LOCUS       NM_006226               6696 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens phospholipase C like 1 (inactive) (PLCL1), mRNA.
ACCESSION   NM_006226 NM_001114661
VERSION     NM_006226.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6696)
  AUTHORS   Hu,Y., Ye,S., Kong,J., Zhou,Q., Wang,Z., Zhang,Y., Yan,H., Wang,Y.,
            Li,T., Xie,Y., Chen,B., Zhao,Y., Zhang,T., Zheng,X., Niu,J., Hu,B.,
            Wang,S., Chen,Z. and Zheng,C.
  TITLE     DOT1L protects against podocyte injury in diabetic kidney disease
            through phospholipase C-like 1
  JOURNAL   Cell Commun Signal 22 (1), 519 (2024)
   PUBMED   39456056
  REMARK    GeneRIF: DOT1L protects against podocyte injury in diabetic kidney
            disease through phospholipase C-like 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6696)
  AUTHORS   Pan,Z., Huang,J., Song,H., Xiao,Y., Liu,T., Zeng,Y., Zhu,H. and
            Yang,K.
  TITLE     PLCL1 suppresses tumour progression by regulating
            AMPK/mTOR-mediated autophagy in renal cell carcinoma
  JOURNAL   Aging (Albany NY) 15 (19), 10407-10427 (2023)
   PUBMED   37801481
  REMARK    GeneRIF: PLCL1 suppresses tumour progression by regulating
            AMPK/mTOR-mediated autophagy in renal cell carcinoma.
REFERENCE   3  (bases 1 to 6696)
  AUTHORS   Luo,S., Li,X.F., Yang,Y.L., Song,B., Wu,S., Niu,X.N., Wu,Y.Y.,
            Shi,W., Huang,C. and Li,J.
  TITLE     PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3
            inflammasomes in rheumatoid arthritis
  JOURNAL   Adv Rheumatol 62 (1), 25 (2022)
   PUBMED   35820936
  REMARK    GeneRIF: PLCL1 regulates fibroblast-like synoviocytes inflammation
            via NLRP3 inflammasomes in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6696)
  AUTHORS   Tan,L.J., Li,X.H., Li,G.G., Hu,Y., Chen,X.D. and Deng,H.W.
  TITLE     Identification of novel pleiotropic gene for bone mineral density
            and lean mass using the cFDR method
  JOURNAL   Ann Hum Genet 85 (6), 201-212 (2021)
   PUBMED   34115876
  REMARK    GeneRIF: Identification of novel pleiotropic gene for bone mineral
            density and lean mass using the cFDR method.
REFERENCE   5  (bases 1 to 6696)
  AUTHORS   Oue,K., Zhang,J., Harada-Hada,K., Asano,S., Yamawaki,Y.,
            Hayashiuchi,M., Furusho,H., Takata,T., Irifune,M., Hirata,M. and
            Kanematsu,T.
  TITLE     Phospholipase C-related Catalytically Inactive Protein Is a New
            Modulator of Thermogenesis Promoted by beta-Adrenergic Receptors in
            Brown Adipocytes
  JOURNAL   J Biol Chem 291 (8), 4185-4196 (2016)
   PUBMED   26706316
REFERENCE   6  (bases 1 to 6696)
  AUTHORS   Liu,Y.Z., Wilson,S.G., Wang,L., Liu,X.G., Guo,Y.F., Li,J., Yan,H.,
            Deloukas,P., Soranzo,N., Chinappen-Horsley,U., Cervino,A.,
            Williams,F.M., Xiong,D.H., Zhang,Y.P., Jin,T.B., Levy,S.,
            Papasian,C.J., Drees,B.M., Hamilton,J.J., Recker,R.R., Spector,T.D.
            and Deng,H.W.
  TITLE     Identification of PLCL1 gene for hip bone size variation in females
            in a genome-wide association study
  JOURNAL   PLoS One 3 (9), e3160 (2008)
   PUBMED   18776929
  REMARK    GeneRIF: PLCL1 is a novel gene associated with variation in hip
            bone size, which has a role in the pathogenesis of hip fractures
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
            Erratum:[PLoS ONE. 2009;4(2). doi:
            10.1371/annotation/951f0d10-0b78-4d6b-94c9-8ae6cc4178dd.
