LOCUS       NM_002657               5656 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PLAG1 like zinc finger 2 (PLAGL2), mRNA.
ACCESSION   NM_002657
VERSION     NM_002657.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5656)
  AUTHORS   Monno,M., Ogiri,M., Seishima,R., Suzuki,Y., Hattori,K., Matsui,S.,
            Shigeta,K., Okabayashi,K. and Kitagawa,Y.
  TITLE     POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal
            cancer associated with MUC2 expression
  JOURNAL   Cell Biochem Funct 42 (2), e3989 (2024)
   PUBMED   38500386
  REMARK    GeneRIF: POFUT1 and PLAGL2 are characteristic markers of mucinous
            colorectal cancer associated with MUC2 expression.
REFERENCE   2  (bases 1 to 5656)
  AUTHORS   Chen,W., He,Q., Liu,J., Li,N., Xiao,K. and Chen,H.
  TITLE     PLAGL2 promotes Snail expression and gastric cancer progression via
            UCA1/miR-145-5p/YTHDF1 axis
  JOURNAL   Carcinogenesis 44 (4), 328-340 (2023)
   PUBMED   36999803
  REMARK    GeneRIF: PLAGL2 promotes Snail expression and gastric cancer
            progression via UCA1/miR-145-5p/YTHDF1 axis.
REFERENCE   3  (bases 1 to 5656)
  AUTHORS   Wang,G., Shen,K., Xiao,J., Fan,H., Wang,Y., Liu,K., Zhou,X.,
            Cheng,Q., Miao,Y., Xu,Z. and Yang,L.
  TITLE     Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated
            malignant phenotypes in gastric cancer
  JOURNAL   J Gene Med 25 (6), e3487 (2023)
   PUBMED   36807469
  REMARK    GeneRIF: Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated
            malignant phenotypes in gastric cancer.
REFERENCE   4  (bases 1 to 5656)
  AUTHORS   Lin,Y., Lin,P., Guo,W., Huang,J., Xu,X. and Zhuang,X.
  TITLE     PLAGL2 promotes the stemness and is upregulated by transcription
            factor E2F1 in human lung cancer
  JOURNAL   Environ Toxicol 38 (4), 941-949 (2023)
   PUBMED   36620907
  REMARK    GeneRIF: PLAGL2 promotes the stemness and is upregulated by
            transcription factor E2F1 in human lung cancer.
REFERENCE   5  (bases 1 to 5656)
  AUTHORS   Keck,M.K., Sill,M., Wittmann,A., Joshi,P., Stichel,D., Beck,P.,
            Okonechnikow,K., Sievers,P., Wefers,A.K., Roncaroli,F., Avula,S.,
            McCabe,M.G., Hayden,J.T., Wesseling,P., Ora,I., Nister,M.,
            Kranendonk,M.E.G., Tops,B.B.J., Zapotocky,M., Zamecnik,J.,
            Vasiljevic,A., Fenouil,T., Meyronet,D., von Hoff,K., Schuller,U.,
            Loiseau,H., Figarella-Branger,D., Kramm,C.M., Sturm,D., Scheie,D.,
            Rauramaa,T., Pesola,J., Gojo,J., Haberler,C., Brandner,S.,
            Jacques,T., Sexton Oates,A., Saffery,R., Koscielniak,E.,
            Baker,S.J., Yip,S., Snuderl,M., Ud Din,N., Samuel,D., Schramm,K.,
            Blattner-Johnson,M., Selt,F., Ecker,J., Milde,T., von Deimling,A.,
            Korshunov,A., Perry,A., Pfister,S.M., Sahm,F., Solomon,D.A. and
            Jones,D.T.W.
  TITLE     Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key
            feature of the novel tumor type CNS embryonal tumor with PLAGL
            amplification
  JOURNAL   Acta Neuropathol 145 (1), 49-69 (2023)
   PUBMED   36437415
  REMARK    GeneRIF: Amplification of the PLAG-family genes-PLAGL1 and
            PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor
            with PLAGL amplification.
            Erratum:[Acta Neuropathol. 2023 Apr;145(4):511-514. doi:
            10.1007/s00401-023-02538-4.. PMID: 36786841]
REFERENCE   6  (bases 1 to 5656)
  AUTHORS   Landrette,S.F., Kuo,Y.H., Hensen,K., Barjesteh van Waalwijk van
            Doorn-Khosrovani,S., Perrat,P.N., Van de Ven,W.J., Delwel,R. and
            Castilla,L.H.
  TITLE     Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia
            in cooperation with Cbfb-MYH11
  JOURNAL   Blood 105 (7), 2900-2907 (2005)
   PUBMED   15585652
  REMARK    GeneRIF: Plag1 and Plagl2 are novel leukemia oncogenes that act by
            expanding hematopoietic progenitors expressing CbF beta-SMMHC.
