LOCUS       NM_021623               5530 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing A2 (PLEKHA2),
            transcript variant 1, mRNA.
ACCESSION   NM_021623 XM_496973 XM_940486
VERSION     NM_021623.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5530)
  AUTHORS   Li,H., Hou,S., Wu,X., Nandagopal,S., Lin,F., Kung,S. and
            Marshall,A.J.
  TITLE     The tandem PH domain-containing protein 2 (TAPP2) regulates
            chemokine-induced cytoskeletal reorganization and malignant B cell
            migration
  JOURNAL   PLoS One 8 (2), e57809 (2013)
   PUBMED   23460911
  REMARK    GeneRIF: This study identified TAPP2 as a novel regulator of
            malignant B cell migration.
REFERENCE   3  (bases 1 to 5530)
  AUTHORS   Costantini,J.L., Cheung,S.M., Hou,S., Li,H., Kung,S.K.,
            Johnston,J.B., Wilkins,J.A., Gibson,S.B. and Marshall,A.J.
  TITLE     TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion
            through interaction with the cytoskeletal protein utrophin:
            expression of a novel cell adhesion-promoting complex in B-cell
            leukemia
  JOURNAL   Blood 114 (21), 4703-4712 (2009)
   PUBMED   19786618
  REMARK    GeneRIF: These findings identify TAPP2 as a novel link between PI3K
            signaling and the cytoskeleton with potential relevance for
            leukemia progression.
REFERENCE   4  (bases 1 to 5530)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   5  (bases 1 to 5530)
  AUTHORS   Kimber,W.A., Deak,M., Prescott,A.R. and Alessi,D.R.
  TITLE     Interaction of the protein tyrosine phosphatase PTPL1 with the
            PtdIns(3,4)P2-binding adaptor protein TAPP1
  JOURNAL   Biochem J 376 (Pt 2), 525-535 (2003)
   PUBMED   14516276
REFERENCE   6  (bases 1 to 5530)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098787.1, AF286164.1, AA985353.1, DC332022.1, AC108863.4 and
            BQ025762.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021623.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291842.1, SRR1660803.217482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617275.5/ ENSP00000482228.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AK098787.1         112-213
            103-825             AF286164.1         139-861
            826-960             AA985353.1         68-202              c
            961-1345            DC332022.1         189-573
            1346-5163           AC108863.4         74629-78446
            5164-5530           BQ025762.1         16-382              c
FEATURES             Location/Qualifiers
     source          1..5530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.22"
     gene            1..5530
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /note="pleckstrin homology domain containing A2"
                     /db_xref="GeneID:59339"
                     /db_xref="HGNC:HGNC:14336"
                     /db_xref="MIM:607773"
     exon            1..100
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            101..264
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1401
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tandem PH Domain containing protein-2; pleckstrin homology
                     domain-containing family A member 2; TAPP-2; tandem PH
                     domain-containing protein 2; PH domain-containing family A
                     member 2; pleckstrin homology domain containing, family A
                     (phosphoinositide binding specific) member 2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 2 isoform 1"
                     /protein_id="NP_067636.1"
                     /db_xref="CCDS:CCDS75732.1"
                     /db_xref="GeneID:59339"
                     /db_xref="HGNC:HGNC:14336"
                     /db_xref="MIM:607773"
                     /translation="MPYVDRQNRICGFLDIEEHENSGKFLRRYFILDTQANCLLWYMD
                     NPQNLAMGAGAVGALQLTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDMK
                     DWVEALNQASKITVPKGGGLPMTTEVLKSLAAPPALEKKPQVAYKTEIIGGVVVHTPI
                     SQNGGDGQEGSEPGSHTILRRSQSYIPTSGCRASTGPPLIKSGYCVKQGNVRKSWKRR
