LOCUS       NM_019091              13892 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing A3 (PLEKHA3),
            mRNA.
ACCESSION   NM_019091
VERSION     NM_019091.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13892)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 13892)
  AUTHORS   Venditti,R., Masone,M.C., Rega,L.R., Di Tullio,G., Santoro,M.,
            Polishchuk,E., Serrano,I.C., Olkkonen,V.M., Harada,A., Medina,D.L.,
            La Montagna,R. and De Matteis,M.A.
  TITLE     The activity of Sac1 across ER-TGN contact sites requires the
            four-phosphate-adaptor-protein-1
  JOURNAL   J Cell Biol 218 (3), 783-797 (2019)
   PUBMED   30659099
  REMARK    GeneRIF: The activity of Sac1 across ER-TGN contact sites requires
            the four-phosphate-adaptor-protein-1.
REFERENCE   3  (bases 1 to 13892)
  AUTHORS   Liu,Y., Kahn,R.A. and Prestegard,J.H.
  TITLE     Interaction of Fapp1 with Arf1 and PI4P at a membrane surface: an
            example of coincidence detection
  JOURNAL   Structure 22 (3), 421-430 (2014)
   PUBMED   24462251
  REMARK    GeneRIF: Binding sites on Fapp1 protein for Arf1 and
            phosphatidylinositol-4-phosphate minimally overlap
REFERENCE   4  (bases 1 to 13892)
  AUTHORS   Lenoir,M., Whittaker,S.B. and Overduin,M.
  TITLE     Secondary structure and 1H, 13C, 15N resonance assignments of the
            Golgi-specific PH domain of FAPP1
  JOURNAL   Biomol NMR Assign 5 (2), 185-187 (2011)
   PUBMED   21298564
  REMARK    GeneRIF: We report the complete (1)H, (13)C and (15)N resonance
            assignments of the FAPP1-PH in its free state and those induced by
            PtdIns(4)P or detergent micelles.
REFERENCE   5  (bases 1 to 13892)
  AUTHORS   He,J., Scott,J.L., Heroux,A., Roy,S., Lenoir,M., Overduin,M.,
            Stahelin,R.V. and Kutateladze,T.G.
  TITLE     Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase
            recognition by the FAPP1 pleckstrin homology (PH) domain
  JOURNAL   J Biol Chem 286 (21), 18650-18657 (2011)
   PUBMED   21454700
  REMARK    GeneRIF: Molecular basis of phosphatidylinositol 4-phosphate and
            ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH)
            domain.
REFERENCE   6  (bases 1 to 13892)
  AUTHORS   Lenoir,M., Coskun,U., Grzybek,M., Cao,X., Buschhorn,S.B., James,J.,
            Simons,K. and Overduin,M.
  TITLE     Structural basis of wedging the Golgi membrane by FAPP pleckstrin
            homology domains
  JOURNAL   EMBO Rep 11 (4), 279-284 (2010)
   PUBMED   20300118
  REMARK    GeneRIF: The micelle-bound structure of the FAPP1 pleckstrin
            homology domain reveals how its prominent wedge independently
            tubulates Golgi membranes by leaflet penetration.
REFERENCE   7  (bases 1 to 13892)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 13892)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
REFERENCE   9  (bases 1 to 13892)
  AUTHORS   Godi,A., Di Campli,A., Konstantakopoulos,A., Di Tullio,G.,
            Alessi,D.R., Kular,G.S., Daniele,T., Marra,P., Lucocq,J.M. and De
            Matteis,M.A.
  TITLE     FAPPs control Golgi-to-cell-surface membrane traffic by binding to
            ARF and PtdIns(4)P
  JOURNAL   Nat Cell Biol 6 (5), 393-404 (2004)
   PUBMED   15107860
  REMARK    GeneRIF: Data show that FAPP1 and 2 are essential components of a
            phosphatidylinositol 4-phosphate- and ADP-ribosylation
            factor-regulated machinery that controls generation of constitutive
            post-Golgi carriers.
