LOCUS       NM_001197026            7774 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing A8 (PLEKHA8),
            transcript variant 1, mRNA.
ACCESSION   NM_001197026
VERSION     NM_001197026.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7774)
  AUTHORS   Yuan,T., Wang,J., Shi,C., Wang,Y., Xia,B., Xu,W., Yang,H., Yang,Y.,
            Ye,M.T., Khalid,S., Liang,Y., Tian,C., You,M.J. and Wang,Y.
  TITLE     Downregulation of FAPP2 gene induces cell autophagy and inhibits
            PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic leukemia
  JOURNAL   Hematol Oncol 40 (2), 249-257 (2022)
   PUBMED   34796518
  REMARK    GeneRIF: Downregulation of FAPP2 gene induces cell autophagy and
            inhibits PI3K/AKT/mTOR pathway in T-cell acute lymphoblastic
            leukemia.
REFERENCE   2  (bases 1 to 7774)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7774)
  AUTHORS   Fan,W., Du,F. and Liu,X.
  TITLE     Phosphatidylinositol 4-phosphate adaptor protein 2 accelerates the
            proliferation and invasion of hepatocellular carcinoma cells by
            enhancing Wnt/beta-catenin signaling
  JOURNAL   J Bioenerg Biomembr 52 (5), 301-309 (2020)
   PUBMED   32914361
  REMARK    GeneRIF: Phosphatidylinositol 4-phosphate adaptor protein 2
            accelerates the proliferation and invasion of hepatocellular
            carcinoma cells by enhancing Wnt/beta-catenin signaling.
REFERENCE   4  (bases 1 to 7774)
  AUTHORS   Zhu,Q., Dong,Y.C., Zhang,L., Ma,X. and Xia,H.F.
  TITLE     miR-98 is involved in missed abortion by targeting GDF6 and FAPP2
  JOURNAL   Reproduction 159 (5), 525-537 (2020)
   PUBMED   32045359
  REMARK    GeneRIF: miR-98 is involved in missed abortion by targeting GDF6
            and FAPP2.
REFERENCE   5  (bases 1 to 7774)
  AUTHORS   Kong,L. and Dong,L.
  TITLE     FAPP2 Accelerates the Proliferation and Invasion of Hepatocellular
            Carcinoma Cells via Wnt/beta-Catenin Signaling
  JOURNAL   J Environ Pathol Toxicol Oncol 39 (4), 309-316 (2020)
   PUBMED   33389903
  REMARK    GeneRIF: FAPP2 Accelerates the Proliferation and Invasion of
            Hepatocellular Carcinoma Cells via Wnt/beta-Catenin Signaling.
REFERENCE   6  (bases 1 to 7774)
  AUTHORS   Yamaji,T., Kumagai,K., Tomishige,N. and Hanada,K.
  TITLE     Two sphingolipid transfer proteins, CERT and FAPP2: their roles in
            sphingolipid metabolism
  JOURNAL   IUBMB Life 60 (8), 511-518 (2008)
   PUBMED   18459163
  REMARK    Review article
REFERENCE   7  (bases 1 to 7774)
  AUTHORS   D'Angelo,G., Polishchuk,E., Di Tullio,G., Santoro,M., Di Campli,A.,
            Godi,A., West,G., Bielawski,J., Chuang,C.C., van der Spoel,A.C.,
            Platt,F.M., Hannun,Y.A., Polishchuk,R., Mattjus,P. and De
            Matteis,M.A.
  TITLE     Glycosphingolipid synthesis requires FAPP2 transfer of
            glucosylceramide
  JOURNAL   Nature 449 (7158), 62-67 (2007)
   PUBMED   17687330
  REMARK    GeneRIF: by coupling the synthesis of glycosphingolipids with their
            export to the cell surface, FAPP2 emerges as crucial in determining
            the lipid identity and composition of the plasma membrane
REFERENCE   8  (bases 1 to 7774)
  AUTHORS   Vieira,O.V., Gaus,K., Verkade,P., Fullekrug,J., Vaz,W.L. and
            Simons,K.
  TITLE     FAPP2, cilium formation, and compartmentalization of the apical
            membrane in polarized Madin-Darby canine kidney (MDCK) cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18556-18561 (2006)
   PUBMED   17116893
  REMARK    GeneRIF: Data demonstrate FAPP2 is required for cilium formation in
            polarized MDCK cells.
