LOCUS       NM_032726               3092 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phospholipase C delta 4 (PLCD4), mRNA.
ACCESSION   NM_032726
VERSION     NM_032726.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Li,Y. and Luan,C.
  TITLE     PLCE1 Promotes the Invasion and Migration of Esophageal Cancer
            Cells by Up-Regulating the PKCalpha/NF-kappaB Pathway
  JOURNAL   Yonsei Med J 59 (10), 1159-1165 (2018)
   PUBMED   30450849
  REMARK    GeneRIF: PLCE1 activated NF-kappaB [nuclear factor kappa B ]
            signaling by up-regulating PKCalpha [protein kinase C alpha ],
            which could promote invasion and migration of esophageal cancer
            cells.
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Maziarz,M., Broselid,S., DiGiacomo,V., Park,J.C., Luebbers,A.,
            Garcia-Navarrete,L., Blanco-Canosa,J.B., Baillie,G.S. and
            Garcia-Marcos,M.
  TITLE     A biochemical and genetic discovery pipeline identifies PLCdelta4b
            as a nonreceptor activator of heterotrimeric G-proteins
  JOURNAL   J Biol Chem 293 (44), 16964-16983 (2018)
   PUBMED   30194280
  REMARK    GeneRIF: PLCD4 functions as a nonreceptor activator of G-proteins.
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Kunrath-Lima,M., de Miranda,M.C., Ferreira,A.D.F., Faraco,C.C.F.,
            de Melo,M.I.A., Goes,A.M., Rodrigues,M.A., Faria,J.A.Q.A. and
            Gomes,D.A.
  TITLE     Phospholipase C delta 4 (PLCdelta4) is a nuclear protein involved
            in cell proliferation and senescence in mesenchymal stromal stem
            cells
  JOURNAL   Cell Signal 49, 59-67 (2018)
   PUBMED   29859928
  REMARK    GeneRIF: PLCdelta4 knockdown demonstrated that it is essential for
            hASC proliferation, without inducing cell death. An increase of
            cells in G1, and a reduction of cells on interphase and G2/M in
            knockdown cells were seen.
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Gong,B., Shen,W., Xiao,W., Meng,Y., Meng,A. and Jia,S.
  TITLE     The Sec14-like phosphatidylinositol transfer proteins
            Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+
            signaling
  JOURNAL   Elife 6, e26362 (2017)
   PUBMED   28463110
  REMARK    GeneRIF: Here, the authors report that the zebrafish/human
            phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase
            proteins to transduce Wnt signals from Frizzled to phospholipase C
            (PLC).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Leung,D.W., Tompkins,C., Brewer,J., Ball,A., Coon,M., Morris,V.,
            Waggoner,D. and Singer,J.W.
  TITLE     Phospholipase C delta-4 overexpression upregulates ErbB1/2
            expression, Erk signaling pathway, and proliferation in MCF-7 cells
  JOURNAL   Mol Cancer 3, 15 (2004)
   PUBMED   15140260
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Ananthanarayanan,B., Das,S., Rhee,S.G., Murray,D. and Cho,W.
  TITLE     Membrane targeting of C2 domains of phospholipase C-delta isoforms
  JOURNAL   J Biol Chem 277 (5), 3568-3575 (2002)
   PUBMED   11706040
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Kim,H., Suh,P.G., Ryu,S.H. and Park,S.H.
  TITLE     Assignment of the human PLC delta4 gene (PLCD4) to human chromosome
            band 2q35 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 254-255 (1999)
   PUBMED   10702683
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Zauli,G., Previati,M., Caramelli,E., Bassini,A., Falcieri,E.,
            Gibellini,D., Bertolaso,L., Bosco,D., Robuffo,I. and Capitani,S.
  TITLE     Exogenous human immunodeficiency virus type-1 Tat protein
            selectively stimulates a phosphatidylinositol-specific
            phospholipase C nuclear pathway in the Jurkat T cell line
  JOURNAL   Eur J Immunol 25 (9), 2695-2700 (1995)
   PUBMED   7589147
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Berridge,M.J.
