LOCUS       NM_001001974            3741 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens pleckstrin homology domain containing A1 (PLEKHA1),
            transcript variant 2, mRNA.
ACCESSION   NM_001001974
VERSION     NM_001001974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3741)
  AUTHORS   Huang,Q. and Xiang,Y.
  TITLE     Polymorphisms in Selected Genes and Their Association with
            Age-Related Macular Degeneration in a Chinese Population
  JOURNAL   Med Sci Monit 24, 1693-1700 (2018)
   PUBMED   29565837
  REMARK    GeneRIF: investigated the association of PLEKHA1 958A/G,
            polymorphisms with Age-Related Macular Degeneration (AMD) risk.
            PLEKHA1 958A/G polymorphism was associated with a decreased AMD
            risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019;
            allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014)
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3741)
  AUTHORS   Kortvely,E. and Ueffing,M.
  TITLE     Gene Structure of the 10q26 Locus: A Clue to Cracking the
            ARMS2/HTRA1 Riddle?
  JOURNAL   Adv Exp Med Biol 854, 23-29 (2016)
   PUBMED   26427389
  REMARK    GeneRIF: Studies indicate that the high-risk allele of the 10q26
            locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high
            linkage disequilibrium.
REFERENCE   3  (bases 1 to 3741)
  AUTHORS   Gupta,D., Gupta,V., Singh,V., Chawla,S., Parveen,F., Agrawal,S. and
            Phadke,S.R.
  TITLE     Study of Polymorphisms in CX3CR1, PLEKHA1 and VEGF genes as risk
            factors for age-related macular degeneration in Indian patients
  JOURNAL   Arch Med Res 45 (6), 489-494 (2014)
   PUBMED   25050486
  REMARK    GeneRIF: CX3CR1 (T280M and V249I) and PLEKHA1 (A320T) polymorphisms
            were not found to be associated with age-related macular
            degeneration in an Indian population.
REFERENCE   4  (bases 1 to 3741)
  AUTHORS   Mahajan,A., Go,M.J., Zhang,W., Below,J.E., Gaulton,K.J.,
            Ferreira,T., Horikoshi,M., Johnson,A.D., Ng,M.C., Prokopenko,I.,
            Saleheen,D., Wang,X., Zeggini,E., Abecasis,G.R., Adair,L.S.,
            Almgren,P., Atalay,M., Aung,T., Baldassarre,D., Balkau,B., Bao,Y.,
            Barnett,A.H., Barroso,I., Basit,A., Been,L.F., Beilby,J.,
            Bell,G.I., Benediktsson,R., Bergman,R.N., Boehm,B.O.,
            Boerwinkle,E., Bonnycastle,L.L., Burtt,N., Cai,Q., Campbell,H.,
            Carey,J., Cauchi,S., Caulfield,M., Chan,J.C., Chang,L.C.,
            Chang,T.J., Chang,Y.C., Charpentier,G., Chen,C.H., Chen,H.,
            Chen,Y.T., Chia,K.S., Chidambaram,M., Chines,P.S., Cho,N.H.,
            Cho,Y.M., Chuang,L.M., Collins,F.S., Cornelis,M.C., Couper,D.J.,
            Crenshaw,A.T., van Dam,R.M., Danesh,J., Das,D., de Faire,U.,
            Dedoussis,G., Deloukas,P., Dimas,A.S., Dina,C., Doney,A.S.,
            Donnelly,P.J., Dorkhan,M., van Duijn,C., Dupuis,J., Edkins,S.,
            Elliott,P., Emilsson,V., Erbel,R., Eriksson,J.G., Escobedo,J.,
            Esko,T., Eury,E., Florez,J.C., Fontanillas,P., Forouhi,N.G.,
            Forsen,T., Fox,C., Fraser,R.M., Frayling,T.M., Froguel,P.,
            Frossard,P., Gao,Y., Gertow,K., Gieger,C., Gigante,B., Grallert,H.,
            Grant,G.B., Grrop,L.C., Groves,C.J., Grundberg,E., Guiducci,C.,
            Hamsten,A., Han,B.G., Hara,K., Hassanali,N., Hattersley,A.T.,
            Hayward,C., Hedman,A.K., Herder,C., Hofman,A., Holmen,O.L.,
            Hovingh,K., Hreidarsson,A.B., Hu,C., Hu,F.B., Hui,J.,
            Humphries,S.E., Hunt,S.E., Hunter,D.J., Hveem,K., Hydrie,Z.I.,
            Ikegami,H., Illig,T., Ingelsson,E., Islam,M., Isomaa,B.,
