LOCUS       NM_014935               7412 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing A6 (PLEKHA6),
            mRNA.
ACCESSION   NM_014935
VERSION     NM_014935.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7412)
  AUTHORS   Sluysmans,S., Mean,I., Xiao,T., Boukhatemi,A., Ferreira,F.,
            Jond,L., Mutero,A., Chang,C.J. and Citi,S.
  TITLE     PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes
            ATPase ATP7A to the cell periphery and regulate copper homeostasis
  JOURNAL   Mol Biol Cell 32 (21), ar34 (2021)
   PUBMED   34613798
  REMARK    GeneRIF: PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the
            Menkes ATPase ATP7A to the cell periphery and regulate copper
            homeostasis.
REFERENCE   2  (bases 1 to 7412)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7412)
  AUTHORS   Spellmann,I., Rujescu,D., Musil,R., Meyerwas,S., Giegling,I.,
            Genius,J., Zill,P., Dehning,S., Cerovecki,A., Seemuller,F.,
            Schennach,R., Hartmann,A.M., Schafer,M., Muller,N., Moller,H.J. and
            Riedel,M.
  TITLE     Pleckstrin homology domain containing 6 protein (PLEKHA6)
            polymorphisms are associated with psychopathology and response to
            treatment in schizophrenic patients
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 51, 190-195 (2014)
   PUBMED   24576533
  REMARK    GeneRIF: This study demonistrated that PLEKHA6 polymorphisms are
            associated with psychopathology and response to treatment in
            schizophrenic patients.
            Erratum:[Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr
            3;58:106. Meyerwas, Sebastian [added]]
REFERENCE   4  (bases 1 to 7412)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   5  (bases 1 to 7412)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   6  (bases 1 to 7412)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   7  (bases 1 to 7412)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 7412)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 7412)
  AUTHORS   Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
            Lauffenburger,D.A. and White,F.M.
  TITLE     Time-resolved mass spectrometry of tyrosine phosphorylation sites
            in the epidermal growth factor receptor signaling network reveals
            dynamic modules
  JOURNAL   Mol Cell Proteomics 4 (9), 1240-1250 (2005)
   PUBMED   15951569
REFERENCE   10 (bases 1 to 7412)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606489.26, AB023186.1, AL592114.13 and BC073995.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014935.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152475.1, AB023186.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272203.8/ ENSP00000272203.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL606489.26        11875-11887         c
            14-456              AB023186.1         1-443
            457-457             AL592114.13        107269-107269       c
            458-2839            AB023186.1         445-2826
            2840-2840           AL592114.13        69467-69467         c
            2841-2936           AB023186.1         2828-2923
            2937-2937           AL592114.13        68062-68062         c
            2938-3983           AB023186.1         2925-3970
            3984-7022           AL592114.13        58224-61262         c
            7023-7412           BC073995.1         1722-2111
FEATURES             Location/Qualifiers
     source          1..7412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..7412
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="pleckstrin homology domain containing A6"
                     /db_xref="GeneID:22874"
                     /db_xref="HGNC:HGNC:17053"
                     /db_xref="MIM:607771"
     exon            1..236
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..317
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..432
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..3477
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="phosphoinositol 3-phosphate-binding protein 3; PH
                     domain-containing family A member 6"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 6"
                     /protein_id="NP_055750.2"
