LOCUS       NM_001144382            4161 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens phospholipase C like 2 (PLCL2), transcript variant 1,
            mRNA.
ACCESSION   NM_001144382
VERSION     NM_001144382.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4161)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4161)
  AUTHORS   Huang,X., Zhu,Z., Chen,Y., Li,J., Xia,N., Chen,S., Geng,W. and
            Ye,Z.
  TITLE     Two Novel SNPs in the PLCL2 Gene Associated with Large Artery
            Atherosclerotic Stroke Identified by Fine-Mapping
  JOURNAL   J Mol Neurosci 70 (4), 496-503 (2020)
   PUBMED   31970634
  REMARK    GeneRIF: Two Novel SNPs in the PLCL2 Gene Associated with Large
            Artery Atherosclerotic Stroke Identified by Fine-Mapping.
REFERENCE   4  (bases 1 to 4161)
  AUTHORS   Dmitriev,A.A., Beniaminov,A.D., Melnikova,N.V., Pushkova,E.N.,
            Gerashchenko,G.V., Kudryavtseva,A.V. and Kashuba,V.I.
  TITLE     [Functional Hypermethylation of ALDH1L1, PLCL2, and PPP2R3A in
            Colon Cancer]
  JOURNAL   Mol Biol (Mosk) 54 (2), 204-211 (2020)
   PUBMED   32392189
  REMARK    GeneRIF: [Functional Hypermethylation of ALDH1L1, PLCL2, and
            PPP2R3A in Colon Cancer].
REFERENCE   5  (bases 1 to 4161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4161)
  AUTHORS   Raychaudhuri,S., Thomson,B.P., Remmers,E.F., Eyre,S., Hinks,A.,
            Guiducci,C., Catanese,J.J., Xie,G., Stahl,E.A., Chen,R.,
            Alfredsson,L., Amos,C.I., Ardlie,K.G., Barton,A., Bowes,J.,
            Burtt,N.P., Chang,M., Coblyn,J., Costenbader,K.H., Criswell,L.A.,
            Crusius,J.B., Cui,J., De Jager,P.L., Ding,B., Emery,P., Flynn,E.,
            Harrison,P., Hocking,L.J., Huizinga,T.W., Kastner,D.L., Ke,X.,
            Kurreeman,F.A., Lee,A.T., Liu,X., Li,Y., Martin,P., Morgan,A.W.,
            Padyukov,L., Reid,D.M., Seielstad,M., Seldin,M.F., Shadick,N.A.,
            Steer,S., Tak,P.P., Thomson,W., van der Helm-van Mil,A.H., van der
            Horst-Bruinsma,I.E., Weinblatt,M.E., Wilson,A.G., Wolbink,G.J.,
            Wordsworth,P., Altshuler,D., Karlson,E.W., Toes,R.E., de Vries,N.,
            Begovich,A.B., Siminovitch,K.A., Worthington,J., Klareskog,L.,
            Gregersen,P.K., Daly,M.J. and Plenge,R.M.
  CONSRTM   BIRAC Consortium; YEAR Consortium
  TITLE     Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with
            rheumatoid arthritis risk
  JOURNAL   Nat Genet 41 (12), 1313-1318 (2009)
   PUBMED   19898481
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4161)
  AUTHORS   Kanematsu,T., Yasunaga,A., Mizoguchi,Y., Kuratani,A., Kittler,J.T.,
            Jovanovic,J.N., Takenaka,K., Nakayama,K.I., Fukami,K., Takenawa,T.,
            Moss,S.J., Nabekura,J. and Hirata,M.
  TITLE     Modulation of GABA(A) receptor phosphorylation and membrane
            trafficking by phospholipase C-related inactive protein/protein
            phosphatase 1 and 2A signaling complex underlying brain-derived
            neurotrophic factor-dependent regulation of GABAergic inhibition
  JOURNAL   J Biol Chem 281 (31), 22180-22189 (2006)
   PUBMED   16754670
REFERENCE   8  (bases 1 to 4161)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 4161)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 4161)
  AUTHORS   Otsuki,M., Fukami,K., Kohno,T., Yokota,J. and Takenawa,T.
