LOCUS       NM_002655               7311 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PLAG1 zinc finger (PLAG1), transcript variant 1, mRNA.
ACCESSION   NM_002655 XM_937873
VERSION     NM_002655.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7311)
  AUTHORS   Li,J., Li,Y., Wang,D., Liao,R. and Wu,Z.
  TITLE     PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib
            induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner
            in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 143 (2024)
   PUBMED   38745179
  REMARK    GeneRIF: PLAG1 interacts with GPX4 to conquer vulnerability to
            sorafenib induced ferroptosis through a PVT1/miR-195-5p
            axis-dependent manner in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7311)
  AUTHORS   Macagno,N., Kervarrec,T., Thanguturi,S., Sohier,P., Pissaloux,D.,
            Mescam,L., Jullie,M.L., Frouin,E., Osio,A., Faisant,M., Le
            Loarer,F., Cribier,B., Calonje,E., Luna,E.V.E., Massi,D., Goto,K.,
            Nishida,H., Paindavoine,S., Houlier,A., Tantot,J., Benzerdjeb,N.,
            Tirode,F., De la Fouchardiere,A. and Battistella,M.
  TITLE     SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions
            Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors
  JOURNAL   Mod Pathol 37 (3), 100430 (2024)
   PUBMED   38266920
  REMARK    GeneRIF: SOX10-Internal Tandem Duplications and PLAG1 or HMGA2
            Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed
            Tumors.
REFERENCE   3  (bases 1 to 7311)
  AUTHORS   Gonzalez,M.F.
  TITLE     Pleomorphic adenoma with extensive squamous and mucinous metaplasia
            and a novel MALAT1::PLAG1 fusion gene
  JOURNAL   Cytopathology 35 (2), 283-285 (2024)
   PUBMED   38084640
  REMARK    GeneRIF: Pleomorphic adenoma with extensive squamous and mucinous
            metaplasia and a novel MALAT1::PLAG1 fusion gene.
REFERENCE   4  (bases 1 to 7311)
  AUTHORS   Keyvani Chahi,A., Belew,M.S., Xu,J., Chen,H.T.T., Rentas,S.,
            Voisin,V., Krivdova,G., Lechman,E., Marhon,S.A., De Carvalho,D.D.,
            Dick,J.E., Bader,G.D. and Hope,K.J.
  TITLE     PLAG1 dampens protein synthesis to promote human hematopoietic stem
            cell self-renewal
  JOURNAL   Blood 140 (9), 992-1008 (2022)
   PUBMED   35639948
  REMARK    GeneRIF: PLAG1 dampens protein synthesis to promote human
            hematopoietic stem cell self-renewal.
REFERENCE   5  (bases 1 to 7311)
  AUTHORS   Murase,T., Ishibashi,K., Okumura,Y., Ueda,K., Nakano,S., Fujii,K.,
            Masaki,A., Nagao,T. and Inagaki,H.
  TITLE     Pleomorphic adenoma: detection of PLAG1 rearrangement-positive
            tumor components using whole-slide fluorescence in situ
            hybridization
  JOURNAL   Hum Pathol 120, 26-34 (2022)
   PUBMED   34906590
  REMARK    GeneRIF: Pleomorphic adenoma: detection of PLAG1
            rearrangement-positive tumor components using whole-slide
            fluorescence in situ hybridization.
REFERENCE   6  (bases 1 to 7311)
  AUTHORS   Kas,K., Voz,M.L., Hensen,K., Meyen,E. and Van de Ven,W.J.
  TITLE     Transcriptional activation capacity of the novel PLAG family of
            zinc finger proteins
  JOURNAL   J Biol Chem 273 (36), 23026-23032 (1998)
   PUBMED   9722527
REFERENCE   7  (bases 1 to 7311)
  AUTHORS   Voz,M.L., Astrom,A.K., Kas,K., Mark,J., Stenman,G. and Van de
            Ven,W.J.
  TITLE     The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas
            results in upregulation of PLAG1 gene expression under control of
            the LIFR promoter
  JOURNAL   Oncogene 16 (11), 1409-1416 (1998)
   PUBMED   9525740
REFERENCE   8  (bases 1 to 7311)
  AUTHORS   Kas,K., Roijer,E., Voz,M., Meyen,E., Stenman,G. and Van de Ven,W.J.
