LOCUS       NM_001012973             776 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens placenta associated 9 (PLAC9), transcript variant 1,
            mRNA.
ACCESSION   NM_001012973 XM_166090
VERSION     NM_001012973.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Ouyang,C., Pu,Y.Z., Qin,X.H., Shen,J., Liu,Q.H., Ma,L. and Xue,L.
  TITLE     Placenta-specific 9, a putative secretory protein, induces G2/M
            arrest and inhibits the proliferation of human embryonic hepatic
            cells
  JOURNAL   Biosci Rep 38 (6) (2018)
   PUBMED   30291214
  REMARK    GeneRIF: Plac9 is a novel protein that is localized to the
            cytoplasm and may be secreted through the classic endoplasmic
            reticulum-Golgi route. The overexpression of Plac9 inhibits cell
            growth and induces G2/M phase arrest. Conclusion: Our findings
            reveal a novel role for Plac9 in regulating cell growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Galaviz-Hernandez,C., Stagg,C., de Ridder,G., Tanaka,T.S., Ko,M.S.,
            Schlessinger,D. and Nagaraja,R.
  TITLE     Plac8 and Plac9, novel placental-enriched genes identified through
            microarray analysis
  JOURNAL   Gene 309 (2), 81-89 (2003)
   PUBMED   12758124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356095.11.
            
            On May 17, 2019 this sequence version replaced NM_001012973.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM768761.1, BM798972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372263.4/ ENSP00000361337.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL356095.11        136674-136770
            98-195              AL356095.11        146026-146123
            196-316             AL356095.11        148167-148287
            317-776             AL356095.11        148844-149303
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..776
                     /gene="PLAC9"
                     /note="placenta associated 9"
                     /db_xref="GeneID:219348"
                     /db_xref="HGNC:HGNC:19255"
                     /db_xref="MIM:612857"
     exon            1..97
                     /gene="PLAC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..327
                     /gene="PLAC9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; placenta-specific protein 9; placenta specific
                     9"
                     /codon_start=1
                     /product="placenta-specific protein 9 isoform 1 precursor"
                     /protein_id="NP_001012991.1"
                     /db_xref="CCDS:CCDS31232.1"
                     /db_xref="GeneID:219348"
                     /db_xref="HGNC:HGNC:19255"
                     /db_xref="MIM:612857"
                     /translation="MRPLLCALTGLALLRAAGSLAAAEPFSPPRGDSAQSTACDRHMA
                     VQRRLDVMEEMVEKTVDHLGTEVKGLLGLLEELAWNLPPGPFSPAPDLLGDGF"
     exon            98..195
                     /gene="PLAC9"
                     /inference="alignment:Splign:2.1.0"
     exon            196..316
                     /gene="PLAC9"
                     /inference="alignment:Splign:2.1.0"
     exon            317..776
                     /gene="PLAC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      429..434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAC9"
                     /note="hexamer: AATAAA"
     polyA_site      447
                     /gene="PLAC9"
                     /note="major polyA site"
     regulatory      747..752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAC9"
                     /note="hexamer: ATTAAA"
     polyA_site      776
                     /gene="PLAC9"
ORIGIN      
        1 agacgcggcg ctgcgctcgg ccaggccggc accatgcggc ccctgctctg cgcgctgacc
       61 ggactggccc tgctccgcgc cgcgggctct ttggccgctg ccgaaccctt cagccctccg
      121 cgaggagact cagctcagag cacagcgtgt gacagacaca tggctgtgca acgccgtcta
      181 gatgtcatgg aggagatggt agagaagacc gtggatcacc tggggacaga ggtgaaaggc
      241 ctgctgggcc tgctggagga gctggcctgg aacctgcccc cgggaccctt cagccccgct
      301 cccgaccttc tcggagatgg cttctgagcc ctggagctgg agcccagcag ttggaggtgg
      361 tgcacctgcc aggcagcgcc cacagaacca gccctgtcct ctcgacttcc ttccttagct
      421 tcatgtgaaa taaaagctat tctggtctcc tctgtgtctg ctgacagagt aacccgttta
      481 actacagcct cctctcactc cacttccatg cctggaggaa gcctgcaacc ccctccaggc
      541 tcagacctgg ggacaccccc actcctgtca tttatagggg cagatggagc aggggttgat
      601 tcacacagat gggggccctt tgagtggcct tgcttctcaa aatgtggcca taggtgaaaa
      661 gcaaggggat cagggtctca ggacccaccc agactgttta atccaaatct gcattgcaat
      721 gagaccccca gggattttat gtgtccatta aagtggtttg ttgttgtttt taaaaa
//
