LOCUS       NM_014638               4870 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipase C eta 2 (PLCH2), transcript variant 1,
            mRNA.
ACCESSION   NM_014638 XM_371214
VERSION     NM_014638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4870)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   2  (bases 1 to 4870)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 4870)
  AUTHORS   Hu,Z., Xia,Y., Guo,X., Dai,J., Li,H., Hu,H., Jiang,Y., Lu,F.,
            Wu,Y., Yang,X., Li,H., Yao,B., Lu,C., Xiong,C., Li,Z., Gui,Y.,
            Liu,J., Zhou,Z., Shen,H., Wang,X. and Sha,J.
  TITLE     A genome-wide association study in Chinese men identifies three
            risk loci for non-obstructive azoospermia
  JOURNAL   Nat Genet 44 (2), 183-186 (2011)
   PUBMED   22197933
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4870)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   5  (bases 1 to 4870)
  AUTHORS   Lo Vasco,V.R.
  TITLE     Role of phosphoinositide-specific phospholipase C eta2 in isolated
            and syndromic mental retardation
  JOURNAL   Eur Neurol 65 (5), 264-269 (2011)
   PUBMED   21474938
  REMARK    GeneRIF: PLCH2 might be a putative candidate gene for the
            neurodevelopmental delay observed in patients bearing 1p36.3
            deletions.
            Review article
REFERENCE   6  (bases 1 to 4870)
  AUTHORS   Balamurugan,K., Pomeroy,R., Duncan,G. and Tracey,M.
  TITLE     Investigating SNPs flanking the D1S80 locus in a Tamil population
            from India
  JOURNAL   Hum Biol 82 (2), 221-226 (2010)
   PUBMED   20649401
  REMARK    GeneRIF: The researchers investigated the D1S80 minisatellite and
            associated single nucelotide polymorphisms in a Tamil population in
            India.
REFERENCE   7  (bases 1 to 4870)
  AUTHORS   Zhou,Y., Sondek,J. and Harden,T.K.
  TITLE     Activation of human phospholipase C-eta2 by Gbetagamma
  JOURNAL   Biochemistry 47 (15), 4410-4417 (2008)
   PUBMED   18361507
  REMARK    GeneRIF: Purified Gbeta 1gamma 2 stimulated the activity of
            purified PLC-eta2 in a concentration-dependent manner similar to
            that observed with purified PLC-beta2.
REFERENCE   8  (bases 1 to 4870)
  AUTHORS   Zhou,Y., Wing,M.R., Sondek,J. and Harden,T.K.
  TITLE     Molecular cloning and characterization of PLC-eta2
  JOURNAL   Biochem J 391 (Pt 3), 667-676 (2005)
   PUBMED   16107206
  REMARK    GeneRIF: The molecular cloning and sequencing of phospholipase C
            eta2 are reported.
REFERENCE   9  (bases 1 to 4870)
  AUTHORS   Nakahara,M., Shimozawa,M., Nakamura,Y., Irino,Y., Morita,M.,
            Kudo,Y. and Fukami,K.
  TITLE     A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme
  JOURNAL   J Biol Chem 280 (32), 29128-29134 (2005)
   PUBMED   15899900
  REMARK    GeneRIF: PLC(eta)2 is a neuron-specific isozyme that may be
            important for the formation and/or maintenance of the neuronal
            network in the postnatal brain
REFERENCE   10 (bases 1 to 4870)
  AUTHORS   Stewart,A.J., Mukherjee,J., Roberts,S.J., Lester,D. and
            Farquharson,C.
  TITLE     Identification of a novel class of mammalian
            phosphoinositol-specific phospholipase C enzymes
  JOURNAL   Int J Mol Med 15 (1), 117-121 (2005)
   PUBMED   15583837
  REMARK    GeneRIF: molecular cloning of PLC-eta1 and PLC-eta2
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139246.21, DQ176850.1, BC043358.1 and BX117873.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014638.3.
