LOCUS       NM_001372062            8900 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens phospholipase D family member 5 (PLD5), transcript
            variant 5, mRNA.
ACCESSION   NM_001372062 XM_006711752
VERSION     NM_001372062.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8900)
  AUTHORS   Liu,J., Li,J., Ma,Y., Xu,C., Wang,Y. and He,Y.
  TITLE     MicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to
            downregulate cell proliferation and metastasis to mitigate prostate
            cancer
  JOURNAL   Bioengineered 12 (1), 3240-3251 (2021)
   PUBMED   34238129
  REMARK    GeneRIF: MicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to
            downregulate cell proliferation and metastasis to mitigate prostate
            cancer.
REFERENCE   2  (bases 1 to 8900)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8900)
  AUTHORS   Chimusa,E.R., Zaitlen,N., Daya,M., Moller,M., van Helden,P.D.,
            Mulder,N.J., Price,A.L. and Hoal,E.G.
  TITLE     Genome-wide association study of ancestry-specific TB risk in the
            South African Coloured population
  JOURNAL   Hum Mol Genet 23 (3), 796-809 (2014)
   PUBMED   24057671
REFERENCE   4  (bases 1 to 8900)
  AUTHORS   Wojczynski,M.K., Li,M., Bielak,L.F., Kerr,K.F., Reiner,A.P.,
            Wong,N.D., Yanek,L.R., Qu,L., White,C.C., Lange,L.A.,
            Ferguson,J.F., He,J., Young,T., Mosley,T.H., Smith,J.A., Kral,B.G.,
            Guo,X., Wong,Q., Ganesh,S.K., Heckbert,S.R., Griswold,M.E.,
            O'Leary,D.H., Budoff,M., Carr,J.J., Taylor,H.A. Jr., Bluemke,D.A.,
            Demissie,S., Hwang,S.J., Paltoo,D.N., Polak,J.F., Psaty,B.M.,
            Becker,D.M., Province,M.A., Post,W.S., O'Donnell,C.J., Wilson,J.G.,
            Harris,T.B., Kavousi,M., Cupples,L.A., Rotter,J.I., Fornage,M.,
            Becker,L.C., Peyser,P.A., Borecki,I.B. and Reilly,M.P.
  TITLE     Genetics of coronary artery calcification among African Americans,
            a meta-analysis
  JOURNAL   BMC Med Genet 14, 75 (2013)
   PUBMED   23870195
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8900)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   6  (bases 1 to 8900)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 8900)
  AUTHORS   Anney,R., Klei,L., Pinto,D., Regan,R., Conroy,J., Magalhaes,T.R.,
            Correia,C., Abrahams,B.S., Sykes,N., Pagnamenta,A.T., Almeida,J.,
            Bacchelli,E., Bailey,A.J., Baird,G., Battaglia,A., Berney,T.,
            Bolshakova,N., Bolte,S., Bolton,P.F., Bourgeron,T., Brennan,S.,
            Brian,J., Carson,A.R., Casallo,G., Casey,J., Chu,S.H., Cochrane,L.,
            Corsello,C., Crawford,E.L., Crossett,A., Dawson,G., de Jonge,M.,
            Delorme,R., Drmic,I., Duketis,E., Duque,F., Estes,A., Farrar,P.,
            Fernandez,B.A., Folstein,S.E., Fombonne,E., Freitag,C.M.,
            Gilbert,J., Gillberg,C., Glessner,J.T., Goldberg,J., Green,J.,
            Guter,S.J., Hakonarson,H., Heron,E.A., Hill,M., Holt,R., Howe,J.L.,
            Hughes,G., Hus,V., Igliozzi,R., Kim,C., Klauck,S.M., Kolevzon,A.,
            Korvatska,O., Kustanovich,V., Lajonchere,C.M., Lamb,J.A.,
            Laskawiec,M., Leboyer,M., Le Couteur,A., Leventhal,B.L.,
            Lionel,A.C., Liu,X.Q., Lord,C., Lotspeich,L., Lund,S.C.,
            Maestrini,E., Mahoney,W., Mantoulan,C., Marshall,C.R.,
            McConachie,H., McDougle,C.J., McGrath,J., McMahon,W.M.,