                     FFALDDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRDNLFEIITSSRTF
                     YVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTRPGSSSLSSGPNSILCRG
                     RPPLEEKKALCKAPSVASSWQPWTPVPQAGEKLLPPGDTSEDSLFTPRPGEGSAPGVL
                     PSSRIRHRSEPQHPKEKPFMFNLDDENIRTSDV"
     exon            265..321
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..370
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..468
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..609
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..756
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..825
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..896
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..960
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1038
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..5530
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5506..5511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /note="hexamer: AATAAA"
     polyA_site      5530
                     /gene="PLEKHA2"
                     /gene_synonym="TAPP2"
                     /note="major polyA site"
ORIGIN      
        1 agacccagaa atccctggag cgcggcggac ccggcggccg gaggggcgac cccgcccgat
       61 gtaacgcgcc ccgcccgagc cccggcccct gcacgggggg ggtgatgtga gcagagccca
      121 ggaatgcctt atgtggatcg gcagaaccga atctgtgggt ttctggacat cgaggagcat
      181 gagaacagcg gcaagtttct gcggaggtac ttcattctgg acacccaggc taactgcctc
      241 ctctggtata tggacaaccc ccagaatctg gcaatggggg caggagctgt tggagctttg
      301 cagctgacct acatctcgaa ggtgagcata gctaccccaa aacagaaacc aaaaactcca
      361 ttttgctttg ttatcaatgc cctgtctcag agatatttcc ttcaagccaa tgatcagaaa
      421 gatatgaagg actgggttga agccctgaac caagccagca agatcaccgt tcccaaaggt
      481 gggggcctac ccatgaccac tgaagttctc aagagcttag cagctcctcc agccctggag
      541 aagaagccac aggtggccta caagacggag atcattggag gggtggtggt ccacacaccc
      601 atcagccaga acggtgggga tgggcaggaa gggagtgagc ccgggtccca caccatcctt
      661 cgaaggtctc agagttacat ccccacgtca ggctgccgtg cttccactgg gcctcccctc
      721 attaagagtg gttactgcgt gaagcaaggg aatgtgcgga agagctggaa acgtcgcttc
      781 tttgcacttg atgactttac catctgctac ttcaagtgtg agcaggaccg agaaccactg
      841 cgcaccatat ttcttaagga tgttctgaag acccatgaat gtctggtcaa gtctggtgat
      901 ctcttaatga gggacaacct gtttgaaata ataacaagct ccaggacctt ctacgtacag
      961 gcagacagtc cagaagacat gcacagctgg attaaggaga ttggcgcagc tgtccaggcc
     1021 ctcaagtgcc accccagaga aacgtccttt tctagatcca tttctttgac ccgacctgga
     1081 agctccagcc tttcaagtgg gcccaactct atcctgtgca gggggcggcc acctttggag
     1141 gaaaagaaag ccctctgcaa agccccctct gtggcctcct cctggcagcc ctggacacct
     1201 gtcccccagg ctggggagaa gctgcttcca cctggagaca cttcagagga ctccttgttc
     1261 acgcctcgtc ctggggaggg cagcgctcct ggggtgctgc ccagctcccg gataaggcac
     1321 agatcggagc cccagcaccc caaggagaag ccgtttatgt tcaaccttga tgatgaaaac
     1381 atacggacct ctgatgtgtg atggagcaca gtgccatggg agggagggag ggagggagga
     1441 cttgagagaa ggaggctgtg actcagtttc tctaccttgt tggagggtag tcagaggcct
     1501 ttatgtcact catattcctg tggatgctct ttgggaggga ggggcccatc cagctgggct
     1561 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtaata tcaacgcagt gtatttaatt
     1621 tggggaagtc actaggttag aactgtaggc atactcagtg gagaggaagc tacctattct
     1681 attctaacta ttctgaggtc ttcctggaga gggattgttt tagcagctcc tctccagagg
     1741 gggctggaag tccagtttca ccaatgacca agttttattt ccttgtcctt gttttagttt
     1801 tttcattttg ttttcagtcc aggtgcctcg cagctctttt ggaatgggcc agcattagtc
     1861 taattttaag cgctatgtgt tttgtaccct tgcaaacttg ctttctcttt cttcttgctg
     1921 ttgccctttg aatgaagcct tgtgtgcttg catgatcaga ccctgtaata ggatgaattt
     1981 ccatgcactt aacatgaaga gatacaaaaa gaatctagag agagatatat atttttaatg
     2041 aaatagaagc ttggcataga aacattgatt tagatgttat gagttgctgg ccagagattc
     2101 ctcagataaa agagcctaga aaattgagtt ttgagcgggc atggtggctc acgcctgtaa
     2161 tgccagtagt ttgggaggct gaggcgggtg gatcacctga ggtcaggagt tcgagatcag
     2221 cctggccaac atggtgaaac cccgcctcta ctaaaaaata tgcaaaatta gccgggcgtg