  TITLE     Identification and characterization of a new phospholipase C-like
            protein, PLC-L(2)
  JOURNAL   Biochem Biophys Res Commun 266 (1), 97-103 (1999)
   PUBMED   10581172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AEKP01168581.1, AB029015.1 and N93050.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001144382.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029015.1, SRR1660807.173479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615277.5/ ENSP00000478458.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AEKP01168581.1     103369-103372
            5-4151              AB029015.1         1-4147
            4152-4161           N93050.1           14-23               c
FEATURES             Location/Qualifiers
     source          1..4161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..4161
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /note="phospholipase C like 2"
                     /db_xref="GeneID:23228"
                     /db_xref="HGNC:HGNC:9064"
                     /db_xref="MIM:614276"
     exon            1..412
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3469
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inactive phospholipase C-like protein 2; PLC-L2; PLC-L(2);
                     PLC-epsilon-2; phospholipase C-L2; phospholipase
                     C-epsilon-2"
                     /codon_start=1
                     /product="inactive phospholipase C-like protein 2 isoform
                     1"
                     /protein_id="NP_001137854.1"
                     /db_xref="CCDS:CCDS74911.1"
                     /db_xref="GeneID:23228"
                     /db_xref="HGNC:HGNC:9064"
                     /db_xref="MIM:614276"
                     /translation="MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGH
                     GRARYDSGGVSNGDCSLGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLP
                     RRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYH
                     RYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAF
                     SVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMF
                     SEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEV
                     FHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSK
                     EGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQF
                     RGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAF
                     FASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKIL
                     IKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSI
                     CKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRI
                     DSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF
                     SANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQR
                     TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGY
                     RHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIK
                     TVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDN
                     TPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQK
                     AAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQI
                     HFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE"
     exon            413..2899
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3103
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3179
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3289
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..4161
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3649..3654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /note="hexamer: AATAAA"
     polyA_site      3669
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /note="major polyA site"
     regulatory      4131..4136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /note="hexamer: ATTAAA"
     polyA_site      4161
                     /gene="PLCL2"
                     /gene_synonym="PLCE2"
                     /note="major polyA site"
ORIGIN      
        1 ggggccgcgc gcggcggccc gaggcggcgg cggggacgcg gggacgcgag gacgcggctt
       61 tgtgcaggcg ggtcgcgggg cgcccatggc ggagtgcggc cgggggggcg ccgccggcgg
      121 ggccctgccc acctccccgg gcccggccct cggcgccaag ggcgccctga aagccggagt
      181 gggggaaggc ggtggcgggg gaggtcgcct cggccacggg cgggcgcgct atgacagcgg
      241 cggggtttcc aacggagact gcagcctcgg cgtgtccggg gacgaagccc gggctagccc
      301 taccagggga ccccgcggcg ttgcgctcgc cccgaccccc agcgcggtcg tctgtaccct
      361 cccccgggag agcaagccgg gcggcctgcc ccgccggagc agcatcatca aggatggtac
      421 aaaacagaag agggaacgga aaaagacagt ctcattcagc agcatgccaa cagagaagaa
