctgtt
     1621 acagtcctga gggagggacg aaagcactgt tcggctctaa agaaggttct gctccatatc
     1681 ggctgagaag aaaatctgaa ccttcctcac ggtcacataa agttttgaag accagtgaaa
     1741 cagcacaaga catccaaaag gtttctagag aggaaggatc tccccagctg tcttcagcaa
     1801 ggccgtctcc tgcccagaga aatagtcagc ctagcagttc taccatgatc agcgtgcttc
     1861 gagcgggtgg agctctcaga aacatctgga ccgatcacca gatcaggcaa gccttgtttc
     1921 ccagccgacg gtccccgcag gagaatgagg atgatgaaga tgattatcag atgttcgtgc
     1981 cgtcattttc ctcctcagat ctgaactcta ccagactatg tgaagatagc acttctagtc
     2041 gcccttgcag ctggcatatg ggacagatgg agtccacaga gacctccagc tctggtcaca
     2101 ggattgtcag gcgggccagc agtgctgggg agagcaacac atgccctcct gaaataggaa
     2161 ctagtgacag aactagggaa ctgcagaaca gccccaaaac agaagggcag gaggagatga
     2221 ctccctttgg gtcatccata gagttgacta ttgatgacat agaccatgtc tatgataaca
     2281 tcagttatga ggacttaaaa ctaatggttg ctaagcggga agaagctgaa tccactccct
     2341 ctaaatcagc cagggactcc gttcgcccca agagcacccc agagttagcc ttcacaaaga
     2401 ggcaagctgg ccacagtaag ggctctcttt acgcacaaac agatggcacc ctctcaggtg
     2461 gagaggcatc cagccaaagc acgcatgaac tccaagcggt tgaggagaac atctatgaca
     2521 ccatagggct cccagatcct ccgtcgctgg gttttaagtg cagcagccta aagcgtgcaa
     2581 agcggagcac ctttttgggt ctggaggccg acttcgtgtg ctgtgacagc ctgaggccat
     2641 ttgtttccca agacagcctc cagctcagtg aggacgaagc cccttaccat caggccactc
     2701 ccgatcatgg ttatctgagt ttgctgtatg actctcccag tggtaacttg tctatgcctc
     2761 ataagcctgt atctgataaa ctgtccgaag aagtagatga aatctggaat gacctggaaa
     2821 attacatcaa gaaaaatgaa gacaaggcca gagaccgtct cctggcagcg tttcctgtga
     2881 gcaaggatga tgtgccagac aggctgcacg cagagagcac ccctgagctg agccgggacg
     2941 tggggcgctc tgtgtccacg ctgtccctgc ctgagagcca ggctctcctc acgcccgtga
     3001 agagcagggc tggcagagcc agccgcgcca actgcccctt tgaggaagac ctgatttcta
     3061 aagaaggctc ctttatgagc cttaaccggc tttctctggc tagtgaaatg cccctcatgg
     3121 acaatcccta cgacctggcc aacagtggcc tgtctcaaac agacccagaa aaccctgacc
     3181 tggggatgga ggccacagat aagacaaaaa gcagggtgtt tatgatggct cggcagtaca
     3241 gtcagaagat taagaaggcg aatcaacttt taaaagtgaa aagtctggag ctggagcagc
     3301 cgccggccag tcagcatcag aaatccatgc acaaagacct ggctgccatc ttggaagaga
     3361 agaagcaagg agggcccgcc attggtgcca ggattgctga gtattcccag ttgtatgacc
     3421 agattgtatt cagagagtct cccttgaaaa ttcagaagga tggctgggcc agccctcaag
     3481 aatcctccct cctgaggtct gtgtcacctt cccaggtcca ccatggtagt ggagactggc
     3541 ttctgcattc aacctatagt aatggagagt tagcagattt ctgtctccca ccagagcaag
     3601 acttgaggtc aagatatccc acgtttgaga tcaatacaaa aagtactccc aggcaattgt
     3661 ccgcagcttg ctctgtgcct tctcttcaaa cctctgaccc tctgccaggc tctgtgcaga
     3721 gatgcagcgt ggtagtaagt cagcccaaca aagagaactg gtgtcaggac catctttaca
     3781 actccttggg tcggaaaggg atcagcgcta aatctcagcc ttatcacagg tcccagtcat
     3841 cttcctccgt cttgatcaac aaatcaatgg attccatcaa ctaccctagt gatgtgggaa
     3901 agcagcagct gctgtcttta cacagaagtt caaggtgtga gagtcaccag gacttgctgc
     3961 cagatattgc tgactcgcat caacagggca ctgaaaaact ctcagatctc acactccaag
     4021 actcacagaa agttgtggtg gtcaatagaa atttaccctt aaatgcccaa attgcaacac
     4081 agaattattt ttccaatttc aaagagactg atggagatga agatgactat gtggaaatca
     4141 agtcagaaga agatgagtcg gagttggagc tatctcacaa tcgtagaagg aaatctgact
     4201 caaagtttgt ggatgctgac ttttctgata atgtctgcag cggcaacaca ttgcattctt
     4261 tgaatagtcc gcgcactcca aaaaagccgg ttaacagcaa acttggcctt tcaccatatc
     4321 tgacaccata taatgattct gacaaactga atgactatct ttggaggggg ccatctccca
     4381 atcaacaaaa tattgtccag tctctaaggg aaaaatttca gtgtctcagt tcaagcagct