            Jackson,A.U., Jafar,T., James,A., Jia,W., Jockel,K.H., Jonsson,A.,
            Jowett,J.B., Kadowaki,T., Kang,H.M., Kanoni,S., Kao,W.H.,
            Kathiresan,S., Kato,N., Katulanda,P., Keinanen-Kiukaanniemi,K.M.,
            Kelly,A.M., Khan,H., Khaw,K.T., Khor,C.C., Kim,H.L., Kim,S.,
            Kim,Y.J., Kinnunen,L., Klopp,N., Kong,A., Korpi-Hyovalti,E.,
            Kowlessur,S., Kraft,P., Kravic,J., Kristensen,M.M., Krithika,S.,
            Kumar,A., Kumate,J., Kuusisto,J., Kwak,S.H., Laakso,M., Lagou,V.,
            Lakka,T.A., Langenberg,C., Langford,C., Lawrence,R., Leander,K.,
            Lee,J.M., Lee,N.R., Li,M., Li,X., Li,Y., Liang,J., Liju,S.,
            Lim,W.Y., Lind,L., Lindgren,C.M., Lindholm,E., Liu,C.T., Liu,J.J.,
            Lobbens,S., Long,J., Loos,R.J., Lu,W., Luan,J., Lyssenko,V.,
            Ma,R.C., Maeda,S., Magi,R., Mannisto,S., Matthews,D.R., Meigs,J.B.,
            Melander,O., Metspalu,A., Meyer,J., Mirza,G., Mihailov,E.,
            Moebus,S., Mohan,V., Mohlke,K.L., Morris,A.D., Muhleisen,T.W.,
            Muller-Nurasyid,M., Musk,B., Nakamura,J., Nakashima,E., Navarro,P.,
            Ng,P.K., Nica,A.C., Nilsson,P.M., Njolstad,I., Nothen,M.M.,
            Ohnaka,K., Ong,T.H., Owen,K.R., Palmer,C.N., Pankow,J.S.,
            Park,K.S., Parkin,M., Pechlivanis,S., Pedersen,N.L., Peltonen,L.,
            Perry,J.R., Peters,A., Pinidiyapathirage,J.M., Platou,C.G.,
            Potter,S., Price,J.F., Qi,L., Radha,V., Rallidis,L., Rasheed,A.,
            Rathman,W., Rauramaa,R., Raychaudhuri,S., Rayner,N.W., Rees,S.D.,
            Rehnberg,E., Ripatti,S., Robertson,N., Roden,M., Rossin,E.J.,
            Rudan,I., Rybin,D., Saaristo,T.E., Salomaa,V., Saltevo,J.,
            Samuel,M., Sanghera,D.K., Saramies,J., Scott,J., Scott,L.J.,
            Scott,R.A., Segre,A.V., Sehmi,J., Sennblad,B., Shah,N., Shah,S.,
            Shera,A.S., Shu,X.O., Shuldiner,A.R., Sigurdsson,G., Sijbrands,E.,
            Silveira,A., Sim,X., Sivapalaratnam,S., Small,K.S., So,W.Y.,
            Stancakova,A., Stefansson,K., Steinbach,G., Steinthorsdottir,V.,
            Stirrups,K., Strawbridge,R.J., Stringham,H.M., Sun,Q., Suo,C.,
            Syvanen,A.C., Takayanagi,R., Takeuchi,F., Tay,W.T., Teslovich,T.M.,
            Thorand,B., Thorleifsson,G., Thorsteinsdottir,U., Tikkanen,E.,
            Trakalo,J., Tremoli,E., Trip,M.D., Tsai,F.J., Tuomi,T.,
            Tuomilehto,J., Uitterlinden,A.G., Valladares-Salgado,A.,
            Vedantam,S., Veglia,F., Voight,B.F., Wang,C., Wareham,N.J.,
            Wennauer,R., Wickremasinghe,A.R., Wilsgaard,T., Wilson,J.F.,
            Wiltshire,S., Winckler,W., Wong,T.Y., Wood,A.R., Wu,J.Y., Wu,Y.,
            Yamamoto,K., Yamauchi,T., Yang,M., Yengo,L., Yokota,M., Young,R.,
            Zabaneh,D., Zhang,F., Zhang,R., Zheng,W., Zimmet,P.Z.,
            Altshuler,D., Bowden,D.W., Cho,Y.S., Cox,N.J., Cruz,M., Hanis,C.L.,
            Kooner,J., Lee,J.Y., Seielstad,M., Teo,Y.Y., Boehnke,M.,
            Parra,E.J., Chambers,J.C., Tai,E.S., McCarthy,M.I. and Morris,A.P.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes
            (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D)
            Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium;
            Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in
            muylti-Ethnic Samples (T2D-GENES) Consortium
  TITLE     Genome-wide trans-ancestry meta-analysis provides insight into the
            genetic architecture of type 2 diabetes susceptibility
  JOURNAL   Nat Genet 46 (3), 234-244 (2014)
   PUBMED   24509480
REFERENCE   5  (bases 1 to 3741)
  AUTHORS   Hogan,A., Yakubchyk,Y., Chabot,J., Obagi,C., Daher,E., Maekawa,K.