REFERENCE   7  (bases 1 to 5656)
  AUTHORS   Yang,M.C., Weissler,J.C., Terada,L.S., Deng,F. and Yang,Y.S.
  TITLE     Pleiomorphic adenoma gene-like-2, a zinc finger protein,
            transactivates the surfactant protein-C promoter
  JOURNAL   Am J Respir Cell Mol Biol 32 (1), 35-43 (2005)
   PUBMED   15361364
  REMARK    GeneRIF: PLAGL2 may modulate SP-C expression during lung
            development.
REFERENCE   8  (bases 1 to 5656)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 5656)
  AUTHORS   Furukawa,T., Adachi,Y., Fujisawa,J., Kambe,T., Yamaguchi-Iwai,Y.,
            Sasaki,R., Kuwahara,J., Ikehara,S., Tokunaga,R. and Taketani,S.
  TITLE     Involvement of PLAGL2 in activation of iron deficient- and
            hypoxia-induced gene expression in mouse cell lines
  JOURNAL   Oncogene 20 (34), 4718-4727 (2001)
   PUBMED   11498794
REFERENCE   10 (bases 1 to 5656)
  AUTHORS   Kas,K., Voz,M.L., Hensen,K., Meyen,E. and Van de Ven,W.J.
  TITLE     Transcriptional activation capacity of the novel PLAG family of
            zinc finger proteins
  JOURNAL   J Biol Chem 273 (36), 23026-23032 (1998)
   PUBMED   9722527
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121897.32 and BC023655.2.
            
            On Sep 14, 2007 this sequence version replaced NM_002657.2.
            
            Summary:  Pleiomorphic adenoma gene-like 2 is a zinc-finger protein
            that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83784.1, AF006005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246229.5/ ENSP00000246229.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL121897.32        20696-20709         c
            15-1824             BC023655.2         1-1810
            1825-5656           AL121897.32        5470-9301           c
FEATURES             Location/Qualifiers
     source          1..5656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..5656
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /note="PLAG1 like zinc finger 2"
                     /db_xref="GeneID:5326"
                     /db_xref="HGNC:HGNC:9047"
                     /db_xref="MIM:604866"
     exon            1..103
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /inference="alignment:Splign:2.1.0"
     exon            104..477
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1708
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /note="C2H2-type zinc finger protein; pleiomorphic
                     adenoma-like protein 2; pleiomorphic adenoma gene-like 2"
                     /codon_start=1
                     /product="zinc finger protein PLAGL2"
                     /protein_id="NP_002648.1"
                     /db_xref="CCDS:CCDS13197.1"
                     /db_xref="GeneID:5326"
                     /db_xref="HGNC:HGNC:9047"
                     /db_xref="MIM:604866"
                     /translation="MTTFFTSVPPWIQDAKQEEEVGWKLVPRPRGREAESQVKCQCEI
                     SGTPFSNGEKLRPHSLPQPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMY
                     CDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKV
                     CLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKD
                     FLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVL
                     CMASRDVMGTKAFPGMLPMGMYGAHIPTMPSTGVPHSLVHNTLPMGMSYPLESSPISS
                     PAQLPPKYQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLD
                     EALLAKSPANLSEALCAANVDFSHLLGFLPLNLPPCNPPGATGGLVMGYSQAEAQPLL
                     TTLQAQPQDSPGAGGPLNFGPLHSLPPVFTSGLSSTTLPRFHQAFQ"
     exon            478..5656
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2519..2524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /note="hexamer: AATAAA"