            Melhem,N.M., Merikangas,A., Migita,O., Minshew,N.J., Mirza,G.K.,
            Munson,J., Nelson,S.F., Noakes,C., Noor,A., Nygren,G., Oliveira,G.,
            Papanikolaou,K., Parr,J.R., Parrini,B., Paton,T., Pickles,A.,
            Piven,J., Posey,D.J., Poustka,A., Poustka,F., Prasad,A.,
            Ragoussis,J., Renshaw,K., Rickaby,J., Roberts,W., Roeder,K.,
            Roge,B., Rutter,M.L., Bierut,L.J., Rice,J.P., Salt,J., Sansom,K.,
            Sato,D., Segurado,R., Senman,L., Shah,N., Sheffield,V.C.,
            Soorya,L., Sousa,I., Stoppioni,V., Strawbridge,C., Tancredi,R.,
            Tansey,K., Thiruvahindrapduram,B., Thompson,A.P., Thomson,S.,
            Tryfon,A., Tsiantis,J., Van Engeland,H., Vincent,J.B., Volkmar,F.,
            Wallace,S., Wang,K., Wang,Z., Wassink,T.H., Wing,K., Wittemeyer,K.,
            Wood,S., Yaspan,B.L., Zurawiecki,D., Zwaigenbaum,L., Betancur,C.,
            Buxbaum,J.D., Cantor,R.M., Cook,E.H., Coon,H., Cuccaro,M.L.,
            Gallagher,L., Geschwind,D.H., Gill,M., Haines,J.L., Miller,J.,
            Monaco,A.P., Nurnberger,J.I. Jr., Paterson,A.D.,
            Pericak-Vance,M.A., Schellenberg,G.D., Scherer,S.W.,
            Sutcliffe,J.S., Szatmari,P., Vicente,A.M., Vieland,V.J.,
            Wijsman,E.M., Devlin,B., Ennis,S. and Hallmayer,J.
  TITLE     A genome-wide scan for common alleles affecting risk for autism
  JOURNAL   Hum Mol Genet 19 (20), 4072-4082 (2010)
   PUBMED   20663923
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 8900)
  AUTHORS   McCauley,J.L., Zuvich,R.L., Bradford,Y., Kenealy,S.J.,
            Schnetz-Boutaud,N., Gregory,S.G., Hauser,S.L., Oksenberg,J.R.,
            Mortlock,D.P., Pericak-Vance,M.A. and Haines,J.L.
  TITLE     Follow-up examination of linkage and association to chromosome 1q43
            in multiple sclerosis
  JOURNAL   Genes Immun 10 (7), 624-630 (2009)
   PUBMED   19626040
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445704.18, AL360271.12, AL583845.16 and AL591686.10.
            
            On Aug 6, 2019 this sequence version replaced XM_006711752.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101373.1, SRR14372080.2167368.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536534.7/ ENSP00000440896.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               AL445704.18        135512-136121       c
            611-747             AL360271.12        54360-54496         c
            748-916             AL583845.16        46770-46938         c
            917-1028            AL583845.16        23745-23856         c
            1029-1156           AL591686.10        151877-152004       c
            1157-1354           AL591686.10        56357-56554         c
            1355-1491           AL591686.10        45779-45915         c
            1492-1660           AL591686.10        39560-39728         c
            1661-1775           AL591686.10        32557-32671         c
            1776-8900           AL591686.10        14875-21999         c
FEATURES             Location/Qualifiers
     source          1..8900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..8900
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /note="phospholipase D family member 5"
                     /db_xref="GeneID:200150"
                     /db_xref="HGNC:HGNC:26879"
     exon            1..610
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2032
