LOCUS       XM_005250978           14804 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens plectin (PLEC), transcript variant X1,
            mRNA.
ACCESSION   XM_005250978
VERSION     XM_005250978.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005250978.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14804
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..14804
                     /gene="PLEC"
                     /gene_synonym="EBS1; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD;
                     EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; LGMDR17; PCN;
                     PLEC1; PLEC1b; PLTN"
                     /note="plectin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 3 mRNAs, 64 ESTs, 4023
                     long SRA reads, 9 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     27 samples with support for all annotated introns"
                     /db_xref="GeneID:5339"
                     /db_xref="HGNC:HGNC:9069"
                     /db_xref="MIM:601282"
     CDS             110..13780
                     /gene="PLEC"
                     /gene_synonym="EBS1; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD;
                     EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; LGMDR17; PCN;
                     PLEC1; PLEC1b; PLTN"
                     /codon_start=1
                     /product="plectin isoform X1"
                     /protein_id="XP_005251035.1"
                     /db_xref="GeneID:5339"
                     /db_xref="HGNC:HGNC:9069"
                     /db_xref="MIM:601282"
                     /translation="MSGAGGAFASPREVLLERPCWLDGGCEPARRGYLYQQLCCVDER
                     DRVQKKTFTKWVNKHLIKHWRAEAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG
                     RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV
                     SGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNK
                     VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPD
                     VQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK
                     EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQ
                     LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD
                     LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP
                     ATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS
                     HRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL
                     ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK
                     ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDV
                     REAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK
                     AVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
                     EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL
                     IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH
                     HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ
                     RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS
                     LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA
                     QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT
                     DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA
                     LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES
                     VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL
                     EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ
                     SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA
                     EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL
                     QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV
                     AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ
                     AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
                     LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE
                     EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER
                     VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI
                     EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG
                     RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA
                     LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL
                     QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE
                     QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK
                     AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE
                     LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA
                     EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ
                     QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI
                     GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL
                     KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ
                     LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
                     AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS
                     FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLL
                     KATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGP
                     ELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV
                     HSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPET
                     GLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTA
                     EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVID
                     RELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPS
                     DMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPY
                     TGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEET
                     SRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELY
                     SELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK
                     VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDL
                     SELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLV
                     DPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
                     RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDP
                     NTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQID
                     IPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEI
                     IRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGT
                     GSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEA
                     VRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLA
                     TGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRR
                     CRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEV
                     TKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP
                     IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKD
                     HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNT
                     EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMS
                     VYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAK
                     NLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLAS
                     WSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
                     ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQ
                     RFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLK
                     ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGS
                     RRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA"
ORIGIN      
        1 ggagagcgaa gccggcagcc tcgcagcgtg ggctggaagc agaggcgccg ccgcggtcca
       61 gctccccgca ctgtccgtgg gccgaaccag ggctccggcc gtggccggca tgtcgggggc
      121 ggggggcgcc tttgcctcgc cgagggaggt cttgctggag cggccgtgct ggctggacgg
      181 gggctgcgag ccggcccgca ggggctacct ctaccagcag ctgtgctgcg tagatgagcg
      241 ggatcgtgtg cagaagaaaa ccttcaccaa gtgggtcaac aagcacctca tcaagcactg
      301 gcgggcagag gcccagaggc acatcagtga cctgtatgaa gacctccgcg atggccacaa
      361 cctcatctcc ctgctggagg tcctctcggg ggacagcctg ccccgggaga aggggaggat
      421 gcgtttccac aagctgcaga atgtccagat tgccctggac tacctccggc accgccaggt
      481 gaagctggtg aacatcagga atgatgacat cgctgacggc aaccccaagc tgacccttgg
      541 cctcatctgg acaatcattc tgcacttcca gatctcagat atccaggtga gtgggcagtc
      601 ggaggacatg acggccaagg agaagctgct gctgtggtcg cagcgaatgg tggaggggta
      661 ccagggcctg cgatgcgaca acttcacctc cagctggaga gacggccgcc tcttcaatgc
      721 catcatccac cggcacaagc ccctgctcat cgacatgaac aaggtgtacc ggcagaccaa
      781 cctggagaac ctggaccagg ccttctctgt ggcggagcgg gacctgggag tgacgcggct
      841 cctggaccct gaggacgtgg atgtccctca gcccgacgag aagtccatca tcacctacgt
      901 ctcgtcgctg tatgacgcca tgccccgcgt gccggacgtg caggatgggg tgagggccaa
      961 cgagctgcag ctgcgctggc aggagtaccg ggagctggtg ctgctgctgc ttcagtggat
     1021 gcgacaccac acggccgcct ttgaggaacg caggttcccc tccagcttcg aggagattga
     1081 gatcctgtgg tctcagttcc tgaagtttaa ggagatggag ctaccagcca aggaggccga
     1141 caagaacagg tccaagggca tctaccaatc cctggaggga gcggtgcaag caggccagct
     1201 caaggtgccc cctggctacc acccgctgga tgtggagaag gagtggggca agctgcacgt
     1261 ggccatcctg gagcgggaga agcagctccg cagcgagttt gagaggctgg agtgtcttca
     1321 gcgcatcgtg accaagctgc agatggaggc ggggctgtgt gaggagcagc tgaaccaggc
     1381 cgacgccctg ctgcagtcgg atgtccggct gctggctgca ggcaaagtgc cacagcgggc
     1441 gggggaggtg gaacgggact tggacaaggc ggatagcatg atccggctgc tcttcaacga
     1501 cgtgcagacc ctcaaggatg gacggcaccc gcagggcgag cagatgtacc gcagggtgta
     1561 ccgtctgcac gagcgcctgg tagccatccg caccgagtac aacctacggc tgaaggcagg
     1621 cgtggcggcc cctgcaaccc aggtggccca ggtgactctg cagagtgtgc agaggcgccc
