LOCUS       NM_004573               4627 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phospholipase C beta 2 (PLCB2), transcript variant 1,
            mRNA.
ACCESSION   NM_004573
VERSION     NM_004573.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4627)
  AUTHORS   Phoenix,K.N., Yue,Z., Yue,L., Cronin,C.G., Liang,B.T.,
            Hoeppner,L.H. and Claffey,K.P.
  TITLE     PLCbeta2 Promotes VEGF-Induced Vascular Permeability
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (10), 1229-1241 (2022)
   PUBMED   35861069
  REMARK    GeneRIF: PLCbeta2 Promotes VEGF-Induced Vascular Permeability.
REFERENCE   2  (bases 1 to 4627)
  AUTHORS   Zhang,H., Xie,T., Shui,Y. and Qi,Y.
  TITLE     Knockdown of PLCB2 expression reduces melanoma cell viability and
            promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals
  JOURNAL   Mol Med Rep 21 (1), 420-428 (2020)
   PUBMED   31746389
  REMARK    GeneRIF: Knockdown of PLCB2 expression reduces melanoma cell
            viability and promotes melanoma cell apoptosis by altering
            Ras/Raf/MAPK signals.
REFERENCE   3  (bases 1 to 4627)
  AUTHORS   Bertagnolo,V., Grassilli,S., Volinia,S., Al-Qassab,Y., Brugnoli,F.,
            Vezzali,F., Lambertini,E., Palomba,M., Piubello,Q., Orvieto,E.,
            Natali,C., Piva,R., Croce,C.M. and Capitani,S.
  TITLE     Ectopic expression of PLC-beta2 in non-invasive breast tumor cells
            plays a protective role against malignant progression and is
            correlated with the deregulation of miR-146a
  JOURNAL   Mol Carcinog 58 (5), 708-721 (2019)
   PUBMED   30582225
  REMARK    GeneRIF: High PLCB2 expression is associated with breast cancer.
REFERENCE   4  (bases 1 to 4627)
  AUTHORS   Brugnoli,F., Grassilli,S., Lanuti,P., Marchisio,M., Al-Qassab,Y.,
            Vezzali,F., Capitani,S. and Bertagnolo,V.
  TITLE     Up-modulation of PLC-beta2 reduces the number and malignancy of
            triple-negative breast tumor cells with a CD133+/EpCAM+ phenotype:
            a promising target for preventing progression of TNBC
  JOURNAL   BMC Cancer 17 (1), 617 (2017)
   PUBMED   28870198
  REMARK    GeneRIF: this work adds substantial information about the role of
            PLC-beta2 in invasive breast tumors, demonstrating that its
            up-regulation in cells with a basal-B triple-negative phenotype is
            sufficient to down-modulate the expression of surface antigens
            crucial for malignancy and to reduce the number of cells with a
            stem-like phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4627)
  AUTHORS   Mao,G., Jin,J., Kunapuli,S.P. and Rao,A.K.
  TITLE     Nuclear factor-kappaB regulates expression of platelet
            phospholipase C-beta2 (PLCB2)
  JOURNAL   Thromb Haemost 116 (5), 931-940 (2016)
   PUBMED   27465150
REFERENCE   6  (bases 1 to 4627)
  AUTHORS   Zauli,G., Previati,M., Caramelli,E., Bassini,A., Falcieri,E.,
            Gibellini,D., Bertolaso,L., Bosco,D., Robuffo,I. and Capitani,S.
  TITLE     Exogenous human immunodeficiency virus type-1 Tat protein
            selectively stimulates a phosphatidylinositol-specific
            phospholipase C nuclear pathway in the Jurkat T cell line
  JOURNAL   Eur J Immunol 25 (9), 2695-2700 (1995)
   PUBMED   7589147
REFERENCE   7  (bases 1 to 4627)
  AUTHORS   Buhl,A.M., Osawa,S. and Johnson,G.L.