            
            Summary: PLCH2 is a member of the PLC-eta family of the
            phosphoinositide-specific phospholipase C (PLC) superfamily of
            enzymes that cleave PtdIns(4,5) P2 to generate second messengers
            inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005
            [PubMed 16107206]).[supplied by OMIM, Jun 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ176850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378486.8/ ENSP00000367747.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL139246.21        29479-29504
            27-2828             DQ176850.1         1-2802
            2829-2829           BC043358.1         1997-1997
            2830-4863           DQ176850.1         2804-4837
            4864-4868           BX117873.1         470-474
            4869-4870           AL139246.21        58721-58722
FEATURES             Location/Qualifiers
     source          1..4870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..4870
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /note="phospholipase C eta 2"
                     /db_xref="GeneID:9651"
                     /db_xref="HGNC:HGNC:29037"
                     /db_xref="MIM:612836"
     exon            1..424
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..4551
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /EC_number="3.1.4.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phospholipase C-like 4; phospholipase C-eta2;
                     phospholipase C-like protein 4; phosphoinositide
                     phospholipase C-eta-2; phosphoinositide phospholipase
                     C-like 4; 1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-2"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-2 isoform 1"
                     /protein_id="NP_055453.2"
                     /db_xref="CCDS:CCDS59959.1"
                     /db_xref="GeneID:9651"
                     /db_xref="HGNC:HGNC:29037"
                     /db_xref="MIM:612836"
                     /translation="MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVER
                     CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEG
                     RQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDE
                     DSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD
                     TDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGV
                     TLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSH
                     YFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTS
                     KILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSS
                     EDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDAST
                     NRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDA
                     GASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSR
                     ALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIY
                     PSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMC
                     QGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPV
                     DCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFS
                     SMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGR
                     PPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAP
                     EAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGR
                     PPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHL
                     PVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSS
                     SSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNP
                     NLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTA
                     DDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS
                     LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGT
                     PEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL"
     exon            425..571
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            572..815
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            816..945
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1116
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1210
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1414
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1535
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1707
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1815
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1959
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2052
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2135
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2233
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2416
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2524
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2649
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2734
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2881
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2961
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3259
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..4870
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4844..4849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /note="hexamer: ATTAAA"
     polyA_site      4870
                     /gene="PLCH2"
                     /gene_synonym="PLC-eta2; PLC-L4; PLCeta2; PLCL4"
                     /note="major polyA site"
ORIGIN      
        1 gtcctttgct cccccagcct tgggaggcgg ctgcgtcagg gattccttgg tggccctgga
       61 gggtggatag gctggcctgg gggccatcag gacagcaggt gacggtcagg ccaatgccag
      121 ccgggcctgg gcacagccct gtgggggctt cggagggccc tgaggaggag gaggaagagg
      181 cagaggagag aaggccccac ggaggtcctg tcgccagcgc tgccactgcc tgacctccgc
      241 tgcccgaagg ccggtgggcc tctgtggcct ccgtgaagca ggcccggctg tcgtcaggcc
      301 atgtctggtc catggccctc ccccgacagc cggaccaagg gaacggtggc ctggctggcg
      361 gaggtactcc tctgggttgg agggagtgtg gtgctgtctt cagagtggca gctcggcccc
      421 ctggtggagc ggtgcatggg tgccatgcaa gaggggatgc agatggtgaa gctgcgtggc
      481 ggctccaagg gcctggtccg cttctactac ctggacgagc accgctcctg catccgctgg
      541 aggccctcac gcaagaacga gaaggccaag atctccatcg actccatcca ggaggtgagt
      601 gaggggcggc agtcggaggt cttccagcgc taccctgacg gcagcttcga ccccaactgc
      661 tgcttcagca tctaccacgg cagccaccgc gagtcgctgg acctggtctc caccagcagc
      721 gaggtggcgc gcacctgggt cactggcctg cgctacctca tggccggcat cagcgacgag
      781 gacagcctgg ctcgccgcca gcgcaccagg gaccagtggc tgaagcagac gtttgacgag
      841 gccgacaaga acggggatgg cagcctgagc attggcgagg tcctgcagct gctgcacaag
      901 ctcaacgtga acctgccccg gcagagggtg aagcagatgt tcagggaagc ggacacggat
      961 gaccaccaag ggacgctggg ttttgaagag ttctgtgcct tctacaagat gatgtccacc
     1021 cgccgggacc tctacctgct catgctgacc tacagcaacc acaaggacca cctggatgcc
     1081 gccagcctgc agcgcttcct gcaggtggag cagaagatgg cgggtgtgac cctcgagagc
     1141 tgccaggaca tcatcgagca gtttgagcca tgcccagaaa acaagagtaa ggggctgctg
     1201 ggcattgatg gcttcaccaa ctacaccagg agccctgctg gtgacatctt caaccctgag
     1261 caccaccatg tgcaccagga catgacgcag ccgctgagcc actacttcat cacctcgtcc
     1321 cacaacacct acctcgtggg tgaccagctc atgtcccagt cacgggtgga catgtatgct
     1381 tgggtcctgc aggctggctg ccgctgcgtg gaggtggact gctgggatgg gcccgacggg
     1441 gagcccattg tgcaccatgg ctacactctg acttccaaga tcctcttcaa agacgtcatt
     1501 gaaaccatca acaaatatgc cttcatcaag aatgagtacc cagtgatcct gtccatcgaa
     1561 aaccactgca gtgtcatcca gcagaagaaa atggcccagt atctgactga catccttggg
     1621 gacaagctgg acctgtcatc agtgagcagt gaagatgcca ccacactccc ctctccacag
     1681 atgctcaagg gcaagatcct cgtgaagggg aagaagctcc cagccaacat cagcgaggat
     1741 gcggaggaag gcgaggtgtc tgatgaggac agtgctgatg agattgacga tgactgcaag