     1681 cgagctggag gactccactc tgcgctacct gcaggacctg ctggcctggg tggaggagaa
     1741 ccagcaccgt gtggatggcg ctgagtgggg tgtggacctg cccagcgtgg aggcgcagct
     1801 gggcagccac cgaggcctgc accagtccat cgaagaattc cgggccaaga tcgagcgggc
     1861 acggagtgac gagggccagc tctcccccgc cacccggggt gcctaccgtg actgcctggg
     1921 tcggctggac ctgcagtacg ccaagctgct gaactcctcc aaggcccgcc tcaggtccct
     1981 ggagagcttg cacagctttg tggcagccgc cactaaggag ctaatgtggc tgaatgagaa
     2041 ggaggaggag gaggtgggct tcgactggag cgaccgcaac accaacatga ccgccaagaa
     2101 ggagagctac tcggcgctga tgcgggagct ggagctgaag gagaagaaga tcaaggagct
     2161 ccaaaatgct ggggaccggc tgctgcggga ggaccacccg gcccggccca cggtggagtc
     2221 cttccaggcg gccctgcaga cgcagtggag ctggatgcta cagctgtgct gctgtatcga
     2281 ggcacacctg aaggagaacg ctgcctactt tcagttcttc tcagatgtgc gggaggccga
     2341 ggggcagttg cagaagctgc aggaggcact gcgtaggaaa tacagttgtg atcgctccgc
     2401 caccgtcacc cggctggagg acctgctgca ggatgcccag gacgagaagg aacagctgaa
     2461 cgagtacaag ggccacctct caggcctggc caagcgggcc aaggccgtcg tgcagctgaa
     2521 gccccgccac ccagcccacc ccatgcgggg ccgcctgccc ctgctggccg tgtgcgacta
     2581 taagcaggtg gaggtgactg tgcacaaggg tgacgagtgc cagctggtgg gccctgcaca
     2641 gccgtcccac tggaaggtgc tcagcagctc cggcagcgag gccgccgtgc cctccgtgtg
     2701 cttcctggtg cccccgccca accaggaggc ccaggaggcc gtcaccaggc tggaggccca
     2761 gcaccaggcc ctggtcacgc tgtggcacca gttgcacgtg gacatgaaga gccttctggc
     2821 ctggcagagc cttcgccgcg acgtgcagct catccgctcc tggtccctgg ccacgttccg
     2881 caccctgaag ccagaggagc agcgccaagc cctgcacagc ctggagctgc actaccaggc
     2941 cttcctgcgg gacagccagg acgcgggcgg cttcggaccc gaggaccggc tgatggctga
     3001 gcgcgagtac ggctcctgca gccaccacta ccagcagctg ctgcagagcc tggaacaggg
     3061 tgcacaggaa gagtctcgct gccagcgctg catctccgag ctcaaagaca tccggctgca
     3121 gctggaggcc tgtgagacgc gcaccgtgca ccgcctgcgg ctgccgctgg acaaagagcc
     3181 ggcacgggag tgtgcccagc gcatcgccga gcagcagaag gcacaggcag aggtggaggg
     3241 gctgggcaag ggggtcgccc ggctctctgc cgaggccgag aaggtcttgg ccctaccaga
     3301 gccatcgcct gcggccccca cgctgcgctc ggagctggag ctgacgctgg gcaagctgga
     3361 gcaggtccgc agcctgtctg ccatctacct ggagaagctc aagaccatca gcctggtgat
     3421 ccgcggcacg cagggggccg aggaggtgct cagggcccac gaggagcagc tcaaggaggc
     3481 ccaggccgtg ccggccaccc tcccggagct cgaggccacc aaggcctctc tgaagaagct
     3541 gcgggcccag gccgaggcac agcagcccac gttcgacgcc ctgcgggatg agctgcgggg
     3601 ggcacaggag gtgggggagc gactgcagca gcggcacggg gagcgggacg tggaggtgga
     3661 gcgctggcgg gagcgggtcg cccagttgct tgagcgctgg caggctgtgc tggcccagac
     3721 cgacgtgcgg cagcgcgagc tcgagcaact gggccgccag ctgcgttact accgcgagag
     3781 tgcagacccc ttgggcgcct ggctgcagga cgccaggcgg cggcaggagc agatccaggc
     3841 catgccgctg gccgacagcc aggctgtgcg ggagcagctg cggcaggagc aggccctgct
     3901 ggaggagatc gagcgccacg gcgagaaggt cgaggagtgc cagaggtttg cgaaacagta
     3961 catcaacgcc atcaaggact atgaactcca gctggtgacg tacaaggcgc agcttgagcc
     4021 ggtggcctcc ccggccaaga agcccaaggt ccagtcggga tcagagagtg tcatccagga
     4081 gtacgtggac ctgcgtacgc actacagcga gctgaccaca ctgacgagcc agtacatcaa
     4141 gttcatcagc gagactctgc ggcgcatgga ggaggaggag aggctggctg agcagcagcg
     4201 ggcagaggag cgcgagcggc tggccgaggt ggaggccgcg ctggagaagc agcggcagct
     4261 ggccgaggcg cacgcccagg caaaggcaca ggcggagcgg gaggcgaagg agctgcagca