      481 gatcagcagt gcaagtgatt gtattaattc aatggttgag ggttcagaac tcaaaaaggt
      541 tcgctccaac tctagaattt atcataggta ctttttactg gatgctgaca tgcagagcct
      601 aaggtgggag ccatctaaga aggattctga gaaagccaag attgacatta aatccatcaa
      661 ggaagtgaga acaggaaaaa acacagacat attccgcagc aatggcattt ctgaccagat
      721 atctgaagat tgtgcgtttt ccgtcatata tggagagaat tatgagtcac tggatttggt
      781 tgccaactcc gcagatgttg caaacatctg ggttacagga ctgcggtacc taatttctta
      841 tggaaaacat acacttgata tgttagaaag tagccaagat aacatgagga cttcttgggt
      901 ttcacaaatg tttagtgaaa ttgatgtaga taaccttgga catataactc tgtgtaatgc
      961 tgtgcaatgt atcagaaacc tcaatcctgg tttaaaaacg agcaaaattg agcttaagtt
     1021 caaagaattg cataaatcaa aggacaaagc tggtaccgag gtcacaaagg aagaatttat
     1081 tgaggttttt catgagcttt gtactagacc tgaaatttat ttccttttag ttcagttttc
     1141 aagcaataaa gaattccttg ataccaagga ccttatgatg tttcttgagg cagaacaggg
     1201 tgtggcacat ataaatgagg aaataagcct tgaaattatt cacaaatatg aaccatccaa
     1261 agagggtcag gaaaagggct ggctctccat agacgggttc actaattacc ttatgtcacc
     1321 tgactgttat atattcgatc cagaacataa gaaggtctgt caggatatga agcaacctct
     1381 gtctcattac tttataaact catctcataa tacatactta atagaggatc agttccgagg
     1441 tccctccgac atcacaggat atattcgagc tcttaaaatg ggttgccgga gtgttgaatt
     1501 agatgtatgg gatgggccgg acaatgaacc tgtaatttac acaggccaca ccatgacctc
     1561 tcagatagtt ttccgcagtg tcattgatat tattaacaag tatgcattct ttgcttcaga
     1621 gtatcctctt atcttgtgtt tagaaaacca ctgttccatt aaacaacaga aggtaatggt
     1681 tcagcacatg aagaaacttt taggagacaa gctctataca acatcaccca atgttgagga
     1741 atcttatcta ccatccccag atgtcctgaa agggaaaata ctaattaaag caaagaagct
     1801 gtcctcaaat tgctctgggg tagaaggaga tgttactgac gaagatgaag gagcagaaat
     1861 gtctcagagg atgggaaaag agaacatgga gcaacccaat aatgtgcctg tgaagcgatt
     1921 tcagctttgt aaagaactgt ctgaactggt cagcatctgc aaatcagttc agttcaaaga
     1981 atttcaggtg tcgtttcagg ttcagaagta ctgggaagtc tgttccttta atgaagtgct
     2041 tgccagcaag tacgccaatg aaaatccagg ggactttgta aattacaaca aacgttttct
     2101 tgctagggtt tttcccagtc caatgagaat tgattccagt aacatgaatc ctcaagattt
     2161 ttggaaatgt ggttgccaaa ttgtagccat gaactttcag acaccaggac tgatgatgga
     2221 cctgaatatt ggctggttta ggcagaacgg aaactgtggc tatgtcctcc ggccagccat
     2281 catgagggag gaggtctcct tcttcagcgc caatacaaaa gactctgtcc caggggtctc
     2341 acctcaactt cttcacatta aaatcatcag tgggcagaac tttcccaagc ccaaaggatc
     2401 aggtgccaaa ggtgatgtgg tagatcctta tgtctatgtt gaaatccatg gaatccctgc
     2461 tgattgtgca gaacaaagga caaaaacagt gcaccagaat ggagacgctc ccatttttga
     2521 tgaaagcttt gaatttcaaa tcaacctgcc tgaactggcc atggtgcgct ttgtagtgct
     2581 ggatgatgac tacattgggg atgaattcat cggccagtac acaattccct ttgaatgttt
     2641 acagacgggc taccgccatg tccccctgca gtccttaact ggagaggtcc ttgcacatgc
     2701 ttctttattt gtccacgtgg ctattactaa ccgaagagga ggaggaaagc ctcataaaag
     2761 gggcctttct gtgagaaaag ggaagaaatc cagggaatat gcatctttga gaacactgtg
     2821 gattaaaacc gtggatgagg tattcaagaa tgcccagccc cctatacggg atgccacaga
     2881 tctgagagaa aacatgcaga atgcggtggt gtcattcaag gagctgtgtg gcctctcctc
     2941 tgtggccaat ctcatgcagt gcatgttggc ggtgtctccc cgctttctgg ggcccgataa
     3001 cacaccccta gtggtcctaa atctcagcga gcagtacccc acaatggagc tgcagggaat
     3061 tgtgccggag gttctgaaga agatcgtaac aacttatgac atgatgattc agtccctcaa
     3121 ggcgttgatt gaaaatgcag atgctgtata tgaaaagatc gtacattgtc agaaggcagc
     3181 catggaattc catgaacact tgcacagcat aggcaccaag gaaggtttga aggaaagaaa
     3241 actacaaaaa gcagtggaga gctttacctg gaatattacc atcttaaagg gacaagcaga
     3301 tcttttgaaa tatgctaaga atgagacatt ggagaacctg aaacaaatcc attttgctgc
     3361 tgtttcatgt ggactgaata aaccaggcac cgaaaatgct gatgtccaga agccacgccg
     3421 gagcttggaa gtcatacccg aaaaagcaaa cgatgaaact ggagaatgag gaaacttaca
     3481 ataaaccatt atggagttta taactctagg accaattgta gtcagatggg acatttgctt
     3541 tgcactcact aatgagaata atattcggga ttttaaagca caactggaat agctaattac
     3601 agtctattaa aactgtgaat gtatgtagca atcctgcgtg tgaaggcaaa taaactcttt
     3661 aacaggcaat tatattgctg gccaaaatat gctatatttg tatacaaaga cattctaact
     3721 cagttccagt atgaagaaag attattcact ctagctccac tgagaaacat tttcctaagt
     3781 gaaaacaatt tcttaagatg gaaatggatt ggattgtcaa attattattt attggagaaa
     3841 aaaacctgat ctacacattt ttacttatat ggggttgcca gagtctctgg gttctagatg
     3901 attttggtgg catgcttgct gagccataat tactaaagag aatgtaagtg gacgggttcc
     3961 ctgaatcccc ggggtccttg gagagccatc gaggagaatg tgcaattgga ctgaagctcc
     4021 ctggctgaag atacatgccg agtcagcaca tgggtagaga tgatgtaaaa gcagccaatc
     4081 tggaaacaat acattgtaaa tagtttttca ttgtatgaag tagtgttcac attaaaaaga
     4141 tgttttatga tatttctcca a
//
