LOCUS       NM_016619               1374 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens placenta associated 8 (PLAC8), transcript variant 2,
            mRNA.
ACCESSION   NM_016619
VERSION     NM_016619.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Li,P., Xu,M., Zhang,Z., Zhang,X., Xie,F. and Zhang,X.
  TITLE     Identification of PLAC8 as a Potential Biomarker for the Diagnosis
            of Interstitial Cystitis
  JOURNAL   Comb Chem High Throughput Screen 27 (13), 1938-1947 (2024)
   PUBMED   38441011
  REMARK    GeneRIF: Identification of PLAC8 as a Potential Biomarker for the
            Diagnosis of Interstitial Cystitis.
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Zhang,Y., Guo,X., Chen,Z. and Guo,R.
  TITLE     Low m6A modification-mediated upregulation of PLAC8 promotes
            trophoblast cell invasion and migration in preeclampsia
  JOURNAL   Eur J Med Res 28 (1), 466 (2023)
   PUBMED   37885015
  REMARK    GeneRIF: Low m6A modification-mediated upregulation of PLAC8
            promotes trophoblast cell invasion and migration in preeclampsia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Deng,B., Zhang,S., Zhou,Y., Zhu,Y., Fei,J. and Li,A.
  TITLE     PLAC8 contributes to the malignant behaviors of cervical cancer
            cells by activating the SOX4-mediated AKT pathway
  JOURNAL   Histochem Cell Biol 159 (5), 439-451 (2023)
   PUBMED   36602585
  REMARK    GeneRIF: PLAC8 contributes to the malignant behaviors of cervical
            cancer cells by activating the SOX4-mediated AKT pathway.
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Mao,M., Chen,Y., Yang,J., Cheng,Y., Xu,L., Ji,F., Zhou,J.,
            Zhang,X., Li,Z., Chen,C., Ju,S., Zhang,J. and Wang,L.
  TITLE     Modification of PLAC8 by UFM1 affects tumorous proliferation and
            immune response by impacting PD-L1 levels in triple-negative breast
            cancer
  JOURNAL   J Immunother Cancer 10 (12) (2022)
   PUBMED   36543379
  REMARK    GeneRIF: Modification of PLAC8 by UFM1 affects tumorous
            proliferation and immune response by impacting PD-L1 levels in
            triple-negative breast cancer.
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Ugalde,A.P., Bretones,G., Rodriguez,D., Quesada,V., Llorente,F.,
            Fernandez-Delgado,R., Jimenez-Clavero,M.A., Vazquez,J., Calvo,E.,
            Tamargo-Gomez,I., Marino,G., Roiz-Valle,D., Maeso,D.,
            Araujo-Voces,M., Espanol,Y., Barcelo,C., Freije,J.M., Lopez-Soto,A.
            and Lopez-Otin,C.
  TITLE     Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a
            key host factor for SARS-CoV-2 entry into human cells
  JOURNAL   EMBO J 41 (21), e110727 (2022)
   PUBMED   36124427
  REMARK    GeneRIF: Autophagy-linked plasma and lysosomal membrane protein
            PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Mourtada-Maarabouni,M., Watson,D., Munir,M., Farzaneh,F. and
            Williams,G.T.
  TITLE     Apoptosis suppression by candidate oncogene PLAC8 is reversed in
            other cell types
  JOURNAL   Curr Cancer Drug Targets 13 (1), 80-91 (2013)
   PUBMED   22920440
  REMARK    GeneRIF: Data suggest that overexpression of PLAC8 induces
            apoptosis in some cells (CEM-C7 cells; Jurkat T cells); expression
            of PLAC8 has anti-apoptosis effect in other cells (adherent cell
            lines; HEK293T cells; MCF-10A cells).
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Jimenez-Preitner,M., Berney,X., Uldry,M., Vitali,A., Cinti,S.,
            Ledford,J.G. and Thorens,B.
  TITLE     Plac8 is an inducer of C/EBPbeta required for brown fat
            differentiation, thermoregulation, and control of body weight
  JOURNAL   Cell Metab 14 (5), 658-670 (2011)
   PUBMED   21982742
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Wu,S.F., Huang,Y., Hou,J.K., Yuan,T.T., Zhou,C.X., Zhang,J. and
            Chen,G.Q.
  TITLE     The downregulation of onzin expression by PKCepsilon-ERK2 signaling
            and its potential role in AML cell differentiation
  JOURNAL   Leukemia 24 (3), 544-551 (2010)
   PUBMED   20072156
  REMARK    GeneRIF: phorbol 12-myristate 13-acetate(PMA)downregulates onzin
            expression through PKCepsilon-ERK2 signaling pathway, which favors
            monocytic differentiation of leukemic cells.
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Galaviz-Hernandez,C., Stagg,C., de Ridder,G., Tanaka,T.S., Ko,M.S.,
            Schlessinger,D. and Nagaraja,R.