     4321 gcgcatgcag gaggaggtgg tgcggcggga ggaggcggcg gtggacgcgc agcagcagaa
     4381 gcgcagcatt caggaggagc tgcagcagct gcggcagagc tcggaggcgg agatccaggc
     4441 caaggcccgg caggcagagg cggctgagcg cagccggctg cgcatcgagg aggagatccg
     4501 cgtggtgcgc ctgcagttgg aggccaccga gcgccagcgt ggcggggctg agggggagct
     4561 gcaggcactg cgtgcacggg cggaggaggc tgaggcacaa aagcgacagg cgcaggagga
     4621 ggccgagcgc ttgcggaggc aggtgcagga cgagagccag cgtaagcggc aggcggaggt
     4681 ggagctggcc tcgcgcgtga aggccgaggc cgaggcggcg cgcgagaagc agcgggccct
     4741 gcaggccctg gaggagctgc ggctgcaggc ggaggaggcg gagcggcgcc tgcggcaggc
     4801 cgaggtggag cgagcgcggc aggtacaggt ggccctggag acggcgcagc gcagtgcaga
     4861 ggcggagctg cagagcaaac gcgcctcctt cgccgagaag acggcacagc tggagcgctc
     4921 cctgcaggag gaacacgtgg ctgtggcaca gctgcgggag gaggctgagc ggcgggcaca
     4981 gcagcaggcc gaggccgagc gggcgcgcga ggaggcagag cgggagctgg agcgctggca
     5041 gctcaaggcc aacgaggcgc tacggctgcg gctgcaggcg gaggaggtgg cgcagcagaa
     5101 gagcctggcg caggccgagg ctgagaagca gaaggaggag gcggagcgcg aggcgcggcg
     5161 gcgcggcaag gcggaggagc aggccgtccg gcagcgggag ctggctgaac aagagctgga
     5221 gaagcagcgg cagctggcgg aaggcaccgc gcagcagcgc ctggccgcgg agcaggagtt
     5281 gatccggctg cgggccgaga cggagcaggg ggagcagcag cggcagctgc tggaggagga
     5341 gctggcccgg ctgcagcgtg aggcggctgc agccacgcag aaacggcagg agctggaagc
     5401 cgagctggcc aaggtgcggg ccgagatgga ggtgctgctg gccagcaagg cgagggctga
     5461 ggaggagtcg cgctccacca gcgagaagtc caagcagagg ctggaggccg aggccggccg
     5521 gttccgcgag ctggccgagg aggccgcccg cctgcgtgcc ctggcggaag aggccaagcg
     5581 gcagcggcag ctggccgagg aagacgcggc gcggcagcgg gccgaggcgg agcgggtgct
     5641 tgcggagaag ctggccgcca tcggcgaggc cacgcggctc aagacggagg cggagatcgc
     5701 gctcaaggag aaggaggcgg agaacgagcg cctgcggcgg ctggcggagg acgaggcctt
     5761 ccagcggcgg cggctggagg agcaggccgc gcaacacaag gctgacatcg aggagcgcct
     5821 ggcccagctg cgcaaggcat cggacagcga gctggagcgg cagaaggggc tggtggagga
     5881 cacgctgagg cagcggcggc aggtggagga ggagatcctg gcgctgaagg cgagcttcga
     5941 gaaggcggcc gctggcaagg cggagctgga gctggagctg ggacgcatcc gcagcaacgc
     6001 ggaggacacg ctgcgcagca aggagcaggc cgagctggag gctgcgaggc agcggcagct
     6061 ggcggcggag gaggagcggc ggcgccgtga ggctgaggag cgcgtgcaga agagcctggc
     6121 ggccgaggag gaggccgcac ggcagcggaa ggcggcgctg gaggaagtcg agcggctgaa
     6181 agccaaggtg gaggaggcgc ggcgcctgcg ggagcgagcg gagcaggagt cggcgcggca
     6241 gctgcagctg gcccaggagg ccgcccagaa gcggctgcag gcggaagaga aggcacacgc
     6301 cttcgcggtg cagcagaagg agcaggagct acagcagacg ctgcagcagg agcagagcgt
     6361 gctggaccag ctgcgcggcg aggcggaggc ggcccggcgg gcggctgagg aggcggagga
     6421 ggcccgggtg caggcggagc gtgaggcggc gcagtcccgg cggcaggtgg aagaggccga
     6481 gcggctgaag cagtcggcag aggagcaggc acaggcccgg gctcaggcac aggcggctgc
     6541 agagaagctg cgcaaggagg ccgagcaaga ggcggcgcgg cgggcacagg cggagcaggc
     6601 ggccctgcgg cagaagcagg cagctgacgc ggagatggag aagcataaga aattcgccga
     6661 gcagacgctg cggcagaagg cgcaggtgga gcaggagctg acaacactgc ggctgcagct
     6721 ggaggagacc gaccaccaga agaacctgct ggacgaggag ctgcagcggc tgaaggcgga
     6781 ggccacggag gccgcacgcc agcgcagcca ggtggaggag gagctcttct cggtgcgcgt
     6841 gcagatggag gagctgagca agctcaaggc acgcatcgag gctgagaacc gcgcactcat
     6901 cttgcgtgac aaggacaata cgcagcgctt cctgcaggag gaggctgaga agatgaagca