  TITLE     A 2-Mb YAC contig and physical map covering the chromosome 8q12
            breakpoint cluster region in pleomorphic adenomas of the salivary
            glands
  JOURNAL   Genomics 43 (3), 349-358 (1997)
   PUBMED   9268638
REFERENCE   9  (bases 1 to 7311)
  AUTHORS   Kas,K., Voz,M.L., Roijer,E., Astrom,A.K., Meyen,E., Stenman,G. and
            Van de Ven,W.J.
  TITLE     Promoter swapping between the genes for a novel zinc finger protein
            and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12)
            translocations
  JOURNAL   Nat Genet 15 (2), 170-174 (1997)
   PUBMED   9020842
  REMARK    Erratum:[Nat Genet 1997 Apr;15(4):411]
REFERENCE   10 (bases 1 to 7311)
  AUTHORS   Saal,H.M., Harbison,M.D. and Netchine,I.
  TITLE     Silver-Russell Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301499
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U65002.1 and AC107952.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002655.2.
            
            Summary: Pleomorphic adenoma gene 1 encodes a zinc finger protein
            with 2 putative nuclear localization signals. PLAG1, which is
            developmentally regulated, has been shown to be consistently
            rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is
            activated by the reciprocal chromosomal translocations involving
            8q12 in a subset of salivary gland pleomorphic adenomas. Three
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U65002.1, SRR1660807.253401.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316981.8/ ENSP00000325546.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1845              U65002.1           7-1851
            1846-7311           AC107952.5         24501-29966         c
FEATURES             Location/Qualifiers
     source          1..7311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..7311
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /note="PLAG1 zinc finger"
                     /db_xref="GeneID:5324"
                     /db_xref="HGNC:HGNC:9045"
                     /db_xref="MIM:603026"
     exon            1..153
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /inference="alignment:Splign:2.1.0"
     exon            154..258
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /inference="alignment:Splign:2.1.0"
     exon            259..357
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /inference="alignment:Splign:2.1.0"
     exon            358..716
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..1977
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein PLAG1; pleiomorphic adenoma gene 1;
                     COL1A2/PLAG1 fusion; HAS2/PLAG1 fusion"
                     /codon_start=1
                     /product="zinc finger protein PLAG1 isoform a"
                     /protein_id="NP_002646.2"
                     /db_xref="CCDS:CCDS6165.1"
                     /db_xref="GeneID:5324"
                     /db_xref="HGNC:HGNC:9045"
                     /db_xref="MIM:603026"
                     /translation="MATVIPGDLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFN
                     SVEKLKVHSYSHTGERPYKCIQQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFH
                     RKDHLKNHLHTHDPNKETFKCEECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFE
                     STGVLLEHLKSHAGKSSGGVKEKKHQCEHCDRRFYTRKDVRRHMVVHTGRKDFLCQYC