REFERENCE   9  (bases 1 to 7774)
  AUTHORS   Vieira,O.V., Verkade,P., Manninen,A. and Simons,K.
  TITLE     FAPP2 is involved in the transport of apical cargo in polarized
            MDCK cells
  JOURNAL   J Cell Biol 170 (4), 521-526 (2005)
   PUBMED   16103222
  REMARK    GeneRIF: FAPP2 plays a specific role in apical transport in MDCK
            cells.
REFERENCE   10 (bases 1 to 7774)
  AUTHORS   Godi,A., Di Campli,A., Konstantakopoulos,A., Di Tullio,G.,
            Alessi,D.R., Kular,G.S., Daniele,T., Marra,P., Lucocq,J.M. and De
            Matteis,M.A.
  TITLE     FAPPs control Golgi-to-cell-surface membrane traffic by binding to
            ARF and PtdIns(4)P
  JOURNAL   Nat Cell Biol 6 (5), 393-404 (2004)
   PUBMED   15107860
  REMARK    GeneRIF: Data show that FAPP1 and 2 are essential components of a
            phosphatidylinositol 4-phosphate- and ADP-ribosylation
            factor-regulated machinery that controls generation of constitutive
            post-Golgi carriers.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007285.3, AK294857.1 and AI954066.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001197026.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.200738.1, AK294857.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449726.6/ ENSP00000397947.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC007285.3         66765-66765
            2-1670              AK294857.1         2-1670
            1671-1671           AC007285.3         112443-112443
            1672-2015           AK294857.1         1672-2015
            2016-7280           AC007285.3         117245-122509
            7281-7774           AI954066.1         27-520              c
FEATURES             Location/Qualifiers
     source          1..7774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..7774
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /note="pleckstrin homology domain containing A8"
                     /db_xref="GeneID:84725"
                     /db_xref="HGNC:HGNC:30037"
                     /db_xref="MIM:608639"
     exon            1..391
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1911
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology domain-containing family A member 8;
                     phosphoinositol 4-phosphate adapter protein 2;
                     serologically defined breast cancer antigen NY-BR-86;
                     phosphatidylinositol-four-phosphate adapter protein 2; PH
                     domain-containing family A member 8; pleckstrin homology
                     domain containing, family A (phosphoinositide binding
                     specific) member 8; phosphatidylinositol 4-phosphate
                     adaptor protein-2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 8 isoform 1"
                     /protein_id="NP_001183955.1"
                     /db_xref="CCDS:CCDS56473.1"
                     /db_xref="GeneID:84725"
                     /db_xref="HGNC:HGNC:30037"
                     /db_xref="MIM:608639"
                     /translation="MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSI
                     QMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQK
                     EKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCN
                     TFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELS
                     TCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGM
                     ENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEA
                     FLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEA
                     DVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVR
                     GVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLY
                     EVHGLESDEVV"
     exon            392..508
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..664
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..789
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..948
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..989
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1147
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1304
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1390
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1449
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1580
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1651
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1713
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..7774
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7754..7759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /note="hexamer: AATAAA"
     polyA_site      7774
                     /gene="PLEKHA8"
                     /gene_synonym="FAPP2"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcgccgt ggcgccgcct gcgaccggca gctcgttcgc cgcactttgg aggcttcggc
       61 tgcccctccg acccacgtag ggcccggacc cgggcctcct tgtgaacagc gtgccggctt
      121 cgccccacgg gttcaccggc tggctgggct tcaagcgccg aggccgccgc agtgaccccg
      181 cccccgggcc gaggatgtga ggcgggccgg gcgtccccac accgggcccg ggcgccggga
      241 gtgggcgtct gggcagcgcc aggcgatggc cctgctgctg gtgctcctcg cctcttgggg
      301 cctggggcag tgagggggcc ggcgggcgtg ggccgagtgg ccgcgggcgc catggagggg
      361 gtgctgtaca agtggaccaa ctatctgagc ggttggcagc ctcgatggtt ccttctctgt
      421 gggggaatat tgtcctatta tgattctcct gaagatgcct ggaaaggttg caaagggagc
      481 atacaaatgg cagtctgtga aattcaagtt cattctgtag ataatacacg catggacctg
      541 ataatccctg gggaacagta tttctacctg aaggccagaa gtgtggctga aagacagcgg
      601 tggctggtgg ccctgggatc agccaaggct tgcctgactg acagtaggac ccagaaggag
      661 aaagagtttg ctgaaaacac tgaaaacttg aaaaccaaaa tgtcagaact aagactctac
      721 tgtgacctcc ttgttcagca agtagataaa acaaaagaag tgaccacaac tggtgtgtcc
      781 aattctgagg agggaattga tgtgggaact ttgctgaaat caacctgtaa tacttttctg
      841 aagaccttgg aagaatgcat gcagatcgca aatgcagcct tcacctctga gctgctctac
      901 cgcactccac caggatcacc tcagctggcc atgctcaagt ccagcaagat gaaacatcct
      961 attataccaa ttcataattc attggaaagg caaatggagt tgagcacttg tgaaaatgga
     1021 tctttaaata tggaaataaa tggtgaggaa gaaatcctaa tgaaaaataa gaattcctta
     1081 tatttgaaat ctgcagagat agactgcagc atatcaagtg aggaaaatac agatgataat
     1141 ataacagtcc aaggtgaaat aaggaaggaa gatggaatgg aaaacctgaa aaatcatgac
     1201 aataacttga ctcagtctgg atcagactca agttgctctc cggaatgcct ctgggaggaa
     1261 ggcaaagaag ttatcccaac tttctttagt accatgaaca caagctttag tgacattgaa
     1321 cttctggaag acagtggcat tcccacagaa gcattcttgg catcatgtta tgctgtggtt
     1381 ccagtattag acaaacttgg ccctacagtg tttgctcctg ttaagatgga tcttgttgga
     1441 aatattaaga aagtaaatca gaagtatata accaacaaag aagagtttac cactctccag
     1501 aagatagtgc tgcacgaagt ggaggcggat gtagcccagg ttaggaactc agcgactgaa
     1561 gccctcttgt ggctgaagag aggtctcaaa tttttgaagg gatttttgac agaagtgaaa
     1621 aatggggaga aggatatcca gacagcccta aataatgcat atggtaaaac attgcggcaa
     1681 caccatggct gggtagttcg aggggttttt gcgttagctt taagggcagc tccatcctat
     1741 gaagattttg tggccgcgtt aaccgtaaag gaaggtgacc accagaaaga agctttcagt
     1801 attgggatgc agagggacct cagcctttac ctccctgcca tggagaagca gctggccata
     1861 ctggacactt tatatgaggt ccacgggctg gaatctgatg aggtggtatg atggctgctg
     1921 ggcagcacct cctaacttca gggaataagt gctaaagtgt tttgttgccc tacttaattt