            Chinnapen-Horsley, Usha [corrected to Chinappen-Horsley, Usha];
            Cervino, Alesandra [corrected to Cervino, Alessandra]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6696)
  AUTHORS   Murakami,A., Matsuda,M., Nakasima,A. and Hirata,M.
  TITLE     Characterization of the human PRIP-1 gene structure and
            transcriptional regulation
  JOURNAL   Gene 382, 129-139 (2006)
   PUBMED   16952428
  REMARK    GeneRIF: PRIP-1 plays an important role in type A receptor
            signaling for gamma-aminobutyric acid in the brain
REFERENCE   8  (bases 1 to 6696)
  AUTHORS   Qi,C., Chang,J., Zhu,Y., Yeldandi,A.V., Rao,S.M. and Zhu,Y.J.
  TITLE     Identification of protein arginine methyltransferase 2 as a
            coactivator for estrogen receptor alpha
  JOURNAL   J Biol Chem 277 (32), 28624-28630 (2002)
   PUBMED   12039952
REFERENCE   9  (bases 1 to 6696)
  AUTHORS   Otsuka,T., Kohno,T., Mori,M., Noguchi,M., Hirohashi,S. and
            Yokota,J.
  TITLE     Deletion mapping of chromosome 2 in human lung carcinoma
  JOURNAL   Genes Chromosomes Cancer 16 (2), 113-119 (1996)
   PUBMED   8818658
REFERENCE   10 (bases 1 to 6696)
  AUTHORS   Kohno,T., Otsuka,T., Takano,H., Yamamoto,T., Hamaguchi,M.,
            Terada,M. and Yokota,J.
  TITLE     Identification of a novel phospholipase C family gene at chromosome
            2q33 that is homozygously deleted in human small cell lung
            carcinoma
  JOURNAL   Hum Mol Genet 4 (4), 667-674 (1995)
   PUBMED   7633416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011997.8, DA414853.1, DA193701.1, BC111985.1, BP340710.1,
            AC020719.5 and T87219.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006226.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.92891.1,
                                           SRR1660803.201773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428675.6/ ENSP00000402861.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC011997.8         81207-81315
            110-555             DA414853.1         1-446
            556-765             DA193701.1         340-549
            766-2505            BC111985.1         1-1740
            2506-2698           BP340710.1         379-571
            2699-3821           BC111985.1         1934-3056
            3822-6408           AC020719.5         93736-96322         c
            6409-6696           T87219.1           24-311              c
FEATURES             Location/Qualifiers
     source          1..6696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..6696
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /note="phospholipase C like 1 (inactive)"
                     /db_xref="GeneID:5334"
                     /db_xref="HGNC:HGNC:9063"
                     /db_xref="MIM:600597"
     exon            1..747
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..3795
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /note="phospholipase C, epsilon; PLC-L1; phospholipase
                     C-deleted in lung carcinoma; phospholipase C-related but
                     catalytically inactive protein; phospholipase C-like 1;
                     protein phosphatase 1, regulatory subunit 127"
                     /codon_start=1
                     /product="inactive phospholipase C-like protein 1"
                     /protein_id="NP_006217.3"
                     /db_xref="CCDS:CCDS2326.2"
                     /db_xref="GeneID:5334"
                     /db_xref="HGNC:HGNC:9063"
                     /db_xref="MIM:600597"
