LOCUS       NM_133373               6132 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens phospholipase C delta 3 (PLCD3), mRNA.
ACCESSION   NM_133373
VERSION     NM_133373.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6132)
  AUTHORS   Dou,X.L., Xia,F.D. and Li,X.Y.
  TITLE     Circ_0003747 promotes thyroid cancer progression by sponging
            miR-338-3p to upregulate PLCD3 expression
  JOURNAL   Epigenetics 18 (1), 2210339 (2023)
   PUBMED   37166441
  REMARK    GeneRIF: Circ_0003747 promotes thyroid cancer progression by
            sponging miR-338-3p to upregulate PLCD3 expression.
REFERENCE   2  (bases 1 to 6132)
  AUTHORS   Wang,M., Gao,M., Chen,Y., Wu,J., Wang,X. and Shu,Y.
  TITLE     PLCD3 promotes malignant cell behaviors in esophageal squamous cell
            carcinoma via the PI3K/AKT/P21 signaling
  JOURNAL   BMC Cancer 23 (1), 921 (2023)
   PUBMED   37773107
  REMARK    GeneRIF: PLCD3 promotes malignant cell behaviors in esophageal
            squamous cell carcinoma via the PI3K/AKT/P21 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6132)
  AUTHORS   Ma,Y., Liu,Y., Shu,B., Yang,J., Lv,L., Zhou,L., Wang,L. and Shi,Z.
  TITLE     CircMAP3K4 protects human lens epithelial cells from H2O2-induced
            dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related
            cataract
  JOURNAL   Cell Cycle 22 (3), 303-315 (2023)
   PUBMED   36071682
  REMARK    GeneRIF: CircMAP3K4 protects human lens epithelial cells from
            H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in
            age-related cataract.
REFERENCE   4  (bases 1 to 6132)
  AUTHORS   Lin,L., Wen,J., Lin,B., Chen,H., Bhandari,A., Qi,Y., Zheng,D. and
            Wang,O.
  TITLE     Phospholipase C Delta 3 inhibits apoptosis and promotes
            proliferation, migration, and invasion of thyroid cancer cells via
            Hippo pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (4), 481-491 (2021)
   PUBMED   33674820
  REMARK    GeneRIF: Phospholipase C Delta 3 inhibits apoptosis and promotes
            proliferation, migration, and invasion of thyroid cancer cells via
            Hippo pathway.
REFERENCE   5  (bases 1 to 6132)
  AUTHORS   Zhou,X., Liao,X., Wang,X., Huang,K., Yang,C., Yu,T., Han,C.,
            Zhu,G., Su,H., Han,Q., Chen,Z., Huang,J., Gong,Y., Ruan,G., Ye,X.
            and Peng,T.
  TITLE     Noteworthy prognostic value of phospholipase C delta genes in early
            stage pancreatic ductal adenocarcinoma patients after
            pancreaticoduodenectomy and potential molecular mechanisms
  JOURNAL   Cancer Med 9 (3), 859-871 (2020)
   PUBMED   31808619
  REMARK    GeneRIF: Noteworthy prognostic value of phospholipase C delta genes
            in early stage pancreatic ductal adenocarcinoma patients after
            pancreaticoduodenectomy and potential molecular mechanisms.
REFERENCE   6  (bases 1 to 6132)
  AUTHORS   Pawelczyk,T. and Matecki,A.
  TITLE     Phospholipase C-delta3 binds with high specificity to
            phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in
            bilayer membranes
  JOURNAL   Eur J Biochem 262 (2), 291-298 (1999)
   PUBMED   10336610
REFERENCE   7  (bases 1 to 6132)
  AUTHORS   Kim,H., Suh,P.G., Ryu,S.H. and Park,S.H.
  TITLE     Assignment of the human PLC delta3 gene (PLCD3) to human chromosome
            band 17q21 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 209-210 (1999)
   PUBMED   10702670
REFERENCE   8  (bases 1 to 6132)
  AUTHORS   Pawelczyk,T. and Matecki,A.
  TITLE     Localization of phospholipase C delta3 in the cell and regulation
            of its activity by phospholipids and calcium
  JOURNAL   Eur J Biochem 257 (1), 169-177 (1998)
   PUBMED   9799116
REFERENCE   9  (bases 1 to 6132)
  AUTHORS   Ghosh,S., Pawelczyk,T. and Lowenstein,J.M.
  TITLE     Phospholipase C isoforms delta 1 and delta 3 from human
            fibroblasts. High-yield expression in Escherichia coli, simple
            purification, and properties
  JOURNAL   Protein Expr Purif 9 (2), 262-278 (1997)
   PUBMED   9056492
REFERENCE   10 (bases 1 to 6132)
  AUTHORS   Pawelczyk,T. and Matecki,A.
