LOCUS       NM_021796               1119 bp    mRNA    linear   PRI 21-AUG-2023
DEFINITION  Homo sapiens placenta enriched 1 (PLAC1), transcript variant 1,
            mRNA.
ACCESSION   NM_021796
VERSION     NM_021796.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Wang Z, Deng L, Xu X and Zhao L.
  TITLE     Differential expression of PLAC1 and Netrin-1 in liver metastasis
            of colorectal cancer and its predictive value
  JOURNAL   BMC Gastroenterol 23 (1), 275 (2023)
   PUBMED   37568074
  REMARK    GeneRIF: Differential expression of PLAC1 and Netrin-1 in liver
            metastasis of colorectal cancer and its predictive value.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Conese M, Napolitano O, Laselva O, Di Gioia S, Nappi L, Trabace L
            and Matteo M.
  TITLE     The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem
            Cells-Derived PLAC1 Involved?
  JOURNAL   Int J Mol Sci 24 (4), 3612 (2023)
   PUBMED   36835024
  REMARK    GeneRIF: The Oncogenic Theory of Preeclampsia: Is Amniotic
            Mesenchymal Stem Cells-Derived PLAC1 Involved?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Devor EJ, Santillan DA, Warrier A, Scroggins SM and Santillan MK.
  TITLE     Placenta-specific protein 1 (PLAC1) expression is significantly
            down-regulated in preeclampsia via a hypoxia-mediated mechanism
  JOURNAL   J Matern Fetal Neonatal Med 35 (25), 8419-8425 (2022)
   PUBMED   34565269
  REMARK    GeneRIF: Placenta-specific protein 1 (PLAC1) expression is
            significantly down-regulated in preeclampsia via a hypoxia-mediated
            mechanism.
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Chen R, Sheng C, Ma R, Zhang L, Yang L and Chen Y.
  TITLE     PLAC1 is an independent predictor of poor survival, and promotes
            cell proliferation and invasion in cervical cancer
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34523695
  REMARK    GeneRIF: PLAC1 is an independent predictor of poor survival, and
            promotes cell proliferation and invasion in cervical cancer.
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Chen Y, Stagg C, Schlessinger D and Nagaraja R.
  TITLE     PLAC1 affects cell to cell communication by interacting with the
            desmosome complex
  JOURNAL   Placenta 110, 39-45 (2021)
   PUBMED   34118612
  REMARK    GeneRIF: PLAC1 affects cell to cell communication by interacting
            with the desmosome complex.
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Fujito N, Samura O, Miharu N, Tanigawa M, Hyodo M and Kudo Y.
  TITLE     Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial
            cells-missing 1 (GCM1) in mothers with pre-eclampsia
  JOURNAL   Hiroshima J Med Sci 55 (1), 9-15 (2006)
   PUBMED   16594548
  REMARK    GeneRIF: Plasma PLAC1 and glial cells-missing 1 mRNAs appear
            promising as noninvasively measurable molecular markers for
            pre-eclampsia
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Massabbal E, Parveen S, Weisoly DL, Nelson DM, Smith SD and Fant M.
  TITLE     PLAC1 expression increases during trophoblast differentiation:
            evidence for regulatory interactions with the fibroblast growth
            factor-7 (FGF-7) axis
  JOURNAL   Mol Reprod Dev 71 (3), 299-304 (2005)
   PUBMED   15803460
  REMARK    GeneRIF: PLAC1 expression is upregulated during trophoblast
            differentiation, localizing primarily to the differentiated
            syncytiotrophoblast.
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Concu M, Banzola I, Farina A, Sekizawa A, Rizzo N, Marini M,
            Caramelli E and Carinci P.
  TITLE     Rapid clearance of mRNA for PLAC1 gene in maternal blood after
            delivery
  JOURNAL   Fetal Diagn Ther 20 (1), 27-30 (2005)
   PUBMED   15608456
  REMARK    GeneRIF: mRNA transcripts from placenta-expressed specific gene are
            detectable in maternal blood and rapidly disappear after delivery
REFERENCE   9  (bases 1 to 1119)
  AUTHORS   Fant M, Weisoly DL, Cocchia M, Huber R, Khan S, Lunt T and
            Schlessinger D.
  TITLE     PLAC1, a trophoblast-specific gene, is expressed throughout
            pregnancy in the human placenta and modulated by keratinocyte
            growth factor
  JOURNAL   Mol Reprod Dev 63 (4), 430-436 (2002)
   PUBMED   12412044
  REMARK    GeneRIF: PLAC1, a trophoblast-specific gene, is
            Trophoblast-specific expression throughout gestation and
            responsiveness to KGF are consistent with a fundamental role for
            PLAC1 at the maternal-fetal interface.
