LOCUS       NM_173542               4787 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens phospholipase B domain containing 2 (PLBD2),
            transcript variant 1, mRNA.
ACCESSION   NM_173542
VERSION     NM_173542.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4787)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4787)
  AUTHORS   Jensen,A.G., Chemali,M., Chapel,A., Kieffer-Jaquinod,S., Jadot,M.,
            Garin,J. and Journet,A.
  TITLE     Biochemical characterization and lysosomal localization of the
            mannose-6-phosphate protein p76 (hypothetical protein LOC196463)
  JOURNAL   Biochem J 402 (3), 449-458 (2007)
   PUBMED   17105447
  REMARK    GeneRIF: describe the identification of p76 by MS and we analyze
            several of its biochemical characteristics
REFERENCE   3  (bases 1 to 4787)
  AUTHORS   Morgan,C.P., Insall,R., Haynes,L. and Cockcroft,S.
  TITLE     Identification of phospholipase B from Dictyostelium discoideum
            reveals a new lipase family present in mammals, flies and
            nematodes, but not yeast
  JOURNAL   Biochem J 382 (Pt 2), 441-449 (2004)
   PUBMED   15193148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030618.2, AC010178.40 and CN412955.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173542.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.117570.1, BC030618.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280800.5/ ENSP00000280800.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1574              BC030618.2         15-1588
            1575-1575           AC010178.40        40974-40974         c
            1576-2554           BC030618.2         1590-2568
            2555-2811           CN412955.1         129-385
            2812-4787           AC010178.40        37210-39185         c
FEATURES             Location/Qualifiers
     source          1..4787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..4787
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /note="phospholipase B domain containing 2"
                     /db_xref="GeneID:196463"
                     /db_xref="HGNC:HGNC:27283"
                     /db_xref="MIM:620097"
     exon            1..304
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1784
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PLB homolog 2; mannose-6-phosphate protein
                     associated protein p76; lamina ancestor homolog 2;
                     LAMA-like protein 2; phospholipase B-like 2 32 kDa form;
                     phospholipase B-like 2 45 kDa form; putative phospholipase
                     B-like 2; 76 kDa protein; phospholipase B
                     domain-containing protein 2"
                     /codon_start=1
                     /product="putative phospholipase B-like 2 isoform 1
                     precursor"
                     /protein_id="NP_775813.2"
                     /db_xref="CCDS:CCDS9168.1"
                     /db_xref="GeneID:196463"
                     /db_xref="HGNC:HGNC:27283"
                     /db_xref="MIM:620097"
                     /translation="MVGQMYCYPGSHLARALTRALALALVLALLVGPFLSGLAGAIPA
                     PGGRWARDGQVPPASRSRSVLLDVSAGQLLMVDGRHPDAVAWANLTNAIRETGWAFLE
                     LGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEYEVGYCERLKSFLE
                     ANLEWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKFTIKPLGFLLLQ
                     LSGDLEDLELALNKTKIKPSLGSGSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKK
                     YWLQFREGPWGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALW
                     KYVRPRGCVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPS
                     PGSRVLTILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDW
                     FSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACNPQPNGENAISAR
                     SDLNPANGSYPFQALRQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSP
                     FSGLLHMGQPDLWKFAPVKVSWD"
     exon            305..398
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            399..557
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            558..658
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            659..873
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            874..971
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1132
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1228
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1300
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1453
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1616
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..4787
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4705..4710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /note="hexamer: AATAAA"
     polyA_site      4715
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /note="major polyA site"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /note="hexamer: AATAAA"
     polyA_site      4787
                     /gene="PLBD2"
                     /gene_synonym="P76"
                     /note="major polyA site"
ORIGIN      
        1 agcattgtgc ggtcatggtg ggccagatgt actgctaccc cggcagccac ctggcccggg
       61 cgctgacgcg ggcgctggcg ctggccctgg tgctggccct gctggtcggg ccgttcctga
      121 gcggcctggc gggggcgatc ccagcgccgg ggggccgctg ggcgcgcgat gggcaggtcc
      181 ctccagcctc ccgcagccgc tcggtgctcc tggacgtctc ggcgggccag ctgcttatgg
      241 tggacggacg ccaccctgac gccgtggcct gggccaacct caccaacgcc atccgcgaga
      301 ctgggtgggc cttcctggag ctgggcacaa gtggccaata caatgacagc ttgcaggcct
      361 atgcagccgg tgtggtggag gctgctgtgt cggaggagct catctacatg cactggatga
      421 acacggtggt gaattactgc ggccccttcg agtatgaagt cggctactgc gagaggctga
      481 agagcttcct ggaggccaac ctagagtgga tgcaggaaga gatggagtca aacccagact
      541 caccttactg gcaccaggtg cggctgaccc tcctgcagct gaaaggcctg gaggacagct
      601 acgaaggccg tgtgagcttc ccagctggga agttcaccat caaacccttg gggttcctcc
      661 tgctgcagct ctctggggac ctggaagacc tggagctggc cctgaacaag accaagatca
      721 aaccttctct gggctctggc tcctgttctg ccctcatcaa gctgctccct ggccagagtg
      781 acctcctggt tgcccacaac acctggaaca actaccagca catgctgcgt gtcatcaaga
      841 agtactggct ccagttccgg gaaggcccct ggggggacta cccgctggtt cccggcaaca
      901 agctggtctt ctcctcctac cccggcacca tcttctcctg cgacgacttc tacatcctgg
      961 gcagtgggct ggtgacactg gagaccacca ttggcaacaa gaacccagcc ctgtggaagt
     1021 atgtgcggcc caggggctgt gtgctggagt gggtacgcaa catcgtggcc aaccgcctgg
     1081 cctcggatgg ggccacctgg gcagacatct tcaagaggtt caacagcggc acgtataaca
     1141 accagtggat gatcgtggac tacaaggcgt tcatcccggg tgggcccagc cccgggagcc
     1201 gggtgcttac catcctggag cagatccccg gcatggtggt ggtggctgac aagacctcgg
     1261 agctctacca gaagacctac tgggccagct acaacatacc gtccttcgag actgtgttca
     1321 atgccagtgg gctgcaggcc ctagtggccc agtatgggga ctggttttct tatgacggga
     1381 gcccccgggc ccagatcttc cggcggaacc agtcactggt acaagacatg gactccatgg
     1441 tcaggctgat gaggtacaat gacttcctcc atgaccctct gtcactgtgc aaagcctgca
     1501 acccccagcc caatggggag aatgctatct ccgcccgctc cgacctcaac ccggccaatg
     1561 gctcctaccc cttccaggcc ctgcgtcagc gctcccatgg gggtatcgat gtgaaggtga
     1621 ccagcatgtc actggccagg atcctgagcc tgctggcggc cagcggtccc acgtgggacc
     1681 aggtgccccc gttccagtgg agcacctcgc ccttcagcgg cctgctgcac atgggccagc
     1741 cagacctctg gaagttcgcg cctgtcaagg tttcatggga ctgaagttct gtccctgctc
     1801 tgctgctttc gcccctgctg accctcgtca gggtcacccc cgtcccaagg ccaccggact