     6961 ggtggcggag gaggccgcgc ggctgagtgt ggcggcccaa gaggctgcgc gactgcggca
     7021 gctggcagag gaggacctgg cacagcagcg ggccttggca gagaagatgc tcaaggagaa
     7081 gatgcaggcg gtgcaggagg ccacgcgact caaggctgag gcggaactgc tgcagcagca
     7141 gaaggagctt gcgcaggagc aggcgcggcg gctgcaggag gacaaggagc agatggcgca
     7201 gcagctggcg gaggagacgc agggcttcca gcggacgctg gaggccgagc ggcagcggca
     7261 gctggagatg agcgctgagg ctgagcgcct caagctgcgt gtggccgaga tgagccgagc
     7321 ccaggcccgc gctgaggagg acgcccagcg cttccggaag caggcggagg agatcggtga
     7381 gaagctgcac cgcacggagc tcgccaccca ggagaaggtg accctggtgc agacactgga
     7441 gatccagcga cagcagagtg accatgatgc cgagcgcctg cgggaggcca tcgctgagct
     7501 ggagcgtgag aaggagaagc tccaacagga ggccaaactg ctgcagctca agtctgagga
     7561 gatgcagacg gtgcagcagg agcagctgct gcaggagacg caggccctgc agcaaagctt
     7621 cctctctgaa aaggacagcc tgctacagcg ggagcgcttc atcgagcagg agaaggccaa
     7681 gctggagcag ctcttccagg acgaggtggc caaggcacag cagctgcgtg aggagcagca
     7741 gcggcagcag cagcagatgg agcaggaacg gcagcggctg gtggccagca tggaggaggc
     7801 gcggcggcgg cagcatgagg ccgaggaggg cgtgcggcgc aagcaggagg agctgcagca
     7861 gctggagcag cagcggcggc agcaggagga gctgctggct gaggagaacc agaggctgcg
     7921 tgagcagctg cagctcctgg aggagcagca ccgggccgcg ctggcgcact cagaggaggt
     7981 cactgcctcg caggtggctg ccacaaagac cctgcccaat ggccgggatg cacttgatgg
     8041 ccccgcggca gaggcagagc cggagcacag cttcgatggc ctgcggcgga aggtgtcagc
     8101 tcagaggctg caggaggccg gcatcctgag tgcggaggag ctgcagcggt tggcgcaggg
     8161 ccacaccacg gtggacgagc tcgcacggcg ggaagacgtg cgccactacc tgcagggccg
     8221 cagcagtatc gcagggctgt tgctgaaggc caccaatgag aagctgagtg tttacgccgc
     8281 cctgcagagg cagctgctga gtcccggcac ggccctcatc ctgctggagg cgcaggcggc
     8341 ctcaggcttc ctgctggacc ctgtgcggaa ccggcggctg accgtcaacg aggctgtgaa
     8401 ggagggtgtg gtgggccccg agctgcacca caagctgctg tcggccgagc gcgccgtcac
     8461 tggctacaag gacccctaca ctggccagca gatctctctc ttccaagcca tgcagaaggg
     8521 cctcatcgtc cgggagcacg gcatccgcct gctggaggcc cagatcgcca cgggcggcgt
     8581 tatcgacccc gtgcacagcc accgcgtgcc cgtggacgtg gcctaccggc gcggctactt
     8641 cgacgaggag atgaaccgcg tcctggcgga ccccagcgac gacaccaagg gcttctttga
     8701 ccccaacacg cacgagaacc tcacgtacct gcagctactg gagcgctgcg tggaggaccc
     8761 cgagacgggc ctgtgccttc tgccactcac ggataaggct gccaagggcg gggagctggt
     8821 ctacactgac tccgaggccc gggacgtctt tgagaaggcc accgtgtctg cgccgttcgg
     8881 caagttccag ggcaagacgg tgaccatttg ggagatcatc aactcggaat acttcacggc
     8941 agagcagcgg cgggacctgc tgcggcagtt ccgcacgggc cggatcacag tggagaagat
     9001 catcaagatc atcatcacgg tggtggagga gcaggagcag aagggccggc tttgctttga
     9061 gggcctgcgc agcctggtgc cagccgccga gctgctggag agcagggtca tcgaccgcga
     9121 gctctaccag cagctgcagc gaggtgagcg ctctgtgcga gacgtagccg aggtggacac
     9181 tgtgcggcgg gctctccggg gtgccaacgt catcgcgggt gtatggctgg aggaggcggg
     9241 gcagaagctg agtatctaca atgccctgaa gaaagacctg ctgccatccg acatggccgt
     9301 ggccctgttg gaagcccagg ccggcaccgg gcacatcatc gaccccgcca ccagcgcccg
     9361 gctgaccgtg gacgaggcag tgcgtgctgg cctggtgggc cccgagtttc atgagaagct
     9421 gctatcagcc gagaaggctg tgacagggta cagggacccc tacacagggc agagcgtctc
     9481 cctgttccag gccctgaaga agggcctcat tccccgggag cagggcctgc gcctgttgga