REFERENCE   10 (bases 1 to 1119)
  AUTHORS   Cocchia M, Huber R, Pantano S, Chen EY, Ma P, Forabosco A, Ko MS
            and Schlessinger D.
  TITLE     PLAC1, an Xq26 gene with placenta-specific expression
  JOURNAL   Genomics 68 (3), 305-312 (2000)
   PUBMED   10995572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075086.1 and AC004383.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021796.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA827997.1, BC022335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359237.9/ ENSP00000352173.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1114              AK075086.1         13-1126
            1115-1119           AC004383.1         150396-150400       c
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1119
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /note="placenta enriched 1"
                     /db_xref="GeneID:10761"
                     /db_xref="HGNC:HGNC:9044"
                     /db_xref="MIM:300296"
     exon            1..144
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            145..216
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /inference="alignment:Splign:2.1.0"
     exon            217..1119
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..913
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /note="cancer/testis antigen 92; placenta-specific protein
                     1; placenta specific 1"
                     /codon_start=1
                     /product="placenta-specific protein 1 precursor"
                     /protein_id="NP_068568.1"
                     /db_xref="CCDS:CCDS14642.1"
                     /db_xref="GeneID:10761"
                     /db_xref="HGNC:HGNC:9044"
                     /db_xref="MIM:300296"
                     /translation="MKVFKFIGLMILLTSAFSAGSGQSPMTVLCSIDWFMVTVHPFML
                     NNDVCVHFHELHLGLGCPPNHVQPHAYQFTYRVTECGIRAKAVSQDMVIYSTEIHYSS
                     KGTPSKFVIPVSCAAPQKSPWLTKPCSMRVASKSRATAQKDEKCYEVFSLSQSSQRPN
                     CDCPPCVFSEEEHTQVPCHQAGAQEAQPLQPSHFLDISEDWSLHTDDMIGSM"
     regulatory      1091..1096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /note="hexamer: AATAAA"
     regulatory      1096..1101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /note="hexamer: AATAAA"
     polyA_site      1113
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /note="major polyA site"
     polyA_site      1119
                     /gene="PLAC1"
                     /gene_synonym="CT92; OOSP2B; OOSP2L"
                     /note="major polyA site"
ORIGIN      
        1 atcagaagga tttgtataaa gagtgactct cctatgaagg taaaggccac ccctcttcag
       61 ttccagtgac tgagatacat ttttccaatc ctgggggcaa atacagacac agcaagttcc
      121 ttcttccctt tggaaatttg gcagctgcct tcaccagtga gcacaaagcc acatttcaaa
      181 ggaaactgac aaattatccc cagctgccag aagaagaaat cctcactgga cggcttcctg
      241 tttcctgtgg ttcattatct gattggctgc agggatgaaa gtttttaagt tcataggact
      301 gatgatcctc ctcacctctg cgttttcagc cggttcagga caaagtccaa tgactgtgct
      361 gtgctccata gactggttca tggtcacagt gcaccccttc atgctaaaca acgatgtgtg
      421 tgtacacttt catgaactac acttgggcct gggttgcccc ccaaaccatg ttcagccaca
      481 cgcctaccag ttcacctacc gtgttactga atgtggcatc agggccaaag ctgtctctca
      541 ggacatggtt atctacagca ctgagataca ctactcttct aagggcacgc catctaagtt
      601 tgtgatccca gtgtcatgtg ctgcccccca aaagtcccca tggctcacca agccctgctc
      661 catgagagta gccagcaaga gcagggccac agcccagaag gatgagaaat gctacgaggt
      721 gttcagcttg tcacagtcca gtcaaaggcc caactgcgat tgtccacctt gtgtcttcag
      781 tgaagaagag catacccagg tcccttgtca ccaagcaggg gctcaggagg ctcaacctct
      841 gcagccatct cactttcttg atatttctga ggattggtct cttcacacag atgatatgat
      901 tgggtccatg tgatcctcag gtttggggtc tcctgaagat gctatttcta gaattagtat
      961 atagtgtaca aatgtctgac aaataagtgc tcttgtgacc ctcatgtgag cacttttgag
     1021 aaagagaaac ctatagcaac ttcatgaatt aagccttttt ctatattttt atattcatgt
     1081 gtaaacaaaa aataaaataa aattctgatc gcataaaaa
//