     1861 tctaactcca gcccctcctg ggggcttcgt tctctgatct ggggtctgag tcatctcctc
     1921 ctagagtggg tcacgaacct gatggggctc agaactgacc ccctctctcc cccgaggtgg
     1981 gtgggcaccg tggcgtctct tctgccctgc cctaaatctc ccactctctg tttctgtctg
     2041 tttcctactg ctgctctctc aacctcattc ccacctctgg ggccccttcc tcgtgcttct
     2101 ccttcctgag ggtttgggaa ggtcctgggg cagactctgg ggctcccatg gggtggaagg
     2161 agcctgttcc agcacccttc tcccagctgc attcccacgg gtggccctgg agctggtgag
     2221 ctttgtctgg gcgttgtctt cggctggcat tgctcctccc agctctggcc cctctgctcc
     2281 ctcaggaagc agtcccctcg tctccctttc tgggcagctt ccttgaggac agaaacttga
     2341 aaacaaacac aaaccaaagt ttctggccat ctgtggctgg agggttctga atgtcctctc
     2401 tccatgtcag gcagagggtc agcccccatg cttctgcctc aggccccacc ccaccccacc
     2461 ccaggcctgc ccctcacctc agggccatac ccacagcgcc ctgatggagg aaccagaccg
     2521 caggctgtgc caccattaaa caagagcggc tgtggcccca tgctgtgctt cttggggtgg
     2581 cagggaaggt ggggtcagcg ctttttctcc tctcaggttt gggttctgcg ccatccccca
     2641 tgcagcctcc tgtgcagccc tctgtctgtc cttctgtcca ttcattcatc tgccaacata
     2701 ctcacccatc atccatctgc acagccttcc acccacccat ccgtcttcca tcatccatcc
     2761 atccatctac ctatccattt atcatccatc cactcaccca tccaaccacc catccaacca
     2821 ttcagccatc tccatctgtc cattttcttt cttcttcttt tttttttgtt tttgtttttt
     2881 ctgagtggga gtttcactct attgcccagg ctggagtgca atggcataat ctctgctcac
     2941 tgcaacctct gcttcctggg ttcaagcgat tctcctgcct tagcttccca agtagctggg
     3001 gttacaggca tgagccacca tgcctggcta attttgtatt tttagtagag acagggtttc
     3061 accatgttgg ccaggctggt ctcgaactcc tggcctcaag tgatccgccc gtcttggcct
     3121 cccaaagtgc ttggattaca gatgtgagcc cccgcacctg gcctcatttg tccattttcc
     3181 atccacttac ccacccaccc atttactcat ccagccattg actcatccat ccacctatga
     3241 gatcagacag ggagggatcc ttttttgtat tggtctgtat accacagcat ggcttacgaa
     3301 gttcttatct atctatcacc catccaccca cccatttatc tacccaccca ttcatccacc
     3361 cacccatcca actacctatc cattcatcca tccacccatc tgccaacgca tccatccatc
     3421 cacccaccca atcatctacc cactcaccta tccacccatc cacctaccta tttgtcaccc
     3481 atccacccat ccatccatcc aatcacccat ccaaccatca atccaaccat tttcatctgt
     3541 tcattttcca tccatctacc cgtccaccca ttcactcctc catccaccta cctatccatt
     3601 tatcacccat ttacccatcc atccatccat ccttccaacc atttatccac ccatccaaac
     3661 atttccatct gtttttccat ccatctaccc atccacccat tcactcatcc atccaccttc
     3721 ctatccattt atcatccatc tacccactca cccatccatc caaccttcca accatttatc
     3781 cacccatcca actatttcca tctgttcatt ttccacccat ttacccatct actaattcac
     3841 tcatccatcc acctacctat ccatttatca tccatctacc cactcaccca tccatccatc
     3901 cttccaacca tttatccacc catccaacca tttccatctg ttcatttcca tccatctacc
     3961 catctaccca ttcactcatc cgtccaccta tccatttatc acccatctac ccatccatcc
     4021 acccactcat ccatccattc atccatccac ccacccaccc gtccatccac ctacctattc
     4081 atttatcacc catccatcca cacacgggtc tgtgcagatt cattaatatc cacccatgca
     4141 tccatattta tctattttct atccatcagc catccattca ttcatatcca tccatccatc
     4201 tatccatcca gatgtttatt gagcacctgt gttctgggtc ctatttggga gccttgttaa
     4261 ccaccaagac cttcctaagc catattgtgg tatacagaca gatacaaaaa aaaaggctct
     4321 ctccctgtct gatctcatgc agcctgcctt ggagacaaga ctctcccagt gctgtgtgct
     4381 tggagagagg aaagcacaca gccctggagt cagagacctg ggtttcaatt ctgtctccac
     4441 ctcttattag ctagctatgg actcctctct gagcctcgat tacctcatct gtgaaatggg
     4501 gtaatggtgt gagcagcgtt tccctggggg atgtgatgca gcccacttgg ggcctcatgc
     4561 actcagcatc tctttattag caaacactta ttgaacccct agtacatgcc aggcactgtt
     4621 atgaggtccc ggggatactt tataacaaaa gggacagaag cattcctgct cttgtgaagt
     4681 ttacattgac tagatagtaa acaaaataaa tgaaatatgc agtgtgtcag tgctggtaaa
     4741 cccgtggaga aaataaagca aggttggggt ctggggttgg gaattga
//