REFERENCE   10 (bases 1 to 13892)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009948.3, BM794932.1, AK074209.1 and BC039812.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019091.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF286162.1, SRR1660807.218785.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234453.10/ ENSP00000234453.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC009948.3         87047-87061
            16-570              BM794932.1         1-555
            571-1283            AK074209.1         531-1243
            1284-1610           BC039812.1         824-1150
            1611-2305           AK074209.1         1571-2265
            2306-2485           BC039812.1         1846-2025
            2486-13892          AC009948.3         111647-123053
FEATURES             Location/Qualifiers
     source          1..13892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..13892
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /note="pleckstrin homology domain containing A3"
                     /db_xref="GeneID:65977"
                     /db_xref="HGNC:HGNC:14338"
                     /db_xref="MIM:607774"
     exon            1..453
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1316
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /note="four-phosphate-adaptor protein 1; phosphoinositol
                     4-phosphate adapter protein 1;
                     phosphatidylinositol-four-phosphate adapter protein 1;
                     FAPP-1; PH domain-containing family A member 3; pleckstrin
                     homology domain containing, family A (phosphoinositide
                     binding specific) member 3"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 3"
                     /protein_id="NP_061964.3"
                     /db_xref="CCDS:CCDS33336.1"
                     /db_xref="GeneID:65977"
                     /db_xref="HGNC:HGNC:14338"
                     /db_xref="MIM:607774"
                     /translation="MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSI
                     KMAVCEIKVHSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKK
                     EKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLS
                     ATCNTFITTLEECVKIANAKFKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSS
                     ERSSHSIKEPVSTLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASAT
                     IPEESRLMAKKQSESEDTLPSFSS"
     exon            454..570
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..726
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..863
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1028
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1072
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1188
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..13892
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /note="major polyA site"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      2485