                     AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNVSVPIKDELLPVMSLPSSE
                     LLSKPFTNTLQLNLYNTPFQSMQSSGSAHQMITTLPLGMTCPIDMDTVHPSHHLSFKY
                     PFSSTSYAISIPEKEQPLKGEIESYLMELQGGVPSSSQDSQASSSSKLGLDPQIGSLD
                     DGAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQEEAH
                     SSVSQLPPQTQDLQDPANTIGLGSLHSLSAAFTSSLSTSTTLPRFHQAFQ"
     exon            717..7311
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7045..7050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /note="hexamer: AATATA"
     polyA_site      7063
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /note="major polyA site"
     regulatory      7203..7208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /note="hexamer: ATTAAA"
     polyA_site      7221
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
     regulatory      7289..7294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
                     /note="hexamer: AATAAA"
     polyA_site      7311
                     /gene="PLAG1"
                     /gene_synonym="PSA; SGPA; SRS4; ZNF912"
ORIGIN      
        1 gcatacacta caatggctgc tggaaagagg cgtaaggaaa caatttccag gcccgccgcg
       61 tccagcccga aatatgagaa aaaaattatt agaaattccg cgggcggtgt agaggcggcg
      121 gacgggccgg agggaggatg ttaaagcccc gcggttgcct cttggtgctg ccttggccgt
      181 atttggcacc cagaatgctt cattctgtga cggtctatta ataaggttgc cttgctagag
      241 tttggagcag ggcctcagat tggccaaaat gggaaggatt ggattccact ctcttccacg
      301 aagagtcaat gggactggct aagatcaaag tctgaggctt tttccatcag taatcagtcc
      361 ctttttgctt tcttttacga ccacatgaaa cttgagaagc cacctaaagc tatatcattt
      421 agtggagttg ggcagttccc aagtgtccaa caagaaggcc tggtttaggc tgcgatggcc
      481 actgtcattc ctggtgattt gtcagaagta agagataccc agaaagtccc ttcagggaaa
      541 cgtaagcgtg gtgaaaccaa accaagaaaa aactttcctt gccaactgtg tgacaaggcc
      601 tttaacagtg ttgagaaatt aaaggttcac tcctactctc acacaggaga gaggccctac
      661 aagtgcatac aacaagactg caccaaggcc tttgtttcta agtacaaatt acaaaggcac
      721 atggctactc attctcctga gaaaacccac aagtgtaatt attgtgagaa aatgtttcac
      781 cggaaagatc atctgaagaa tcacctccat acacacgacc ctaacaaaga gacgtttaag
      841 tgcgaagaat gtggcaagaa ctacaatacc aagcttggat ttaaacgtca cttggccttg
      901 catgccgcaa caagtggtga cctcacctgt aaggtatgtt tgcaaacttt tgaaagcacg
      961 ggagtgcttc tggagcacct taaatctcat gcaggcaagt cgtctggtgg ggttaaagaa
     1021 aaaaagcacc agtgcgaaca ttgtgatcgc cggttctaca cccgaaagga tgtccggaga
     1081 cacatggtgg tgcacactgg aagaaaggac ttcctctgtc agtattgtgc acagagattt
     1141 gggcgaaagg atcacctgac tcgacatatg aagaagagtc acaatcaaga gcttctgaag
     1201 gtcaaaacag aaccagtgga tttccttgac ccatttacct gcaatgtgtc tgtgcctata
     1261 aaagacgagc tccttccggt gatgtcctta ccttccagtg aactgttatc aaagccattc
     1321 acaaacactt tgcagttaaa cctctacaac actccatttc agtccatgca gagctcggga
     1381 tctgcccacc aaatgatcac aactttacct ttgggaatga catgcccaat agatatggac
     1441 actgttcatc cctctcacca cctttctttc aaatatccgt tcagttctac ctcatatgca
     1501 atttctattc ctgaaaaaga acagccatta aagggggaaa ttgagagtta cctgatggag
     1561 ttacaaggtg gcgtgccctc ttcatcccaa gattctcaag catcgtcatc atctaagcta
     1621 gggttggatc ctcagattgg gtccctagat gatggtgcag gagacctctc cctatccaaa
     1681 agctctatct ccatcagtga ccccctaaac acaccagcat tggatttttc tcagttgttt
     1741 aatttcatac ctttaaatgg tcctccctat aatcctctat cagtggggag ccttggaatg
     1801 agctattccc aggaagaagc acattcttct gtttcccagc tccccccaca aacacaggat