                     /translation="MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRD
                     RRSGVALPGAAGTPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSE
                     KKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDI
                     SAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL
                     RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLK
                     EAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDAND
                     LMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPE
                     QKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGS
                     DNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMK
                     KVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSR
                     RMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIA
                     NEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHT
                     GWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGAC
                     AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVV
                     LDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKA
                     QKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKEL
                     CGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYD
                     LMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWN
                     ITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSLEAIEEKES
                     SEENGKL"
     exon            748..3222
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3426
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3502
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3612
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..6696
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5219..5224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /note="hexamer: AGTAAA"
     polyA_site      5239
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /note="major polyA site"
     regulatory      6674..6679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
                     /note="hexamer: AATAAA"
     polyA_site      6696
                     /gene="PLCL1"
                     /gene_synonym="PLCE; PLCL; PLDL1; PPP1R127; PRIP"
ORIGIN      
        1 agagctgagt ggaggccgcc gccgccgccg cacttcctgg gaccgctgcg ccgcagtccg
       61 cgggcaggtg gcgggtgcgc ccggccgcag tcgcccggct ctggccccta tcgggccgcc
      121 ggcgtccggg ctccagaggc cgcctggctg ggcgcccggt gccttttgtc tggcgcaggg
      181 ccggcgtttg catcacattt cggatacctc cctctctttt tcgcctctcc ttctgcctcc
      241 cgctcacatc gcctccccac tcccgccacc gtcccccgcc ggactgctag cctcctagac
      301 cgaagcccga ggacgtctct gcccgagcga tgtcccctct ccagaaagtt gccgccgccg
      361 ccgccgccgc cgccactgcc gccgctgggc ggtgaaacaa agtctggcgg ggccgcctcc
      421 cggtgcagga gcgcaccggt gcctagcggc tggactccgc tgccgggcgt cccgctttcc
      481 cccggggagc cctaaacgct ccaggccatg gccgagggcg cggccggcag ggaggatccg
      541 gcgccgcccg acgcggcggg gggcgaagac gacccccgag tgggcccgga tgccgccggg
      601 gactgcgtga cggcggcctc tgggggccgg atgagggacc gtcgcagcgg ggtcgcactg
      661 ccaggcgccg cggggacccc agcggacagc gaggcgggcc tcctggaggc agcacgggcg
      721 accccccggc gcagcagcat catcaaggat ccttcaaacc aaaaatgtgg tggaagaaag
      781 aaaaccgtgt ctttcagcag catgccatcg gaaaagaaaa ttagcagtgc aaatgactgc
      841 atcagcttca tgcaagctgg ctgtgagttg aagaaagtcc ggccaaattc tcgcatttac
      901 aaccgttttt tcactctgga cacagacctt caagctcttc gctgggaacc ttcaaagaaa
      961 gacctcgaga aagccaagct tgatatttct gccataaaag agatcagact ggggaaaaac