  TITLE     Inositol trisphosphate and calcium signalling
  JOURNAL   Nature 361 (6410), 315-325 (1993)
   PUBMED   8381210
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP361394.1, BC006355.2 and
            AC012510.8.
            
            On Nov 22, 2018 this sequence version replaced NM_032726.3.
            
            Summary: This gene encodes a member of the delta class of
            phospholipase C enzymes. Phospholipase C enzymes play a critical
            role in many cellular processes by hydrolyzing phosphatidylinositol
            4,5-bisphosphate into two intracellular second messengers, inositol
            1,4,5-trisphosphate and diacylglycerol. Expression of this gene may
            be a marker for cancer. [provided by RefSeq, Jan 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223203.1, SRR1803613.250629.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450993.7/ ENSP00000388631.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BP361394.1         135-144
            11-1149             BC006355.2         1-1139
            1150-1150           AC012510.8         75318-75318
            1151-2521           BC006355.2         1141-2511
            2522-2522           AC012510.8         83722-83722
            2523-3092           BC006355.2         2513-3082
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..3092
                     /gene="PLCD4"
                     /note="phospholipase C delta 4"
                     /db_xref="GeneID:84812"
                     /db_xref="HGNC:HGNC:9062"
                     /db_xref="MIM:605939"
     exon            1..172
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            173..227
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2494
                     /gene="PLCD4"
                     /EC_number="3.1.4.11"
                     /note="PLC delta4; phosphoinositide phospholipase
                     C-delta-4"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-4"
                     /protein_id="NP_116115.1"
                     /db_xref="CCDS:CCDS46516.1"
                     /db_xref="GeneID:84812"
                     /db_xref="HGNC:HGNC:9062"
                     /db_xref="MIM:605939"
                     /translation="MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDG
                     MTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNL
                     DLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQ
                     RLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSAD
                     GQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSK
                     DGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCV
                     EVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQ
                     QTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEA
                     EPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSF
                     THSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQE
                     LWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPF
                     KAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPY
                     WGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGI
                     SLRPASIFVYICIQEGLEGDES"
     exon            228..386
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            387..615
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            616..745
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..977
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1179
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1324
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1477
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1654
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1811
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1928
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2101
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2237
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2387
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..3092