     1861 cttcaggatc ctgcaaacac tatagggctt gggtctctgc actcactgtc agcagctttc
     1921 accagcagtt taagcacaag taccaccctc ccacgtttcc atcaagcttt tcagtaggat
     1981 tctgggacat ggattcatta cagaaatgta tgtgtagctg tgccctagat gaccattttt
     2041 attttagtgc ctactttaaa acagtataaa aatttctgct tttgtataat acaaattttc
     2101 attaagccag tataaaatag aaactagctt ttaaactgag ctttggaacc atttgtgttc
     2161 agttaagttt acctgggtat tttgtcctga ttcactgcca attgtcacat tttaagactt
     2221 ttttttttcc atataggaaa gccattatta gtagtaaact tttacaaatc ccattttcaa
     2281 attactttta gatcttaaaa ttttcatttt tgtctaataa cagtggctct accttttgac
     2341 atctggctca ttaaaaaatt tagcaataga atgtaaattg tataaaaagt ttgtgaataa
     2401 ctcaagggtt taaattttct tactagcttc taaatggatt aataatcaag tgcttcaaat
     2461 gaattaagag tccagtttcg gaagataata aatgtttgtt agatacacca taatttcaga
     2521 tcagtatatt ctgaagactc cctgttgtct ggctaaaata tttgccatct ttattatgag
     2581 cctttaagga aaacaaaccc taaacacaaa gcatcagtat ttatagcaaa aagagactct
     2641 gttaggtgac atggcatttc gtgtcactta atagttggcc ctaaattagt acacaggata
     2701 ttttgtcgtg tttcatcctt cttaacatgc tatcttttca tttaataata gtaatagtgt
     2761 atggcattgg ggtcttcaga gtcgatatat aggtagatct ctttagtctt ttccaccttt
     2821 cacatccaag gggtgggtca agtgcagcca gcaatttatt ttcattgttg gcccacggtt
     2881 agtccataat ctagagccat tgtggaactg cagccatgag gtgtgtttat cccacagtgg
     2941 attgactcag cctctgtggg tgacagactt ctaagcagga agatagacgt gaagcacatg
     3001 gttacatttg ggaacttgtg tagggatcat ggcccctgta gccagggtta aaaactggac
     3061 tttttagaag taaagtaaaa gcatatcgct tatatcattt cttgctgaat ttgatatgtt
     3121 tttctttccc ttaagaatca aaagcagaaa acaaaaacaa cagtcctact ccgatgttat
     3181 ctttctgatt caatgtgaat ccatctttcc ttgcaatatt ttggatggag aatttgaagt
     3241 taaatgcatt agaaaactac ctgatgaact accacaaagt tttaagtgac tagaaatata
     3301 tacagtaaaa tcccactttc atgcatctct gggaaatgat aggagtattg caaataagtt
     3361 gagtttgtag agggtaacaa agtaaagtaa aacaaaccta tcttggttaa catgaaaata
     3421 acaattgaga atatattata ttcactgaat aattataggc ttttcctcac attagacaac
     3481 caacataatc ttcttaaagg tctaattaat atatttttct aagggtcagt tgggacatta
     3541 acctaagaaa catatctatt aagcacttgt taacacctta ttttaggacc ctttccgttg
     3601 gggatggggg caagggtggg aggtttttag aagagtatat atctctttaa aaaaaaacag
     3661 aaagaaaaat atttctgagc actcattagc cctatatgga aacttctttc ctttttgtag
     3721 ggccagttat cactgcagat tgcaatgttt accaagaatt tctaaaaatg agtgcagatt
     3781 actgaatata atacattatt taaaatattt gggagtagta taatttgtgg agaaatgtaa
     3841 attgtaataa tgtaaatggg ggcttcaata tatatatata atacacacac acacacacat
     3901 gcacacatac cgcacttcat agaatcaaag ttgctctctg aaggagcttt ggctcctgat
     3961 attttatcat gctcctatat ttttttaatc cttggagcag tagtttttat acttatgtat
     4021 ttaaatttta ttatgaaaaa ttacatttat taaaaaagtg tgttccaaag gcattaaaat
     4081 tatatatgtt aataaggaag tacattttta aatttttcaa actgctccta gcttttgatt
     4141 aggagaatat tttttctgaa agtaggcttt tcgctctgct tcattactgc ttcctttagt
     4201 ttctatgaaa cagattgctt acctaaatct ttagttgaat gattagtgtt caatattgct
     4261 ttaatcacca tataaaagga aaaaaattgg tgacagagca caaatagaaa acctattttt
     4321 aaatagaaat cacaaatagc aagtgtggaa gcactacttt attctgttta aaatgtactt
     4381 aagaagtcat caaattagtg aactgagaca ttggccttag taggctgtat tcactgctaa
     4441 tttaaaaaag ggagtaccag gatttattaa gtaaagcatt ttggaaatgg ggaatagcgc
     4501 catatatgta tgtatgtgta tgtgtgtgtg tgtgtgtgta tatatacaca cacacacaca