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /note="isoform 1 is encoded by transcript variant 5;
                     inactive phosphatidylcholine-hydrolyzing phospholipase D5;
                     inactive choline phosphatase 5; inactive phospholipase D5;
                     inactive PLD 5"
                     /codon_start=1
                     /product="inactive phospholipase D5 isoform 1"
                     /protein_id="NP_001358991.1"
                     /db_xref="CCDS:CCDS1621.2"
                     /db_xref="GeneID:200150"
                     /db_xref="HGNC:HGNC:26879"
                     /translation="MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSV
                     KQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEK
                     NCQNKCRIALVENIPEGLNYSENAPFHLSLFQGWMNLLNMAKKSVDIVSSHWDLNHTH
                     PSACQGQRLFEKLLQLTSQNIEIKLVSDVTADSKVLEALKLKGAEVTYMNMTAYNKGR
                     LQSSFWIVDKQHVYIGSAGLDWQSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFK
                     SRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVID
                     DAKQYVYIAVMDYLPISSTSTKRTYWPDLDAKIREALVLRSVRVRLLLSFWKETDPLT
                     FNFISSLKAICTEIANCSLKVKFFDLERENACATKEQKNHTFPRLNRNKYMVTDGAAY
                     IGNFDWVGNDFTQNAGTGLVINQADVRNNRSIIKQLKDVFERDWYSPYAKTLQPTKQP
                     NCSSLFKLKPLSNKTATDDTGGKDPRNV"
     exon            611..747
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            748..916
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1028
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1156
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1354
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1491
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1660
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1775
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..8900
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6809..6814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /note="hexamer: AATAAA"
     polyA_site      6835
                     /gene="PLD5"
                     /gene_synonym="PLDC"
     regulatory      8880..8885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /note="hexamer: AATAAA"
     polyA_site      8900
                     /gene="PLD5"
                     /gene_synonym="PLDC"
                     /note="major polyA site"
ORIGIN      
        1 agtaggtgcc gcaaggagcc ggcgagcgga gcgcccgctc gggaccgcag ccgccgggcg
       61 acgtcgccgc cgcaccgggc acttctgtct ccccggagca ggttcctttc cctccctgtc
      121 ccctctcgtc ccccttctcc ccgtccgtcc ccctccgccc ccgcccccgc ccccgcccgc
      181 acctcgccct ccctccttcc gccccgcgcc tcccgcgatc gccccctccc gcccggccgc
      241 gctcccagct ggcgctcagc accccgcgct ccccgcgccc gctcgctcct ccagctcctc
      301 cagctcagtc tccagctcca cctccggctc ccgctgggcc tcccgctcgc cctccgcgcc
      361 cggctccccg cgcgcccgtc ccgagtccgc tgctcgccgg cggccgcccg gtcatgtcag
      421 gatggagatc cggcagcacg agtggctctc ggcctccccc catgagggct tcgagcagat
      481 gaggctcaaa agccgcccca aggagccctc cccaagcctg acccgagtgg gcgcgaactt
      541 ctacagcagc gtcaagcagc aggactacag cgccagcgtc tggcttcgga ggaaagacaa
      601 gctggagcac tcccagcaga agtgcatcgt gatctttgcc ctggtgtgct gctttgccat
      661 tctggttgca ctgatctttt cagccgtgga catcatggga gaggatgagg atggactctc
      721 agaaaaaaat tgccaaaata aatgtcgaat tgccctggtg gaaaatattc ctgaaggcct