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
     regulatory      13871..13876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      13892
                     /gene="PLEKHA3"
                     /gene_synonym="FAPP1"
ORIGIN      
        1 atccaggaag tgaaatcgac gtcggggtca atgaaaacaa acggggagcc cagggggaag
       61 gaaggcaggc gaggaagagg cagcgccggg gcgccggagg gagcagccgg gctgcggaag
      121 cgcgagcagg aggccggtcg cgggcgcatt tttgccgttg tcgcggccgc cgccgccgag
      181 gcttacccgg gaatgtctgg gcccgcgcct cgcggccccc aagctccacg ctgcgcccgc
      241 tgtcccggcc tctaaaggcc gccacgtccc tgcggcgcgc gcaggcagaa agcggcttcg
      301 tgccggcgga gggggcccgg gcgggccggg aggggctgcc ccaggccctg cgcctacccc
      361 atcaccgcgg ccggcgccgg gccgggagga tgcgcggtgt ggggctctga agcatggagg
      421 gggtgttgta caagtggacc aactatctca caggctggca gcctcgttgg tttgttttag
      481 ataatggaat cttatcctac tatgattcac aagatgatgt ttgcaaaggg agcaaaggaa
      541 gcataaagat ggcagtttgt gaaattaaag ttcattcagc agacaacaca agaatggaat
      601 taatcattcc tggagagcag catttctaca tgaaggcagt gaatgcagct gaaagacaga
      661 ggtggctggt cgctctgggg agctccaaag catgtttgac tgatacaagg actaaaaaag
      721 aaaaagaaat aagtgaaacc agtgaatcgc tgaaaaccaa aatgtctgaa cttcgcctct
      781 actgtgacct cttaatgcag caagttcata caatacagga atttgttcac catgatgaga
      841 atcattcatc tcctagtgca gagaacatga atgaagcctc ttctctgctt agtgccacgt
      901 gtaacacatt catcacaacg cttgaggaat gtgtgaagat agccaatgcc aagtttaaac
      961 ctgagatgtt tcaactgcac catccggatc ccttagtttc tcctgtgtca ccttctcctg
     1021 ttcaaatgat gaagcgttct gtcagccacc ctggttcttg cagttcagag aggagtagcc
     1081 actctataaa agaaccagta tctacacttc accgactctc ccagcgacgc cgaagaacct
     1141 actcagatac agattcttgt agtgatattc ctcttgaaga cccagataga cctgttcact
     1201 gttcaaaaaa tacacttaat ggagatttgg catcagcaac cattcctgaa gaaagcagac
     1261 ttatggccaa aaaacaatct gaatcagaag atactcttcc atccttctct tcctgaagaa
     1321 actgaagtgt ccaacttcct ctaagtattg ctatgcaaaa gctgctgtaa ttaaactatt
     1381 gttataggga gtagtttttt cccttaggac tctgcacttt atagaatgtt gtaaaacaga
     1441 caaacaagaa aacaaaccac atacttttga agtgtatttt atctttatat agtttgtttg
     1501 caagagtatt ttcctaataa cttcacagta tgaatgtgca tctttttttt ttgaacaaat
     1561 gatggtgtaa cattttgaca tccataagga caaatgtaga tatttttctt aaaaactctg
     1621 aggggactga cagcatggtc agggtgtatt gtagcttata aacatgaaat cttataaggt
     1681 ttcagtttga cagaagtgtg atatatgtaa cttgtgccat ggaccaaatg gtcactttac
     1741 cacagctaaa aatgagttac gatagcagct tgatggtgat tgtattgtat tcctttaatc
     1801 aaaaaggaaa cacaatattc taagtatctt tagcccaaat accatgacat attgagcatc
     1861 tttaaataac cagactgtat tgtccttcat atgtgaagtt gacactactg atttgtcaat
     1921 accaaatttt gggttaaagt gtttaatttt tatgtattta ttttcttgtt gcctcaaaag
     1981 atgattgcat tctaactttt gtgacctacc aaatttaaga tgtgtatacg ttgttcttta
     2041 cgttgttcta gaaaagagat tttaatgctg tagtgacttt gctcacttac actagagaaa
     2101 taaacaactt tcaatggaag agaattttag tgcttttttt ttcctaaaat agatattaag