                     /gene="PLCD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3076..3081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCD4"
                     /note="hexamer: AATACA"
     polyA_site      3092
                     /gene="PLCD4"
                     /note="major polyA site"
ORIGIN      
        1 agtcacagca gccagctgct gtagaagagg ggaggaaaca agccagtgca aggggagcaa
       61 aagagaaaag gagccaggct gggcttcctg atcccacagc atcgcagagc tcgggaggca
      121 cagctcacag acacaggaaa cacaggactg ctattctgct ctcctgccca cggtgatctg
      181 gtgccagctg gtggaacagt gggtgatggc gtccctgctg caagaccagc tgaccactga
      241 tcaggacttg ctgctgatgc aggaaggcat gccgatgcgc aaggtgaggt ccaaaagctg
      301 gaagaagcta agatacttca gacttcagaa tgacggcatg acagtctggc atgcacggca
      361 ggccaggggc agtgccaagc ccagcttctc aatctctgat gtggagacaa tacgtaatgg
      421 ccatgattcc gagttgctgc gtagcctggc agaggagctc cccctggagc agggcttcac
      481 cattgtcttc catggccgcc gctccaacct ggacctgatg gccaacagtg ttgaggaggc
      541 ccagatatgg atgcgagggc tccagctgtt ggtggatctt gtcaccagca tggaccatca
      601 ggagcgcctg gaccaatggc tgagcgattg gtttcaacgt ggagacaaaa atcaggatgg
      661 taagatgagt ttccaagaag ttcagcggtt attgcaccta atgaatgtgg aaatggacca
      721 agaatatgcc ttcagtcttt ttcaggcagc agacacgtcc cagtctggaa ccctggaagg
      781 agaagaattc gtacagttct ataaggcatt gactaaacgt gctgaggtgc aggaactgtt
      841 tgaaagtttt tcagctgatg ggcagaagct gactctgctg gaatttttgg atttcctcca
      901 agaggagcag aaggagagag actgcacctc tgagcttgct ctggaactca ttgaccgcta
      961 tgaaccttca gacagtggca aactgcggca tgtgctgagt atggatggct tcctcagcta
     1021 cctctgctct aaggatggag acatcttcaa cccagcctgc ctccccatct atcaggatat
     1081 gactcaaccc ctgaaccact acttcatctg ctcttctcat aacacctacc tagtggggga
     1141 ccagctttgt ggccagagca gcgtcgaggg atatatacgg gccctgaagc gggggtgccg
     1201 ctgcgtggag gtggatgtat gggatggacc tagcggggaa cctgtcgttt accacggaca
     1261 caccctgacc tcccgcatcc tgttcaaaga tgtcgtggcc acagtagcac agtatgcctt
     1321 ccagacatca gactacccag tcatcttgtc cctggagacc cactgcagct gggagcagca
     1381 gcagaccatg gcccgtcatc tgactgagat cctgggggag cagctgctga gcaccacctt
     1441 ggatggggtg ctgcccactc agctgccctc gcctgaggag cttcggagga agatcctggt
     1501 gaaggggaag aagttaacac ttgaggaaga cctggaatat gaggaagagg aagcagaacc
     1561 tgagttggaa gagtcagaat tggcgctgga gtcccagttt gagactgagc ctgagcccca
     1621 ggagcagaac cttcagaata aggacaaaaa gaagaaatcc aagcccatct tgtgtccagc
     1681 cctctcttcc ctggttatct acttgaagtc tgtctcattc cgcagcttca cacattcaaa
     1741 ggagcactac cacttctacg agatatcatc tttctctgaa accaaggcca agcgcctcat
     1801 caaggaggct ggcaatgagt ttgtgcagca caatacttgg cagttaagcc gtgtgtatcc
     1861 cagcggcctg aggacagact cttccaacta caacccccag gaactctgga atgcaggctg
     1921 ccagatggtg gccatgaata tgcagactgc agggcttgaa atggacatct gtgatgggca
     1981 tttccgccag aatggcggct gtggctatgt gctgaagcca gacttcctgc gtgatatcca
     2041 gagttctttc caccctgaga agcccatcag ccctttcaaa gcccagactc tcttaatcca
     2101 ggtgatcagc ggtcagcaac tccccaaagt ggacaagacc aaagaggggt ccattgtgga
     2161 tccactggtg aaagtgcaga tctttggcgt tcgtctagac acagcacggc aggagaccaa
     2221 ctatgtggag aacaatggtt ttaatccata ctgggggcag acactatgtt tccgggtgct
     2281 ggtgcctgaa cttgccatgc tgcgttttgt ggtaatggat tatgactgga aatcccgaaa
     2341 tgactttatt ggtcagtaca ccctgccttg gacctgcatg caacaaggtt accgccacat
     2401 tcacctgctg tccaaagatg gcatcagcct ccgcccagct tccatctttg tgtatatctg
     2461 catccaggaa ggcctggagg gggatgagtc ctgaggtggg catttcacgg gaagggttgg
     2521 tgtgctggct ttagacgggg agaaacatct ggaaggatgc tcgagagaac aaatggaggt
     2581 ggtgaaaatc aagctttgga ttgtgcattc ctaggcacaa aattacctca ttcttcctaa
     2641 caagcaatct gggacctgat tttccacctt ttttctcttt tcttcccttc ctttgttttc
     2701 ataagccttt ggtatctttc ctgccctttt cctttgtgta ctctatactg gagttccctt
     2761 cttcctcttg ctgtaggctc aatcccatac cgacatctac aactaatctt tcccatcaac
     2821 tctgtgtgaa ggcaggttgc aactagaaat tcagaggggc ttggaataga gaaacctaaa
     2881 gaagcatcat cccctccatc cccaacttcc tcaaagccca aagccaaggg aaggataaat
     2941 caaggctcaa ggcttcccca gcaaagatta gggaaagaga cttgacccca ggactgtact
     3001 acgactctta agagaacact gcacagcact caaagtcccc cactggactg cttcctcctt
     3061 agccccactg gtataaatac atctctctcc aa
//