      781 taactattca gaaaatgcac catttcactt atcacttttc caaggctgga tgaatttact
      841 caacatggcc aaaaagtctg ttgacatagt gtcttcccat tgggatctca accacactca
      901 tccatcagca tgtcagggtc aacgtctttt tgaaaagttg ctccagctga cttcgcaaaa
      961 tattgaaatc aagctagtga gtgatgtaac agctgattca aaggtattag aagccttgaa
     1021 attaaaggga gccgaggtga cgtacatgaa catgaccgct tacaacaagg gccggctgca
     1081 gtcctccttc tggatcgtgg acaaacagca cgtgtatatc ggcagtgccg gtttggactg
     1141 gcaatccctg ggacagatga aagaactcgg tgtcatcttc tacaactgca gctgcctggt
     1201 cctagattta caaaggatat ttgctctata tagttcatta aaattcaaaa gcagagtgcc
     1261 tcaaacctgg tccaaaagac tctatggagt ctatgacaat gaaaagaaat tgcaacttca
     1321 gttgaatgaa accaaatctc aagcatttgt atcgaattct ccaaaactct tttgccctaa
     1381 aaacagaagt tttgacatag atgccatcta cagtgtgata gatgatgcca agcagtatgt
     1441 gtacatcgct gtcatggact acctgcctat ctccagcaca agcaccaaaa ggacttactg
     1501 gccagacttg gatgcaaaaa taagagaagc attagtttta cgaagcgtta gagttcgact
     1561 ccttttaagc ttctggaagg aaactgatcc ccttacgttt aactttattt catctcttaa
     1621 agcgatttgc actgaaatag ccaactgcag tttgaaagtt aaattttttg atctggaaag
     1681 agagaatgct tgtgctacaa aagaacaaaa gaatcacacc tttcctaggt taaatcgcaa
     1741 caagtacatg gtgacagatg gagcagctta tattggaaat tttgattggg tagggaatga
     1801 tttcactcag aatgctggca cgggccttgt tatcaaccag gcagatgtga ggaacaacag
     1861 aagcatcatt aagcaactta aagatgtgtt tgaaagggac tggtattcac cgtatgccaa
     1921 aaccttacag ccaaccaaac agccgaactg ctcaagcctg ttcaaactca aacccctctc
     1981 caacaaaact gccacagacg acacaggcgg aaaggatccc cggaacgtat aacatgatga
     2041 agaaactgac aggacagctc tgtatttcat atttatacat aaaggacttg aggagagaaa
     2101 aaacacttta atatgtctct ttttttaggg aaaaagcaca cttataaaaa atattctctg
     2161 aacaacacat aatacctatc taacaatatc ttagcgtcgt gtacactaaa attaagactt
     2221 ttgtatttgt tacctctgac agagaatgtc attctggcgt agaagttagt ttttacgttt
     2281 gcatacaaat tttaagactt tcattcctgc tcctttctag ttttagaact ttttctgctg
     2341 acctacccgg tcagttgtta ggaagcttag catgaggtgg gctctttaac accattctga
     2401 gaactgttga tttagagagg aaggtgagga ttttgccttg gagaagagac tgataaaacc
     2461 aagtgtttat tcttgtaaat cgtctccaag acctacacag tcagctaagc atgaatagct
     2521 tacatctcat gccagccttc aacacccttg aaaaatatcc ttttctgtct tgctcatttt
     2581 cttcttatac cataagtttt atttggtatc attttctctt ctcacaaaat gttcctatta
     2641 tatagcattt tctgtattca cctcaacatt acttctaact atgataacat cttttgaaaa
     2701 catacaaatt tttcagaatg gatactaagt ggaaatagca gtctttcatt ttcacctttc
     2761 aactgaatcc ttttttcccc taccgaattg gtatttaaaa aaaatcacag tcagcaatat
     2821 gtatcctttc tctcaagctc agaaaaatta tgtagccacc tgctaatatc cagcaagcta
     2881 tcaagtctgc attttgggaa taaagtagtt tttcacattt ttgttcagtt tatggtatta
     2941 taaaggaaaa aatctctatg cgtcagtgga ttttaatttc tttagaatca ttatgctgtt
     3001 aagagtatgc cagcaaacgt ttctagagct atttaatata ccttctgcta tttaatatac
     3061 caaatgcttt tcagagaaat gcaatttaaa tactgtgctt aacatatttt actaagaagc
     3121 agaaatattg aattattgtt ctataacgta attgtgtgtt gttgttttat atctatacaa
     3181 tatatacccc tgtattaatg gagaccattg ctacactagg gagaggcatg gcctcttcag
     3241 agcccacagc aggtggccgg gatgtccagt tccaatgttg ttcccgactc tgtgactcaa
     3301 agcggagccc ctcactgctt ggcctcgggc ttctcttggt aatgtagacg gtaataactc
     3361 acctacctcg caaggatgtt gtcacggtag gaaatattta taacttgttt tgaaatcaaa
     3421 agaacctata taaatgctaa gcattataat atataatctt tttcttgaaa taaactttgt