     2161 ctgctgttgt aaagtattgt ttgcagctct ttccaatatc tagagacatt tttatttatg
     2221 aatatttata caaaaaggaa ttctgtcaag atgactgctc tatatcactt gagaatggca
     2281 ttatttaatt aaagaacaaa tagcattttt tggtagtgcc tgtccatacc tattgtcatt
     2341 gtttgccttg taatctgttt ttttgaattc attttgggct gatagttttg tttaaggttt
     2401 tggataagga gcactttaaa acaaactggt gtgttgtttt taagttaatc atatgtttaa
     2461 taaatgcgtg gtttttgcat tcaaacacat catataatac attgtatttt ttacattcat
     2521 tgatattctg tctaatcttt attaggcact aatataattc taatggattt gagtttgttt
     2581 gtatatttag gcctgctggt gaagacacaa atgaagcata atttttgttg cctgtgagct
     2641 tagaatggtg tgacctattt cattttattt caatttatct tgtaagttta tgtgggatat
     2701 tttaaaataa ttaatatttg gtatttgttt aaaaaactgt aattataggc cttccatctt
     2761 aagtttaaga tggacataaa cagtctatac attaatatgt gtttgggtaa actgtatgct
     2821 acttgaagtg tttgtaattt taaataacac acaggtcatc agactactct atattcagtg
     2881 gagtctttgc ctgctcataa gttgtacttc atatgtctaa tttgaaaaaa aaagtttgat
     2941 aatgtagtaa gttatgacgt tgagcaggta atcaggtttt tcttgttttt tttttttttt
     3001 taaattttgt agtaagaact tgcacagtat taagaccatg aaggtcaggg tgctattgat
     3061 tgggagtttt ttctggtagt gagttttttt gcagtaatag gtttataagg aaaacaccgt
     3121 aacaagcttt tgaacttata gaaaataatc acatccattt tctattgctt tacccaaata
     3181 gatgggttcg tgaagagttt tctgtgaata ttttaaaaat acaatgcaat tatttctggt
     3241 ttgtatcatt ttttccccct taaaacaggt ccttgaacag gtttgcggta tccctaagta
     3301 tgtcttttgt tatgacttgg agccactttt tgttgttatt gttaggaacc aaacacatct
     3361 gtgaaatcat tttttttgtg ggagtataaa tatatcttga attatatcca ggttttgatc
     3421 agtgaattag tagcatgaag aaacctataa agcttaaggg aaccttgcat tttgaggagt
     3481 cctttatttt caagtgtgcc tgactttttt gaattttaag aaaaagatga accatataac
     3541 aattctgtaa gaattttagc ttgtcaagtt gttctatact ttatagaaaa attattggtt
     3601 attattagtt attagtagtc cctttttttt gctttgtcta ggtcatgggg ttattgagaa
     3661 acatgaaaag ttattgagaa atttggaggt tctcttggca gcctatcagt gatcttctaa
     3721 gcaaaagcag tgcttgtttt tcatttcaag tgcttgctca ctattctttg ggaatcgcag
     3781 gcctccatga ctaaagggat tttgatacaa ttcttttata aatgagctga atttgaattt
     3841 tcttacatca tatgggatta ttgcatgatc ttcagtcagg aaaaatccag aaatggatgc
     3901 tattgcttaa acttaaattc caaggcagaa gatagagtat cttcatttcc acagatgccc
     3961 tagaaccttt gaccttgaat tgtagttttt cagtatgtat tatcacattt agaaatgtaa
     4021 aaatcacaag atctcaggaa atgcgccctt gtgatatgtt aataccagat tgctgtttac
     4081 actaattcca tatacatgat aataccacta atttggactc tgctagttct tttatttaat
     4141 aaggcacctc taggtctgta ctttgagcct tgatctgggt acttggtaca gagggagtgt
     4201 cctggcctga aagaaagcca gattaggctg caggagttcc tttgaggagg tctgtctttt
     4261 aataaccctg gcgggtaaat gaatggtagg tagctggtag gtaggccttc ttgttcatgt
     4321 ctttctgtct ccccaatcca ctctttgaat tcatgttgaa ttcttaactt gaaattctgt
     4381 tgtttttttt ttaattttag ctttcttttt attaaactag ttaatgtaca tagtttgaaa
     4441 aaatcaaata gaactaaaag gtttatagtg aaaaagtgta gttccctctt ccccagttta