     2281 gtggtgcagg cctgtaatcc cagctactca gaggctgagg caggagattc acttgaaccc
     2341 aggaggtgga ggttgcagtg agccaagatc gcgccattgc actccagtca gggcaacaag
     2401 agtgaaactc cgtctcaaaa tataaaagaa aattgagtgt cccacccaaa ttttagggcg
     2461 tacctccttc catttgataa gaagatgcta tttccagtgt ccctgggaga attcttccat
     2521 ccagtttata tggtgaattg ccaccagcgt tccctaaagg aagagagaac ttagcttatt
     2581 tctgtctgtg acttttatca gctagatcag ttaattgtat ttttaaatta aaaattagta
     2641 actagaggaa gagactaaga gaactatttt tacctgagta aatgctctcc tcttcttgtg
     2701 tccaaatcta atgcagaggt gaaaacactt gatgagaaaa tcctttgtgg cttgagggga
     2761 atcatgtttc tttcaggacg tgttgtttcc ctgaagtcta tgtcacactg agaacttttt
     2821 ctgactgcac tgctttggag ctattcattt aaattgagtt tggcctagtt ttcctggtat
     2881 aaaacaggaa atctacattg ttccctcttt ctctcccttc catcccttcc cctgcctttc
     2941 ctatacacgc tggtgtgctt ttgccctcag aaattcttgg tttgggagtt atgtattttt
     3001 gagtgatcga ggttatgaca tacttggagc ggcatgattt caagaagcca ttccaaattc
     3061 ttatagctcc ttagctctgg ttttactctc gtattttccc caagaaaatt ttttggctat
     3121 tcaaagaaag cacaaaatat gtgatgtgga actcatgaaa atagggactt ttgatatctc
     3181 tttaaatatt ccctgactca cggaaaagat gtcctctttt ggtgtataca ttgtgaaaat
     3241 ctacccattt atctctctct ctctcttttc ttttaaataa attatctgat aaggccggca
     3301 aggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgagcgg atcacgaggt
     3361 caggagatcg agaccgcggt gaaaccccgt ctctactaaa aatacgaaaa aaaaattagc
     3421 cgggcgcagt ggcaggcgcc tgtagtccca gctacttggg aggctgcggc aggagaatgg
     3481 tgtgaacctg ggaggcggag cttgcagtga gccaagatcg cgccactgca ctccagcctg
     3541 ggcgacagag caagactcca tctcaaaaaa aaaattatct gataggttac tattgctaaa
     3601 ttaattggcc attataataa gctgatttgt ttcttattca gcaagatctc ttttgagaat
     3661 gtgacaaatt aaacatacat agaatccata tggtattatc ctgataaagg gaaacgagga
     3721 cactaagact gtcaaatgga aatcttcttg tcaattggca aacacttggg aattccacat
     3781 tagagcattg cttgttttta attttttttt tttaattttt aaaagacagg gtctcactct
     3841 cttacccagg ctagagtgca gtggtgtgat catagttcat cataactttg aatctctggg
     3901 cttaagcaat cctcccatgt tagcttccca agtagctagg actacagggt tgtgctacca
     3961 cgcctggcta atttttaatt tttttttatc tacagagcct ggctatgttg cccaggctct
     4021 ctcaaactcc tggcccaagt gatcctcctg ccttggcctc ctaaagtgtt gggattacag
     4081 gtgtgagcca ctgcacctag ccagaacatc gttaatgtag ttcaatatga gataaattat
     4141 tatcttcaat gaaacaagct ctaaaagcat tccattccta aattgtattt caaacttcct
     4201 attttgttga tatttcttaa cttctggcca gttttggacc ataatctttt aatgtgaacc
     4261 aaagatggta cgtatttgac caaagcagtt agttttaaat gtataaaatt gaaccaaatg
     4321 gaaaaaatag gttggggatg cagtatagat tagtgactaa gtgcataggc tctggagtaa
     4381 atctgagttt tttttttttt aaaggaacta aaaaatgtac tgcattttct ttgtggaata
     4441 aaagccttgc ctgagttgtg ctattttcat aaggcttttg aagtggtctt gacccactgt
     4501 gtgtaacagt atttcaggtg gtcctcccca tggctgaata atgccatcca ttattcttta
     4561 atttttattt ttagaaacag tgtttcactc tgtcacccag gctggagtgc agtggcctga
     4621 tcatggctca ctgcagcctg gacctcctgg gctcaagtga tcttcctgcc tcacagcctc
     4681 ccaaagtact cagattatag gtgtgagcca ccacgcctgg ccaccatcta ttacttttga
     4741 aatcttcaaa agacttgctt actcaatgtc agctgatggt tggtaaaaat aatttggcct
     4801 ttagtgttaa gtgagacatc ataagggtat tgaggtatac attatggaga ttgatgtcag
     4861 gtcagaatat tggagttata catctatttc tgagttgaat actcagctcc cacgagaaag
     4921 aaagtagttt taaggtccag cttcttagtc tacttgaagc aaattttttt tcttttatat
     4981 ttctgaatat aaatatactc ttatatgggc taaaaagacc ccatgaataa atagcaggtt
     5041 cagtagttga ggagtggagt ttagtaggtt tgttttcagt ataaattaga taacatgtgg
     5101 aggtcacagc attttggaaa ttgagtgtcc ccaagtgagc tttgtttata aactttcaaa
     5161 atgtcggaag tggacaggtt tgttaaatct tgtctgccag cacccttttc ttcctttgtt
     5221 ccttttcctc tctgtgttat tgcctgcggc agccagtcct tcatactaga tagagttcag
     5281 ataaagcaaa cgtttggcaa aaacatactg tttgacctcc tccccctctg cttatgaagg
     5341 ggtagcatga ttctgtgttt taaagcagtg atgtttcagc tgtgaaatgc actcgctgta
     5401 agctctaggc tgagtgcatg gaaactgtta cgcttctcat tttatgtgat ctcctaattg
     5461 gtatgtagca aaaattttct aaaactgttt tgtggcttgt tttgtaataa aaccatgtga
     5521 aatactgaaa
//
