LOCUS       NM_024829               1960 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipase B domain containing 1 (PLBD1), mRNA.
ACCESSION   NM_024829
VERSION     NM_024829.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1960)
  AUTHORS   Vanhaverbeke,M., Vausort,M., Veltman,D., Zhang,L., Wu,M.,
            Laenen,G., Gillijns,H., Moreau,Y., Bartunek,J., Van De Werf,F.,
            Devaux,Y., Janssens,S. and Sinnaeve,P.R.
  CONSRTM   EU-CardioRNA COST Action CA17129
  TITLE     Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New Independent
            Predictors of Left Ventricular Dysfunction After Acute Myocardial
            Infarction
  JOURNAL   Circ Genom Precis Med 12 (12), e002656 (2019)
   PUBMED   31756302
  REMARK    GeneRIF: Peripheral Blood RNA Levels of QSOX1 and PLBD1 Are New
            Independent Predictors of Left Ventricular Dysfunction After Acute
            Myocardial Infarction.
REFERENCE   2  (bases 1 to 1960)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (bases 1 to 1960)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   4  (bases 1 to 1960)
  AUTHORS   Xu,S., Zhao,L., Larsson,A. and Venge,P.
  TITLE     The identification of a phospholipase B precursor in human
            neutrophils
  JOURNAL   FEBS J 276 (1), 175-186 (2009)
   PUBMED   19019078
REFERENCE   5  (bases 1 to 1960)
  AUTHORS   Morgan,C.P., Insall,R., Haynes,L. and Cockcroft,S.
  TITLE     Identification of phospholipase B from Dictyostelium discoideum
            reveals a new lipase family present in mammals, flies and
            nematodes, but not yeast
  JOURNAL   Biochem J 382 (Pt 2), 441-449 (2004)
   PUBMED   15193148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008114.25.
            
            On Nov 23, 2018 this sequence version replaced NM_024829.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.50959.1,
                                           SRR1660809.77520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240617.10/ ENSP00000240617.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC008114.25        89879-90180         c
            303-522             AC008114.25        75490-75709         c
            523-606             AC008114.25        64505-64588         c
            607-745             AC008114.25        63061-63199         c
            746-886             AC008114.25        58867-59007         c
            887-1031            AC008114.25        57956-58100         c
            1032-1232           AC008114.25        33808-34008         c
            1233-1373           AC008114.25        33557-33697         c
            1374-1559           AC008114.25        29230-29415         c
            1560-1666           AC008114.25        28459-28565         c
            1667-1960           AC008114.25        25958-26251         c
FEATURES             Location/Qualifiers
     source          1..1960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..1960
                     /gene="PLBD1"
                     /note="phospholipase B domain containing 1"
                     /db_xref="GeneID:79887"
                     /db_xref="HGNC:HGNC:26215"
                     /db_xref="MIM:618486"
     exon            1..302
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1849
                     /gene="PLBD1"
                     /note="PLB homolog 1; putative phospholipase B-like 1;
                     LAMA-like protein 1; lamina ancestor homolog 1;
                     phospholipase B domain-containing protein 1"
                     /codon_start=1
                     /product="phospholipase B-like 1 precursor"
                     /protein_id="NP_079105.4"
                     /db_xref="CCDS:CCDS31751.1"
                     /db_xref="GeneID:79887"
                     /db_xref="HGNC:HGNC:26215"
                     /db_xref="MIM:618486"
                     /translation="MTRGGPGGRPGLPQPPPLLLLLLLLPLLLVTAEPPKPAGVYYAT