     1021 acggaaacat ttagaaacaa tggccttgct gaccagatct gtgaggactg tgccttttcc
     1081 atactccacg gggaaaacta tgagtctctg gacctagttg ccaattcagc agatgtggca
     1141 aacatctggg tgtctgggtt acggtacctg gtttctcgaa gtaagcagcc tcttgatttt
     1201 atggagggca accagaacac accacggttc atgtggttga aaacagtgtt tgaagcagca
     1261 gatgttgatg ggaatgggat tatgttggaa gacacctctg tagagttaat aaaacaactc
     1321 aaccctactc tgaaggaagc caagatcagg ttaaagttta aagaaatcca gaagagcaag
     1381 gaaaaactaa ccacccgcgt gaccgaagag gaattttgtg aagctttttg tgaactttgc
     1441 accaggccag aagtgtattt cttacttgta cagatatcta aaaacaaaga atatttggat
     1501 gccaatgatc tcatgctctt tttagaagct gagcaaggag tcacccatat caccgaggat
     1561 atatgcttag acatcataag gagatacgaa ctttctgaag agggacgtca aaaagggttt
     1621 cttgcaattg atggctttac ccagtattta ttgtcatcag aatgtgacat ttttgatcct
     1681 gagcaaaaga aggttgccca agatatgacc cagccattat ctcactacta tatcaatgcc
     1741 tctcataaca cctatctaat agaagaccag ttcagggggc cagctgacat caatgggtac
     1801 attagagctt tgaaaatggg ctgtcgaagc gttgaactcg atgtaagtga tggttcagat
     1861 aatgaaccaa tcctttgtaa tcgaaataac atgacaaccc atgtttcctt tcgaagtgtc
     1921 atagaggtaa taaataaatt tgcctttgtt gcttctgaat acccactcat tctttgcttg
     1981 ggaaatcact gctccttgcc gcagcagaag gtaatggctc aacagatgaa aaaggtcttt
     2041 ggcaataaac tctatactga agcacctttg ccctcagaat cctacctccc atcaccagaa
     2101 aaattaaaaa gaatgatcat tgtgaaagga aagaagttgc cttctgatcc agatgtgtta
     2161 gaaggagaag taacagatga agatgaagaa gctgaaatgt ctcgaaggat gtcggtagat
     2221 tacaatggtg agcagaagca aatccgactc tgtagggagc tctctgattt ggtgtctatt
     2281 tgtaaatctg ttcaatacag ggattttgaa ctatctatga aaagccaaaa ctattgggaa
     2341 atgtgttcat ttagtgaaac agaggccagc cgcattgcaa atgagtaccc agaggatttt
     2401 gttaattata ataagaagtt cttatcaaga atctatccaa gtgccatgag gatcgattcc
     2461 agtaacttga atccacagga cttttggaat tgtggctgtc agattgtagc aatgaatttt
     2521 cagactccgg gtccaatgat ggaccttcac acgggctggt ttcttcaaaa cgggggatgt
     2581 ggttatgttc taaggccgtc tataatgcga gatgaagttt cttacttcag cgcaaataca
     2641 aagggcattc tacctggggt gtctcctcta gctcttcata tcaagatcat cagtggtcag
     2701 aatttcccaa agcccaaggg agcttgtgcc aaaggggatg tcatagatcc ctatgtttgt
     2761 atagagatac acggaattcc agcggattgt tcggaacaaa gaactaaaac tgtacagcaa
     2821 aacagtgata atcctatttt tgatgaaact tttgagttcc aagtaaacct acctgagctg
     2881 gccatgatcc gttttgttgt tctggatgat gactacattg gggatgagtt tatagggcaa
     2941 tatacgatac catttgaatg tttgcagcct ggatatcggc atgttcccct gcgttctttt
     3001 gtgggtgaca tcatggagca cgtaaccctt tttgtccaca tagcaataac taatcgaagt
     3061 ggaggaggaa aggcacagaa gcgcagtctt tcagtgagaa tggggaagaa agttcgggaa
     3121 tataccatgc tcaggaatat cggtcttaaa accattgatg acatctttaa aatagcggtt
     3181 catccattac gagaagccat agatatgaga gaaaatatgc agaatgcaat cgtgtctatt
     3241 aaggaactat gtggactccc tccaattgcc agtctgaagc agtgcctgtt aactctgtca
     3301 tctcggctca tcaccagtga caatactcct tcagtctcac ttgtgatgaa agacagcttt
     3361 ccttacctgg agcctctggg tgcaattcca gatgtgcaga aaaagatgct gactgcttat
     3421 gatctgatga ttcaagagag ccggtttctc atagaaatgg cggacacagt ccaggaaaag
     3481 attgtacagt gtcagaaagc agggatggag ttccatgaag aacttcataa tttgggggca
     3541 aaagaaggct tgaagggaag aaaactcaac aaagcaactg agagctttgc ttggaacatt
     3601 acagtattga agggccaagg agatctgttg aagaatgcca agaatgaagc tatagaaaac
     3661 atgaagcaga tccagctggc atgcctgtcc tgtggactga gtaaagcccc cagcagcagt
     3721 gctgaggcca agagcaagcg cagcctggaa gccatagagg agaaggaaag tagtgaggag
     3781 aatgggaagc tgtgactctg ggcattatcg acacgttcac ccatcttatc aaggactctg
     3841 gtttctcatt cttgttttct ttctttaaat gttttataag ttcacaaaat ggtgccctat
