LOCUS       NM_001005473            7706 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phosphatidylinositol specific phospholipase C X domain
            containing 3 (PLCXD3), mRNA.
ACCESSION   NM_001005473 XM_293875
VERSION     NM_001005473.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7706)
  AUTHORS   Aljaibeji,H., Mohammed,A.K., Alkayyali,S., Hachim,M.Y., Hasswan,H.,
            El-Huneidi,W., Taneera,J. and Sulaiman,N.
  TITLE     Genetic Variants of the PLCXD3 Gene Are Associated with Risk of
            Metabolic Syndrome in the Emirati Population
  JOURNAL   Genes (Basel) 11 (6), 665 (2020)
   PUBMED   32570874
  REMARK    GeneRIF: Genetic Variants of the PLCXD3 Gene Are Associated with
            Risk of Metabolic Syndrome in the Emirati Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7706)
  AUTHORS   Li,Z., Zheng,Z., Ruan,J., Li,Z., Zhuang,X. and Tzeng,C.M.
  TITLE     Integrated analysis miRNA and mRNA profiling in patients with
            severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3
            expression
  JOURNAL   Oncotarget 7 (33), 52781-52796 (2016)
   PUBMED   27486773
  REMARK    GeneRIF: One potential miRNA-target gene pair, miR-34c-3p and
            PLCXD3 (Phosphatidylinositol-Specific Phospholipase C, X Domain
            Containing 3), was identified in patients with severe
            oligozoospermia.
REFERENCE   4  (bases 1 to 7706)
  AUTHORS   Balendra,R., Uphill,J., Collinson,C., Druyeh,R., Adamson,G.,
            Hummerich,H., Zerr,I., Gambetti,P., Collinge,J. and Mead,S.
  TITLE     Variants of PLCXD3 are not associated with variant or sporadic
            Creutzfeldt-Jakob disease in a large international study
  JOURNAL   BMC Med Genet 17, 28 (2016)
   PUBMED   27055460
  REMARK    GeneRIF: We found no supportive evidence that PLCXD3 variants are
            associated with sporadic Creutzfeldt-Jakob disease.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648329.1, AK127142.1 and AC008830.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001005473.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127142.1, BX648329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150, SAMN03267760
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377801.8/ ENSP00000367032.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               BX648329.1         29-291
            264-1040            AK127142.1         264-1040
            1041-7706           AC008830.7         79823-86488
FEATURES             Location/Qualifiers
     source          1..7706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..7706
                     /gene="PLCXD3"
                     /note="phosphatidylinositol specific phospholipase C X
                     domain containing 3"
                     /db_xref="GeneID:345557"
                     /db_xref="HGNC:HGNC:31822"
                     /db_xref="MIM:617016"
     exon            1..178
                     /gene="PLCXD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1041
                     /gene="PLCXD3"
                     /codon_start=1
                     /product="PI-PLC X domain-containing protein 3"
                     /protein_id="NP_001005473.1"
                     /db_xref="CCDS:CCDS34150.1"
                     /db_xref="GeneID:345557"
                     /db_xref="HGNC:HGNC:31822"
                     /db_xref="MIM:617016"
                     /translation="MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYI
                     DEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTK
                     PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQ
                     MLKDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWAN
                     TTDPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAM
                     MQWVRTQKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT"
     exon            179..887
                     /gene="PLCXD3"
                     /inference="alignment:Splign:2.1.0"
     exon            888..7706
                     /gene="PLCXD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7685..7690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCXD3"
                     /note="hexamer: AATAAA"
     polyA_site      7706
                     /gene="PLCXD3"
                     /note="major polyA site"
ORIGIN      
        1 attggattag cggcagcagc ctgccagcct gcccgaggag tgctgggacc agcgcgctgc
       61 acgccgactg gcacgatggc ctcgtctcag gggaaaaacg agctgaaatt agccgactgg
      121 atggcaactc tgccggagag catgcacagc atccccctca ccaatttagc cattccaggg
      181 tctcatgatt ccttcagctt ctacattgat gaagcctctc cagtaggtcc tgagcagcca
      241 gaaactgtcc agaattttgt ctctgtgttt ggaactgtgg ccaaaaagct catgcggaaa
      301 tggttagcca ctcagacaat gaattttact ggccagctag gagctggaat tcgttatttt
      361 gatcttcgaa tttccaccaa gcccagagac cccgacaatg aactctattt tgctcatggt
      421 ttgttcagtg ccaaagtcaa tgaaggcctt gaggagatca atgcattcct cacagatcac
      481 cataaggagg tagtgttctt ggacttcaac cacttttatg ggatgcagaa atatcaccat
      541 gaaaaactgg tccaaatgct gaaagacatc tatggaaata aaatgtgccc agcgattttt
      601 gcccaggaag ttagtttaaa gtacctgtgg gagaaggact atcaagtgct ggtcttctac
      661 catagtccag tggctctgga agtgcccttt ctctggcctg ggcagatgat gccagcaccc
      721 tgggccaaca ccacagaccc cgagaaactg atccagtttc ttcaagcatc catcactgag
      781 agaagaaaga agggatcgtt ttttatatct caggtggtgc tgacccccaa agctagcact
      841 gtggtcaaag gggtggcaag tggcctcaga gaaacaatca cagaaagagc tcttcctgcc
      901 atgatgcagt gggtccgcac gcagaagcca ggagagagtg gcatcaatat tgtcactgcc
      961 gattttgtag aacttggtga ctttatcagc actgtcataa agctcaacta tgtctttgat
     1021 gaaggagaag ccaacacttg atagcactac ttggagtttc catgaataag atggagaaag
     1081 ctcattgtat tagggcatac tatctgtaaa cactctgatc ttcctattcc actgagtctc
     1141 tgaagggaat agggctggta gtgggtggga aaaggggaaa aactgtttct tcagtgatta
     1201 caatcatact cttcattact ataaatattt catttcccat ttgatgagca aaatctactt
     1261 ctagtgttag gaataaaaaa aaaagaccag taactttgtt tttcaaaatt agtctttgta
     1321 acatagaatt catgagtgtt tacttgatta ggttctctat ttccagccta tgactcctac
     1381 gctgtctata ccctgcaacc tttctgctcc ctctcttgct cgctcttttt aatcagatgc
     1441 tgtatgggaa tcaaaacaat tgaatgccca acattttgtg tattacattg ttgtcttaaa
     1501 acttactagt tttgtgggac ttgttataat gctctatagt catccacagt tgggcaatca
     1561 tagctaattt ttggtcatag aaaatctgca tcaaatcagt ttccatgcat cagtaatatt
     1621 gaaggtcata atcagtgatt tttgttatat gaaaataata gtgtttcaca gtatttctat
     1681 ttaaggcagc tataaatata ggagaaaaat gtttttggag agctgtgaat gccaatttca
     1741 gagggaaaaa tggttgaggg gtgaaagaga tgtatggcat tttaatttgg caatctctta
     1801 aataatattg ccctgcaagt acccagtaaa tggtaaggta caagtgtgtt aaaattgaaa
     1861 actctgaaaa taactcttta aaaagccctc ttaatgatgc tcttgatgaa agaaaaagac
     1921 agaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaaggaagaa
     1981 aggaagggag ggaggaaggg agggaagaag ggagggaagg acagaaggaa ggacgggagg
     2041 aaggaaggaa gggaggaagg aaggaaggaa gagagggagg gagggaggaa gagagggagg
