LOCUS       NM_001413064            7721 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens phosphatidylinositol specific phospholipase C X domain
            containing 2 (PLCXD2), mRNA.
ACCESSION   NM_001413064
VERSION     NM_001413064.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7721)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 7721)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055748.21.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.17763.1,
                                           SRR1660805.43560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636933.2/ ENSP00000490816.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-733               AC055748.21        62651-63383         c
            734-1194            AC055748.21        29673-30133         c
            1195-1436           AC055748.21        23931-24172         c
            1437-7721           AC055748.21        11052-17336         c
FEATURES             Location/Qualifiers
     source          1..7721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..7721
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /note="phosphatidylinositol specific phospholipase C X
                     domain containing 2"
                     /db_xref="GeneID:257068"
                     /db_xref="HGNC:HGNC:26462"
                     /db_xref="MIM:617015"
     exon            1..733
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..1596
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /note="phospholipase C X-domain containing protein 2"
                     /codon_start=1
                     /product="PI-PLC X domain-containing protein 2"
                     /protein_id="NP_001399993.1"
                     /db_xref="GeneID:257068"
                     /db_xref="HGNC:HGNC:26462"
                     /db_xref="MIM:617015"
                     /translation="MLAVRKARRKLRMGTICSPNPSGTKTSSEVCNADWMASLPPHLH
                     NLPLSNLAIPGSHDSFSYWVDEKSPVGPDQTQAIKRLARISLVKKLMKKWSVTQNLTF
                     REQLEAGIRYFDLRVSSKPGDADQEIYFIHGLFGIKVWDGLMEIDSFLTQHPQEIIFL
                     DFNHFYAMDETHHKCLVLRIQEAFGNKLCPACSVESLTLRTLWEKNCQVLIFYHCPFY
                     KQYPFLWPGKKIPAPWANTTSVRKLILFLETTLSERASRGSFHVSQAILTPRVKTIAR
                     GLVGGLKNTLVHRNLPAILDWVKTQKPGAMGVNIITSDFVDLVDFAATVIKLNDLLQE
                     DTALAKC"
     exon            734..1194
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1436
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..7721
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7584..7589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /note="hexamer: AATAAA"
     polyA_site      7608
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /note="major polyA site"
     regulatory      7687..7692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
                     /note="hexamer: AATAAA"
     polyA_site      7721
                     /gene="PLCXD2"
                     /gene_synonym="PLCXD-2"
ORIGIN      
        1 gctgggagtc ctggtgccgc cggctgcact tctgtgtgtc tttcaggaag ccacagggca
       61 gggggcgtct gtgcagagaa gcgggggagt gagtagcagg caggcccagc ttgtgtacca