  TITLE     Expression, purification and kinetic properties of human
            recombinant phospholipase C delta 3
  JOURNAL   Acta Biochim Pol 44 (2), 221-229 (1997)
   PUBMED   9360711
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY169731.1, BC072384.1,
            AL834392.1, BU621728.1 and AC002117.2.
            
            On Nov 23, 2018 this sequence version replaced NM_133373.4.
            
            Summary: This gene encodes a member of the phospholipase C family,
            which catalyze the hydrolysis of phosphatidylinositol
            4,5-bisphosphate to generate the second messengers diacylglycerol
            and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3
            mediate a variety of cellular responses to extracellular stimuli by
            inducing protein kinase C and increasing cytosolic Ca(2+)
            concentrations. This enzyme localizes to the plasma membrane and
            requires calcium for activation. Its activity is inhibited by
            spermine, sphingosine, and several phospholipids. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB075844.1, BC072384.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619929.5/ ENSP00000479636.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                HY169731.1         19-35
            18-1554             BC072384.1         1-1537
            1555-3441           AL834392.1         1415-3301
            3442-3451           BU621728.1         18-27               c
            3452-6132           AC002117.2         13951-16631         c
FEATURES             Location/Qualifiers
     source          1..6132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..6132
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /note="phospholipase C delta 3"
                     /db_xref="GeneID:113026"
                     /db_xref="HGNC:HGNC:9061"
                     /db_xref="MIM:608795"
     exon            1..268
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2475
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /EC_number="3.1.4.11"
                     /note="PLC delta3; 1-phosphatidylinositol-4,5-bisphosphate
                     phosphodiesterase delta-3; phosphoinositide phospholipase
                     C-delta-3"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-3"
                     /protein_id="NP_588614.1"
                     /db_xref="CCDS:CCDS74077.1"
                     /db_xref="GeneID:113026"
                     /db_xref="HGNC:HGNC:9061"
                     /db_xref="MIM:608795"
                     /translation="MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTK
                     RPGLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPR
                     APSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEA
                     QRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDM
                     NDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELL
                     EFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTC
                     VFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGE
                     PVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTIL
                     GDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEE
                     EEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKL
                     IREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLN
                     AGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHS
                     IVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYD
                     ATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQRS"
     exon            269..430
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            431..659
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..789
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1018
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1220
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1365
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1518
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1665
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1816
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1933