     polyA_site      2543
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /note="major polyA site"
     regulatory      5632..5637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
                     /note="hexamer: ATTAAA"
     polyA_site      5656
                     /gene="PLAGL2"
                     /gene_synonym="ZNF900"
ORIGIN      
        1 acaatgcacc gcacaatggc ccgaccgccg ccactaccgg ggcctgaggg ggcctggcgg
       61 agcccgagcg cggcccggcc cgcagcgtgg ggccccgagc gcggtgaaga gattgttttc
      121 tgaaagctgc gttggaggct gtgacagagc tgagagcctg tgtggagcgg atggggaggc
      181 tttctcaata acatggccct ttgccattag ccttgccatg accacatttt tcaccagcgt
      241 ccccccctgg attcaagatg caaagcagga ggaggaagtg ggctggaaac tagttcccag
      301 gcctcggggc cgggaggcgg agagtcaagt gaagtgccaa tgtgaaattt cgggaacacc
      361 tttctcaaat ggggagaagc tgaggcctca cagcctcccg caaccagagc agagaccata
      421 tagctgccct cagctgcact gtggcaaggc ttttgcttcc aaatacaagc tgtataggca
      481 catggccacc cactcagccc agaaacccca ccagtgtatg tactgtgata agatgtttca
      541 ccgcaaggac catctgcgga accatctgca gacccatgat cctaacaaag aggccctcca
      601 ctgctctgag tgcggtaaga attacaatac gaagctgggc taccggcgcc acctggccat
      661 gcatgctgcc agcagcggtg acctcagctg caaggtgtgc ctgcagacct ttgagagtac
      721 ccaggccctg ctagagcacc tgaaggccca ctcacgccgg gtagcaggcg gtgccaagga
      781 gaagaagcac ccctgtgacc actgcgaccg gcggttctat actcgtaagg atgtacggcg
      841 gcacctagtg gtgcacacag gccgtaagga cttcctgtgc cagtactgtg cccagcggtt
      901 tggccgtaag gaccacctga cgcgtcatgt caagaagagc cactcgcagg agctgctcaa
      961 gatcaagaca gagcccgtgg acatgttagg cctactcagc tgcagctcca cagtcagtgt
     1021 gaaggaagag ctgagccctg tgctgtgcat ggcctctcgg gacgtaatgg ggaccaaggc
     1081 cttccctggc atgttgccca tgggcatgta tggtgcccac atccctacca tgcccagcac
     1141 gggcgtgcca cactccctgg tgcacaacac gctgcccatg ggtatgagct accctctgga
     1201 atcctcacct atctcttccc cagctcagct ccctccaaaa taccagcttg gatctacctc
     1261 atacttgccc gacaaattgc ccaaagtgga ggtggatagt tttctggcgg agcttcctgg
     1321 aagcctgtct ctctcatccg ctgaacccca gcccgcctca cctcagccgg cggcagctgc
     1381 ggccctccta gatgaagcac tgcttgccaa gagccccgcc aacctctctg aggccctctg
     1441 cgctgctaat gtggacttct cccacctact gggctttctt ccactcaacc tgcccccgtg
     1501 taacccacct ggggccacag gaggcctggt catgggctac tcccaggctg aggcacagcc
     1561 cctgcttacc actttgcaag ctcagcctca agattcccca ggagctgggg gaccactgaa
     1621 ctttgggcct ctgcactcct tgcctcctgt cttcacgtct ggcctgagta gcaccaccct
     1681 gcctcgtttc catcaagcat tccagtagcc cccacagagg ccctcagctc agtttttggc
     1741 tctgttatgg agccttagta cccaccccgt ctgtgtcccc catgaaggca gctgagcttt
     1801 cagagctggg ttcaaaaaaa aaaattccag tgtctgtata caggagcact tggtttgggg
     1861 gttcaggctc taggatcgat tccagaagga gccttgagcc ccaaccccgt gaaaagatct
     1921 cataccgtag gacttcaggt attatttact tttatttttt tgacctgaat cgggagccac
     1981 acttggccct cttcctctcc aaagcgccag aacctccttc tctttggaga atggggaggc
     2041 ctcttggaga cacagagggt ttcaccttgg atgacctcta gagaaattgc ccaagaagcc
     2101 caccttctgg tcccaacctg cagaccccac agcagtcagt tggtcaggcc ctgctgtaga
     2161 aggtcacttg gctccattgc ctgcttccaa ccaatgggca ggagagaagg cctttatttc
     2221 tcgcccaccc attcctcctg taccagcacc tccgttttca gtcagtgttg tccagcaacg
     2281 gtaccgttta cacagtcacc tcagacacac catttcacct cccttgccaa gctgttagcc
     2341 ttagagtgat tgcagtgaac actgtttaca caccgtgaat ccattcccat cagtccattc
     2401 cagttggcac cagcctgaac catttggtac ctggtgttaa ctggagtcct gtttacaagg
     2461 tggagtcggg gcttgctgac ttctcttcat ttgaggtcac atttttcccc cgtggggaaa
     2521 taaactgact ttggactgct tcagtctctg ccatcttcca tgactgcatt tgttcctgcc
     2581 tgcctcggcg gtatccacag aagacaggca agaggattgg agcagttttc tcacaggtct
     2641 gcaattctgt ttttctccaa gtacattatg accccctcat ccttctcttg aactggagag
