LOCUS       NM_021200               1977 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing B1 (PLEKHB1),
            transcript variant 1, mRNA.
ACCESSION   NM_021200
VERSION     NM_021200.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Zhou,Y., Zhang,Z., Wang,H., Xia,Y., Li,X., Yan,Y., Zou,W., Zeng,L.
            and Huang,X.
  TITLE     In vitro interaction between coxsackievirus B3 VP1 protein and
            human pleckstrin homology domain retinal protein (PHR1)
  JOURNAL   Virus Genes 51 (2), 182-189 (2015)
   PUBMED   26318175
  REMARK    GeneRIF: The human PHR1, a PH domain-containing protein with low
            expression in the heart and high expression in the brain, interacts
            with coxsackievirus B3 VP1, a major structural protein of
            coxsackievirus B3.
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Tan,B., Brown,D., Xu,S. and Valle,D.
  TITLE     PHR1 is a vesicle-bound protein abundantly expressed in mature
            olfactory neurons
  JOURNAL   Laryngoscope 120 (5), 1002-1010 (2010)
   PUBMED   20301200
  REMARK    GeneRIF: Phr1 is widely and abundantly expressed throughout mature
            olfactory neurons and other primary sensory neurons, but its
            absence does not appear to affect olfactory morphology,
            regeneration, sensory function, or adaptation.
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Andrews,K.L., Potdar,P.D., Nettesheim,P. and Ostrowski,L.E.
  TITLE     KPL1, which encodes a novel PH domain-containing protein, is
            induced during ciliated cell differentiation of rat tracheal
            epithelial cells
  JOURNAL   Exp Lung Res 26 (4), 257-271 (2000)
   PUBMED   10923244
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Xu,S., Ladak,R., Swanson,D.A., Soltyk,A., Sun,H., Ploder,L.,
            Vidgen,D., Duncan,A.M., Garami,E., Valle,D. and McInnes,R.R.
  TITLE     PHR1 encodes an abundant, pleckstrin homology domain-containing
            integral membrane protein in the photoreceptor outer segments
  JOURNAL   J Biol Chem 274 (50), 35676-35685 (1999)
   PUBMED   10585447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000860.4 and AP002993.3.
            
            On Nov 23, 2018 this sequence version replaced NM_021200.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89715.1, AK314748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354190.10/ ENSP00000346127.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AP000860.4         89124-89169
            47-122              AP000860.4         91555-91630
            123-275             AP000860.4         93096-93248
            276-378             AP000860.4         94331-94433
            379-418             AP000860.4         95518-95557
            419-523             AP000860.4         98346-98450
            524-623             AP000860.4         103296-103395
            624-1977            AP002993.3         59592-60945
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1977
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /note="pleckstrin homology domain containing B1"
                     /db_xref="GeneID:58473"
                     /db_xref="HGNC:HGNC:19079"
                     /db_xref="MIM:607651"
     exon            1..46
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..760
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /note="isoform a is encoded by transcript variant 1; PH
                     domain containing, retinal 1; pleckstrin homology
                     domain-containing family B member 1; evectin-1; PH
                     domain-containing family B member 1; PH domain-containing
                     protein in retina 1; pleckstrin homology domain retinal
                     protein 1; pleckstrin homology domain containing, family B