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2100
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2236
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2386
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..6132
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /note="hexamer: AATAAA"
     polyA_site      3421
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /note="major polyA site"
     polyA_site      3442
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /note="major polyA site"
     regulatory      6102..6107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
                     /note="hexamer: AACAAG"
     polyA_site      6132
                     /gene="PLCD3"
                     /gene_synonym="PLC-delta-3"
ORIGIN      
        1 cttcgctcgc cgcctcgctc agagccgggg ccgggccaga gcggcgcccc gctgccctgt
       61 ccccgcgtgc agaccccggg cccggccccg gccccccgcc aagccatgct gtgcggccgc
      121 tggaggcgtt gccgccgccc gcccgaggag cccccggtgg ccgcccaggt cgcagcccaa
      181 gtcgcggcgc cggtcgctct cccgtccccg ccgactccct ccgatggcgg caccaagagg
      241 cccgggctgc gggcgctgaa gaagatgggc ctgacggagg acgaggacgt gcgcgccatg
      301 ctgcggggct cccggctccg caagatccgc tcgcgcacgt ggcacaagga gcggctgtac
      361 cggctgcagg aggacggcct gagcgtgtgg ttccagcggc gcatcccgcg tgcgccatcg
      421 cagcacatct tcttcgtgca gcacatcgag gcggtccgcg agggccacca gtccgagggc
      481 ctgcggcgct tcgggggtgc cttcgcgcca gcgcgctgcc tcaccatcgc cttcaagggc
      541 cgccgcaaga acctggacct ggcggcgccc acggctgagg aagcgcagcg ctgggtgcgc
      601 ggtctgacca agctccgcgc gcgcctggac gccatgagcc agcgcgagcg gctagaccac
      661 tggatccact cctatctgca ccgggctgac tccaaccagg acagcaagat gagcttcaag
      721 gagatcaaga gcctgctgag aatggtcaac gtggacatga acgacatgta cgcctacctc
      781 ctcttcaagg agtgtgacca ctccaacaac gaccgtctag agggggctga gatcgaggag
      841 ttcctgcggc ggctgctgaa gcggccggag ctggaggaga tcttccatca gtactcgggc
      901 gaggaccgcg tgctgagtgc ccctgagctg ctggagttcc tggaggacca gggcgaggag
      961 ggcgccacac tggcccgcgc ccagcagctc attcagacct atgagctcaa cgagacagcc
     1021 aagcagcatg agctgatgac actggatggc ttcatgatgt acctgttgtc gccggagggg
     1081 gctgccttgg acaacaccca cacgtgtgtg ttccaggaca tgaaccagcc ccttgcccac
     1141 tacttcatct cttcctccca caacacctat ctgactgact cccagatcgg ggggcccagc
     1201 agcaccgagg cctatgttag ggcctttgcc cagggatgcc gctgcgtgga gctggactgc
     1261 tgggaggggc caggagggga gcccgtcatc tatcatggcc ataccctcac ctccaagatt
     1321 ctcttccggg acgtggtcca agccgtgcgc gaccatgcct tcacgctgtc cccttaccct
     1381 gtcatcctat ccctggagaa ccactgcggg ctggagcagc aggctgccat ggcccgccac
     1441 ctctgcacca tcctggggga catgctggtg acacaggcgc tggactcccc aaatcccgag
     1501 gagctgccat ccccagagca gctgaagggc cgggtcctgg tgaagggaaa gaagttgccc
     1561 gctgctcgga gcgaggatgg ccgggctctg tcggatcggg aggaggagga ggaggatgac
     1621 gaggaggaag aagaggaggt ggaggctgca gcgcagaggc ggctggccaa gcagatctcc
     1681 ccggagctgt cggccctggc tgtgtactgc cacgccaccc gcctgcggac cctgcaccct
     1741 gcccccaacg ccccacaacc ctgccaggtc agctccctca gcgagcgcaa agccaagaaa
     1801 ctcattcggg aggcagggaa cagctttgtc aggcacaatg cccgccagct gacccgcgtg
     1861 tacccgctgg ggctgcggat gaactcagcc aactacagtc cccaggagat gtggaactcg
     1921 ggctgtcagc tggtggcctt gaacttccag acgccaggct acgagatgga cctcaatgcc
     1981 gggcgcttcc tagtcaatgg gcagtgtggc tacgtcctaa aacctgcctg cctgcggcaa
     2041 cctgactcga cctttgaccc cgagtaccca ggacctccca gaaccactct cagcatccag
     2101 gtgctgactg cacagcagct gcccaagctg aatgccgaga agccacactc cattgtggac
     2161 cccctggtgc gcattgagat ccatggggtg cccgcagact gtgcccggca ggagactgac
     2221 tacgtgctca acaatggctt caacccccgc tgggggcaga ccctgcagtt ccagctgcgg
     2281 gctccggagc tggcactggt ccggtttgtg gtggaagatt atgacgccac ctcccccaat
     2341 gactttgtgg gccagtttac actgcctctt agcagcctaa agcaagggta ccgccacata
     2401 cacctgcttt ccaaggacgg ggcctcactg tcaccagcca cgctcttcat ccaaatccgc
     2461 atccagcgct cctgagggcc cacctcactc gccttggggt tctgcgagtg ccagtccaca
     2521 tcccctgcag agccctctcc tcctctggag tcaggtggtg ggagtaccag ccccccagcc
     2581 cacccacttg gcccactcag cccattcacc aggcgctggt ctcacctggg tgctgagggc
     2641 tgcctgggcc cctcctgaag aacagaaagg tgttcatgtg acttcagtga gctccaaccc
     2701 tggggccctg agatggcccc agctcctctt gtcctcagcc cacccctcat tgtgacttat
