LOCUS       NM_001256470            4797 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing A5 (PLEKHA5),
            transcript variant 4, mRNA.
ACCESSION   NM_001256470
VERSION     NM_001256470.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4797)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 4797)
  AUTHORS   Sluysmans,S., Mean,I., Xiao,T., Boukhatemi,A., Ferreira,F.,
            Jond,L., Mutero,A., Chang,C.J. and Citi,S.
  TITLE     PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes
            ATPase ATP7A to the cell periphery and regulate copper homeostasis
  JOURNAL   Mol Biol Cell 32 (21), ar34 (2021)
   PUBMED   34613798
  REMARK    GeneRIF: PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the
            Menkes ATPase ATP7A to the cell periphery and regulate copper
            homeostasis.
REFERENCE   3  (bases 1 to 4797)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   4  (bases 1 to 4797)
  AUTHORS   Gordon,D.E., Jang,G.M., Bouhaddou,M., Xu,J., Obernier,K.,
            White,K.M., O'Meara,M.J., Rezelj,V.V., Guo,J.Z., Swaney,D.L.,
            Tummino,T.A., Huttenhain,R., Kaake,R.M., Richards,A.L.,
            Tutuncuoglu,B., Foussard,H., Batra,J., Haas,K., Modak,M., Kim,M.,
            Haas,P., Polacco,B.J., Braberg,H., Fabius,J.M., Eckhardt,M.,
            Soucheray,M., Bennett,M.J., Cakir,M., McGregor,M.J., Li,Q.,
            Meyer,B., Roesch,F., Vallet,T., Mac Kain,A., Miorin,L., Moreno,E.,
            Naing,Z.Z.C., Zhou,Y., Peng,S., Shi,Y., Zhang,Z., Shen,W.,
            Kirby,I.T., Melnyk,J.E., Chorba,J.S., Lou,K., Dai,S.A.,
            Barrio-Hernandez,I., Memon,D., Hernandez-Armenta,C., Lyu,J.,
            Mathy,C.J.P., Perica,T., Pilla,K.B., Ganesan,S.J., Saltzberg,D.J.,
            Rakesh,R., Liu,X., Rosenthal,S.B., Calviello,L., Venkataramanan,S.,
            Liboy-Lugo,J., Lin,Y., Huang,X.P., Liu,Y., Wankowicz,S.A., Bohn,M.,
            Safari,M., Ugur,F.S., Koh,C., Savar,N.S., Tran,Q.D., Shengjuler,D.,
            Fletcher,S.J., O'Neal,M.C., Cai,Y., Chang,J.C.J., Broadhurst,D.J.,
            Klippsten,S., Sharp,P.P., Wenzell,N.A., Kuzuoglu-Ozturk,D.,
            Wang,H.Y., Trenker,R., Young,J.M., Cavero,D.A., Hiatt,J.,
            Roth,T.L., Rathore,U., Subramanian,A., Noack,J., Hubert,M.,
            Stroud,R.M., Frankel,A.D., Rosenberg,O.S., Verba,K.A., Agard,D.A.,
            Ott,M., Emerman,M., Jura,N., von Zastrow,M., Verdin,E.,
            Ashworth,A., Schwartz,O., d'Enfert,C., Mukherjee,S., Jacobson,M.,
            Malik,H.S., Fujimori,D.G., Ideker,T., Craik,C.S., Floor,S.N.,
            Fraser,J.S., Gross,J.D., Sali,A., Roth,B.L., Ruggero,D.,
            Taunton,J., Kortemme,T., Beltrao,P., Vignuzzi,M., Garcia-Sastre,A.,
            Shokat,K.M., Shoichet,B.K. and Krogan,N.J.
  TITLE     A SARS-CoV-2 protein interaction map reveals targets for drug
            repurposing
  JOURNAL   Nature 583 (7816), 459-468 (2020)
   PUBMED   32353859
REFERENCE   5  (bases 1 to 4797)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4797)
  AUTHORS   Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
            Lauffenburger,D.A. and White,F.M.