     2701 gggaagaaat gaaaggcatg cccacgtccg tcacctcccc atcccctagt ccccaccttg
     2761 aacatcatga gctgttgtta ttagtcttgg aagcagagtc tgggttggtg tggatagcaa
     2821 aggaggaagt ctgagcccct cattggtctt cctcccacct gtcccttttc cgggaagttg
     2881 tggaattgtt ggaagaagag tttgcagaag gttaggaatg ggtagatagc taagtcctaa
     2941 tctatgggta cattgttgtg tcccaaacca aaattttcct tatccacaat gtcccttctg
     3001 tctcttccac tttacagtgg actcggccac tgtgcatagg cttctctgct ctccatcaaa
     3061 tcacttccac tttcctgtgc ccccaccccc gcctccagtt ttccgctagt atccggcaag
     3121 gtttcttgca acaaatgatt agttcttttc ttctgactcg tggggctccc tgctgcagag
     3181 agcacagccc ttgcctggag cccaggaacc ccatccttgc ttcatctcag ttcttcatgg
     3241 gcttcactct tcccactcac ggaagggagg tagctcaggg acctccactg tgggaccctt
     3301 gagacgcttc cactctgatt cagaaacaca cttctacctc tttactgtta actcttaaca
     3361 gatgcagtca gcagtttctg ggcacttctc tcagtaggtg cctcatgctg acttctccag
     3421 tagggtttca ggacaaacta ccaaggaatt gcctcagcct cctaccagtc ctccctcacc
     3481 caccttctgt ctaggttcac ttggtttgtc atcaggaact gagcaggtcc aggactcagc
     3541 tttctgcttc agcctaagcc agtactcctt gtttgaggta aaagccttaa aatttagctc
     3601 cctagctctt gattagaagc aatttggagt aagtgtgttt tgatttaggc agggtagctt
     3661 gggatacctt tttaaaaaca ccagatatta aaatgtctgg caaggttaga atcagactag
     3721 atgatttgct tctaaaaatt agtttcagtg agtcccaggg actaattaag gtttatttta
     3781 aaaagtgtct accttggtac gcagccacct cctgcatgct gtgcatgtta ttgggacttg
     3841 tattataggt gatggtatgt gagaatccag ttgggactcg ctgttgccat cctctttgtt
     3901 gtatctggtt ttcatcacta gactcagcaa cccttctcac cttaactgcc accttcccta
     3961 cactctcagt ttacagaggc cactgggcct ctggctgcag aatacaaagt cccgggctgt
     4021 tagaggagtc ctttcctctc tgcctgccct ttcctgtccc tccctcgaat tctctctccc
     4081 cgtaagtgat gctggaaaag tcataggact ggcaaagcaa ctgtttaaac cctttgtaac
     4141 cggggccttg cccccacctc ctgtcttttc tccttgcctt ccccactcct gtgtcctccc
     4201 atctatcctg tctttccttt cctcctctca gtgtcctcag cacccacaag gaattttcct
     4261 atcactgtga actttgctgg tacagaggaa taatatctgc cttcaccttt ttttttttgg
     4321 accatagcta gccagtcatt tcttaaacct cccttcctaa aatctggggg gtcgggggga
     4381 aagaaaaaaa aagccttagt ggcctggttg ttcaaaggat aagaatagct ttatcctgca
     4441 ctcagtaccc gaactcactt cagtatgctt actgaggcca tgagaacctg aggggcatct
     4501 gcccaggaca ggagccatgg catatgacaa agaccaatga gggaccagga aaaaaagtga
     4561 tgtccccttt ccctgccacc tccagcctct gccagcaatg agctgtcccc ctcccaccct
     4621 acacagtagc tggtcagggc tgagtacagt cctgggggta aggggatgac atgcccaggt
     4681 gtcagctcaa aggatctctg catcatcttg aggtgggagg cagggaaagg agcgccaatg
     4741 aggttccctg caacccccgc cctccagccc accgcccaac cttttacaaa tggcattttc
     4801 ttaattgaaa atccgggaag caggtgtgat tacttttttg ctcgtagata ttgtcctaag
     4861 ttggaattct cccactgccc taaaactttc cctagtagtc ctttaaactc ccccctccct
     4921 ttttggtagc tgttttctcc gtcctctctc cacctgccct cttatctagg agctgtttgt
     4981 aagcacgatt tttttaacag gttatattgt acaggatcaa tattttgctt tttaacaagg
     5041 atatttatgt aataagaaac tttgccttag gcaggtgttg gccagaaaag tccagattcc
     5101 tctgggatcc caccctggcc tctcctggaa ctctgaacct gctgtggaag gaattggcca
     5161 tgaccttcac ctctggagag tagggtctat ggcgagggaa aagggtgttc accatgataa
     5221 cctagtgcct ccatagaggg gtttggaaaa attccagtcc gatttctttg tgtgtcagct
     5281 gacttcctta gctgattgtt cccacttgca cctctccacc tttggcacta gaactcctga
     5341 gacaccactt ctcatgcttc tccctcccta ccagcggtca aggctttgga gccactcttt
     5401 tgtaactcca gattatttaa agagaaaagt acaagacaga aatcttctag cactttgtaa
     5461 acacagtgaa taacctcttg gagtattttt ggctttatat aaaacaaggt ttttaattgt
     5521 aaagtataag tgccattaga aaatgcacag ggcatatctt tgttaaagta gatttttcaa
     5581 tgttttacag aattacattt tcaaaaaaag gtttttataa tgaagttgtt tattaaaaac
     5641 ttctgaatga tgtgtt
//
