LOCUS       NM_000932               4192 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens phospholipase C beta 3 (PLCB3), transcript variant 1,
            mRNA.
ACCESSION   NM_000932
VERSION     NM_000932.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Falzone,M.E. and MacKinnon,R.
  TITLE     The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2
            hydrolysis
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2315011120 (2023)
   PUBMED   37991948
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Grebert,C., Becq,F. and Vandebrouck,C.
  TITLE     Phospholipase C controls chloride-dependent short-circuit current
            in human bronchial epithelial cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 320 (2), L205-L219 (2021)
   PUBMED   33236921
  REMARK    GeneRIF: Phospholipase C controls chloride-dependent short-circuit
            current in human bronchial epithelial cells.
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Esquina,C.M., Garland-Kuntz,E.E., Goldfarb,D., McDonald,E.K.,
            Hudson,B.N. and Lyon,A.M.
  TITLE     Intramolecular electrostatic interactions contribute to
            phospholipase Cbeta3 autoinhibition
  JOURNAL   Cell Signal 62, 109349 (2019)
   PUBMED   31254604
  REMARK    GeneRIF: Intramolecular electrostatic interactions contribute to
            phospholipase Cbeta3 autoinhibition.
            Erratum:[Cell Signal. 2019 Nov;63:109376. doi:
            10.1016/j.cellsig.2019.109376.. PMID: 31377106]
REFERENCE   4  (bases 1 to 4192)
  AUTHORS   Zauli,G., Previati,M., Caramelli,E., Bassini,A., Falcieri,E.,
            Gibellini,D., Bertolaso,L., Bosco,D., Robuffo,I. and Capitani,S.
  TITLE     Exogenous human immunodeficiency virus type-1 Tat protein
            selectively stimulates a phosphatidylinositol-specific
            phospholipase C nuclear pathway in the Jurkat T cell line
  JOURNAL   Eur J Immunol 25 (9), 2695-2700 (1995)
   PUBMED   7589147
REFERENCE   5  (bases 1 to 4192)
  AUTHORS   Mazuruk,K., Schoen,T.J., Chader,G.J. and Rodriguez,I.R.
  TITLE     Structural organization and expression of the human
            phosphatidylinositol-specific phospholipase C beta-3 gene
  JOURNAL   Biochem Biophys Res Commun 212 (1), 190-195 (1995)
   PUBMED   7612006
REFERENCE   6  (bases 1 to 4192)
  AUTHORS   Lagercrantz,J., Carson,E., Phelan,C., Grimmond,S., Rosen,A.,
            Dare,E., Nordenskjold,M., Hayward,N.K., Larsson,C. and Weber,G.
  TITLE     Genomic organization and complete cDNA sequence of the human
            phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)
  JOURNAL   Genomics 26 (3), 467-472 (1995)
   PUBMED   7607669
REFERENCE   7  (bases 1 to 4192)
  AUTHORS   Sinke,R.J. and Geurts van Kessel,A.G.
  TITLE     Localization of the human phosphatidylinositol-specific
            phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13
  JOURNAL   Genomics 25 (2), 568-569 (1995)
   PUBMED   7789993
REFERENCE   8  (bases 1 to 4192)
  AUTHORS   Weber,G., Friedman,E., Grimmond,S., Hayward,N.K., Phelan,C.,
            Skogseid,B., Gobl,A., Zedenius,J., Sandelin,K., Teh,B.T. et al.
  TITLE     The phospholipase C beta 3 gene located in the MEN1 region shows
            loss of expression in endocrine tumours
  JOURNAL   Hum Mol Genet 3 (10), 1775-1781 (1994)
   PUBMED   7849701
REFERENCE   9  (bases 1 to 4192)
  AUTHORS   Carozzi,A.J., Kriz,R.W., Webster,C. and Parker,P.J.
  TITLE     Identification, purification and characterization of a novel
            phosphatidylinositol-specific phospholipase C, a third member of
            the beta subfamily
  JOURNAL   Eur J Biochem 210 (2), 521-529 (1992)
   PUBMED   1333955
REFERENCE   10 (bases 1 to 4192)
  AUTHORS   Banno,Y., Yada,Y. and Nozawa,Y.
  TITLE     Purification and characterization of membrane-bound phospholipase C
            specific for phosphoinositides from human platelets
  JOURNAL   J Biol Chem 263 (23), 11459-11465 (1988)
   PUBMED   2841328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001453.6 and BC142681.1.
            
            On Mar 5, 2020 this sequence version replaced NM_000932.4.