  TITLE     Mitogen-activated protein kinase activation requires two signal
            inputs from the human anaphylatoxin C5a receptor
  JOURNAL   J Biol Chem 270 (34), 19828-19832 (1995)
   PUBMED   7649993
REFERENCE   8  (bases 1 to 4627)
  AUTHORS   Park,D., Jhon,D.Y., Kriz,R., Knopf,J. and Rhee,S.G.
  TITLE     Cloning, sequencing, expression, and Gq-independent activation of
            phospholipase C-beta 2
  JOURNAL   J Biol Chem 267 (23), 16048-16055 (1992)
   PUBMED   1644792
REFERENCE   9  (bases 1 to 4627)
  AUTHORS   Berstein,G., Blank,J.L., Jhon,D.Y., Exton,J.H., Rhee,S.G. and
            Ross,E.M.
  TITLE     Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11,
            its physiologic regulator
  JOURNAL   Cell 70 (3), 411-418 (1992)
   PUBMED   1322796
REFERENCE   10 (bases 1 to 4627)
  AUTHORS   Banno,Y., Yada,Y. and Nozawa,Y.
  TITLE     Purification and characterization of membrane-bound phospholipase C
            specific for phosphoinositides from human platelets
  JOURNAL   J Biol Chem 263 (23), 11459-11465 (1988)
   PUBMED   2841328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA981116.1, AB209583.1,
            M95678.1 and BU147302.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004573.2.
            
            Summary: The protein encoded by this gene is a phosphodiesterase
            that catalyzes the hydrolysis of phosphatidylinositol
            4,5-bisphosphate to the second messengers inositol
            1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein
            is activated by G proteins and has been shown to be involved in the
            type 2 taste receptor signal transduction pathway. In addition,
            nuclear factor kappa B can regulate the transcription of this gene,
            whose protein product is also an important regulator of platelet
            responses. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291657.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260402.8/ ENSP00000260402.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               DA981116.1         39-280
            243-2865            AB209583.1         1-2623
            2866-4626           M95678.1           2755-4515
            4627-4627           BU147302.1         296-296
FEATURES             Location/Qualifiers
     source          1..4627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4627
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /note="phospholipase C beta 2"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
     exon            1..347
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..3821
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /EC_number="3.1.4.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphoinositide phospholipase C-beta-2;
                     1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
                     beta-2"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform 1"
                     /protein_id="NP_004564.2"
                     /db_xref="CCDS:CCDS42020.1"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
                     /translation="MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKG
                     YYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVV
                     SGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLN
                     SEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPR
                     PEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEP
                     SGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAG
                     QFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIA
                     ESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPS
                     PEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEE
                     EVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQ
                     KNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAG
                     CQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVAT
                     TLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF
                     EKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIF
                     LEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVN
                     GALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELER
                     RGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEG
                     PEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELK
                     ALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIK
                     QMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACL
                     RTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL"
     exon            348..425
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..494
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..635
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..715
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..769
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..845
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..946
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1113
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1260
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1418
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1501
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1586
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1749
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1862
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1959
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2044
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2169
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2324
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2489
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2589
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2694
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2789
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2865
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2910
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3133
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3299
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3376
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3472
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3530
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3617
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..4627
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4606..4611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4627
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcagtg accacaggcc cccatggcag gcagggcggg tgggaggagg gtgatttaca
       61 aggcagatgg gcctctggct acagctcagt cctgcactca gccagggcca ccccaggggc
      121 tataagagca actagatttc tggagcagct cggggatggg tgccatttga gcccagcttg
      181 gctccccctc ctggctggcc tccttcctgc ccttctgcct gcctgtgtct gctgagattc
      241 tgcaaagagg aacgcttggc accatgtctc tgctcaaccc tgtcctgctg ccccccaagg
      301 tgaaggccta tctgagccaa ggggagcgct tcatcaaatg ggatgatgaa actacagttg
      361 cctctccagt tatcctccgt gtggatccta agggctacta cttatactgg acgtatcaaa
      421 gtaaggagat ggagtttctg gatatcacca gcatccggga tactcgcttt gggaagtttg
      481 ccaagatgcc caagagccag aagctccggg acgtcttcaa catggacttt cctgataaca
      541 gtttcctgct gaagacactc acggtggtgt ccggcccgga catggtggac ctcaccttcc
      601 acaacttcgt ctcctacaag gagaacgtgg gcaaggcctg ggctgaggac gtactggccc
      661 tagtcaaaca tccgctgacg gccaacgcct cccgcagcac cttcctggac aagatccttg
      721 tgaagctcaa gatgcagctc aactctgaag ggaagattcc ggtgaagaac tttttccaga
      781 tgtttcctgc tgaccgcaag cgggtggaag ctgctctcag tgcctgccac ctccccaaag
      841 gcaaaaatga cgccatcaat cctgaggact tcccagaacc tgtctacaag agtttcctca
      901 tgagcctctg tcctcggcca gaaatagatg agatcttcac ttcttaccat gctaaggcca
      961 aaccctacat gacgaaggag cacctgacca aattcatcaa ccagaaacag cgggactccc
     1021 ggcttaactc cctgctgttc ccgccagcac ggcctgacca ggtgcagggc ctcatcgaca
     1081 agtatgagcc cagtggcatc aatgcacaga ggggccagct gtcacctgaa ggcatggtct
     1141 ggtttctctg tgggccagag aacagcgtgc tggcccagga caagctgctg ctccaccacg
     1201 acatgacgca gccactcaat cattacttca tcaactcgtc ccacaacacc tacctgacag
     1261 ccggccagtt ctcaggcctc tcctcggctg agatgtaccg ccaggtgctg ctctctggct