      121 gcccagtgac atatatagaa acataaatca ggctagagcc ggcgcgcccg ggcgcgcacc
      181 tgtgtatgga cccgcaggca tgtctgtaca ctgggtgggc acctgtcttg tgagtggctc
      241 cgggtgtggc tgctcctcgg actttcagtt tatgtaagat ttatctctag gggcctacct
      301 tcccccatct ccagagggga acataagaag tttaacggag ctgggactga gcagattaag
      361 ggagtggagc ggaggctggg ccggagagag tggggactgt gagtgctagt gggtaaggat
      421 ccatctgttt gccccgtccc ccagccagaa aggcattttg gaaagactgg cgtggcaagc
      481 gtcgccctga aacgtccaca gagcccaaga agtgatgatc actgagtgag tggcactggg
      541 ctgagactgg ccagtttgtt aacaacaggg atgctagcag ttaggaaggc caggaggaaa
      601 ctcaggatgg ggaccatctg ctcccccaac cccagcggga caaagacatc atcggaggtc
      661 tgcaatgccg actggatggc ctcgctcccc cctcacctcc acaacctccc cctttccaat
      721 ctggcaatcc caggctcaca tgattcattc agctactggg tggatgaaaa gtccccagtg
      781 gggcctgacc aaacccaagc tatcaaacgc ctcgccagga tctccttggt gaagaagcta
      841 atgaagaagt ggtctgtgac tcagaacctg acatttcgag aacagctgga agctgggatc
      901 cgctactttg acctgcgtgt gtcttccaaa ccaggggatg ccgaccagga gatctacttc
      961 atccatgggc tttttggcat caaggtctgg gatgggctga tggaaattga ctcgtttctt
     1021 acacagcacc cccaggagat tatcttcctg gatttcaacc acttctatgc catggatgag
     1081 acccatcaca aatgcctggt tctgcggatc caggaggcct ttggaaacaa gctgtgccca
     1141 gcctgcagtg tggaaagttt gacgctgcga actctgtggg agaagaactg ccaggttctt
     1201 attttctacc actgtccctt ctacaagcag taccccttcc tgtggccagg aaagaagatt
     1261 ccagcgccct gggcaaacac cacaagtgtg cgcaaactaa tcctcttctt ggagaccact
     1321 ctgagtgagc gggcctcacg gggctccttc catgtctccc aagcgatcct cacccccaga
     1381 gtgaagacca ttgcccgggg cttggttggg ggcctcaaga acacgctggt tcataggaat
     1441 cttcctgcca tcctggactg ggtgaaaact cagaagcctg gagccatggg tgtcaacatc
     1501 atcacatctg acttcgtgga cctggtggac tttgctgcga ctgtcatcaa gttgaatgac
     1561 ctcctacagg aggacacagc tctggctaaa tgctgattta atttttaatt taaccttaat
     1621 gttgaatttg ttgatccagg gtagagttct aaaggatgtc ctgttaggat ggcccctggg
     1681 gcagtgatga tgaagtaaga ggaagatggc ttttttttct cccttcctca cagggccatt
     1741 tagataaaat tacagggcta ttaattgcat ttttcccaaa tgagactttt tttaaaactt
     1801 aagtccaagg gaagaaagca cgcttcatgt gaccaaggtc aggacctccc cagtggctta
     1861 tggtggtgaa tggaatttgg aaataggatc tctaggaccc attggggtat tgagtgtccc
     1921 cctaattggc ccagctccct attgtcgtct ggggtgttgt gtttgagccg gtgaaaaagt
     1981 tgaaccagaa acacattcct ggtgaaaaag actggctcat tgcagctgtg gaccaccatc
     2041 tggggtggat ctaacatcaa ccaggggctc tgagggggaa aagagccaag caccaggtct
     2101 ctctaggatt gttggatgtc accacttttc tgagagagta ggactcattt atcactaaga
     2161 tgtttcaaac acaagctgtt ctttcatagc gtatactggt aactggtcac ctcattcttc
     2221 agataaacag tgcatactac ccttagtatc agaaacatgc ttcccagttt taaaacttgg
     2281 attcctttct atttcttttg gccccttctt aaaagtgaaa agaacaatga tgggagatct
     2341 ttttagcgtg gggcccaaca agagatagat atgcatgttt gctgcatgcc agatatcttt
     2401 tatttaattc tacagctttt tccagaatgg ctgccaggta gagcacctgc atcattttgg
     2461 caaagtcctc tttggagtgg ggtcttcaag cctgatcttg gaattgcgtt ttattattgt
     2521 ctgcctagga ctcaggtctg cactgtggga cacaacgcta agtggaaggc cccttatcca
     2581 tggcaccatg gaagcaggcg caggatgcat gggaaactgc aatggcatta aaggaggaag
     2641 ctccaagtgg atttggagcc attctataac tccttgaaaa caagactacc tcggggatat