     3901 atggggtatt ggacatagat attttcacaa tgtcagtatt tcagtgtagt taatttatct
     3961 aaattaaagc ctttagtatc agtgttttaa attctgagac atgtgtcaac acccctgtgt
     4021 ggatgcctgt ggaagagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtggca gagagagaga
     4081 aagagagaga gagagagaaa ttctgttaaa atctattctg tgttgcatta ttcatttagt
     4141 gagttattcc ttgatcattt tgggacaatt gttttaatct gaaattctaa agagcactta
     4201 ctgtaacctg ttgctgtgtt taatttgact tctctgcctt tgacatttaa tttagtgatc
     4261 ttagcatagc ttattattga aggaagccaa atttatcaaa gcatagatgt tttggtagat
     4321 taaatataga ttagaaaaat tcctaagaat cagagtagaa ataaaagtga atgaaagatt
     4381 aaacagatga tgagaatttc taaaaagatt agcaaggtca tttcttcagt cagaaaactt
     4441 taaaaaatat ttattaaata aaatcaattt ttaggaagtt ttctgtagtc atttactaaa
     4501 catatgattt cactagaaaa gctgatcata agtgaattta tacctacctg tgtggtactc
     4561 tgaaacacac tgaaagctct gttgcaatta ggattttgat gtgacaataa tattgttgta
     4621 taatttcgag atttgtagga aggtctcatt cttccaagct gagagtctag cactcatttt
     4681 ctataacaga tatggcagct tagaggtgtt ggctttgttt ggatgtaatt tagggtacta
     4741 aatttaaatt taaagatatt gttcaaacaa tatcatatca tcacattgag ctgatataaa
     4801 ttctgtgggt ccgataatat ctttgtgata atttaagagc taaccagtta ccacacatct
     4861 atgatataac cctaacacac acagaaaagc atacatgcaa aaagaaatga ctaattaggg
     4921 tacatttata attgcatcta ggtaattttt accctaatgt cttcataaag tacttgagtg
     4981 taatgtttgt tacctccaac agaactaaat gttctatggt tatgaaagaa tatatttatt
     5041 taaagcattg cttttatttt gaaaagcttc ttaattaatt tgattaacaa atatgctaat
     5101 ttggggaaac ctagagaaga taattgttga aattttgcaa atataaacat ctcctatagc
     5161 ttctgtgtta tttctgactt cttaacacta ttatgtttat gttgcacatt actgaaagag
     5221 taaagatatg aaaaaaacac ttattgtttt cttttattgt gaattgaaaa agcaaagcta
     5281 atgaaaatgg gttactacat caaaaatatc ttaaagagtt tgctatttcc atggaccaga
     5341 tatgatgaaa ttattccctg ggtttaaaac tgggcactcg aggaggaggt acctgaagtc
     5401 atttgaaggc aagtttccaa tgatgctaca atggcctgaa aaaatttctt taccctctgt
     5461 tatatttaac ttgctggtag gaggaatagt ggaatgcagg tgttaagccc tttgtggtga
     5521 aaaagaggtt ctatagacag aaacaaaacc caccttacat cagctgattg gttgatttta
     5581 ctagtgtacc tcttcatcta cttgaattct atttggtaaa tccatgtctt tactggatat
     5641 acagttaggt gggaagagga gataaaggat gacaaactct caaacaatat ttatacattt
     5701 atttactcca gggtcaaatc caatccttgg aagtagcttc tctagtttat tttatttgtc
     5761 ccagagctct actcacactt aggacccacc caaaaattct caaaaacgta atatggattc
     5821 tgcctcatct gatgctattt ctggcagtgg gttgtcagcc atactctgct tcattccact
     5881 gggtgtcctt gctagatggg gagtgagatg tggagcaggg aggagctttg gattctggga
     5941 gtggaggtgg caagggaaaa gtctcctagt ctcctgtgat gttcctgcct ccagatagaa
     6001 tagcaaaaac aaacaatttt tttttgtgta ttatgcctcc atgacattgt tacattctat
     6061 gaggagcatc tgtctccttt ctagacttga actgtggtag aaaaagcccc cttctctctt
     6121 ctatctactt agatttggtg atgctaggaa tgtagtgttt tagatattaa ttctattttt
     6181 atttattcat ttttacatca ccaataggat ctgaggtgga gatggcgggt attatcactg
     6241 gcattttaca ggtgagaaag cccaaagcca ctgaggtaat taatggaata attgattttg
     6301 aacttgggtc tgtctgattt catgtgcaag attatatact tagtgatttt gattttaagt
     6361 ttattcttaa cattttaaac cagactatta actcttacct ttataaccac agatacaaag
     6421 aactgtatca tttattttct gaatataaaa tattaatggt caatataaaa atacaaaaat
     6481 agagaactat atacaacaga aaagcaaaat tacccactaa taacattttg atttatatcc
     6541 ctttagacac tgtttagagt ttatacatat atgtaaatat gcttgtattt taacaaaatt
     6601 gagatattat ataaactgtt tgtagcaggg tgtttaaaat tttaacaata tgttatggat
     6661 atctttctgt gtcaataaat gtgtatttac attaga
//