                     /db_xref="CCDS:CCDS1444.1"
                     /db_xref="GeneID:22874"
                     /db_xref="HGNC:HGNC:17053"
                     /db_xref="MIM:607771"
                     /translation="MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVA
                     FGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILG
                     SIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
                     IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEK
                     AERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHS
                     PSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDL
                     RSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDK
                     RHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQ
                     PRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPK
                     VPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
                     GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEV
                     SALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGP
                     SATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTL
                     PLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTN
                     GLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPR
                     PAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDI
                     NKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEG
                     DSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPAN
                     PLSSESPRGADSSYTMRV"
     exon            433..537
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..610
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..711
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..854
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1337
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1854
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1923
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2004
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2154
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2250
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2362
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2502
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2632
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2739
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2913
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3081
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3215
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3361
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3485
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..7412
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5021..5026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="hexamer: AGTAAA"
     polyA_site      5047
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="major polyA site"
     regulatory      5516..5521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="hexamer: ATTATA"
     polyA_site      5536
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="major polyA site"
     regulatory      7393..7398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="hexamer: AATAAA"
     polyA_site      7412
                     /gene="PLEKHA6"
                     /gene_synonym="PEPP-3; PEPP3"
                     /note="major polyA site"
ORIGIN      
        1 gcctgggaaa gatgctggat cctgcagtaa ccacaacagc atcctctccc tgcgccaggg
       61 acctgccagc cggagagatg actgattaga tcagattaga tccggagccc cgctctgcag
      121 aagggggccc caggggcggg ggaggaggac cccagctggc ctgagctggg gggaggggtg
      181 ccttggggct cgcagagtta gagctttcca gcgcggggat cacacctcag aagccgccac
      241 aatgaaagac ggaacacatt tctacaccca gtgactggcc aggtcccaga ggaaaacaaa
      301 aaatttgact tgaaaatatc gaccttggac atgtccaata aaacaggtgg gaaacgcccg
      361 gctaccacca acagtgacat acccaaccac aacatggtgt ccgaggtccc tccagagcgg
      421 cccagcgtcc gggcaactcg cacagcccgc aaagccgtcg cctttggcaa gcgctcacac
      481 tccatgaagc ggaaccccaa tgcacctgtc accaaggcgg gctggctctt caaacaggcc
      541 agctccgggg ttaagcagtg gaacaagcgc tggttcgtcc tggtggatcg ctgcctcttc