     4501 gcattccaaa gacaaacact tggaactctt agtggtttgt gttagtattt accttcctgt
     4561 ttgaaaatgt tatactactt tttgttgact tatcaatttc agaaacagtt tctcgaatac
     4621 cttttatggt agacaggatt tactttactt aaactctcca cctcccacat ttttcttccc
     4681 ccacccctcc caaaatagat ttatattcac acaactttta gttagaacaa actttttgtg
     4741 aaatagatag acataaatgt agttcactga tgtaccacat ggttaactat cattatttcc
     4801 tttttactag aatgttattt tttctggggt tggtattgcc tgattttcaa atttgcttag
     4861 tttttaatgt acctgtcaca atgactatcc aaaggcttaa atgctgaaaa acatcagata
     4921 atcgtatcaa ttctcttaaa aaagttttta aaaatatttt gtcatccttt agggacattt
     4981 cttccacagt ccttcatctt ctgccatttg tactgttgcc ctccaggcct gttctatggt
     5041 tcagcagtca ttctgaaact ccctttagtt tttagtctca cattaggttt tttttttttt
     5101 tttttttttt tttttttttt tttggcaaag ctcctccacc agtaacttcc taagaaaagg
     5161 tgcatagaaa gtaaagattt taaggcttta caggtctgaa aatgtctcta ctcttgattg
     5221 gtagtttgga gtctggaaaa taacatgcct tcagaatttt aagggcaaca tttcattgtc
     5281 ttaaggcatt tagtttttct gtgagaattc tgataccgtt cctttacctg ggatctgttt
     5341 ttacactctg taagctttta ggaacttctc attacttctg atgtttcata ataatatgtg
     5401 ggtctttatt cattcatctt gatggctact tgacttggtg gaatctttca atttagagat
     5461 ttgtctgctt cagttctggg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgat
     5521 ctttttgaca gttttctctc ttccattttc tttgttctat ctttctagaa tttctgttat
     5581 ttgaatgttg gacctcccag agttggaccg cctctaaatt taaaaagctt tttctctcta
     5641 gttgttcctt aagttatatt atctttgttc tttttgttat cctccagctc ttctgttgaa
     5701 ttttctttat atatatattt taatttctaa gaggtctttt ttttctgttt catttcataa
     5761 aaacctattt ttattttata gattaactgt ttccccatat ctccctgagg ataaaattaa
     5821 gatttttttc ttacatcttt cctgtttctt gaatggttct ccccctcccc caccatgttt
     5881 ctgctttcta tttatttgtt ttgggctctt tcattctgaa gcctttctta gaaatcatct
     5941 attcatatta gtcatgtatt aaaaagctaa tgtcataggt ctttatatgt gggcagggtt
     6001 tataagttgt ctaaagggcc atcaggtaga gttggccttt tctgttgagg tcccctaaat
     6061 ttcagtggag gtcttctctt tggggccagt ttctctagaa aactgggtcc tgatagtagg
     6121 gtaagaaaag acagctgagg accccaagat ttgtatgatg acttttactt aatccctcta
     6181 tcttcatcct ctctcatgcc catccggccc caccccccaa atcctcctct ggctgctgac
     6241 cctcaggttc agtttttcct gtcagtggag gttgagggtg gggcgtaggc tggctgtgga
     6301 gagtagggga gaggacctgg gttccagttg ctctttatac agacttctag tcctgatttc
     6361 agccctatac ctcactctca tcttctacaa tacctagtgc ttccaagtcc tgaacttagt
     6421 agaggtttgg tggggtgtgt ttttgggctt ctcccttttg ggtacttagg ctttaacttc
     6481 ctccactctg ctaggttagg tattgcactt cctcctggtt tttatctgta taaactttgt
     6541 taaaatctca tggctttgtc gtctgtgctt ttttgtggat taatactatt tatattcctt
     6601 taatatcttt tggtggtttg gaggtagagg aaataaattc atgtggttgg tttgtatgtt
     6661 tcactgaaag tctagattta aattctaata gtgtataaaa aataaaaatt ctttagtatt
     6721 aatttgtaat tcattctagt gatttttaat tcatatggtt ttactgtact acctacctca
     6781 tagggttgtg aggattagaa gaatcaattc ataaaaagca gttagaaaag tgctgggcac