  TITLE     Plac8 and Plac9, novel placental-enriched genes identified through
            microarray analysis
  JOURNAL   Gene 309 (2), 81-89 (2003)
   PUBMED   12758124
REFERENCE   10 (bases 1 to 1374)
  AUTHORS   Rissoan,M.C., Duhen,T., Bridon,J.M., Bendriss-Vermare,N.,
            Peronne,C., de Saint Vis,B., Briere,F. and Bates,E.E.
  TITLE     Subtractive hybridization reveals the expression of
            immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel
            transcripts in human plasmacytoid dendritic cells
  JOURNAL   Blood 100 (9), 3295-3303 (2002)
   PUBMED   12384430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000140.1 and AC073840.8.
            
            On Jun 2, 2019 this sequence version replaced NM_016619.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            Sequence Note: This RefSeq transcript was derived from transcript
            and genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000140.1, SRR1163658.121318.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311507.9/ ENSP00000309509.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               AK000140.1         30-692
            664-1374            AC073840.8         40089-40799         c
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..1374
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /note="placenta associated 8"
                     /db_xref="GeneID:51316"
                     /db_xref="HGNC:HGNC:19254"
                     /db_xref="MIM:607515"
     exon            1..64
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /inference="alignment:Splign:2.1.0"
     exon            65..211
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..441
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /note="down-regulated in gastrointestinal cancer protein;
                     placenta specific 8"
                     /codon_start=1
                     /product="placenta-specific gene 8 protein"
                     /protein_id="NP_057703.1"
                     /db_xref="CCDS:CCDS3601.1"
                     /db_xref="GeneID:51316"
                     /db_xref="HGNC:HGNC:19254"
                     /db_xref="MIM:607515"
                     /translation="MQAQAPVVVVTQPGVGPGPAPQNSNWQTGMCDCFSDCGVCLCGT
                     FCFPCLGCQVAADMNECCLCGTSVAMRTLYRTRYGIPGSICDDYMATLCCPHCTLCQI
                     KRDINRRRAMRTF"
     exon            212..336
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /inference="alignment:Splign:2.1.0"
     exon            337..450
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1374
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      705..710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /note="hexamer: TATAAA"
     regulatory      714..719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /note="hexamer: AATGAA"
     polyA_site      731
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
                     /note="major polyA site"
     polyA_site      734
                     /gene="PLAC8"
                     /gene_synonym="C15; DGIC; onzin; PNAS-144"
ORIGIN      
        1 atttgtggtg agattctctc ccaggccaca agacatttcc tgctcggaac cttgtttact
       61 aatttccact gcttttaagg ccctgcactg aaaatgcaag ctcaggcgcc ggtggtcgtt
      121 gtgacccaac ctggagtcgg tcccggtccg gccccccaga actccaactg gcagacaggc
      181 atgtgtgact gtttcagcga ctgcggagtc tgtctctgtg gcacattttg tttcccgtgc
      241 cttgggtgtc aagttgcagc tgatatgaat gaatgctgtc tgtgtggaac aagcgtcgca
      301 atgaggactc tctacaggac ccgatatggc atccctggat ctatttgtga tgactatatg
      361 gcaactcttt gctgtcctca ttgtactctt tgccaaatca agagagatat caacagaagg
      421 agagccatgc gtactttcta aaaactgatg gtgaaaagct cttaccgaag caacaaaatt
      481 cagcagacac ctcttcagct tgagttcttc accatctttt gcaactgaaa tatgatggat
      541 atgcttaagt acaactgatg gcatgaaaaa aatcaaattt ttgatttatt ataaatgaat
      601 gttgtccctg aacttagcta aatggtgcaa cttagtttct ccttgctttc atattatcga
      661 attcgaattt cctggcttat aaacttttta aattacattt gaaatataaa ccaaatgaaa
      721 tattttactg ataagattct tcatgcttct ttgctctcct taaaatgtct ttttcactag
      781 ttagttccaa gggtcagtct cataattttg ttcttatact ttgatttcct ttttcttttt
      841 tttttttttt aatagagttg ggggatcttt ctttcttttt tttttttttt ttttgagata
      901 gagtctcgct ctgttgccca ggctggagtg cagtggcgtg atctcagctc actgcaacct
      961 ccacctcctg gatacaagcg attctgctgc ctcagtctcc cgagtagctg ggattacagg
     1021 ttcccgccac catgcccagc taatttttgt atttttagta gagacggggt ttcaccatct
     1081 tggtcaggct ggtctcgaac tcctgacctc gtgatccacc tgcctcggca tcacaaaatg
     1141 ctgggattac aggcatgagc caccgcgtcc agcctagagt tgggggtctt tctatgttgc
     1201 ccaggctggt cttgaactcc gggcctctag caagcctctc atctcagcct cccaaggtgc
     1261 tggaattaca ggtgtgagcc actgcaccat actttggttt cttagcagga gattttggtt
     1321 cacagtaacc cagctctctt tcatctaaga actttagatg agaaaaaaaa aaaa
//