            
            Summary: This gene encodes a member of the phosphoinositide
            phospholipase C beta enzyme family that catalyze the production of
            the secondary messengers diacylglycerol and inositol
            1,4,5-triphosphate from phosphatidylinositol in G-protein-linked
            receptor-mediated signal transduction. Alternative splicing results
            in multiple transcript variants.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142681.1, SRR11853560.5479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279230.12/ ENSP00000279230.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AP001453.6         23712-23751
            41-455              BC142681.1         1-415
            456-456             AP001453.6         27169-27169
            457-3707            BC142681.1         417-3667
            3708-3708           AP001453.6         39621-39621
            3709-4192           BC142681.1         3669-4152
FEATURES             Location/Qualifiers
     source          1..4192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..4192
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /note="phospholipase C beta 3"
                     /db_xref="GeneID:5331"
                     /db_xref="HGNC:HGNC:9056"
                     /db_xref="MIM:600230"
     exon            1..219
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3825
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /EC_number="3.1.4.11"
                     /note="isoform 1 is encoded by transcript variant 1; PLC
                     beta 3; phosphoinositide phospholipase C-beta-3;
                     1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
                     beta-3; phospholipase C, beta 3
                     (phosphatidylinositol-specific)"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-3 isoform 1"
                     /protein_id="NP_000923.1"
                     /db_xref="CCDS:CCDS8064.1"
                     /db_xref="GeneID:5331"
                     /db_xref="HGNC:HGNC:9056"
                     /db_xref="MIM:600230"
                     /translation="MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLR
                     VDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEK
                     LMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKL
                     KLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLN
                     KLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLI
                     EKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNT
                     YLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDV
                     LEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPG
                     VPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQL
                     GSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEE
                     QTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETK
                     AMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVA
                     MQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSD
                     RKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAA
                     FEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYA
                     EALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLD
                     ASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQER
                     DLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKR
                     YQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNE
                     REKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQR
                     HDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPL
                     VACASNGHAPGSSGHLSGADSESQEENTQL"
     exon            220..297
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            298..366
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            367..507
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            508..587
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            588..641
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            642..717
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            718..818
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            819..985
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1132
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1373
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1458
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1645
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1851
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1948
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2033
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2158
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2313
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2475
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2575
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2680
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2772
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2926
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..2962
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3155
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3309
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3386
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3476
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3534
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3621