     6841 gtagtgtgtt gaataagtgt tagttattaa tattgtttac tatcattatt attattacta
     6901 ctatcagttt tttttttttt ttctgagaca gggtctcact ctttcaccca gtcttgagta
     6961 tagtggagtg atctcagctc actgcagtct cgacctccca ggctcaaatg atccttttac
     7021 ctcagcctcc cgaataacta ggactacagg catgcaccac tactcctggc taatttttgt
     7081 atttttttgt agcagcaggg ttttgccatg ctgttcagac tgatctcaaa ctcctgggct
     7141 caagggatct gcctgccttg actttccaaa attctcggat tacaggcatg agccacactg
     7201 cactctccta tctctctcaa ttcagtaacc tgtttattct tgagtgaaaa tgtttcacca
     7261 taggaagaat tactaatata tgggaaaatc tagtgtttga taatgttgac cctacatttt
     7321 ttttggacag tctctgtcgc ccaggccgga gtgcagtggc gcgatcttgg ctcactgcaa
     7381 cttccacttc ctgggttcaa gcaattctct tgtctcagcc tcctaggcta caggctagga
     7441 ctacaggtgc tcgccaccat gcccagctaa tttttgtatt tttaatagag atggggtttc
     7501 atcatattag tcaggctggt cttgaactcc tgacctcagg tcatctacct gccttggcct
     7561 cccaaagtgt cgggattaca gatgtgagcc accgtgccca gccgaccctg catttaacta
     7621 gacttcatat gaaatgttca ggtgttaggt gttatctttc taagaaacat tcaagcctta
     7681 agaaatccaa tcagttatag ttactttaaa agttttaaaa agagtataac aattttgatg
     7741 tgcttttaag ctttattggt attatatttt gtttttatca tataaatatg aagtatagga
     7801 gataagataa tgcagatgat gtttgttatg ccttacctac cgccagtaga tgtaatactc
     7861 ttaatacatg gagtacagaa atagtagatt cccttcattc ccagtgcaac agtgttggga
     7921 ggtggggcct accaggaggt gtttaggtca tgtgggtacc accctcatga atagattaat
     7981 gccgccgtgt aaagggcttg tgggcgtggg tgaacactct cctgctcttc tgccaaatgt
     8041 ctctcccttc caaaggacgt agtgctctac atagtgttgg aagcgagaga ctgagcccta
     8101 acatgccagt gccttatctt ggatttctca gcctccaaaa ctgtgaaaaa ataaattttc
     8161 attctttatg gtaaattccc atcactgtat ccataacctc ttgtaaatag ttgtacacct
     8221 ttcagaaaat gttgtggact tacataagca aaatgcctgc atttatttca taggtaaaat
     8281 tttaatctat tttctaatca aagtgttttg gggaacattt aatttaaata ctatgttcaa
     8341 tttttttaat ggtctgcttc agattttttt tataagttaa tgttttaaaa caaaataatt
     8401 gtgttctagg tagaagctac tctgagttta ggtttttaaa tctctttcag atattttaag
     8461 tatctttttt gtgtctggat tcagagaggt atgataatga gattctcttc tagaggggaa
     8521 gtgggagtag gtaaccatac tactctttct acggctacag agccgcatac tcgaaggagg
     8581 gagattttta tttgtaagga catttgtatt atctttcatt aaagtagagt cccatgggcg
     8641 tggcaaatgg ctgtaaataa agtaaaagtg gctaaagaaa acagtgcctg ctattagctt
     8701 gatgctggca ttttcttctt tccctggatg tgactgttat tgtctttatt gggtcccctt
     8761 attatctgct ttgatatcca tctctggaac tttgatctct aatttttttt tttttttttt
     8821 gagacagagt ctcactctgt agcccaagtt agagtgcagt gacacgatct tggctcactg
     8881 caacctccac ctccggggct caagcaattc tcgtgactca acatcccaaa tagctgggac
     8941 tgtaggcacg caccaccatg cccagctgat gttttgtatt tttacaaaaa tttttcacca
     9001 tgttggccag ggtggtctca aactcctaag ctcaggagat ccgcctgcct cagcctttga
     9061 aagtgctggg attacaggcg ggagccaccg tgcccgacct gacctctcca tctttggcgt
     9121 ccttatgctg cctcttctcc aaatacatgt tggccagggt ggtctcaaac tcctaagctc