     2701 ttaggatgac tcgtgtgtca ccaagtgaga aatacctagt gttggaacat ttccagtcct
     2761 tctcttgatg gttctacttt ctgcaggttg ttttgagcct accaatcact actgcatgag
     2821 gactttgaaa ctcgagaggg aatttttttt ttatcgataa gaggtgctta tctataagga
     2881 gccctcttgt gttttgattt atttatttat ttatttattt atttatttat agattaaata
     2941 tctgccgtgc ttcttacatc aagagcactc acacaggagc ttactgaact tttcttaccc
     3001 aggatagatg ctgctatggt ctttctgtcc tgaacaggac cacgcatctc agggctgtga
     3061 gtgattcctg actctgctgt tcatgtcctg gctcccccag tcctcctggg gacagtatac
     3121 atgtgtggat gtggtctaga tctgagaagt cactaccaag ccatgcccat gaacgaagat
     3181 aaaatgggtc gtgaagaact attagttcat aagtagaccc tccagaagag tgttgaaaag
     3241 aaaggctcta gaaagaaaac taggcatgga aatgtgtgca ctttgttgct cctcagcacc
     3301 atctgagaat ccctaaggaa gtggcagctt ctggattctt aagaaggaaa tataaacatg
     3361 gagtcccgaa tggatgtatg catttataaa gattgtcaga ctcttcttcc agcagtttcc
     3421 tgtttctgtc ttttgatgcc catagatgga ttttgcatgt tgcttgcaga gaggggtgtc
     3481 ctaggtgagg tactaaaagc acatccacac ccccaactct tggtcttcca ccctatacgt
     3541 tctgtaaaac aatttaagac ctggctttta gcttgcaccc ttgaggaggt cataatagaa
     3601 atgcctctgg gaaaatctgg ttgaactttc ctttttttgc atttgaaccc ctccccaaag
     3661 ggttttctgg gataatgtca aattctgtag ggccttctct ggataagagt aagtaagtgt
     3721 gttccctcgt tttctaaact ttccttcaat tctgatgcta aatgctaatg acaagctctg
     3781 aaatccctgg tctaccctca gggttttatt tttgttgtca tttcattttg cttttgtttt
     3841 taatttttgg tcaattgcta ggggctagat catttcccca ctttttaccc tttgttactt
     3901 ggcaaagaga taaggaggca agaggagaat tactgttctc tgttttattt gagcctcggc
     3961 tttgtccagg tgtttggtgc tatgaggcca ggtgtgttga caagtatcta cacaggatgc
     4021 cagtaacacc caagggctgc tgactgttcc atgaaatgtt tacatgattt tgtcctttag
     4081 ttcttaaata tatggttgca cttcacttgg gttgtaacat ttaagtgcac ctcagtgttt
     4141 gcatgataaa tgtcatcaag catgacacaa aagcccagaa aactgtacca aggttgcatg
     4201 cacggagtcc tgctctgcgt ggtgcgtgca ggtgctcact cctccatgct gcttggagct
     4261 gccagccttg cttgcaattt gaaagtctgc acaagagttc tgggagatag gaggattatt
     4321 tacaattttc ccttgataaa cacctttgca tcagcagaat ctctgcctca agaaaaagtt
     4381 gcttaacata ttgtaaagga tgtgtgcctt ctgctccttg accgtgagac cagacaggag
     4441 aactcaggca tgtgggacag agggaaaaca gattttaggt tcatgactca ttctgcaact
     4501 gccaacaata aaatagtgac ccaaccacat cacttattct cacaagttct ggagaccttt
     4561 cagatcaaaa caaggctctc atacttgctc agaactaact tcaagatcag ctaagaagct
     4621 acttgattga gccaaagagg actttagttt cacagaattt taggtcatat ttattctgaa
     4681 atacaactga gctattcatg agctccctgg accatttccc acacagccat atttccatgg
     4741 ctttgtggca aaggggacca tcaaaggttt tagttcggtt agagtagtgt ttacaggctt
     4801 gaactttgag ccttttagag agaccaccag gatttcatgg atacagaagg attggagaga
     4861 gaggtcgaga tggacttaat ggaagggaat aagttattga acattaaatt ttaaattagt
     4921 ggcagacctc caagagagtc atgccaaaaa agtttttata tttgctgtat taaactcaat
     4981 ggtaattact tttagtcatt ttccttagca ctgaatctaa accctgaatt accgagagca
     5041 gttaagccac agtcccagga ttttattata aactcaaaga aaagcacaaa atctgagccc
     5101 aggtaatgat ccatcttagg aatcctagtt ctttttacat gatctcatat tcatccaaaa
     5161 aaattgtttc ttctcaataa gacaacgtag tagagtattc tggaattaaa tgcagtttta