     9541 cgcccagctg tccacgggcg gcatcgtgga ccccagcaag agccaccgcg tgcccctgga
     9601 tgtcgcctgc gcccgaggct gcctggatga ggagaccagc agggccctgt cggcaccaag
     9661 ggccgacgcc aaggcctaca gtgaccccag cacaggggag ccggccacct acggcgagct
     9721 ccagcagcgg tgccggcccg accagctgac cgggctgagc ctgctgccgc tctcagaaaa
     9781 ggctgctcgg gcccggcagg aggagctcta ctcagagctg caggcccgtg agacctttga
     9841 aaagaccccg gttgaggtcc ccgtgggtgg cttcaagggc aggacggtga cggtgtggga
     9901 gctcatcagc tctgagtact tcactgcgga gcagcggcag gagctgttgc gtcagttccg
     9961 cacgggcaag gtcaccgtgg agaaggtcat caagattctc attaccatcg tggaggaggt
    10021 ggagaccctg cggcaggaga ggctgtcctt cagcggcctc cgtgcccctg tgccagccag
    10081 cgagctcctg gcttccgggg tcctcagcag agcccagttt gagcagctca aggacggcaa
    10141 gacgacggtc aaggaccttt cggagctggg ctccgtgcgg acgctgctgc agggcagtgg
    10201 ctgcctcgcc ggcatctacc tggaggacac caaggagaag gtgtccatct acgaggccat
    10261 gcgccggggc ctgctgagag ccacaacggc tgcgctcctg ctggaggcgc aggcggccac
    10321 tggcttcctg gtggaccccg tgcggaacca gcgcctgtat gtccacgagg ccgtgaaggc
    10381 gggcgtggtg ggccccgagc ttcacgagca gctgctgtct gccgagaagg ccgtcaccgg
    10441 ctacagagac ccctactcgg gcagcaccat ctccctcttc caggccatgc agaagggcct
    10501 ggttctccgg cagcacggca tccgcctgct ggaggcccag atcgccacgg gcggcatcat
    10561 cgaccccgtg cacagccacc gcgtgcctgt ggacgtggcc taccagcgcg gctacttcag
    10621 tgaggagatg aaccgcgtcc tggcggaccc cagcgacgac accaagggct tctttgaccc
    10681 caacacgcat gagaacctca cgtacaggca gctgctggag cggtgcgtgg aggaccccga
    10741 gacgggcttg cgccttctgc cactgaaagg ggcggagaag gctgaggtgg tggagaccac
    10801 gcaggtgtac actgaggagg agacaagaag ggcatttgaa gagacacaga tcgacattcc
    10861 cggcggcggc agccacggcg gctccaccat gtccctgtgg gaggtgatgc agtcggacct
    10921 gatccccgag gagcagcggg cccagctgat ggctgacttc caggccggcc gggtgaccaa
    10981 ggaacgcatg atcatcatca tcatcgagat cattgagaag acagagatca tccgccagca
    11041 gggtctggcc tcctacgact acgtgcgccg ccgcctcacg gctgaggacc tgttcgaggc
    11101 tcggatcatc tctctcgaga cctacaacct gctccgggag ggcaccagga gcctccgtga
    11161 ggctctcgag gcggagtccg cctggtgcta cctctatggc acgggctccg tggctggtgt
    11221 ctacctgccc ggttccaggc agacactgag catctaccag gctctcaaga aagggctgct
    11281 gagtgccgag gtggcccgcc tgctgctgga ggcacaggca gccacaggct tcctgctgga
    11341 cccggtgaag ggggagcggc tgactgtgga tgaggctgtg cggaagggcc tcgtggggcc
    11401 cgagctgcac gaccgcctgc tctcggctga gcgggcggtc accggctacc gtgaccccta
    11461 caccgagcag accatctcgc tcttccaggc catgaagaag gagctgatcc ctactgagga
    11521 ggccctgcgg ctgctggatg cccagctggc caccggcggc atcgtggacc cccgcctggg
    11581 cttccacctt cccctggagg tggcttacca gcgtggctac ctcaacaagg acacgcacga
    11641 ccagctgtca gagcccagcg aggtgcgcag ctacgtggac ccgtccaccg acgagcgcct
    11701 cagctacacg cagctgctca ggcggtgccg tcgtgacgac ggcaccggcc agctgctcct
    11761 gccactgtcg gacgcccgca agctgacctt ccgtggcctg cggaagcaga tcaccatgga
    11821 ggagctggtg cgctcgcagg tcatggacga ggccacggcg ctgcagctgc gggagggcct
    11881 gacctccatc gaggaggtca ccaagaactt gcagaagttc ctggaaggca ccagctgcat
    11941 cgctggtgtc ttcgtggacg ccaccaagga acggctctcg gtgtaccagg ccatgaagaa
    12001 gggcatcatc cgccccggca cagcctttga gctcctggag gcgcaggcgg ccaccggtta
    12061 cgtcatcgac cccatcaagg gactgaagct gacggtggag gaggctgtgc gtatgggcat
    12121 tgtgggcccc gagttcaagg acaagctgct gtcggccgag cgcgccgtca ctgggtacaa