     9181 aggagatccg cctgcctcag cctctgaaag tgctgggatt acaggcggga gccaccgtgc
     9241 ctgacctgac ctctccatct ttggcgtcct tatgctgcct cttctccaaa tacagtaact
     9301 aatctagtat attttcatag gatagaattt gccctttctg tcccataata tgttcctctt
     9361 ccccaaaaag ttttttgttg gtctctttgg taataaaaca tttagagcat ttactgtggg
     9421 ccaggtgctt tacctcatgt tagccttata acagagatgc ggaagtacag gactaccagt
     9481 gcagccaaga tgcacagcac caggattaac tcatgagact gattagaatg atgaatatct
     9541 tattgtatcc tgaaacatta agcctttaag ttatcccttt atttagtatt taaattcaca
     9601 tgcttcttga tttttttgga ctagcattag ttgttgaata aataaataat tcagaatgta
     9661 tccacaaaac ctagaatata tgacagggtg gattcagttt tgcttagtta ctgtagataa
     9721 accaaataaa ttaatgtaaa gggatattaa tgcattaagc aatttttttt gacataaatg
     9781 aagggttgtt tccatgggta atatattcag aatattaaag atgagtaaaa tgtatgacta
     9841 taatgaattc cttcttcact tttactctgg caaggtggga ggagggtgct gttgataatc
     9901 tctgtgcttt tgcaagtttg gcacaaagac ttttactcac ttaaatctca atataaagta
     9961 tattgccaga tctggcagca tggggacaat taggaacaaa ggagagagaa tagaatcagc
    10021 catcaggagc tataaccaca ctcttctttc tcaacctttt ctggtattag taggcagaac
    10081 tccttttgga tgcggtgaag cattttatga gtgaacaatg gtgagtcatg taatgaaagg
    10141 agatgttcta ggaaaacttt tcagtcccgc tcagtgctgc catctttttc tcccagcact
    10201 ctggacttaa aattctgaga gaacagggta tttcccaccc ttcctcttac tttttgaaag
    10261 caatacctga gttattaagc aatcatttag acagtatgaa taaaccaaaa ttcaccttga
    10321 cactccatcc cctagaggta accattcttt tctagtatat attcttccag acctttttcc
    10381 tgtgtattga cttttaaata gatgtacatt gcaatagttt ggattagctc atccatagca
    10441 gggtggttaa ataaacagtg gcactttttt ttttttgaga cagagtctca ccctgtcgcc
    10501 caggctggag tgcaatggcg cgatctcggc tcactgcaac ctttgctttc caggttcaag
    10561 cgattctcct gcctcagcct cccaagtagc tggaattaca ggcgagcacc accatgcctg
    10621 gctaattttt gtatttttgg tagagacggg gttttaccgt gttggtcagg ctggtctcga
    10681 atgcctgacc ttgtgatctg cctgccttgg cctcccagtg tcaggatcct ggccccagtg
    10741 gcacattttt atgatgcatc tggtactaaa gaaggagctg gctttatgac ctttacttga
    10801 gtattttttt gtgtgtgaca gttgaacaat tctgacccct attattgttg gctggacagg
    10861 cattttcttt ttaattcctc tatgcaagga actgtggatt gcttttttct ggatagctag
    10921 aacgaggcca ttttctttca aaagacagtc ctagagtttc cagtggtttt ctttaattgt
    10981 gtatgcgtga gtgtgacagt gtgtgtgcct gtgtctctat ctgtgcatgc atctgtatgc
    11041 acagtttctt agttgtggac aatgcaactt ggaatcattt tagttttcca attgatttta
    11101 aaagtttatc tatagaagat gagacaaatt tgctgtagaa gttaccacta cttggtcaaa
    11161 atagagagtt gtgggttttt ttttttgttt gacaacaatc aaaagtatgg cctacagata
    11221 gtaagggtta accacccaga tttttgtcag ataatatata catgtccatg taattaaaag
    11281 tcttcatttg acaaatttat atggtaaatg agcataaaat gaatatcttt tcagtattag
    11341 aacatttctg tttatgccct attccagtgg tatttgtggt cgctaggggt tgctgggtta
    11401 tccaagtgat tcagcatgcc ttcagaattg gcatcctcgg gtgattgtcc atagcctctt
    11461 gcaatggtgc ctcatcttgg ggaggcttta gaacacagct ctcatttagc ttattattga