     3481 catatcttga tggaatcaac accaggtcct cccccagaat ccacaaagga aaacaaattc
     3541 acagcttcct gttgcaaatg tggatgaaaa gagcacagcc ccacagaaac cctggtggag
     3601 atctggattg tcaacatttc aatagaacat tgcgttgggc tgctttggca tgaataacat
     3661 caacacaaaa ctagacgtcg tgctagagct ggttcttcag gaccataata tacatgtatt
     3721 ttcagagcaa ggaaacactc agttattctt tttcatttct ggagacttga tttctaaatg
     3781 ccaaaagagt gatcgaggag cctgtgaatc ttatccaatg gatttactta atatagaatg
     3841 gctatgttgg ttatccagtg agtgatcaca ttacttccct tcttgttatt tgcaagtatt
     3901 gcttcactag atatttaacc agttgatcaa gagagctgga aggaagctgt atttttaagg
     3961 gtagcatggt tttatgacta attgggagat tctcactgaa attcttcatc aataatagcc
     4021 agtccctaag actctaaata tttaccatat acacaatcca tatttgagtt gggagttata
     4081 actctgccag ttatcccaat aaagtaaacg tggctttggt gatgatttta aaaagaaagc
     4141 agcctgggtg cggtggctca cgcctgtcat cccagcgctt tggaaggcca aggcaggagg
     4201 attgcttgag gccaagagtt tgagaccagc ctgggtagca tagcaagatc ctgcctctaa
     4261 aaataaataa atacagaaag gaaagaagga atcagaatag gagtggagac aaacctacca
     4321 agttcacact cagacaaaca aaagcgacct gagttggttt taaaaaggac atctaaaggg
     4381 agaaaaaaaa accaaataaa ctaaaatttg ttagttctca agttgtcccc tgaagtattc
     4441 atccacagcc atgggacact cataggcttg gtgtcatggg gccccttcac tgtcactatc
     4501 tgctgtatgt gctacgagaa gagaatgtca tccattacgg aatgaccatc attgccattt
     4561 ccttttgagg cctggcaaaa tgctatcacc aggagccgca tcccaggctt ttctgccaag
     4621 cagcagcagc agatgcctac cagacacagc aagcccctaa tcaggggagt ctgggcagcg
     4681 gtggtgactc catggggcca cactgtcctt ctgtggcagc cagaaaagtg acccccatac
     4741 caagagtgtc agaaatgggt tcatgtctcc caagagaaca tttcattctg cagaactttc
     4801 tttcatttgg atgctttagc tatccctcta gagacggctt tcctttcttt tagacttgtt
     4861 tctgtgctaa acaaactatc aacctccatt cccccccacc cctaaatatc ccaggaatta
     4921 ctttccagga gggaaagaat gcaaaacaaa aacaggttaa tttgacaccc tctggtggat
     4981 gtccatgcca gaaattatga ggagcagggt gactactccc cattaacatt cctggattta
     5041 tttcccaaga ggcaaaaagg aaaacaaaca caattagaga ctatatcttg gatttcagta
     5101 ccactaacac taacttagtg ccttatgtat cctcaagtgt tgattttaaa caatgactta
     5161 ttctatgaga acacttctct ctcctgtgga attcaaatga ccttccgatg ggcctaccag
     5221 ttgaaaactt ccatttgagc agtgacagtt tttatgctgc ctgttctctt cccaagcccc
     5281 atcaccttta tccacccccc cgccaaatca aatcattgca cacaccatca aagatcaata
     5341 ctgtgggcct ccactgcatt gtcactggcc actagcctat caaataattg aatctctgct
     5401 tgtccaacca ttggagagga agtggaagag tgagatgaca tccatgcttt gtaaacaaca
     5461 agctttaggt acctgaacct gatagaaaca aggaatgctg aaaatgtccc cactgactta
     5521 aaagaatgct gtaaagagat gctttgcaga cttcctaggt cctgtggcac agagaatgaa
     5581 aaccagcgtc tttaacaagt caaagcagac aaagaaacaa aaggtctgcg gatacacttt
     5641 gcacctgtgt aactctgggc accattcggg ccctctctgt gctactgttt gtctcatgtc
     5701 tgaatggttc ttggtgagag gggtctgatc acatttttgg ttgatctcac cctttgaaaa
     5761 atgtggggga ttttttttga aatgcagtta atggtttaag tgcctcgatg aacctgggat
     5821 ggatagaagc tcatttccca ccagcctgtg gctatactca gtgactctga ttcattctgt
     5881 ttgtttttag gaacttttat tgaactaaat tccaaggggg gagaaaagac cataagaatt
     5941 tcttgataag atcagatcca gggtctatct gtctcaggaa ttctatccta caattaactt
     6001 tttttttttt ccacacgtat gaccactggt gtgtgtttct gtgtccaaaa ttcatttcat
     6061 tatttttaac tttaggaatg taaaacgctg ccattacttg catagaacag ccacttccta
     6121 taatgaaaga tactttgtta ttgtttattc aaactcagtc cttacgaaca gccccatata