            and Gee,S.H.
  TITLE     The phosphoinositol 3,4-bisphosphate-binding protein TAPP1
            interacts with syntrophins and regulates actin cytoskeletal
            organization
  JOURNAL   J Biol Chem 279 (51), 53717-53724 (2004)
   PUBMED   15485858
  REMARK    GeneRIF: syntrophins regulate the localization of TAPP1, which may
            be important for remodeling the actin cytoskeleton in response to
            growth factor stimulation
REFERENCE   6  (bases 1 to 3741)
  AUTHORS   Kimber,W.A., Deak,M., Prescott,A.R. and Alessi,D.R.
  TITLE     Interaction of the protein tyrosine phosphatase PTPL1 with the
            PtdIns(3,4)P2-binding adaptor protein TAPP1
  JOURNAL   Biochem J 376 (Pt 2), 525-535 (2003)
   PUBMED   14516276
  REMARK    GeneRIF: TAPP1 binds to protein tyrosine phosphatase PTPL1.
REFERENCE   7  (bases 1 to 3741)
  AUTHORS   Marshall,A.J., Krahn,A.K., Ma,K., Duronio,V. and Hou,S.
  TITLE     TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase
            signaling in B cells: sustained plasma membrane recruitment
            triggered by the B-cell antigen receptor
  JOURNAL   Mol Cell Biol 22 (15), 5479-5491 (2002)
   PUBMED   12101241
REFERENCE   8  (bases 1 to 3741)
  AUTHORS   Kimber,W.A., Trinkle-Mulcahy,L., Cheung,P.C., Deak,M.,
            Marsden,L.J., Kieloch,A., Watt,S., Javier,R.T., Gray,A.,
            Downes,C.P., Lucocq,J.M. and Alessi,D.R.
  TITLE     Evidence that the tandem-pleckstrin-homology-domain-containing
            protein TAPP1 interacts with Ptd(3,4)P2 and the
            multi-PDZ-domain-containing protein MUPP1 in vivo
  JOURNAL   Biochem J 361 (Pt 3), 525-536 (2002)
   PUBMED   11802782
REFERENCE   9  (bases 1 to 3741)
  AUTHORS   Thomas,C.C., Dowler,S., Deak,M., Alessi,D.R. and van Aalten,D.M.
  TITLE     Crystal structure of the phosphatidylinositol
            3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem
            PH-domain-containing protein 1 (TAPP1): molecular basis of lipid
            specificity
  JOURNAL   Biochem J 358 (Pt 2), 287-294 (2001)
   PUBMED   11513726
REFERENCE   10 (bases 1 to 3741)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001136.2, BC042458.1 and
            AL133603.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 26, 2021 this sequence version replaced NM_001001974.3.
            
            Summary: This gene encodes a pleckstrin homology domain-containing
            adapter protein. The encoded protein is localized to the plasma
            membrane where it specifically binds phosphatidylinositol
            3,4-bisphosphate. This protein may be involved in the formation of
            signaling complexes in the plasma membrane. Polymorphisms in this
            gene are associated with age-related macular degeneration.