  TITLE     Time-resolved mass spectrometry of tyrosine phosphorylation sites
            in the epidermal growth factor receptor signaling network reveals
            dynamic modules
  JOURNAL   Mol Cell Proteomics 4 (9), 1240-1250 (2005)
   PUBMED   15951569
REFERENCE   7  (bases 1 to 4797)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 4797)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 4797)
  AUTHORS   Grottke,C., Mantwill,K., Dietel,M., Schadendorf,D. and Lage,H.
  TITLE     Identification of differentially expressed genes in human melanoma
            cells with acquired resistance to various antineoplastic drugs
  JOURNAL   Int J Cancer 88 (4), 535-546 (2000)
   PUBMED   11058868
REFERENCE   10 (bases 1 to 4797)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092828.16, AB642244.1, AC091805.16 and AL834259.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001256470.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB642244.1, SRR1803612.87482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429027.7/ ENSP00000404296.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC092828.16        66625-66706         c
            83-4338             AB642244.1         90-4345
            4339-4559           AC091805.16        171374-171594       c
            4560-4797           AL834259.1         2151-2388
FEATURES             Location/Qualifiers
     source          1..4797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..4797
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /note="pleckstrin homology domain containing A5"
                     /db_xref="GeneID:54477"
                     /db_xref="HGNC:HGNC:30036"
                     /db_xref="MIM:607770"
     exon            1..156
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..3916
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     phosphoinositol 3-phosphate-binding protein-2; PH
                     domain-containing family A member 5; pleckstrin homology
                     domain containing, family A member 5"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 5 isoform 4"
                     /protein_id="NP_001243399.1"
                     /db_xref="CCDS:CCDS58213.1"
                     /db_xref="GeneID:54477"
                     /db_xref="HGNC:HGNC:30036"
                     /db_xref="MIM:607770"
                     /translation="MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTG
                     EAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVN
                     EQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSN
                     SIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPS
                     FQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKR
                     ITFNFRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYG
                     FQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADL
                     RGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMP
                     SHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQ
                     LYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQR
                     TYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEE
                     LTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKE
                     NEPIITMVHTMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDA
                     KLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRD
                     DLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGI
                     QRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEEEEVVPPRPPL
                     PRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRL
                     YKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIA
                     SYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKK
                     GLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIV
                     QLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSP
                     QDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESS
                     ASPVPSTQPQLTEGSHFMCV"
     exon            157..236
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..294
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..378
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..499
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..604
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..677
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..778
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..894
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..912
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1380
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1846
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1930
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2050
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2104
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2185
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2221
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2284
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2365
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2515
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2617
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2729
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2776
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2965
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3086
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3205
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3415
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3550
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3675
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3821
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3927
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4797
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /note="hexamer: AATAAA"
     polyA_site      4797
                     /gene="PLEKHA5"
                     /gene_synonym="PEPP-2; PEPP2"
                     /note="major polyA site"
ORIGIN      
        1 gttccctcct ccctcggcag ccgcggcggc agcaggagaa ggcggcggcg gcggctaggg
       61 atcagacatg gcggcggatc tgaacctgga gtggatctcc ctgccccggt cctggactta
      121 cgggatcacc aggggcggcc gagtcttctt catcaacgag gaggccaaga gcaccacctg
      181 gctgcacccc gtcaccggcg aggcggtggt caccggacac cggcggcaga gcacagattt
      241 gcctactggc tgggaagaag catatacttt tgaaggtgca agatactata taaaccataa
      301 tgaaaggaaa gtgacctgca aacatccagt cacaggacaa ccatcacagg acaattgtat
      361 ttttgtagtg aatgaacaga ctgttgcaac catgacatct gaagaaaaga aggaacggcc
      421 aataagtatg ataaatgaag cttctaacta taacgtgact tcagattatg cagtgcatcc
      481 aatgagccct gtaggcagaa cttcacgagc ttcaaaaaaa gttcataatt ttggaaagag
      541 gtcaaattca attaaaagga atcctaatgc accggttgtc agacgaggtt ggctttataa
      601 acaggacagt actggcatga aattgtggaa gaaacgctgg tttgtgcttt ctgacctttg
      661 cctcttttat tatagagatg agaaagaaga gggtatcctg ggaagcatac tgttacctag
      721 ttttcagata gctttgctta cctctgaaga tcacattaat cgcaaatatg cttttaaggc
      781 agcccatcca aacatgcgga cctattattt ctgcactgat acaggaaagg aaatggagtt
      841 gtggatgaaa gccatgttag atgctgccct agtacagaca gaacctgtga aaagaattac
      901 ctttaatttc cgagtggaca agattacatc tgaaaatgca ccaactaaag aaaccaataa
      961 cattcccaac catagagtgc taattaaacc agagatccaa aacaatcaaa aaaacaagga
     1021 aatgagcaaa attgaagaaa aaaaggcatt agaagctgaa aaatatggat ttcagaagga
     1081 tggtcaagat agacccttaa caaaaattaa tagtgtaaag ctgaattctc tgccatctga
     1141 atatgagagt gggtcagcat gccctgctca gactgtgcac tacagaccaa tcaacttgag
     1201 cagttcagag aacaaaatag tcaatgttag cctggcagat cttagaggtg gaaatcgccc
     1261 caatacaggg cccttataca cagaggccga tcgagtcata cagagaacaa attcaatgca
     1321 gcagttggaa cagtggatta aaatccagaa ggggaggggt catgaagaag aaaccagggg
     1381 agtaatttct taccaaacat taccaagaaa tatgccaagt cacagagccc agattatggc
     1441 ccgctaccct gaaggttata gaacactccc aagaaacagc aagacaaggc ctgaaagtat
     1501 ctgcagtgta accccttcca ctcatgacaa gacattagga cccggagcgg aggagaaacg