     6181 ttgtggacaa atgtttcatt cttttatctt tctgtacttg ttcccaatga actggtgtgc
     6241 tttattatac accttttaaa ggcaaaatta atataacttc catttggccc aaggtaaaaa
     6301 attttccaat ttgatttgga ttagcatctt tcattttcct tttatatgtt gttaacaaaa
     6361 tagctgctta ccattttcac cttattgact taaatggacg gaggcttttg aatagccctg
     6421 acatcaaccc cagttcgcag cctgtctttc tcatttgaga gaattcccat ctttggctga
     6481 attatgaaga tgctgcttta tacagtgact caatgggtat tcctcagaag tttcttgaag
     6541 atgtaaaaat gaaattttct tatttttgac ccattagcag tcttgtattt acaaggttct
     6601 aaaacttcac tggtcattaa cgcttctttt ggcaatttga aaaaaaaaag ttacatttaa
     6661 tagactatta cacattttct tttgctatgt tcaactacta aacttctaat tctgttacaa
     6721 aaggtatctt gaatttttaa tgttccttta tgtaaatagg ataaacttgt acctggacat
     6781 atctatatta ttaaccttaa gatccctaaa taaatgggtt tgataaaggg ttgaatttgg
     6841 gggaatcatt aaaattatca aacctttcgt ataaccagat gctcagtttt ttcagaagta
     6901 aatattagat ggctttttca tactgtgaga tgaggcattt ctttttctcc tcaagctgat
     6961 ctcagaaaca aatcagtctc tcatcagtaa ccaagctgta ctgtggtaaa ttatgaagaa
     7021 ggtagatgcg actggtccaa tgggcccact gttttgtata ttcacacaag gaggcatctt
     7081 tgaaacacta tacctatctc tttctctaaa aaaaaaaaaa aaaaaaaaaa aaaaaccttt
     7141 ccaataaatg ttcattctga gtacattaat ttttagtgag aaaaagaaac aatcatagag
     7201 accccactag agaacctagt gtctgctcag caaacccata ttgagctgta gagcatactt
     7261 taacagccat ctcaaccagc tcacccaacg tgtaaattcc cttcccattt gggcatagaa
     7321 gttgacagcc tagagtgtca ggacggccga gtggtctgag gctccagact caaggtgaga
     7381 agctgaaaac ctacttgagc caaacaattt ggagtgcttt atatggttcc tttctcaaga
     7441 cccacacagg ataaaatttt gttgatttac taaagtaatt tggatttgag gcagtcttat
     7501 ctctgaaagg atatgcacag catgtaataa ggtgggtgct gttttcataa agagaatcaa
     7561 tctgagaggc atacttttaa aaaaaaaact atcattggag aggttagcaa aggcttaaaa
     7621 gtgaactttg agtctgcaat agtcaatagt attctgattt tattggcagt ttctgaatgc
     7681 tacaatttcg tgtttttttt taaaaaaatg ggctaacagt gcgatgacag tcatgtacaa
     7741 ggagtccaat taaatcatag taagggtgaa gattatttgt gatttatttt tatatgagag
     7801 ataaattagt aaggagaaaa gatctctttt tatgaagtgg atatctggct ctcaaaccca
     7861 ttccttttgg ctcagacatt aaaaaattat taattccctt atggactctc ctattcccca
     7921 tgggcggaaa attctgaaaa gcagatgaga cattctgagc cccttgcaag acaaacacag
     7981 atggtttcta atttagagtt ttcccacaca aatgcacaac caatcttgga aatatgacct
     8041 caattcccag gattaaaaac gttgaaatta tatgttactt tccaatataa atagaggatg
     8101 aagatcttta aagacaactc agaaaatatg atccaataac attcaaatca gagcgtaatc
     8161 tacaatttca cttaatagtt aaaagtgaag attagctgct tctttaaaag gggtgagtta
     8221 ttaaaggcaa catcctagaa aatgtaataa caagaaggca acaccatatt ttcagcaaag
     8281 ttatggtact gataaagcac tttgaaaatc ctctgtagga aaatgtcatt gagaaacaaa
     8341 ggccaatttg tctccagtga taaagctatc tctcattcat atttcatagg tggatctata
     8401 gttttcctgg tgtcttggag agaccctacc tccacagctc ctgcaggagc aaaaccatgt
     8461 tttctgccat gtgagctctc tacactggcc acagctgatt gtaccaaggt tcagtacccg
     8521 acccaaagag actcattttc aggccagagg gcggcctaag gaatgaaagt gtacctagca
     8581 gtggtattct tgtttgatgg tacctggccc caccaatcac ggccctcttt tagggagttt
     8641 gaacaccaga aagtaaatga tgaataggaa gcacagccag aatagacaca gtcaccgtaa
     8701 tggtgactct gagaacagtg acagcagtta cttctgcagt caagacaatt tgaggtcttg
     8761 ttgattcacc attctgctct tagcttactg gagaaatact tgactcctga acaatgagtc
     8821 tggactttgt agttcctggg ttgctttttt tttttcttcc tttcttatgt attgacataa
     8881 ataaactcac attaactgaa
//