    12181 ggacccctac tctgggaagc tcatctccct cttccaggcc atgaagaagg gcctgatcct
    12241 gaaggaccat ggcatccgcc tgctggaggc ccagatcgcc acgggcggca tcatcgaccc
    12301 tgaggagagc caccggctgc ccgtggaggt ggcctacaag cgcggcctct tcgatgagga
    12361 gatgaacgag atcctgaccg acccctcgga cgacaccaag ggcttctttg accctaacac
    12421 ggaggagaac ctcacctacc tgcagctgat ggagcgttgt atcactgacc cccagacggg
    12481 cctgtgtctc ttgccgctga aggagaagaa gcgggagcgg aagacgtcct ccaagtcctc
    12541 cgtgcgcaag cgccgagtgg tcatcgtgga ccccgagacg ggcaaggaga tgtcagtgta
    12601 cgaggcctac cgcaagggcc tgattgacca ccagacgtac ctggagctgt ccgagcagga
    12661 gtgcgagtgg gaggagatca ccatctcctc ctcggacggc gtggtcaagt ccatgatcat
    12721 cgaccgccgc tccgggcgcc agtacgacat cgatgatgcc atcgccaaga acctcatcga
    12781 ccgctcggca ctggaccagt accgcgccgg cacgctctcc atcaccgagt tcgccgacat
    12841 gctctcgggc aacgccggtg gtttccgctc ccgttcctcc tcggtgggat cctcctcctc
    12901 ctaccccatc agccccgccg tctccaggac ccagctggcc tcctggtcag accccactga
    12961 ggagacgggc cccgtggctg gcatcctgga cacggagacg ctggagaagg tgtccatcac
    13021 cgaggccatg caccggaacc tggtggataa catcacgggg cagcggctgc tggaggcgca
    13081 ggcctgcacc gggggcatca tcgaccccag caccggtgag cgcttccctg tcaccgacgc
    13141 cgtcaacaag ggcctggtgg acaagatcat ggtggaccgc atcaacctgg cccagaaggc
    13201 cttctgcggc ttcgaggacc cacgcaccaa gaccaagatg tcggccgccc aggccctgaa
    13261 gaagggctgg ctctactacg aggccggcca gcgcttcctg gaggtgcagt acctgaccgg
    13321 cggcttgatc gagcccgaca cgccgggccg cgtgcccctg gacgaggccc tgcagcgcgg
    13381 cacggtggac gcccgcaccg cacagaagct gcgtgacgtg ggcgcctact ccaagtacct
    13441 cacctgccct aagaccaagc tcaagatctc ctataaggac gcgctggacc gcagcatggt
    13501 ggaggagggc acggggctgc ggctgctgga ggctgccgcg cagtccacca agggctacta
    13561 cagcccctac agcgtcagcg gctccggctc taccgctggc tcccgcaccg gctcgcgcac
    13621 cggctcccgg gccggctccc gccgcggcag ctttgacgcc accggctccg gcttctccat
    13681 gaccttctct tcatcctcct actcctcctc gggctacggc cgccgctacg cctcggggtc
    13741 ctcggcctcc ctggggggcc ctgagtctgc cgtggcctga ggctgcctgc gcccaccccg
    13801 ctctgcatgc ggcccagccc ggctcccacc gaggcgcggg ggccgttttc aacgcttaaa
    13861 ggtgtcttcc tcccaagtgg tgcctaaagt ttaaccaaaa agaccagact aatatattaa
    13921 tatatatctg ctgtccagac agcctgtatc ttgggggaca gggctggccc agccctgctg
    13981 gccgcctcac cccctcgggt ctcctcactc ccttctacct gccactcaca cagccaggtg
    14041 ccttggaggg tcccaagctg ggccccagcc caccctcctg tcttcccagg gtagcccgcc
    14101 tgccagtcct agctgcacag ggcagctggg cccaaccctg tctgtagagg gccctggtgt
    14161 ttctagcact ggcctgcacg gtgggccttg ctggggacgg ggggccccag tcagcctctc
    14221 tcccagtcta cccagagaag ccccttcccc atgggaagac gaggccctcg ggcccagccc
    14281 ccacagtgct gtctgatctg tgctttccag ctcacccccc acactcactc ctgagacccc
    14341 tggcctccgg cgtcagcctc cagcctctgt tcccctagta agtgccttcc atgtcggcct
    14401 ctaaccccag gccccgagga cccagaccca gtggggaggc ggacgttcca gccggcatgg
    14461 ctgggaactg cagacctgtc ctcctggtgg gtccaggggc ccctccagct tgtggagccc
    14521 cacactgggg tgccgcctgc ccgtctctct cccatggagc cccagccccc tttgggccca
    14581 gggacaccag ccaggctctg tgctgaccct cctgttgcac ccagccctgg tctcagcagc
    14641 gaccacccct gcctccaccc tctgagcttt gcatgttcca ctaaccccgg gcgggtggca
    14701 ggtggaggtg tcaggctgct ggcgcctctg caagggcaga acactaacct gaccgtgggc
    14761 ggggccttgc ggtatccgcc cccaataaaa gcaattccaa cctt
//