     1321 gccgttgcgt ggagctagac tgctggaagg ggaaaccccc tgacgaggag cccattatca
     1381 cccatggctt caccatgacc acagacatct tcttcaaaga agcaattgag gctattgcag
     1441 aaagcgcctt taagacctcc ccctatccca tcatcctgtc gtttgagaac catgtggact
     1501 caccccgcca gcaggctaag atggctgagt attgccggac gatctttggg gatatgctgc
     1561 tcacagagcc cctggaaaag ttcccactaa aaccaggtgt ccccctgccc agccctgagg
     1621 atctcagggg caagatcctc atcaagaaca agaagaacca gttttctggc cccacctcct
     1681 ccagtaagga tactggtggg gaggctgagg gcagcagccc acccagtgcc cctgcaggtg
     1741 agggcacagt gtgggctggc gaggaaggga ctgagctgga ggaggaggag gtggaagagg
     1801 aagaggagga ggagtcagga aacctggatg aagaagagat taagaagatg cagtcggatg
     1861 agggcacagc gggcctggaa gtgacggctt atgaggagat gtccagccta gtcaattaca
     1921 tccagcccac caagttcgtc tcctttgagt tctctgccca aaagaaccga agttatgtca
     1981 tctcgtcctt cacagagctc aaggcatatg acctgctctc caaggcctcg gtgcagtttg
     2041 tggactacaa caagcgccag atgagccgca tttaccccaa gggaacccgc atggactcct
     2101 ccaactacat gccccagatg ttctggaatg ctggatgcca gatggttgcc ctcaacttcc
     2161 agacgatgga cttgcccatg cagcagaaca tggcagtatt tgagttcaac gggcagagcg
     2221 gctacctcct caagcatgag ttcatgcgcc ggccggacaa gcagttcaac cccttctcag
     2281 tggaccgcat cgacgtggtg gtggccacca ccctttccat tacggtgatc tctgggcagt
     2341 tcctgtcaga acgcagcgtg cgcacctatg tagaagtgga gctgtttggc cttcctgggg
     2401 accccaagag gcgctatcga actaagctgt cacccagtac taactccatc aatcctgtct
     2461 ggaaggagga gccctttgtc tttgagaaga tcttgatgcc tgagctggcc tccctcagag
     2521 tggctgtgat ggaggaaggc aacaagtttc ttggacaccg catcatcccc atcaatgccc
     2581 taaattctgg gtaccaccac ctgtgcctgc acagtgagag caacatgccc ctcaccatgc
     2641 ctgcgctctt catcttcctg gagatgaagg actacatacc tggtgcttgg gcagatctca
     2701 ctgtggccct cgccaacccc attaagttct tcagtgccca tgacacgaag tctgtgaagc
     2761 tcaaggaggc catgggaggt ctgcctgaga agcccttccc actggcgagt ccagttgcca
     2821 gccaggtcaa tggggcgttg gccccaacga gcaatgggtc accagcagcc agggccgggg
     2881 ccagggaaga ggctatgaaa gaagctgcgg agccgcggac cgccagcctg gaggagctcc
     2941 gggagctaaa gggcgtggtg aagctgcagc ggcggcacga gaaggagctg cgagagttgg
     3001 agcggcgcgg agcgcggcgc tgggaggagc tgctgcagcg gggcgcggcg cagctggcgg
     3061 agctcgggcc accgggcgtg gggggcgtcg gggcctgcaa gctcggtccc ggcaagggct
     3121 ctcgcaagaa gaggagcctg ccccgcgagg agagcgccgg agccgcgccg ggcgagggcc
     3181 ctgagggcgt ggacgggcgc gtgcgggagc tgaaagacag gctggagctg gagctgctgc
     3241 ggcagggcga ggagcagtac gagtgcgttc tgaagcgcaa ggagcagcac gtggccgagc
     3301 aaatctccaa aatgatggag ctggccagag agaaacaggc ggcagagctg aaggccctga
     3361 aggagacgtc ggagaacgac accaaagaga tgaagaaaaa gctggagaca aagagactgg
     3421 agcggatcca gggcatgacc aaagtcacca cagacaagat ggcccaggag aggttgaaga
     3481 gagagattaa caactcccac atccaggaag tagtgcaggt gatcaagcag atgacggaga
     3541 acttggagag gcaccaggag aagctggagg agaagcaggc ggcttgcctg gaacagatac
     3601 gggagatgga aaagcagttc cagaaggagg cgctggcaga gtacgaggcc aggatgaagg
     3661 gtctggaggc agaggtgaag gagtcggtga gggcctgcct caggacctgc tttccctccg
     3721 aggccaagga caagcctgag agggcctgcg agtgcccccc agagctgtgt gagcaggacc
     3781 cactcatagc aaaggcagat gcccaggaga gccgcctctg atgcccccat cccactggga
     3841 catttagcaa ggaggttcag ccccttctct gggatgtggt tctattcccc caggaaaaag
     3901 gagccccagc cttctgaggc tgtgggaacc tgtggctgcc ttggacgctg cagccccctc
     3961 ctcaacggcc aggccagagt ctgagacagg acccaggcac cctcacggca gggcctctct
     4021 ggggcctaga agtcttctca agctgacttc ctacctcccc ctccatctct agataagtgt
     4081 catatatttg ttgagggcaa aagactatgg actggaaggc agaaagtggg atcctggccc
     4141 cactctgcct ttcctattga gcaaccagct ctgggctcag tttcctcacc tggagggttg
     4201 gacccactca cctccactct agccccgaac cctcctgccc caggcttcca ggccccatca
     4261 ggcctgccct gagttggcct tgtccactcc ttgaggcaga tcctggcact acctcacagc
     4321 tccctgggga cggccactcc ctggctgagg gccctcccct cccctctgcc tgtccggaac
     4381 gggaggctga aatggaaaag ctgccttggc cctgcttggc tgagtcacaa ggggcagtgg
     4441 gctcttgggt gctgttccac cctgaccctg gctcacccct cttcctaggc ctgggggcag
     4501 gcagttccta ccatgtaccc ctctcaggct gcctgcctga caaggtcagc atcatttgct
     4561 ctcctgaatt tatgaggttt atttattttt ctctttccta ctcctattaa agaacctcgt
     4621 cccagtg
//