     2101 gagggaggaa gagaggaagg aagaagaaaa agactgcaag ctttcctgcc aatttgggat
     2161 tttcaaatat ttaattctaa attccagatt ttaaggaaga tttttcaaga aactgcaagt
     2221 ttttgacttg aaggaaagaa agaggaaggc tggtagaagc agttagagca atgtgtttga
     2281 aattatgtcc atgaaatcac agggatctct gaaatatctt taggaaactt gaaatttatg
     2341 aggtctgaat ggacttgttt aaaattggct ctgactcctc acttctgagt ttcatcctat
     2401 ccgagggatg agattaaggc agaggcaaaa gtttcacaca aagtttctgc aacctaacgt
     2461 ttaatagtcc gggtctacag ggaagaacaa tgacacagct tgagcgttac ttcctccttc
     2521 gtgtcattgt gatatttgac aactctaaaa aataaaaaaa aaaaacttag agcacaataa
     2581 tccttgccta tgtacttcac aggaatattg tgaggtgttt ataaaattat aaaatttgat
     2641 gaaattctta caattattaa ttattttatt ttcatgttta gaaataatca caccccaata
     2701 gtttcctagg ataatacagt ccatgcaaag tagggtcata gagaaataaa agcatgccct
     2761 cagcttttaa tgaacttaaa tgtagcacat atggcttaat ctcttagact tagataaggg
     2821 agttcaattc aaaaccatat atgtcaagac cacaaataat caagagttga tttcaagatt
     2881 ataaatactc atgatcagaa aatagtactt attagcaatt aaagggagga aaagaaattg
     2941 tttatactga agagaatgtt tatgaggagt gtgtatgtac ctgtggtata ccaaatagca
     3001 tacatgtaca cacaaaaatg tgtgtataca tttgggttgt gtgtatacat cttgccatat
     3061 acaatataca aacatatgcc cattcctgtg atagcataca aattcaaaca tacagaaaca
     3121 cacacagata tggacacagt acaattcttc ttttcaaatg aagacattga taatattaaa
     3181 taatttaatt ttaagactga aacccttaat attgtgtgaa aaagagtaat aaaacctttg
     3241 aaagtagagt agatgatcac atcaaagtat ttttgtaaaa gaattctagt gtaggactta
     3301 attattttta aaatatattt cttctcttct ttccattttc ccttcccttg tagttttatt
     3361 atctttctgt cttttacacc tgctctttat gtgaaaatgt atatgaatcc ttttaaaatg
     3421 attaggatta ttgaaatgta tgtcccgtaa atttggtttt tgggcagact ttctctctaa
     3481 ctggctattc attcatcctt caggaggatc ttagccaaga atatttgcaa tgacacatga
     3541 atttaatttt ataaatataa tggaaaacag atttttcatc atatcatgaa taaaatatag
     3601 aggtaactat gttgtatttt cttgaaccta gatactttct catagtgttt gcttagaatt
     3661 aactttgtcc tatttgtcaa ctgggttctg gaaaaaaaca aacatgatga agcttttgaa
     3721 taattgtgca gttttttaac tagggaaagc tttgtactgc tgctaatgat atgcacccag
     3781 aaaccttgtt agacaaaagg cagtttcaag ccaatgctat ggtttccatg tggacataca
     3841 gtgcctatgt agcaggcact tagagtaaat ggacttgcct taatttataa aggagggaag
     3901 aggtagaagg gaaccatggg tcctccagct agagggggag tttactaaaa gggagtcctt
     3961 ggaaagggga atggagagaa ggtgcctttg actgtcttct atccattagt tctgccctgg
     4021 agcacactgg ggaagcaggc tgcgggcctt ccaaaagtaa aaaatggtga tatgcaatcg
     4081 aagcttatcc ttagcctatg cacatttgtc tcagctgggc attgtctttt cagagagctt
     4141 gtagcacaag ggctacacat gggcgccaag atggtggtag atacaccttg gtgcactttt
     4201 tgttttactt gtttcttaag actatttcac aagtcctgtg aggcaaaaaa acaaaacaaa
     4261 acaaaacaac caaacaaata caatctaact tttacccaat ctacagcagg aaatcaaagg
     4321 agtgggtgga atgagagaaa atatgcaaag agatcatttt taagtttgat ttcctgtctg
     4381 taattttcaa ggactaatat agcaaatttt tcttctgcca ttatcattta tgtctcccta
     4441 tttaccacac aataatgtaa atgcagagaa tgaggaggca tcttttaaaa gccttaggat
     4501 attctatatg atgacctcaa tattgacttt cagccatact gggaaaactt acttttcatg
     4561 gagtgccacc taacagtgaa tgtattagag tataaaatgt ttgccatgta tacacctgta
     4621 tgtgcacata cacacattac acacacacac agaatgcaca tttcacacac atatacttat
     4681 tattcaagtt gaaactgcac tctaatcaat ctgagtctat tgctgtttca actcttaaaa
     4741 tcaatatctc ctacattagt agatataaac ataattcaaa tatttaaata tttaagagga
     4801 gaaaagtaac tagaaaacca atgaaaagtg aggccatcag aaatagaaaa tgcctggcac
     4861 gaacagtcta tctaaattct caatttcact tcaaattaga gaatccataa tggactagaa