      601 tactataaag atgagaagga agagagtatc ctgggcagca tccccctcct gagcttccgg
      661 gtagccgcag tgcagccctc agacaacatc agccggaaac acacgtttaa ggctgagcat
      721 gccggggtcc gcacctactt cttcagtgcc gagagccccg aggagcaaga ggcctggatc
      781 caggccatgg gggaggctgc tcgagtacag atccctccag cccagaagtc agtgccccaa
      841 gctgtgcggc acagccatga gaagccagac tcggagaacg tcccacccag caagcaccac
      901 cagcagccac cccacaacag cctccctaag cctgagccag aggccaagac tcgaggggag
      961 ggtgatggcc gaggctgtga gaaggcagag agaaggcctg agaggccaga agtcaagaaa
     1021 gagcctccgg tgaaagccaa tggcctccca gctggaccgg agccagcctc agagccgggc
     1081 agcccttacc ccgagggccc aagagtgcca gggggtgggg aacagcctgc ccagcccaat
     1141 ggctggcagt accactcccc aagccggcca gggagcacag ctttcccgtc tcaggatgga
     1201 gagactgggg gacaccggcg gagtttccca ccacgcacca accctgacaa aattgcccag
     1261 cgcaagagct ccatgaacca gcttcagcag tgggtgaatc tgcgccgggg ggtacccccg
     1321 cctgaagacc ttcggagtcc ctctaggttc tatcctgtgt ctcgcagggt ccctgagtac
     1381 tatggcccct actcctccca gtaccccgat gattatcagt actacccgcc aggagtgcgg
     1441 ccggagagca tctgttccat gccggcctat gatcggatca gcccgccctg ggccctggag
     1501 gacaagcgcc atgccttccg caatgggggt ggccctgcct accagctgcg agagtggaag
     1561 gagcccgcca gctacgggcg gcaggatgcc accgtctgga tcccaagccc ctcccggcag
     1621 ccagtctatt atgatgagct ggatgccgcc tctagctccc tgcgccgcct gtccctgcag
     1681 ccccgctccc actctgtgcc ccgctcaccc agccagggct cctacagccg tgcccgcatt
     1741 tactcccctg tccgctcacc cagtgcccgt tttgagcggc tgccacctcg cagtgaggac
     1801 atctatgctg accctgctgc ctatgtgatg aggcgatcca tcagctcccc caaggtccct
     1861 ccatacccag aagtgttccg ggacagcctc cacacctaca agttaaacga gcaagacaca
     1921 gataagctgc tgggaaaatt gtgtgagcag aacaaggtgg tgagggagca ggaccggctg
     1981 gtgcagcagc tccgagctga gaaggagagc ctggaaagtg ccttgatggg gacccaccag
     2041 gagctggaga tgtttggaag ccagcccgcc tacccagaaa agctgcgaca caaaaaggat
     2101 tcactgcaga accagctcat caacatccgc gtggagctgt ctcaggcgac cacggccctg
     2161 acaaacagca ccatagagta tgagcacctc gagtctgagg tctctgccct gcacgatgac
     2221 ctctgggagc agctcaattt ggacacccag aatgaggtgc tgaaccggca aatccaaaag
     2281 gagatctgga ggatccagga cgtgatggag gggctgagga agaacaaccc ctcccggggc
     2341 acggacaccg ccaagcacag aggaggactt ggcccctcag ccacctacag ctccaacagc
     2401 ccggccagcc ccctcagctc tgccagcctc accagccccc tgagcccctt ttcactggtg
     2461 tcgggctctc aggggtcccc caccaagcct ggctccaacg agcccaaggc aaactatgaa
     2521 caaagcaaga aagaccccca ccagacattg cccctggaca cccccagaga catcagcctt
     2581 gtgcccacca ggcaagaggt agaggcagag aagcaggcag ctctcaacaa agttggcgtt
     2641 gtgccccctc ggacaaaatc gcccactgat gatgaggtga ccccatcagc agtggtaaga
     2701 aggaatgcca gtgggctcac caatggactc tcctcccagg aacgccccaa gagtgctgtg
     2761 tttcctggcg aggggaaggt caagatgagc gtggaggagc agattgaccg aatgcggcgg
     2821 caccagagtg gctccatgag ggagaagcgg aggagcctgc agctcccggc cagcccggcc
     2881 cccgacccca gtccccggcc agcctacaaa gtggtgcgcc gccaccgcag catccatgag
     2941 gtagacatct ccaacctgga ggcagccctg cgggcagagg agcctggcgg gcatgcctac
     3001 gagacacccc gggaggaaat tgcccggctt cgcaaaatgg agctagagcc ccagcattat
     3061 gacgtggaca tcaataagga gctctccact ccagacaaag tcctcatccc tgaacggtac
     3121 attgacctgg agcctgacac tcccctgagc cctgaggagt tgaaggagaa gcagaagaag
     3181 gtggagagga tcaagacact cattgccaaa tccagtatgc agaacgtggt gcccatcggc
     3241 gagggggact ctgtggacgt gccccaggac tcagagagcc agctgcagga gcaggagaag
     3301 cggattgaaa tctcctgcgc cctggcgacc gaggcctccc gcaggggccg catgctgtct
     3361 gtgcaatgtg ccaccccaag ccctcccacc tcccctgctt ccccggctcc tccagcaaac
     3421 cccctgtcgt ctgaatcccc acggggcgcc gacagcagct ataccatgcg ggtctgagct
     3481 ctgactgcaa gccctggctg aggccaatgc tgtgaagctc cacagagcca cattctgaag
     3541 ccgtcctctg cccacctgag gtcctggctc cccaccctgg ccccctgccc ctgcactccc
     3601 atgggaatgc cgcagggagc caggctgggg ccatgggctg ctgccagagg accgtggata
     3661 cctcagtgtc cacacaccca ccatgcccag ccctggagcc atcactactc acaccgtggt
     3721 cctgggccag ggcctgagat gacagtgggg agcaccatcc tcattaatgt ccaagtcaca
     3781 gggagcctca gccttgccct ggctggggtt gtggtgactc cagtggaaca ttccctgatg
     3841 ggggacatgc cgtggtggag aacacacctg tggctatctt atgtgaggac tagaggtgaa
     3901 gaggagatgg acactgcctc tggagccagc ctgacaccaa ggacagcact tgtcatcatc
     3961 cctatcctcg tcagccccac cctactgcct cagctggacc cagggctttg acacaaaccc