     4441 ttgcttaagg ttcttcataa taactgcttg aatcaacttc ttattttgct cataaaacgt
     4501 tacagatact gatgaggtgt tttatgtata ccagattaaa acaattttgt aagaaccaga
     4561 ggtgtaaaat atactttctt ttacagcaca acttttggaa atggctgacg atgcagcccg
     4621 gattgtactg tagcacatgt tggcatcaac agtatatttt ctcatgctga gtgtcttcat
     4681 gtttcatgta agtcaatctt acttgaaagt ttttagactt ttaacacgat ggccataacc
     4741 tgacaatagt gcccacacct taagaaatgc aataatcctt tcctgttatc cagaaggccc
     4801 aggtagtttt atcctgtgac tcaaaggcag caaggagact ttttcacatt ttaaaaggca
     4861 acgaaagctg ttgaaagaat tatgcttata tctcacattt tggttatatt tgtggtaaca
     4921 ccttaggata acgtaagcca gagatctgta aattggactg cagtctgagg tgcccatttt
     4981 agggtttttg tgctagtatt cttttatgtc attttgatgc agaaattgtg tgactgttga
     5041 aaattaaaat gtagcgggac ccattttctg tacgcagaac cctttacctg tattcctgga
     5101 caaggcctag agaacgagct gctcatcatg tttctaatat aatttctggg gtgaaatgaa
     5161 tgatttcctt actggcttag agaaaaccaa ggtcaataaa atgcagattg acttaactat
     5221 tagaaaagat gggatgactt ctgggaacca cttaactctt caaatgactg ttgaaagaga
     5281 aaaagcaaaa ctgaaatccc accagaccat tttgtgtgcc tgtttctaat cgatacaaag
     5341 ttaagcatga gctaaaatca gacaaagcac tttaaattta tcctttccag agcgctttgc
     5401 acatgcaccc tcctgagttt gggattctgc caaatgacca acttgatcct ggccctgagg
     5461 agtcattggc tgcaggaata gggcaagaat ctatttccta aactacacat aacatgggag
     5521 cctttttttc gttgttttca ggtatattaa agaatgaaat ctttggttac taggtgctga
     5581 ctaataaata acacctttta tattctgacc atttgtcaca tttcattgtg atactgtata
     5641 ctgatctaac tccttatgaa aggcaacaaa caaaaataag acattgaata aaaagcaaaa
     5701 tcaaagaagc taaagagaaa aatgaaggca gatatattgc aactttataa catattctat
     5761 tttattgaag actgcaatta atgcagcaag aatgctttct caagcggtgg cctttgtatt
     5821 ctcattttaa tcaggtgtac attctatggc ctctccccca tgctgttagt ttctatttta
     5881 aaagatacaa taatatatgt agggaaaggg gcctgggctc ttcatttaaa ggtaagcagt
     5941 aatattgagt aagtgacata attctttttc tctttgttaa gtcctatgcc tctttttctt
     6001 aactgtaaaa catagaatat gagcgttttt atcttacaaa taggtaccta aggcatgtga
     6061 ttttattttt aaataacaaa aaataaccca agtttcttgc ttctccaaag tattcttctc
     6121 atagcttata aaagaaagtc cacattgaat agcatggtct gggaacattc cttctttatt
     6181 gtgtttattt gaacatgata tgagtttcca agatgaaatg atcaaaaaag ataagtacca
     6241 caagaaagtt tttttgtttg gttggttttt ttgtttgttt gtttttttct tgagactgag
     6301 tctctccctg ttgcccaagt tggagtgcaa tcttggctca ctgcagcctc cacctccccg
     6361 gttccagcga ttctcctgcc tcagcctctt gaatagctgg gattacaggc gcccgccacc
     6421 acacctggct aatttttgtg ttgttagtag aggcggggtt tcatcatgtt ggccaggctg
     6481 gtctcgaact cctgatctca tgatccgtct gcctcggcct cccagagtgc tgggattaca
     6541 ggcatgagcc actgcgcccg gccaagaaag tatgttttta gaggtgtgtg taagtgcatt
     6601 tgtattacct atgaacaaaa ttacctgact cttgtcccag gaaagctgtt tcgcattttc
     6661 gctttttgat tggtattatc cagttctatg tagttcatat tattgttctg tctgactctc
     6721 agaaattact tcttcacgcc agtgtcttgt tgcatgactt tgatgtcacc tataggaata
     6781 cacctcactg cacgtaagtg ggtatcttac tgtataaaag gtctacatgg ctttaggttt
     6841 taggacaaat gtgtagattt atagaccatt tctgttggcc aggacacaga ttttgagagc
     6901 tgtgtgtata tatatataat catgtttgta tttttttcct gaaagttatc aattgctttt
     6961 gtttaaaaca gtttgtttta gaggtggggt ggggatgtat ataacgagga aaagttatat
     7021 gtactttaaa gtatgtcaag ttcttactag tttcctgtac tgaaggttca atttttttta
     7081 tataagttta cttttcacct gctctattct ttgtggggaa aaaatgcatc tagaaaaaca
     7141 tagtttaaat actgtatata agataatgaa agttagtaac gtccattatt taataaagtt
     7201 tgtaaagtac aaggtaa
//