     4921 tataaattac aaacacatac acacatcttc acttaaagtt gttttaagtt ctttgaagtt
     4981 ctgacatgtt tttagccagg gttatttgtt caggttcttc cttgttagga ttccagactg
     5041 gaaagttgga agtctcagga aatgcatgtt tccatgagtt ttttagtttc acagttttac
     5101 agatccaacg acacaatctt ttaatctttg gtcactcaac caaacaggag ttccgtaggc
     5161 agagtgctca ctttgaattg ctaatagaaa ataatgcaca gtgtcctcag gatatgctaa
     5221 acaaggtttt taagagcatt ttattttaca gcactttagt cttttcagct agatttcagt
     5281 gacactatgg tgtaaatgct atatctgcca taacttattg gtggctcctg tgttacatac
     5341 agttttaaat aatgctctaa attgtttgtt ttcccaatga taatgataaa gtgttctgta
     5401 gaatttgtaa aacatgtcaa ttgaatctgt tgaaaattgt gtaattgtta tttcaattgt
     5461 gatactattt tgtaggtaat agttttaaac gtatatttgt atgagtcaaa agtatgtgct
     5521 tgtatgtggt atgtgtgtgt aagtatataa tatcttatca aaaatcaaac ttatcctaaa
     5581 gaaaaagggc acattgtgac cagccttaat ttattaacac ttttttgttg tttttgcaat
     5641 ttggatttaa aattgaaaca gaaattaagt ttttgttaaa aatggtgtct tttaattttg
     5701 tgaggaatgg gctttagaac ctatctgagt tcccacaagc aaactgtcca ccttgtgagg
     5761 taccccattg cttttcgtaa taatcaaaca tcaattcata tattaacttc attttcatac
     5821 agactaattt gttttcatca acaatagaac cagtacacct ttaaagttga ccttcccaac
     5881 atggcaccca tttttcttta atgataaatt ttccatgaaa aattgtttct ccaaaccatt
     5941 actttttaaa attcaatctt cccaagtaag atgaactgcc ttggtgttag gagagctttt
     6001 aaaggcccat ccatactagg tggttccaac atggttctct tctcgagaaa acaagcatgc
     6061 aacccacaca cttttctggt ctgccccacg tgtagaatta gtctagcaat agaaaactca
     6121 tgactgacaa ggatctacac atgtggtcat gcttgaagca aaaattctgt gaccttcttt
     6181 gggcttggat ctgattacag aatattaatt aactttctta tttcctttct ttctccatcc
     6241 ttagttattc cttttcaata tttagagttg ccaggtaaaa tacaggatat ccagtgaaat
     6301 ttaaatttca gataaacagt atttctttag catatttctc atatatttaa tcagacatac
     6361 tttcacttta aaaaaagttt atctgaaatt caaatgtaac tgggtatgtc ctatatattt
     6421 tttcctaaat ctcacaattc tatccacact gcctttctat ctttttcagc tgggctatct
     6481 ataaggggcg agatctacct ccctccatac ccttgtgttc agacacctta tgaatatctg
     6541 cagtcataat gtccttcaag aaagaaaaca ttggtcagct ctaggtcctg caaatgcttt
     6601 ttgaaggacg aactcaaata cagatgggat aatcaagtaa atatcttcat aggatcaatg
     6661 ccaccatgtt caacacttcc ctttgccagc ctgttgtgag gtccaagttt ccccattaat
     6721 cccttatata gcatttccca gtaactggga caaccaaaaa cacaccgaca tattagaaat
     6781 gctcctgaaa agtggcaaca ccgcctaact cagtaccagg acctctttta aattcaattt
     6841 cttttttctt tcagagagat aacaaacgaa ttcattattt cccccattca catcttacca
     6901 caaattattt ttatcaggtt aaaactggtc atctacggaa ttgtagaaag gtgacatagg
     6961 aactgtcttc actgctggaa gaataaaaga gtctgaggta tagacactgc cctggtgaca
     7021 ccttctcaga acattgttgg gggacagggg aggcaggcgc aagtagggga tagaatctga
     7081 ccctgacatg cagctatcac ctggcagaga gactcgtcaa agcaaattat aacgaccagt
     7141 actatttttt tttggaattg aaaacccaag aagccctaaa ataagaacag tgagatcaaa
     7201 ggctggtttc taaaacaatg cagaaaatag aaccatgttg gaattcctaa attctagctt
     7261 tcaaatacta ctgtttccaa cagtgaatcc ttgacagaga ctgaatgcag atggaatttt
     7321 gaaacatttt cagtagctac ctcctctcct gaaattccta taagtggcag aggaaaatcc
     7381 aaatccttta atataacatg tccatctcat gactcctgct tacacacatt tgtgttgatt
     7441 tgcttcattt ctggaggatg ggaatttgca gagctggtga catttccttc attagacacc
     7501 agaaattcac cagagagaga cagatctgtg ccttctcttt ttaggatctg gttattgata
     7561 ctttaataaa tgtggtgtaa agaaaatcca tggctacagt ctgtatagaa aatgtgaatt
     7621 ttttaaataa gattgtgttc ttaatgtaaa aaataaaagt ttatttgtat tcagtgaaat
     7681 gcctaataaa gtcctggtac caatta
//