                     (evectins) member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family B
                     member 1 isoform a"
                     /protein_id="NP_067023.1"
                     /db_xref="CCDS:CCDS44672.1"
                     /db_xref="GeneID:58473"
                     /db_xref="HGNC:HGNC:19079"
                     /db_xref="MIM:607651"
                     /translation="MSPAAPVPPDSALESPFEEMALVRGGWLWRQSSILRRWKRNWFA
                     LWLDGTLGYYHDETAQDEEDRVLIHFNVRDIKIGPECHDVQPPEGRSRDGLLTVNLRE
                     GGRLHLCAETKDDALAWKTALLEANSTPAPAGATVPPRSRRVCSKVRCVTRSWSPCKV
                     ERRIWVRVYSPYQDYYEVVPPNAHEATYVRSYYGPPYAGPGVTHVIVREDPCYSAGAP
                     LAMGMLAGAATGAALGSLMWSPCWF"
     exon            47..122
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..275
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..378
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..418
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..523
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..623
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1977
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /note="hexamer: AATAAA"
     polyA_site      1977
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /note="major polyA site"
ORIGIN      
        1 gaaatgctgc cctggccacc caggaaccat gagccctgca gccccggtcc cgcctgactc
       61 cgctctggaa agtccttttg aagaaatggc cctggtgagg ggcggctggc tgtggagaca
      121 gagctccatc ctccgccgct ggaagcggaa ctggtttgcc ctgtggctgg acgggaccct
      181 gggatactac cacgatgaga cagcgcagga cgaggaggac cgtgtgctca tccacttcaa
      241 tgtccgtgac ataaagatcg gcccagagtg ccatgatgtg cagcccccag agggccggag
      301 ccgagatggc ctgctgactg tgaacctacg ggaaggcggc cgcctgcacc tctgtgcgga
      361 gaccaaggat gatgccctag catggaagac agcactgctg gaggcaaact ccaccccggc
      421 cccagctgga gccaccgtcc ctcccaggag ccgccgggtt tgctccaagg tcaggtgtgt
      481 gacccgctcg tggagcccct gtaaggttga gaggcggatc tgggtgcgcg tctacagccc
      541 gtaccaagac tactacgagg tggtgccccc caatgcacac gaggccacgt atgtccgcag
      601 ctactacgga ccgccctacg caggccctgg cgtgacgcac gtgatagtgc gggaggatcc
      661 ctgctacagc gccggcgccc ctctggccat gggcatgctt gcgggagccg ccactggggc
      721 ggcgctgggc tcgctcatgt ggtcgccctg ctggttctga gccctgggac tcggagcact
      781 gacccctgcg cttggattgc tagactcctc ttcctcctgg accccatcct ctaccatcca
      841 agccctgtcc cactttggcc ctatcctctc cattagctcc ttccgggttt ggaccattcc
      901 ccccactccc tacccttaat ccccacatgg gaagaagcta tcatcacagg tacaaacatc
      961 gcttgaagtc ttcacatcta ccactagaca cccccaaaat ctgttataga catttatgga
     1021 tacatttcct ctaaacacaa cagggcacag caaatacgac ttcatttggc ttcgagttcc
     1081 ccaggcgctg tagacacaac atgaatcggg ctctctgctc tctccttagg gagctcgagt
     1141 cctggtgggg agaacaggag taaacaagga cttgacaaag ctgaagagtt atcagtcctt
     1201 tgacaaggac aggtggggca gggagcaaga caggtaggct ggaagaacag ttattggcaa
     1261 gtatgcagag ccgtgaacgt catggcatgt ccaaggaatt aaatgggagt tcatttgggc
     1321 tggggtggag gctgggatca gaccgtggtg ggccttcaag ctaaggagct tcctaggtga
     1381 aaggggagat gtgagccttc tctggaggga agtttcatga ttgcatctat aatgaatata
     1441 ttgcctgttt tgtgaatact gacacatgtc catacctaaa acactcctga gtcaagtccc
     1501 atccttccca caaacagctt cctggctggt acccatgata acaattgagc tgaacctggg
     1561 gacccctggt tggggaacag gtgagttcta tttgagactt ccagccctag aaagctgcct
     1621 ccgtccagaa atgcctctca caccaggagc tcggccctct ctttgtagct gtgactgtca
     1681 ccctctcagg ctttgtctca tccttcattc tgaataagat ggcagtgttc tcctctgggg
     1741 cctgatccac ctctacacca gcccaggaag ccccatctgt gcctgccctc aggtggtcca
     1801 ccagtctccc cctttggttc ccttccagtc tcttccccct ttctatccca atcaccaata
     1861 gaaatgctaa catccctgcc tggtagccag actagcccac taaagctccc ctgtaaatgg
     1921 gggctccatt agttctgctg ccgagactaa taaagatttg gttggctcta gcagtaa
//