    11521 tttttttttc ttgttttgca gttgttggct agagaaaagt gtgtagcaat aagtacgcac
    11581 acttactgtg gtttaccatc atgaccatgg atagcaaact gccttttttt ttttttttaa
    11641 ctcctgtgtc atctctgatg ttgtggctaa ttttaagact ttgatttttc agctaggatt
    11701 agcggagaat gacctaccta cttgattaat gatgtctgca tgggcttact aagagggtgt
    11761 ggggaatggt ggcaggggta actatcatcg agaatatagg gcaatgggta tattctaact
    11821 ttgcataact ttgctagatt atatatatct ttactcacaa taagcaaagt tgaacaactt
    11881 aaaattgatt ccctgttttc tgttttcact atccaactag gatgaactct taagttcata
    11941 catatacttt aaaatgggaa caaacatagc ctgtcatgtc tttatttagg ctaagtgcat
    12001 atgtatgtat aagtaatgtg tatatccttc acttattaat agtgccttca tgaattcaaa
    12061 gacccttgtc acatggtgct caggaaaaaa aaagtgccaa tattcttttt ttttttttct
    12121 ctaagaagta ctagtttagg taagtgaaat tcaatagcat atcagtgctt taccttagtc
    12181 actttttgtg ttttgatcac ccttagtcat cactggagag aagagtttga attcatttgt
    12241 ggttttgctt tagtggcaaa cctccttaca gggatgagtt gccctccatt ctccttgcca
    12301 tatttggtta atctaggcca tgacctttga ggggaaaagg cacagattgc aacttttctt
    12361 tcctgctttt gtgaatcagg ccatgttcac gcagggtcct tgaaggtgac ttgagtgagg
    12421 aagctatata ccgatgactt accaattttt ggtcttataa cattctctct cttttttttt
    12481 tttttttttt gtagcatatg gcttcctcta ctgtatgttg gcatttgcca cttttgggga
    12541 tttgactcct gcaggtattt tttttttttt cttttggggg agtgtgacgg cagtggatat
    12601 agtcttagat gatgttttta atagttcaag tccattagtg tcttactcta gagaaaacga
    12661 aagactcact gtgtgagttt tcttgccctc tggttttcag aattctgtgt agtttctcaa
    12721 catttccttt ctacctgtcc tgaagagctc ttatggaaat catggttgaa tgttagtaaa
    12781 tttctaagag ctttccaatg ttgtctataa ttagccaaaa aaagacatat gaacttttct
    12841 cattctgtct acctttttaa aattttattc actttatctt tttctccagt tttgatagat
    12901 gattatagag ttccccaaaa tggccttctt actatttcta tattaggtat attatttcag
    12961 aaaagaaaat aatcacttgg gaatggcggt gagttcaggg ggtctgttaa ccatttaatt
    13021 taggattgtt tatacattta tttacctctt ttaaaaaatt tcttcagtta atattcattg
    13081 accactcact aagtgttatg ttgctagtat ttatctttgc tttctaatta tttttttgta
    13141 atttttttgc tttctaattc ttgagtgaat ttaaaactca ctgctttatt atttaatatc
    13201 ttagatacaa tgactatctt aattataatt ggctttccaa aattttcact ttttttcagt
    13261 taactagttg aatagtattt atcattcaca tttgcaccct aactattgtt ttaacctaaa
    13321 cataaataag caagcattag aaagtagcat aattgctgtt aaaatagtct tttctttgcg
    13381 tgtttaaata ttgttagaaa cataagcaca tgaatttttt tggcctttta aatgtcttta
    13441 ttgtagctag ttataagatg tatatatagc ttatatatgt gtatatacac atacatatat
    13501 atatatacat acatatatat acataaaatg attcttgcaa aagtagttat gggtatttaa
    13561 gtgaaaaatt tgtaagttta gaagttaaga aattggaaat aatggaattg gtttaaaaag
    13621 ctagtctcta aattaactta gaaacctaat agcaaataca gattttgatt gctataacta
    13681 aacactttaa ttttgaaaaa gtttcagaat agaatttcta ttcccagggg aaaataaact
    13741 tcatttaaaa atatatgtat acttattttg tgagtatttt tttcttttcc aaattccaaa
    13801 aggtgtatac tctatatttt tgtcataaaa attctgcttg tcgaaaatat tgtagtaatt
    13861 ttataaattc aataaaacct gagtgatgtg aa
//