     1801 ctcctcaatg gggatgcatc caccaatcga aagcgtgtag aaaacactgc taagaggaaa
     1861 ctggattccc tcatcaaaga gtcgaagatt cgggactgtg aggaccccaa caacttctcc
     1921 gtctccacac tgtccccatc tggaaagctc ggacgcaaga gcaaggctga agaggacgtg
     1981 gagtctgggg aggatgccgg ggccagcaga cgcaatggcc gcctcgtcgt gggaagcttc
     2041 tccaggcgca agaagaaggg cagcaagctg aagaaggcgg ccagcgtgga ggagggagat
     2101 gagggtcagg actccccggg aggccagagc cgaggggcga cccggcagaa gaagaccatg
     2161 aagctgtccc gggccctctc tgacctggtg aagtacacca agtccgtggc cacccacgac
     2221 atagagatgg aggcggcgtc cagctggcag gtgtcgtcct tcagcgagac caaggcccac
     2281 cagattctgc agcagaagcc ggcgcagtac ctacgcttca accagcagca gctctcccgc
     2341 atctacccct cctcctaccg tgtggactcc agcaactaca acccgcagcc cttctggaac
     2401 gccggctgcc aaatggttgc cctgaactac cagtcagagg ggcggatgct gcagctgaac
     2461 cgagccaagt tcagcgccaa cggtggctgc ggctacgtac tcaagcctgg gtgcatgtgc
     2521 cagggcgtgt tcaaccccaa ctcggaggac cccctgcccg ggcagctcaa gaagcagctg
     2581 gtgctccgga tcatcagtgg ccagcagctt cccaagccgc gcgactccat gctgggggac
     2641 cgtggggaga tcatcgaccc ctttgtggag gtggagatca ttgggctccc tgtggactgc
     2701 agcagggagc agacccgcgt ggtggacgac aacgggttca accccacctg ggaggagacc
     2761 ctggttttca tggtgcacat gccggagatc gcgctggtcc gcttcctcgt ctgggaccac
     2821 gatcccatcg ggcgtgactt cattggccag aggacgctgg ccttcagcag catgatgcca
     2881 ggctacagac acgtgtacct agaagggatg gaagaggcct ccatcttcgt gcatgtggct
     2941 gtcagtgaca tcagcggtaa ggtcaagcag gctctgggcc taaaaggcct cttcctccga
     3001 ggcccaaagc ccggctcgct ggacagtcat gctgctgggc ggcccccggc ccggccctcc
     3061 gttagccagc ggatcctgcg gcgcacggcc agcgccccga ccaagagcca gaagccgggc
     3121 cgcaggggct tcccggagct ggtcctgggt acacgggaca caggctccaa gggggtggca
     3181 gacgatgtgg tgccccccgg gcccggacct gctccggaag ccccagccca ggaggggccc
     3241 ggcagcggca gcccccgaga cacccgcccc ctctccacgc agcggccact ccccccactg
     3301 tgcagcctgg aaaccatcgc tgaggagccc gccccaggcc ctggtccccc gccaccagcg
     3361 gctgtcccca ccagctcttc tcagggacgg cccccatacc ccacaggacc cggagccaat
     3421 gtggcaagcc ccctagagga cactgaggag ccccgagaca gcaggcctcg gccgtgcaac
     3481 ggcgagggcg ccggcggggc atacgagagg gcccccggca gccagacgga cggcaggagc
     3541 cagccccgga ccctgggcca cctgcccgtg attagaaggg tgaagagtga ggggcaggtg
     3601 cccacggagc ccctgggagg gtggcggccc ctggccgctc cctttccagc tcctgccgtg
     3661 tactccgatg ccacgggcag tgacccgctg tggcagcggc tggagccatg tggccaccga
     3721 gacagcgttt cctcctcctc cagcatgtca tccagcgaca ctgtcattga cctctccctg
     3781 cccagcctgg gcctgggccg cagccgtgag aacctcgctg gagcccacat gggacgcctg
     3841 ccccccaggc cccactcggc ttcggctgcc cgcccagacc tgccacctgt gaccaagagc
     3901 aaatccaacc ccaaccttcg ggctacaggc cagcggcctc ccatacctga cgaactgcag
     3961 cccaggtccc tggccccaag gatggctggc ctccccttcc ggcctccctg gggctgcctt
     4021 tccctggtgg gcgtgcagga ctgccccgtg gctgccaagt ccaagagcct gggcgacctc
     4081 actgctgatg actttgcccc tagctttgag ggcggctccc gcagactgag ccacagcctg
     4141 ggcctcccgg gagggacacg gcgggtgtcg gggccagggg tgagacggga caccctgaca
     4201 gagcagctgc gctggctcac tgtcttccag caggcaggag acatcacgtc acccaccagc
     4261 ctgggcccgg ctggggaggg ggtggcaggg ggccctggtt ttgtgcggcg ctcctcctcc
     4321 cgcagccaca gccgcgtgcg tgccattgcc agccgggccc gccaggccca ggagcggcag
     4381 cagagactgc agggcctggg ccggcaggga cccccagaag aggagcgggg cacccccgag
     4441 ggcgcctgct ccgtgggcca cgagggcagt gtggatgcac cagcaccctc caagggagcc
     4501 ctcgggccag catccgcggc tgctgaaaac ctggtcctgc tccgcctctg accgtcagtg
     4561 gtgggaacct gggcggctct ggaggcccag ggcaggggtg ggcgtgttgt ttgctcagga
     4621 aacagggcag ccaggccccc aaaactgtgt ccccctggct gccctgtgtc ccctccaccc
     4681 ctgcctccct cctgcccctg ctcccgggga ggaaaggcta aagctgctgg cccggggccc
     4741 acaggagggg cttcgaggct ggccctgcca ggcagttttc ccggcgtttt aggatctgta
     4801 catagagaaa tatttaaatt tttagaagca aaacttatac aacattaaaa tgataccaag
     4861 tccctttcca
//