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..4192
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4172..4177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /note="hexamer: AATAAA"
     polyA_site      4192
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /note="major polyA site"
ORIGIN      
        1 agactggcgg gcgggcgggc actgacgccg cggggccgga gcgggccgcg cggtgggagc
       61 agcggcgccg tcggtccccg tcagggctcc gtgggtcccc gacccgcccc tggccgggcc
      121 atggcgggcg cccagcccgg cgtccacgcg ctgcagttgg agccgcccac cgtggtggag
      181 accctgcggc gcgggagtaa gttcatcaaa tgggacgagg agacctccag tcggaacctg
      241 gtgaccctgc gtgtggaccc caatggcttc ttcttgtact ggacgggccc caacatggag
      301 gtggacacac tggacatcag ttccatcagg gacacacgga caggccggta cgcccgcctg
      361 cccaaggacc ccaagatccg ggaagttctg ggctttgggg gtcccgatgc ccggctggag
      421 gagaagctga tgacggtggt gtctgggcca gacccagtga acacagtgtt cttgaacttc
      481 atggccgtgc aggatgacac agccaaggtc tggtctgagg agctattcaa gctggctatg
      541 aacatcctgg ctcagaacgc ctcccggaac accttcctgc gcaaagcata cacgaagctg
      601 aagctgcagg tgaaccagga tggtcggatc cccgtcaaga acatcctgaa gatgttctca
      661 gcagacaaga agcgggtgga gactgcgctg gaatcctgtg gcctcaaatt caaccggagt
      721 gagtccatcc ggcctgatga gttttccttg gaaatctttg agcggttcct gaacaagctg
      781 tgtctgcggc cggacattga caagatcctg ctggagatag gcgccaaggg caagccatac
      841 ctgacgctgg agcagctcat ggacttcatc aaccagaagc aacgcgaccc gagactcaac
      901 gaagtgctgt acccgcccct gcggccctcc caggcccggc tgctcatcga aaagtatgag
      961 cccaaccagc agtttctgga gcgagaccag atgtccatgg agggctttag ccgctacctg
     1021 ggaggcgagg agaatggcat cctgcccctg gaagccctgg atctgagcac ggacatgacc
     1081 cagccactga gtgcctactt catcaactcc tcgcataaca cctatctcac tgcggggcag
     1141 ctggctggga cctcgtcggt ggagatgtac cgccaggcac tactatgggg ctgccgctgc
     1201 gtggagctgg acgtgtggaa gggacggccg cctgaggagg aacccttcat tacccacggc
     1261 ttcaccatga ccacagaggt gcctctgcgc gacgtgctgg aggccattgc cgagactgcc
     1321 ttcaagacct cgccctaccc cgtcatcctc tccttcgaga accatgtgga ctcggcaaag
     1381 caacaggcaa agatggctga gtactgccgc tccatctttg gagacgcgct actcatcgag
     1441 cctctggaca agtacccgct ggccccaggc gttcccctgc ccagccccca ggacctgatg
     1501 ggccgtatcc tggtgaagaa caagaagcgg caccgaccca gcgcaggtgg cccagacagc
     1561 gccgggcgca agcggcccct ggagcagagc aattctgccc tgagcgagag ctccgcggcc
     1621 accgagccct cctccccgca gctggggtct cccagctctg acagctgccc aggcctgagc
     1681 aatggggagg aggtagggct tgagaagccc agcctggagc ctcagaagtc tctgggtgac
     1741 gagggcctga accgaggccc ctatgttctt ggacctgctg accgtgagga tgaggaggaa
     1801 gatgaggaag aggaggaaca gacagacccc aaaaagccaa ctacagatga gggcacagcc
     1861 agcagcgagg tgaatgccac tgaggagatg tccacgcttg tcaactacat cgaacctgtc
     1921 aagttcaagt cctttgaggc tgctcgaaag aggaacaaat gcttcgagat gtcgtccttt
     1981 gtggagacca aggccatgga gcaactgacc aagagcccca tggagtttgt ggaatacaac
     2041 aagcagcagc tcagccgcat ctaccccaag ggcacccgcg tggactcctc caactacatg
     2101 ccccagctct tctggaacgt agggtgccag cttgttgcgc tcaacttcca gaccctcgat
     2161 gtggcgatgc agctcaacgc gggcgttttt gagtacaacg ggcgcagcgg gtacctgctc
     2221 aagccggagt tcatgcggcg gccggacaag tccttcgacc ccttcactga ggtcatcgtg
     2281 gatggcatcg tggccaatgc cttgcgggtc aaggtgatct cagggcagtt cctgtccgac
     2341 aggaaggtgg gcatctacgt ggaggtggac atgtttggcc tccctgttga tacgcggcgc
     2401 aagtaccgca cccggacctc tcaggggaac tcgttcaacc ccgtgtggga cgaagagccc
     2461 ttcgacttcc ccaaggtggt gctgcccacg ctggcttcac ttcgcattgc agcctttgag
     2521 gaggggggta aattcgtagg gcaccggatc ctgcctgtct ctgccatccg ctccggatac
     2581 cactacgtct gcctgcggaa cgaggccaac caaccgctgt gcctgccggc cctgctcatc
     2641 tacaccgaag cctcggacta cattcctgac gaccaccagg actatgcgga ggccctgatc
     2701 aaccccatta agcacgtcag cctgatggac cagagggccc ggcagctggc cgccctcatt
     2761 ggggagagtg aggctcaggc tggccaagag acgtgccagg acacccagtc tcagcagctg
     2821 gggtctcagc cgtcctcaaa ccccaccccc agcccactgg atgcctcccc ccgccggccc
     2881 cctggcccca ccacctcccc tgccagcacc tccctcagca gcccagggca gcgtgatgat
     2941 ctcatcgcca gcatcctctc agaggtggcc cccaccccgc tggatgagct ccgaggtcac
     3001 aaggctctgg tcaagctccg gagccggcaa gagcgagacc tgcgggagct gcgcaagaag
     3061 catcagcgga aggcagtcac cctcacccgc cgcctgctgg atggcctggc tcaggcacag
     3121 gctgagggca ggtgccggct gcggccaggt gccctaggtg gggccgctga tgtggaggac
     3181 acgaaggagg gggaggacga ggcaaagcgg tatcaggagt tccagaacag acaggtgcag
     3241 agcctgctgg agctgcggga ggcccaggtg gacgcagagg cccagcggag gctggaacac
     3301 ctgagacagg ctctgcagcg gctcagggag gtcgtccttg atgcaaacac aactcagttc
     3361 aagaggctga aagagatgaa cgagagggag aagaaggagc tgcagaagat cctggacaga
     3421 aagcgccata acagcatctc ggaggccaag atgagggaca agcataagaa ggaggcggaa
     3481 ctgacggaga ttaaccgtcg gcacatcact gagtcagtca actccatccg tcggctggag
     3541 gaggcccaga agcagcggca tgaccgtctt gtggctgggc agcagcaggt cctgcaacag
     3601 ctggcagaag aggagcccaa gctgctggcc cagctggccc aggagtgtca ggagcagcgg
     3661 gcgaggctcc cccaggagat ccgccggagc ctgctgggcg agatgccgga ggggctgggg
     3721 gacgggcctc tggtggcctg tgccagcaac ggtcacgcac ccgggagcag cgggcacctg
     3781 tcgggcgctg actcggagag ccaggaggag aacacgcagc tctgaactgg ctgagcgagg
     3841 tggccacagg gccagggcgg gcgctgggtg gagggcagga ggcaatgaca ctaatgcttt
     3901 tttttttttt ttttaacttt ttatctagaa attttatttt tttaaacccg gggcaagtac
     3961 ctcagctaac tcccttcatc ctcctggggc ccctccttcc tgccctcagt cttaggttag
     4021 ggccttggtc agggctttgc tccctgtgac acccacaccc tcgagctagc agcgtctcct
     4081 cccttccccg ggagagctgg ctggagactt ggagctccgg gaagtaggag tcacattttt
     4141 ttctctattc tttggggatt ttttttacat gaataaaagt ggatttcagg ga
//