     2761 gaggagcaag cctgttgctg ccaggagact tggggagcag gacacttgtg ggccctcagt
     2821 tcccctctgt cctcccgtgg gccatcccag cctccttccc ccagaggagc gcagtcactc
     2881 cacttggccc cgaccccgag cttagcccct aagccctcct ttaccccagg ccttcctgga
     2941 ctcctccctc cagctccgga acctgagctc cccttccctt ctcaaagcaa gaagggagcg
     3001 ctgaggcatg aagccctggg gaaactggca gtaggttttg gtttttattt tttgagacag
     3061 ggtctcgctc cgtcgcccag gctggagtgc aatgttgcaa tcatggctca ctgcagcttt
     3121 gaactcccag gctcaagcga tcctcccatc tcagcctcct gagtagctgg gactacaggc
     3181 acaggccacc aaacctggct aatgtttaaa ttttatgtag agatggcggg gggggcgggg
     3241 gtctccctat gttgcccagg ctggtctcga gctcctgacc tcaagtgatc ctcctgcccc
     3301 agcattccaa agtgctggga ttacaggtgt gagccactgc ctggcctggc cgtaggtttg
     3361 taactgtttc atagaagagc cctggagaag acagtagaat gagcctatct agtttaaaaa
     3421 ataaagaagc acgttgattt caccaccgcc actccctgag cacctctatg ctgccacccc
     3481 cacaggccca tgaggaggga cagggctgga tgagtttctt gggcctctcc cctcaacagg
     3541 gcatggactt ggctaagaca gccagggggt ggcagcagga gatgccacag ctctaaatag
     3601 cccgatccct gctcctggct taaagctgct gcgagtatca caagactgtc tgaggatgcc
     3661 aattcagcag gtcagcgcct ccccacaaca cacacacaca cacacacaca cacacactca
     3721 cacatacaca gaggggcctt gaatgaggag gagacaggag tctgagggac cctcagactg
     3781 ccactctcca ggcttggctg ggctcaaggc ccctgtctgc tcagtagggc aaatcccaag
     3841 gacacgggct tcccttcctc cagccagcca gccttttaca caaaggctgg aaacgctgct
     3901 tgggccgcct ctatagaaat gccaggagag cgcactggac actaggcgac agaatctgga
     3961 gaaaatcctg cacccgcccc tgccagcagg gtgaaatgtg gaggcctggt gttttaggtt
     4021 ctgccagcca acagtgccgg cactggacaa gggcagaact tgacattagt ccccagaggg
     4081 tggcctggaa ctgggctggg ataggccttg aactggcccc aagccccaca gaaaccaaaa
     4141 cacagggctg gggcagactc caccttctag caactccaag aactaatgca gaaagtggca
     4201 gtgtcccccg ctccttcatg ctgggagtgg cgtttggctc tggttaattt gtgtgtctga
     4261 aagaggataa tcagaatcaa aagggcccag aaggaatggg ccgagccagg cgggccgggc
     4321 caggcagccc gggcatctgg cactcagggc tgtcagaggg tcaggctgcc aaactgcagc
     4381 ctcaggatgg gaggcacagt gaggctaagt ccagttttag caaatgaaga gccattagca
     4441 ttgcccagcc cctgcagagc caggtctggc caggggctgg ctggggggtc tgggtcaggt
     4501 gagcaccaga cccagggctg agtgcccatc ctgcttggct tctctggttt cgtatctggt
     4561 accaagagga aggggtgaag gctaggatga gggcccaata ctgagaaggc tgccttgaaa
     4621 gggcaagagt cttttttttt tttcttttga gacaaagtct tgctcgtccc ccaggatgga
     4681 gtgcgatggc gtgatctcgg ctcactgcaa cctctgcctc ccgggttcaa gcgattctct
     4741 tgcctcagcc tccggagtag ctgggattac aggcgcccgc caccataccc agctaatttt
     4801 tgtattttta gtagagacgg ggtttcacca tgttggccag gctggtctcg aactcctgac
     4861 ctcaggtgat ccacccgcct tgacctccca aagtgctggg attacaggcg tgagccactg
     4921 cacccagcca aaagggcaag agtctttaag gaagtgaact gggaagcaga agcaagggag
     4981 aaatcacagg gttttttttt tgtttgtttt tttgagatgg agtctcgctc tgtcgcctag
     5041 gctagagtgc agtggcacga ccttggctca ctgcaagctc cgcctcccgg gttcacacca
     5101 ttctcctgcc tcagcttccc aagtagctgg gactacaggc gcccaccacc atgcccggct
     5161 aatttttttg tgtttttagt agagacaggg tttcatagtg ttagccagga tggtctcgat
     5221 ctcctgacct cgtgatccac ccgcctcgcc ctcccaaagt gctgggatta caggcgtgag
     5281 ccaccatgcc cagcctgaaa tcacagcttt ttatcccaga ggcccatggg tagaaacaac
     5341 acatagggct atgttctctc agcccaaagc taagggcagg aaaaaaggca tgggccatag
     5401 gagcctgagt gacttggttt gggacaggag ggttgggggg ctttagaggg gtcaggcagg
     5461 tcctgtgtcc tctcagtttc cctggaaagg ggcttggagg caccagtcat ggacctgaaa
     5521 ggatcagggg gtcagggaat gggtaagttc cagaggatga gaagaggggg aatgggaagt
     5581 cttaaacaca gctactgggg cccagcaact tgccatgtta aaatgcaccc ctagtgactc
     5641 aaagaaccac ccggccagtg gtgcaggagg agagatgtgg cacctgggca cagtgggaag
     5701 gcacggggcc tgcacctcca ccagaggagc cactgctgac ctggaccaag ggggctgctc
     5761 tgtgcccagc tagggaagcc tgggccggct cctgtgctga ggtgctcagg tgctggctga
     5821 gagcccagtt gctgctctaa cttggagtga acctgggtca atagcagctc gtctctggcg
     5881 ggtgggaagg gtctgacaac accaagtttg ccctggaaga agggcagcct taaaggaagg
     5941 cctttggaag ctggcctggt gctgtgggct tgagggactt tgtgtccaag ccctgtcgtc
     6001 ctggctccag cctaggctcc agcactccat ttcttccact gccacctgct gaccaggaat
     6061 accaggacag aaggttttgt tcagctgctt tctttattag aaacaagtga gatgtattga
     6121 gcagaacaac aa
//