     4561 tacttaaatc ttgccctgca tgaaattcaa atacatggag gcacatcttc agggcaccag
     4621 tgttaaaatt ttggagtctt aattttcatg tgtacacctc tttgcctgtt cccaccccca
     4681 gacttgaaat aacacttcag agtaagaggg aattcagcta atttgttttt aaaattgact
     4741 gtagtggtca ctaaaccctt tttgagagaa tttctattaa agatgaggca gactcgctta
     4801 tttgaattgc acaatgttct aacaaggatg taacacagaa ttggcttttt tttccctaga
     4861 aaaagattgt ttgtttctat gtcaactaga tatgattaaa aataagtatt gccaatgctg
     4921 ttttcattct ctagtggcca gaatcattat ccttgaaatt tctggtagtg ccttagcttg
     4981 gttaaaaaaa aaaaaaaaaa aaaaaaaaag ggattaacat taaataaaag tagtttagaa
     5041 tttgggcctc agacaagata ttgaacctca ttcagtttca cttccacatg tatgtacaag
     5101 ttaggtcacc aaacacggaa gtgtgagtgt ggaaggatct tggcactgta agcaatgcta
     5161 tccattgatg tatacaagta cctttatagt tatcgatcac tgttaaaact ttcattttaa
     5221 aatcctatta ccaagttcag ttttttaaaa cttcaattgt cctggctgat tatgcatcac
     5281 tctgtgtgca acttttttat ttcatttagt gtttctttca agctgtgtat ttttgcctat
     5341 ttgttgcttg tgctttattt ttcttagtca tttgtggaat atagtgatat attgtgttaa
     5401 tttggacagt agcggttttt aaaaaccata tactgactga aacatgagcc agagccgatt
     5461 gctttattaa gctaataatg aatgttaaag agtacatatt ttcaggatcg ttcatctagt
     5521 gagcaataca catattatag gccaatattt ttttaaaaaa tagagcttgg tcaacctcta
     5581 tactacacat attacaagat atagcacttt caaaatgaat ctaaaccttt acagaaactt
     5641 tcttataggt tatgcctttt attttaagac ttattataat tcaagtgcca ttagatgata
     5701 tatatgtagg cctttgatat ataatgcttt gtgtacaaaa atggtagatg gtattttaaa
     5761 caggtacatt tttacagtgt tttcttatca atttgctata ttgcacagaa tcagtgtgtg
     5821 tcttttcata aggttttaca atggtttatt tttttacaag gtttacgtgt ctcaaagcac
     5881 actgtcttcc cagtacgtaa gttaaaaaat accagttcac ccaagttgct tctagcctac
     5941 tgagatccat gtgacattgg aggagatctt ttaaatgttt agtattcgtc attagcaatg
     6001 gctggctgtt agttctggta aatgtgtgcc taagttgaat ttgtcttgtt tttctcacac
     6061 tgtgtcagca gccatgtcta caacacagat aagtctgttg tgatcacata gatctacata
     6121 agttgtgcag ttttgtgcta aaaacccata gggagctcct ttgggatcat agaaaagaag
     6181 atcatgcaac cagcattggt gaaggcacac tcagattgca cttagggcct ttctatgatg
     6241 ttgtcaaccc tctgaggatg gaaggcagtg tcttttgatg ttatctagcc tagaaatgac
     6301 acagaactat tgctaatgta taaaacactt cattatataa gcttcagtgg tacagatgaa
     6361 ccagaatgaa tgtttatctt ctcagaaaca ctccttcaat attatattgg atcatgctgc
     6421 taatgtaact tgggctacaa ctcttcatgg tgctacaaac ttctctgtct cattcagtcg
     6481 tattttttta tccatagaaa aaggactaca ttaggtgtaa aagtgtacaa tatattttta
     6541 tactgtgact taatttgtca ttaacaaact tttacaccac cacaatgtat tcatgtgcac
     6601 ttgcaaaagg agatctcgga catgcaaatg ttaccagaac aaacccagct tttgtccaca
     6661 aggtgactgt aactcagaat ggaaagtggg ctttataata gggtgtggag tgaagaacat
     6721 gctgtatgtt actaacagcc ctttgaattt aacaaaaact gggaatccat taggaaacgg
     6781 attgcatcat acctgaacat aagctggact gctgaaattg tatttttagc taatgaaaaa
     6841 gtgtttggac tagtactcta aaaatgttct aatgataaag ttttgagtca aaatagaaaa
     6901 gaaaaaaatc tgcattccag gccgaatttt gtatattttt attgcattta aaattgctat
     6961 tctgtaatat tgggaaatca agtggcttat catgtatatc gtgtacttaa aatgtattca
     7021 caaactactg ttgtatttgt ataaaatata gacaaagatc atattttttg tgtgtgtata
     7081 agctctgtaa aatagcaatc acattatgaa gctgcagtga tactacattt taaacattca
     7141 catccaaaga agcagactat ttattgtcca tataccagat ttaaaatatt aatttgctgc
     7201 taattaaata atagtactgc agcttcttgt ggcctacagt gttatgtttg ctgtaagaat
     7261 aagatatgtg aattccacaa aatatatgaa taaaattata gaatggcttt a
//