     1981 ccagcaacag cctcaaccct ctccaacccc ttcacctggg gggatggaca ggaggtggca
     2041 aaacccagtg cttttataat ttttaaaatg catatgtgtt ttgtttaaag atcaaggtgc
     2101 tatatatttc agttcagcag gcctactgga aaccaaatga taagctgctg tagacttgaa
     2161 cagcaagtta taagagcaga tttaacaaac aaatttgctg ttattgtgta ttgtattgtt
     2221 tttatatttt agtctaatgg gccacccaaa cccaagctga aaatcagcaa attccatatt
     2281 aagtaccata attcatagcc agtgtttcag ccaacttaga ctagacattt ggaggtagta
     2341 taagctgctt tgttgaagct gtgtagagtt tgctgttcct agatgttctt cagtggaccc
     2401 tcttcactgc aactctgtca gtgataaggg cctgtgtagt aaagatgttc agggcattca
     2461 catgaccatg caattgtggg aggcgaagaa gacgtggaca ggagtcccat ccttgctgac
     2521 aggcatgaaa ccgttgctct gagaagatta atggtgtgcc ctagccccaa gttggagggg
     2581 agaatatgag agaggtggga caggtcattt gagatgacac ctcccaactg cctaccattt
     2641 accagcatgt tccccatgca ttatctcaat tggacatcac aagtaatgat acccagaggg
     2701 attattactc cacttcaaaa gcaaggttta gaagttgagg gatctgttca cagtcacata
     2761 gtttttaagc agaggagcca gataatttcc aagtgtgacc tggactgcct ctgcatcaaa
     2821 gtcatatgga gtgcttgttc aaacagcaga ttcccaggcc ttattttggc ctaaagaacc
     2881 agagtctagg tggtgggaca taggaatctg catttcagta aactttacac gtgattcttc
     2941 tgcacacagt attgaagagc aactagatta aattctagtt tacaaaatta ccagttttct
     3001 tcaagaacta aatgatatgt cctttttttt tttttcaaag aggataaggc tgctatttaa
     3061 ataaaatagc taaatggaga gtgagaagtg gagcaggttc attcagcagc attcttaatt
     3121 gagccagcat tgacacccag ccagcaggcc tttgcattgc attcggggac catgactctg
     3181 aatctgctta ccaatcaatc tcggtttaat caccaaaagt gcagagcagg caaaatgcag
     3241 ctgtttatca atctcaaaag ctttgggaca gtgtcatagt tgaaagatga gacttaagaa
     3301 aacagtttct taaacttctt aaaacttaag aaacattgtt tcataaaaca atattgagtg
     3361 ggcattcttc tgcacagtgt gatgctccaa ccctggccct agtctcagta gaccatgctg
     3421 cctcgagtgt gcatcggaga gaagccatgg gtaccttccc cattagaggc tacttccttc
     3481 tagtaacagg aagggaagtt ccagcatgag gtagttatcc agggtagaag gtcctttgag
     3541 gggcttggtt gaattgagag catcatctct agatgatgct gttcctgctg cagatctcta
     3601 ggatggagag aattctctct ttagtcagag aagtttatgt agggaggggt attggttttg
     3661 cctttgtgtg tctttaaaca aatgaacatt tatttagctc agattaatta ggtattttgc
     3721 ccacataaag acttctggaa aatacttaaa cttgaaaaat caacatcaca tgttttaaag
     3781 ctagggagaa agaagggggg tattaaaatg atgttgatta ttttgtattt tgccaaggtg
     3841 tgtgtgtgtt atttccctcc cactctcatg agcagtgagt atagatctcc ttctctgatt
     3901 agtatgaata tgatggcagg actcggggat agtccctgcc cttgacatag ccccctaaaa
     3961 cggaaaaaga aaaagccagt ttttgcttgt actttgaatg aagatgtttt aggcattgta
     4021 ccatttagcg gggatgatac caggtggttg ttagaattgt gcagtgtgat cattctaaac
     4081 agctgctggt gctccctgtc acctcaggtg aactctgtgg tctcttggag aggtagcact
     4141 ctgaaaatac ctcaggtttg ccaccgcaac tctgaataca cacaaaagga aagctgctca
     4201 gcatggccat tttgcatttg tataggtagt gactagatgt acacaactta atttgctggg
     4261 aatgaggggc ttaatattat ctgagatcat tgagaaccca gatcagacag aatagcttga
     4321 ataagttaca ttttccaatt accctttttc cacatctgta gaaagagggt aatatttttt
     4381 aataggtatt ttccccactg gagcatatta cgtttgccta agatgtataa aagtttgttt
     4441 aagatgtgta aaagtttgct taaggaactg aggatcctta aataaaaata ttagaaatta
     4501 gaaattgaac ctaatactaa acagtaaatt cagcttaacc tgaaccttgg catagtcaga
     4561 gcttcctcct acatctaaag tatttgctct ctgttttagt taaagtcata atttgcgctg
     4621 atgtgtaatc actttccaag aagagggcaa tgagaaaaga tatttaaagc tttctctcca
     4681 tagccctcca agacttctgg gacaactaaa tttactttca ccattactgt gagaggaggt
     4741 gagaaaactc tagtattttg ttggcagagt aatcactttg ttctcatcgc tcaaagcatt
     4801 tttaggatta tttttctagc gtaaccttta gagagaactg gaagaaaaag gaaattggtc