     1561 gaggtccatg agagatgaca caatgtggca gctctacgaa tggcagcagc gtcagtttta
     1621 taacaaacag agcaccctcc ctcgacacag tactttgagt agtcccaaaa ccatggtaaa
     1681 tatttctgac cagacaatgc actctattcc cacatcacct tcccacgggt caatagctgc
     1741 ttatcaggga tactcccctc aacgaactta cagatcggaa gtgtcttcac caattcagag
     1801 aggagatgtg acaatagacc gcagacacag ggcccatcac cctaagcatg tctatgtgcc
     1861 tgacagaagg tcagtgccag ctggcctgac tttacagtct gttagtcccc agagcctcca
     1921 agggaaaacg ccagaggagc ttacgctgct gctaataaag ctgagacggc agcaagccga
     1981 actgagtagt atccgggagc atacgttagc acagctcatg cagctaaagc ttgaggccca
     2041 cagcccaaag aatgaaattc tttcacatca tctccaaagg aacaccatat atttggatca
     2101 tcagatgaaa gaaaatgaac ctattatcac catggttcac acaatgattg agaactcggc
     2161 gctaagaccc caactgtacc agcaattctt aagacagaag agcaagataa gtctatattg
     2221 tctgtcacaa gatgaaggta gaggcacatt atacaaatac agacctgaag aagtagatat
     2281 tgatgccaag ttaagccgat tatgtgaaca agataaagtg gtgcatgctc tggaagagaa
     2341 acttcagcaa ctccacaagg agaaatacac gcttgagcaa gctttgctat cagccagcca
     2401 agagatagaa atgcatgcag ataacccagc agccattcag acagtggtgt tacaaaggga
     2461 tgatttacaa aatggactgc ttagtacgtg tcgagaactt tctcgagcca ctgccgaatt
     2521 ggaacgagca tggagagaat atgataagtt agaatacgat gtaactgtta ccaggaacca
     2581 gatgcaagag cagctggatc accttggtga agttcagacg gaatcagcag gaattcagcg
     2641 tgcacagatt cagaaagaac tttggcgaat tcaggatgtc atggaagggc tgagtaaaca
     2701 taagcagcaa agaggtacta cagaaatagg tatgatagga tcaaagcctt tctcaacagt
     2761 taagtacaaa aatgaggaag aggaagtagt cccacctcgt cctccacttc ctcggtccta
     2821 tgactttaca gagcagcctc ccataatccc ccctctgccc agtgatagca gctccttgct
     2881 ctgttatagc aggggcccag ttcatctgcc tgaagaaaag aagatgtatc aagttcaagg
     2941 atatccaaga aatggatctc actgtggtcc agattataga ctctacaaga gtgaaccaga
     3001 gttaacaaca gtggcagaag ttgatgaatc taatggagaa gaaaaatcag aacctgtttc
     3061 agagatagaa acttcagttg ttaaaggttc ccactttcct gttggagtag tccctccaag
     3121 agcaaaatca ccaacacccg aatcttcgac aatagcttcc tatgtaacct tgaggaaaac
     3181 taagaagatg atggatctaa gaacggaaag accaagaagt gcagtggaac agctctgttt
     3241 ggctgaaagt actcgaccaa ggatgactgt ggaagagcaa atggaaagaa taagaagaca
     3301 tcaacaagcg tgcctgaggg agaagaaaaa agggttaaat gttatcggtg cttcagacca
     3361 gtcaccctta caaagccctt caaatttaag ggataatcca tttaggacta ctcagactcg
     3421 aaggagggat gataaggaac tggacactgc cattagagaa aatgatgtaa agccagacca
     3481 tgaaactcct gcaacagaaa ttgttcaact aaaagaaacc gaaccccaaa atgtggactt
     3541 cagcaaagag ttaaaaaaaa ctgaaaacat ttcatatgaa atgctttttg aacctgagcc
     3601 aaatggagta aattctgtgg aaatgatgga taaagaaaga aacaaagaca aaatgcctga
     3661 ggatgttaca ttcagccctc aagatgaaac acagaccgca aatcataaac cagaagagca
     3721 tcctgaagaa aatacaaaga acagtgttga cgaacaggaa gaaactgtta tttcttacga
     3781 atcaactcct gaggtttcta gaggaaatca aacaatggca gtgaaaagtc tgtccccatc
     3841 tcctgagtcc tcggcatcgc cagttccatc cactcagccg cagctcacag aaggatcaca
     3901 tttcatgtgt gtgtagtctt agaagaacta tactgacttc tgttgaaacc attcaaagct
     3961 aaagacatgg accttcagca gtgtaagaag atattgtaca gtatatttta aatctatgaa
     4021 attcatagtt ctgatgcttt tggtcacaga gcatcatttt atcacttctg gaaaatgttt
     4081 attccaaaac agctttaatg gcccatatgt acacttcgta atctcaaggt tattattctg
     4141 acaccagctt gctgctatga tttcagagca cataagtaaa ggtgcttttt aatgtgcagt
     4201 ctatttccag agcttactta gttgctgatt tccagatttc gatgtttctt aagtctaggt
     4261 gaatttatat atatattttt ttgcttttca ttttctaaag ttagttatta tttccattga
     4321 agcttgtttt cttttttttc ttcccatttt agctactgca gtgcttttgt ttcacacttg
     4381 atttgtaaaa attttatata tatgtattta aaatgtgcca ttttattgct aagtgaagta
     4441 tgtcctgttt tctgctataa ttctttctcg gtcagattgc aatgtcagca gttactgcca
     4501 cactcctgtc agcttaaaca caaatgttac tgcttatctt ttcttaaaaa aaaaaaaaac
     4561 aaagtgtagg tattttgaag tactgggctt atatttcatt ggaatacatg tgtacagcaa
     4621 taagcaggtt tccaaatccg gtacttagtt tgtgtacaaa tgtaattatg ttcattgtgt
     4681 atatattata caatgagcac atgtaatgta ttaaaggcta cttactattg tttaaatgca
     4741 aatgttcata tctcatttct ttttttatca tgttaaataa atgttgatgt tcttaaa
//