     4021 agtgctttgc ttatgggtgc tcgctggggt ccggtggaga ctgaccaccc tgcttgagcc
     4081 aaagacaagg tgatgagaga tggggagagg ccattggctc ccagagggaa cagtgctggc
     4141 tgtggctaga gaacagcagg tctgtgcagt gtctgagggc aggttgggaa gggtagcaga
     4201 gagagagaga cagaaagaga gagagagaga gagagagaga gagatcctca gagtggaagg
     4261 agggggaagc agcaggacac attggcaagt caagcaggaa ggagggagat ggaaagggga
     4321 tatcagattg gtttcccccg gtggagcctt aggttagtgc ccagtgcagt gccagactgt
     4381 ctcctctgct cctcccacct catccctagg aggacccacc agtggagcac atgcagcctc
     4441 agtggagatg cttggtgtgg ggatctgggt gaagggggtt gagtagcgac tgcctgggag
     4501 atggctgtta gtaggtctgt gcctggtgtc tgcctcgcca tcctggggta aggggcagag
     4561 agaaggactt gtcttatgta gggtgtggtc agccttgggg ccttacctac ccagttccat
     4621 gatatttctt gccctgttcc ccctggaatg tgcagtgggc cagctgagag tacgccttga
     4681 ggagggggga tgaggcctta atctgggagg cctatccccc tatcccaggc atcccagacg
     4741 aggactggct gaggctaggc gctctcatga tccacctgcc ccgggagggc agcggggaag
     4801 acagagaaaa gcaaacgcat tcctcctcag ctccacccac ctggagacga atgtagccag
     4861 agaggaggaa ggagggaaac tgaagacacc gtggcccctc ggccttctct ctgctagagt
     4921 tgccgctcag aggcttcagc ctgacttcca gcggtcccaa gaacacctac taattcctct
     4981 gcactccttc atggctggga cagttactgg ttcatatgca agtaaagatg acaatttact
     5041 caacaaatat ttatcgagca ccttttatgt accaggcact gttgtaggtg cttaggatat
     5101 tctcatgttt ctgagggatt acagcctggg aggattccac cgatcttcac ttctagcagg
     5161 ttttttaaac gtgacccttg gctgtatttc ccatcttcac agttcaagca ccccaaacct
     5221 gccctttctc ccctgcagac tggcaggtgg gattggctcc caggtcattt cctctctctc
     5281 tctttctccc aagcctttct ccctccacag gaaacagatt tttcagggcc ttccatgcct
     5341 gccactttgt ccgtctcttt tttttttttt aaagtaatat tttttagaaa tacatgtaaa
     5401 ataccaagaa ataatgtctg cgcctctgcc acctctctct catctcttat ttcataaagc
     5461 tggctcttta tgttgcttta catgccttaa tatatgtttt atggagatta tacatattat
     5521 agatctatat atgtaatata tttgtttgga tgtctgatct tttcctacag ttcctgccca
     5581 ggcctgtttt tctctccctt attttccaca tcattcctag catatcaaga ccatacccct
     5641 tgcctttttg atccaaagaa ggggagagga aagacttatt ttaagacatc tattttatgc
     5701 ttttgtttaa aaaaagcaaa tctattttca aattgtgcaa tgtctgaatg gaattggcaa
     5761 atgaggtgag gagatggggt aactgccttt aggtcccaac cctgtgcctg tccctctgcc
     5821 acagtggctt ccttccatcc tattccccag tcacgaaagg gctggtcccc agagctcacc
     5881 cagaaagcat cttgccgggg gcagggcatt ccctcggaag tcctggccta aggattttat
     5941 tacactgtct gctcctgatg accctctgcg gttgtcaggc gtgaatcctc tggaaggaac
     6001 tgtttgcagt tgtatgcaca aaggagaccc atgcaggcat gcaccccaga tgggctgcta
     6061 gactacccct cttcatcagc ctgctggaaa gagcagacag cgtaacagca gcctatgcca
     6121 aacagcacta aggatgtcag tgtacgagac ggtgcgaagc ccagaggagg cggcttggga
     6181 tcctctgggc catccctggc cctgtagcac agacacatac aagttccttg gacttgtcac
     6241 actccttttc acttgatccc tctctggcct gggtcacatt tatgacatcc cccctctgca
     6301 acctttctct ctgggggctg taccaaaggc atggtacctc agtctggtat ccagactgtg
     6361 aaatcagcct ctgggccaag gagggtccta cagacaaggt ggcatctcaa cctcacccaa
     6421 gaaacccccg ggactttacc ccagcaggct gccactgggg caccgaacta agccagctca
     6481 gccttccaag ctgcttagcc tttgtcaacc atcaaagtgg ggaaagggtc tctggccttg
     6541 caaggatttg ggcaggatgg aagtctttgt ctaggtctga aatcaagggc ttgggaatct
     6601 agagcagagc tcctggccag cgtttgaagc ctggcctccc acctggggca tttactgaca
     6661 ccctgtcgcc agcctagaac atcctgctct gaatgaacag agcccagatg ggggtccaga
     6721 gctaagtgac ccacctgggg aagctctgat tattcatcca gggccttctc aatgagcaca
     6781 ttacctccat gatcaataac caagaggctg cagtcaaata ctgctactgt cactttgaag
     6841 attttctaag ggcacaagtg gcacacttgc tctccggcct ttgggagagg catgttcttg
     6901 ggcagggctg gctacggcaa gagggaacca attcctttcc cctttaggca ccctctacct
     6961 ggcagctctt aaaactaaga aaaaatatga tatacacaca cattatatat atatatatat
     7021 atacacacac acacacacac acacgtatat ctatttatgc acatattggg gccaatttga
     7081 tttgctagta ttagacaata aactgtacaa ggaaatttat tatctcagtg tctttattta
     7141 gcataaaagt ggccttagaa gaagggtgaa ggttagatag atggaatctc tgtcagggga
     7201 caaacagctg tagcatcccc ttagcatctt tctagccaat gagccccctc cccaggagga
     7261 gggatggcct gactgaaaca ggtgagagtt tgcttccccc tttcagcagc attcttttta
     7321 gatttaggta ctgaagaatc ccagtgagtt ctgcatttgt atcttgcaag tttgtataaa
     7381 cccaatacag gaaataaaat gaatggtttg ta
//