                     AYWMPAEKTVQVKNVMDKNGDAYGFYNNSVKTTGWGILEIRAGYGSQTLSNEIIMFVA
                     GFLEGYLTAPHMNDHYTNLYPQLITKPSIMDKVQDFMEKQDKWTRKNIKEYKTDSFWR
                     HTGYVMAQIDGLYVGAKKRAILEGTKPMTLFQIQFLNSVGDLLDLIPSLSPTKNGSLK
                     VFKRWDMGHCSALIKVLPGFENILFAHSSWYTYAAMLRIYKHWDFNVIDKDTSSSRLS
                     FSSYPGFLESLDDFYILSSGLILLQTTNSVFNKTLLKQVIPETLLSWQRVRVANMMAD
                     SGKRWADIFSKYNSGTYNNQYMVLDLKKVKLNHSLDKGTLYIVEQIPTYVEYSEQTDV
                     LRKGYWPSYNVPFHEKIYNWSGYPLLVQKLGLDYSYDLAPRAKIFRRDQGKVTDTASM
                     KYIMRYNNYKKDPYSRGDPCNTICCREDLNSPNPSPGGCYDTKVADIYLASQYTSYAI
                     SGPTVQGGLPVFRWDRFNKTLHQGMPEVYNFDFITMKPILKLDIK"
     exon            303..522
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..606
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..745
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..886
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1031
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1232
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1373
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1559
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1666
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1960
                     /gene="PLBD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLBD1"
                     /note="hexamer: AATAAA"
     polyA_site      1960
                     /gene="PLBD1"
                     /note="major polyA site"
ORIGIN      
        1 accacgtgaa gcgtcctcgc ccctcagagc ccggagcagg ccgggctcaa gaaagaggaa
       61 agttgaggac gccccacctc ggagaggcgg cgcccctgag taggccagga gcctctcttg
      121 caacttctgc caccgcgggc caccgcggcc gcctgatccc gcagaggaag gtcgcggccg
      181 tggagcgatg acccgcggcg gtccgggcgg gcgcccgggg ctgccacagc cgccaccgct
      241 tctgctgctg ctgctgctgc tgccgctgtt gttagtcacc gcggagccgc cgaaacctgc
      301 aggagtctac tatgcaactg catactggat gcctgctgaa aagacagtac aagtcaaaaa
      361 tgtaatggac aagaatgggg acgcctatgg cttttacaat aactctgtga aaaccacagg
      421 ctggggcatc ctggagatca gagctggcta tggctctcaa accctgagca atgagatcat
      481 catgtttgtg gctggctttt tggagggtta cctcactgcc ccacacatga atgaccacta
      541 cacaaacctc tacccacagc tgatcacgaa accttccatc atggataaag tgcaggattt
      601 tatggagaag caagataagt ggacccggaa aaatatcaaa gaatacaaga ctgattcatt
      661 ttggagacat acaggctatg tgatggcaca aatagatggc ctctatgtag gagcaaagaa
      721 gagggctata ttagaaggga caaagccaat gaccctgttc cagattcagt tcctgaatag
      781 tgttggagat ctattggatc tgattccctc actctctccc acaaaaaacg gcagcctaaa
      841 ggtttttaag agatgggaca tgggacattg ctccgctctt atcaaggttc ttcctggatt
      901 tgagaacatc ctttttgctc actcaagctg gtacacgtat gcagccatgc tcaggatata
      961 taaacactgg gacttcaacg tcatagataa agataccagc agtagtcgcc tctctttcag
     1021 cagttaccca gggtttttgg agtctctgga tgatttttac attcttagca gtggattgat
     1081 attgctgcag accacaaaca gtgtgtttaa taaaaccctg ctaaagcagg taatacccga
     1141 gactctcctg tcctggcaaa gagtccgtgt ggccaatatg atggcagata gtggcaagag
     1201 gtgggcagac atcttttcaa aatacaactc tggcacctat aacaatcaat acatggttct
     1261 ggacctgaag aaagtaaagc tgaaccacag tcttgacaaa ggcactctgt acattgtgga
     1321 gcaaattcct acatatgtag aatattctga acaaactgat gttctacgga aaggatattg
     1381 gccctcctac aatgttcctt tccatgaaaa aatctacaac tggagtggct atccactgtt
     1441 agttcagaag ctgggcttgg actactctta tgatttagct ccacgagcca aaattttccg
     1501 gcgtgaccaa gggaaagtga ctgatacggc atccatgaaa tatatcatgc gatacaacaa
     1561 ttataagaag gatccttaca gtagaggtga cccctgtaat accatctgct gccgtgagga
     1621 cctgaactca cctaacccaa gtcctggagg ttgttatgac acaaaggtgg cagatatcta
     1681 cctagcatct cagtacacat cctatgccat aagtggtccc acagtacaag gtggcctccc
     1741 tgtttttcgc tgggaccgtt tcaacaaaac tctacatcag ggcatgccag aggtctacaa
     1801 ctttgatttt attaccatga aaccaatttt gaaacttgat ataaaatgaa ggagggagat
     1861 gacggactag aagactgtaa ataagatacc aaaggcacta ttttagctat gtttttccca
     1921 tcagaattat gcaataaaat atattaattt gtcactttca
//