            Alternate splicing results in multiple transcript variants. A
            pseudogene of this gene is found on chromosome 5.[provided by
            RefSeq, Sep 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 5-9 all encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.4551.1,
                                           SRR11853558.3473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368990.8/ ENSP00000357986.3
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               BC001136.2         5-821
            818-818             BC042458.1         2163-2163
            819-1524            BC001136.2         823-1528
            1525-1540           BC042458.1         2870-2885
            1541-3741           AL133603.1         1-2201
FEATURES             Location/Qualifiers
     source          1..3741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..3741
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /note="pleckstrin homology domain containing A1"
                     /db_xref="GeneID:59338"
                     /db_xref="HGNC:HGNC:14335"
                     /db_xref="MIM:607772"
     exon            1..99
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..260
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1334
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     tandem PH domain-containing protein 1; pleckstrin homology
                     domain containing, family A (phosphoinositide binding
                     specific) member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 1 isoform 1"
                     /protein_id="NP_001001974.1"
                     /db_xref="CCDS:CCDS7629.1"
                     /db_xref="GeneID:59338"
                     /db_xref="HGNC:HGNC:14335"
                     /db_xref="MIM:607772"
                     /translation="MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMD
                     NPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVE
                     WVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEV
                     NECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDEN
                     TIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEE
                     MHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTNAATATSHSTASRSNSLV
                     STFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLV
                     DLDDASLPVSDV"
     exon            261..317
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..363
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..461
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..587
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..731
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..800
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..865
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..929
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1019
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..3741
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      3741
                     /gene="PLEKHA1"
                     /gene_synonym="TAPP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgcg ggctggccgt cgcggacgcc gctccgggca gccgagcctc tgtgggagcc
       61 ggggccgcgg cggcgcgggt gctccgggcc gaggccgcgt gtaatgttca agctcagaaa
      121 tgccttatgt ggatcgtcag aatcgcattt gtggttttct agacattgaa gaaaatgaaa
      181 acagtgggaa atttcttcga aggtacttca tactggatac cagagaagat agtttcgtgt
      241 ggtacatgga taatccacag aacctacctt ctggatcatc acgtgttgga gccattaagc
      301 ttacctacat ttcaaaggtt agcgatgcta ctaagctaag gccaaaggcg gagttctgtt
      361 ttgttatgaa tgcaggaatg aggaagtact tcctacaagc caatgatcag caggacctag
      421 tggaatgggt aaatgtgtta aacaaagcta taaaaattac agtaccaaag cagtcagact
      481 cacagcctaa ttctgataac ctaagtcgcc atggtgaatg tgggaaaaag caagtgtctt
      541 acagaactga tattgttggt ggcgtaccca tcattactcc cactcagaaa gaagaagtaa