     4861 tactaggtat tgtagacaca aataagtaac attaggctaa ccccttatga gacatttcca
     4921 cacaatttca tcgtgcctgt acttttctct atggtaaaag ccagtgttta cactttgtag
     4981 ggatcagggt gtatttgttg aattaaacaa aatattttca atgatggcaa gtctcttgac
     5041 ttttgaaagc aagtcagatt ccttatagct aatgctggtg aaaaatgtta aattggagag
     5101 atcccttttg ggagtgaaac caaattgtaa ctatgaggag aagatggtct tctcattggc
     5161 tcttgatgta gctctgaagg gagttccaga agaggagctc tcacagaatg ttgagcctgt
     5221 gggcccaaga cattgacttc gaagggtagt tctcattagg atgtataagt agtggcttga
     5281 ggcaccttct tatcattttt tgcatgttat tctgattatt aaacttcccc caatgtcata
     5341 ttccatgatg agggatttct gaactccata gtccagcgtt gttgcttttc tctcttcttt
     5401 gctactgaaa attgccagca gtaccgccat cagcacacca aatctacccc cacttatgtt
     5461 tgttctgccc catttcccag gagcagcttc tagcacatat gtagagtatc tggcaccacc
     5521 ttagcccagg gctgcgtgcc tgatcagtgg ggattctgtt cccccacccc ccagactgca
     5581 agagcttctt aagaaggagc ccatattccc atttgtagct ggaaagcggg tgaatgacat
     5641 gacatggggc acctaggaaa gatgattatt agaggagtgc agcggaaaaa aatttgcact
     5701 cttctccttt tggttattac tttccaaata tattaacaaa aagttgatgc ttttaacttt
     5761 atattttcag aaaagtgttt ttaattaaaa atatgtgata gggaccaaat aagtaaagta
     5821 catttttctc cactaaattt gaagtgaggg aaagaggagc caaagtaaga gatttttttt
     5881 taaggaaact taatctgatt gtgaaaatca tacatatgga gaaacatcag atcaggcaat
     5941 agagtcagag ggtcatgagc aatagacgat gatgcgaggc atttggggag cttcctggag
     6001 gaaaattaag tttttttcct agcaaactac catgtcctac aagaacttgg ttatataatg
     6061 gtgcgtctct gaatcactga ttaaaaccag ttgcttctga ttttagtcac aggttttaca
     6121 agtattcagc tctccctcat gtttcatttc tttttttaag ataatctatc aacctttttt
     6181 aaattttaaa atttttagat gtagagttta taagtaaaat atatttttag ccattgttct
     6241 gttagctgag ctgatgtgtt tggtcttaga gggcctgact tcagatactc tttgtgatct
     6301 tgtaagggct ctacacaaac ttcattatgt atggtaaatt tgtattctta tggattgtat
     6361 atagaatgct ttcgttagaa gtacattcta cttctgtatg tccctttgta atccgcagtt
     6421 gcttactcag gggtttcata gtcatttcat aaaaaataat tcactagctg tctaatggta
     6481 ttttaagact gtttatctgt atcacaacgt cattaggagt tctttcaaca attccataaa
     6541 tatactgttt actagacctt ccctgtaaat gttcccaatt cccatcctgt ctcagacagt
     6601 caatagtcct gtgtacagtg actatttgca tgatttctca ttgcactgct gcattcaggc
     6661 actccagggc atgattaaac agtcattaac agtgcctctc tggtacagtt gatgcatgca
     6721 ttgatctttc ttctctgctg tttttatata gcctttaatt aaaaggaaaa aaataccact
     6781 actctgcaat gcaaaagtct tcaaaattct ttgtttcctg tattaatcac ttctgttcca
     6841 gagtgaacaa atgttttcag ctaagctatg tgagaatgta agaataatat cctgcttgtt
     6901 ctaaatagtt catatattta aagtgtggtc agtatttcct ccctgtacct tacaaacaga
     6961 aaccaccctg ggatggttga taccccttac aaagtcgatc ttacccacac agactcctgt
     7021 gtatgcgtgt ctgtttatag gtgtatatgg agtcagtgtt gataggaagg atgctctaga
     7081 agtacttctg ttgtttccta gaaggctatg agccagttcc atggcatgtt taatgtataa
     7141 ttcccatgta tcatgagaat ttcactagaa tgtcattaaa cagcccaact acctcatgtg
     7201 aaattggctg tggacaatct gtgtcagatg agaaatgtgt tcagataaat ttaatctggt
     7261 taatagactt aacaaattaa tgtctacata aagaagaaac atgatagacc agatgccaaa
     7321 ggctaaaatg tacatagatt tccttggatt aatttttaag tcactgttta attccatgcc
     7381 tagtattctt atgaatgttt gtggtttcat agatttatgc actttgaata tctgtcacgt
     7441 gcagtgttaa tgttacctgt tcttgtctct cagcattttg aatgagcatc ataatcagag
     7501 tagaaggcaa gttaaactat aaaagtgtca agtggcttgt taacttctta atttaatgga
     7561 cctttactta gaatataata tgttggagcc tcttgggacc aaccgatgag cgacagtttc
     7621 atgtttagat ttgtattgtt tctctgtcca agtccttatt ctctatcttg tggggagggg
     7681 tgacagggga gggttttact ttttttgcaa aaatgtttga aaatatctgt cagattttat
     7741 attcgttagt tataataaac ttatttttaa agta
//