     5221 tggcgtggcg ggactttcca tctctcgttt tgagaatctt gccatgagaa agtgcttccc
     5281 aatgagacat tactacctcc cagctaggag gcttagcaca atgctaaagg tggagcaaca
     5341 gaagaaattc agatggaaat gaaactactt cttcctggga agtaaaagag ctacatgaaa
     5401 ccagtccatc ctgcagattt agttcatgcc acagttgaag tttgtgtgat gtttcttagt
     5461 agctaatttc aaatttttac tgttagattc taagaaacag agtgggctaa tgattggagc
     5521 acagccatga gactccgctc cgttagctga gcatgtgatc ctgtgctaaa tctttcttgg
     5581 ttccttcatc tttgaagatg ctgtctgcta ctttagtgct gactgatttg caaatcttgg
     5641 ttgattagct ccccaatcat aaggtcccta atgattagat taaatgcctt atactcaggg
     5701 ggtgtgcaga tatgctattc ttccttctgt ggcttgggtg gaaaagctgc ttgggcttat
     5761 ttcccaacag tgtgatgtag gatggcagaa cttatctagg aatggcacct ttgatgatcc
     5821 atataatgaa atgtgtagag ctcaaagaaa tctgccaaca tgtatgtgga ctcttgagag
     5881 gtgggctttc ccagtacatg ctaaacagac ttgttatgcc aagaggaagt gaatagaaat
     5941 gatagcatca aatatccaaa ctgacaggaa gtttcttttg catagcatag aacatggttg
     6001 tcttctgagt tccactaatg ttccaggata tcttggccct ctgcctctgg ctgctccctg
     6061 gtgtttggca ccatagcgtt gtcacttaca accattgcct tgggacacac agagtgaact
     6121 gtttgagtga taagtaattt aggtagaaac tttaccctta atttcaaatg ataccaaaca
     6181 gctcattact accccaaggg acgctctccg tagcttctgg attccccagt ttccttctag
     6241 aaacaaggac tccaatagca ctataaccct aaacaggccc taacccagaa gaatacacca
     6301 caaaatgcga ttgattttct caaaatatca cagtcttaga cactatacaa ataattcaag
     6361 aaaattcttt ctaccctgca gtggatatag tattctatta tattctccag caaaactttt
     6421 aggacttttc aaactcattt ctaagccaaa tagtttagat aaatatttac ccttatattt
     6481 ggggggaatt caggctcacc atttgccgag gcaagcccat caacagtcta gaggcatatt
     6541 ctgtgtcatt ccttcccgtc tccttcatag aatactactt tttccttttg tctcctggcc
     6601 attctccatc atctgctgat tattgctaac cacaggatgc tggcaaagct tacagtgata
     6661 ggcacgtgtg ttcagtgatg tccaatacac tcttatcaca gtggttattg cttcttactc
     6721 ttttcaaatg cattattcta cccctcaacc tacatccaat cattagaact atactggagc
     6781 ccagaacttg ggaccaatac ttaattcaaa tagcaggggc ttgctcacaa acattaagcc
     6841 caacaagaag cacagcactt tgaaaagtca aataggcctt tggtagctct gtacatttgc
     6901 agttttacat ttgttattag tttatagcac taataacact tcagtcgtga atctacagtc
     6961 tcaatatgat aagtcttaga acatgttcta gaaatagtgg taccttgctg ctattatact
     7021 tagtaactta taccccaata taataataag tattaaatac agattgtgta tgcattcttt
     7081 gtgtgtatat gccaactgta ctacttaacc tcactgatga gcaattagaa aaatacagaa
     7141 attgtcatag tgaaaataag tcttggtcaa ttcagatgat acgtgaacct gataaatgct
     7201 ctaatagata tgctattttg tcctgtattg cttgttttac agtatggtgc atgttgtttg
     7261 ctaagtaaaa tgataataat aataaagtat accaatttta aggttagaat taaaattttg
     7321 cacatatgct tcttgatatt ctgaaatgta ttctgtggct taattatctt attcatacac
     7381 atttcacttg gctttttacc cctaggaaat aattgtccaa gtatatatct cgtcttcttt
     7441 cttgtaactt tgattaaact gcttacttca acttacaaca ttgtaaagcc agaatacctc
     7501 attttaacag tgaaaaaaaa tatgatgacc tgatgtgttc tcttgtattt gatttgaact
     7561 acctaaatag gcttaactgt aataataaat atacaatttt ggcaggcatt ttttcctttg
     7621 tttggatgaa cattttgtta ttggtccact tctaattttg tcttaaagag ttataaactc
     7681 agtgtcaata aaacatcttg ttatataata ttggacaaaa a
//