      601 atgaatgtgg tgaaagtatt gacagaaata atctgaaacg gtcacaaagc catcttcctt
      661 actttactcc taaaccacct caagatagtg cggttatcaa agctggatat tgtgtaaaac
      721 aaggagcagt gatgaaaaac tggaagagaa gatattttca attggatgaa aacacaatag
      781 gctacttcaa atctgaactg gaaaaggaac ctcttcgtgt aataccactt aaagaggttc
      841 ataaagtcca ggaatgtaag caaagcgaca taatgatgag ggacaacctc tttgaaattg
      901 taacaacgtc tcgaactttc tatgtgcagg ctgatagccc tgaagagatg cacagttgga
      961 ttaaagcagt ctctggcgcc attgtagcac agcggggtcc cggcagatct gcgtcttctg
     1021 agcatccccc cggtccttca gaatccaaac acgctttccg tcctaccaac gcagccaccg
     1081 ccacctcaca ttccacagcc tctcgcagca actctttggt ctcaaccttt accatggaga
     1141 agcgaggatt ttacgagtct cttgccaagg tcaagccagg gaacttcaag gtccagactg
     1201 tctctccaag agaaccagct tccaaagtga ctgaacaagc tctgttaaga cctcaaagta
     1261 aaaatggccc tcaggaaaaa gattgtgacc tagtagactt ggacgatgcg agccttccgg
     1321 tcagtgacgt gtgaggcaga agcgcacgga gcctgcctgc ctctgccgtc ctcagtttcc
     1381 tttcatgagg cttctagcca aagatgataa agggggaaat ggtttttagt gcgtatatta
     1441 tactgcctct taggtgtact ctttataagc tggtaaacca agaatctagg gagtggccaa
     1501 actaaatata atttctttaa aaaagaaaga aaaaggaaaa atccaaaata tctcagtatc
     1561 atctgtctga agcattgtgt gttctcattc gggtggtaac aatgtatgtg taatattttt
     1621 ttcttagtga ttttgacagt ttaaatgttt aacaacttaa agcattaaaa atgcttatta
     1681 ataactttgg tcatttaaaa aatgctacaa tgacttccta ttaaaggttc aatatttaca
     1741 cattcttatt ggttgatatt accacatgaa atattgccag accaagatac ctaaactcat
     1801 gatgtctgtg gtgctgtaaa atttatacta aaatgtggac tattttgaaa ttataaccat
     1861 ttttgatgcc ctgaatcttg aggtgactta ttttgcatag aggatatgga tagaccaaca
     1921 gtaagggttg tgggttatac cggcatagag aaaagaagaa aactagaatt gaaacaactg
     1981 tgtcttagac atttgtttga aaaagcttca tcaggccttg gagcagtcac tgctttattc
     2041 cgcaaaaatt atttggtagg aaatttttgg gagatctgat tttcttatcc aagttttgta
     2101 aatagttgtt atttctatat ttggattggt gaaagacctc aagtttatat gtaaagacat
     2161 aactgccctt agtcatgaaa ttgttgtgac ctctactttt tgtcactaat agcctacatt
     2221 caagtgcctg tgttttttca tcttgtttag gaatgttttg agattaatgt gcttaaaagt
     2281 cctacgtgac tgattttaaa cattgtgata aaattaattt tcagtagaat agttgaatgt
     2341 gttaagatag gattttatgt tagagatacc agaatgctgg tattctacta cttgtgcaat
     2401 atatatgttt taaaaaacaa atttgagaat acatttaatc atagggatat agatataagc
     2461 acctctctaa agaatcttta gtttccgacg ttgaattata gaccagtttg agtaagtact
     2521 gctttttttt tttggagacg ggctctcgct ctgttgctca ggctggagtg cagtggcgtg
     2581 atctcagctc actacagcct ccacctcgtg ggttcaaaca gttgtgctgc ctcagcttcc
     2641 cgagtagcta ggattacagg tgcatgccac cacacctggc taatttttgt attttagtag
     2701 agatggggtt tcaccatgtt ggccaggctc gtctcgaact cctgacttca ggtgatccac
     2761 ccatctcagc ctcccaaagt gctgggatta caggcgtgag ccaccatgcc cggcccataa
     2821 gtaccgtttt tgaggttcag tcttaaacat ttgctttaag aaaacagtct tgaatttcac
     2881 atgctgctat ttttatattt tgccatttta cagtactgtt ttgttttgaa ttcatgcata
     2941 tcattgaaaa tttctcgttt tcattttctt agatgacttc ttgtctgaga cagaaaaatt
     3001 tcctactaca gcagtgcagt ccagaggtta agatgtatta gaattataca atatcagttt
     3061 aaaaatctgt atgcataaag aatgcaccac tcaacttttt tattcataag ctaatatttt
     3121 tttaaagtta cattaagatt ttttctcttt tgcagctaca tttgaaagtg atagaataaa
     3181 gagattttaa tgagttatca ctttttcagc tgatatattc attttaatgg cttttttgaa
     3241 agttcctttt tcatgaacac acccgagaaa tcttaaatag acactttgca atatttaaga
     3301 acctaatgct gtttaatttt ggtacagctt ccacattgca tgttcacttt agtatttgca
     3361 atttgatata tttcatggtg gcaaaatatt agctctgttt tgggacattt taaaatagaa
     3421 ctatccttgt tcgatagcat aggaaaatgt tctggtgatt gtcagggtct cctaatattt
     3481 atctcaattc ttttataagt ctatggaaat tatttaatta ttttaaaacg tacacacttt
     3541 tcttgtaaat atgtcacatc tgagttcaaa aaaattactt tgaatacctt aatatttgct
     3601 gcattttttt ccgtatatat aacatgtctt ctttcagaat gggaatatat gtgtgcctcc
     3661 caacatttac tgttaaagtg tgttatcttt atatgtcaaa ctggttgaac actgtaatga
     3721 gaataaactg cacagagttt a
//
