LOCUS       NM_004585                758 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipase A and acyltransferase 4 (PLAAT4), mRNA.
ACCESSION   NM_004585
VERSION     NM_004585.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 758)
  AUTHORS   Rice,M., Tili,E., Loghmani,H. and Nuovo,G.J.
  TITLE     The differential expression of toll like receptors and RIG-1
            correlates to the severity of infectious diseases
  JOURNAL   Ann Diagn Pathol 63, 152102 (2023)
   PUBMED   36634551
REFERENCE   2  (bases 1 to 758)
  AUTHORS   Rinkenberger,N., Abrams,M.E., Matta,S.K., Schoggins,J.W., Alto,N.M.
            and Sibley,L.D.
  TITLE     Overexpression screen of interferon-stimulated genes identifies
            RARRES3 as a restrictor of Toxoplasma gondii infection
  JOURNAL   Elife 10, e73137 (2021)
   PUBMED   34871166
  REMARK    GeneRIF: Overexpression screen of interferon-stimulated genes
            identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 758)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 758)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 758)
  AUTHORS   Higuchi,E., Chandraratna,R.A., Hong,W.K. and Lotan,R.
  TITLE     Induction of TIG3, a putative class II tumor suppressor gene, by
            retinoic acid in head and neck and lung carcinoma cells and its
            association with suppression of the transformed phenotype
  JOURNAL   Oncogene 22 (30), 4627-4635 (2003)
   PUBMED   12879006
  REMARK    GeneRIF: induction of TIG3 is associated with the suppression of
            anchorage-independent growth in certain aerodigestive tract cancer
            cells
REFERENCE   6  (bases 1 to 758)
  AUTHORS   Deucher,A., Nagpal,S., Chandraratna,R.A., Di Sepio,D.,
            Robinson,N.A., Dashti,S.R. and Eckert,R.L.
  TITLE     The carboxy-terminal hydrophobic domain of TIG3, a class II tumor
            suppressor protein, is required for appropriate cellular
            localization and optimal biological activity
  JOURNAL   Int J Oncol 17 (6), 1195-1203 (2000)
   PUBMED   11078805
REFERENCE   7  (bases 1 to 758)
  AUTHORS   Duvic,M., Helekar,B., Schulz,C., Cho,M., DiSepio,D., Hager,C.,
            DiMao,D., Hazarika,P., Jackson,B., Breuer-McHam,J., Young,J.,
            Clayman,G., Lippman,S.M., Chandraratna,R.A., Robinson,N.A.,
            Deucher,A., Eckert,R.L. and Nagpal,S.
  TITLE     Expression of a retinoid-inducible tumor suppressor,
            Tazarotene-inducible gene-3, is decreased in psoriasis and skin
            cancer
  JOURNAL   Clin Cancer Res 6 (8), 3249-3259 (2000)
   PUBMED   10955811
REFERENCE   8  (bases 1 to 758)
  AUTHORS   Huang,S.L., Shyu,R.Y., Yeh,M.Y. and Jiang,S.Y.
  TITLE     Cloning and characterization of a novel retinoid-inducible gene
            1(RIG1) deriving from human gastric cancer cells
  JOURNAL   Mol Cell Endocrinol 159 (1-2), 15-24 (2000)
   PUBMED   10687848
REFERENCE   9  (bases 1 to 758)
  AUTHORS   DiSepio,D., Ghosn,C., Eckert,R.L., Deucher,A., Robinson,N.,
            Duvic,M., Chandraratna,R.A. and Nagpal,S.
  TITLE     Identification and characterization of a retinoid-induced class II
            tumor suppressor/growth regulatory gene
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14811-14815 (1998)
   PUBMED   9843971
REFERENCE   10 (bases 1 to 758)
  AUTHORS   Duvic,M., Nagpal,S., Asano,A.T. and Chandraratna,R.A.
  TITLE     Molecular mechanisms of tazarotene action in psoriasis
  JOURNAL   J Am Acad Dermatol 37 (2 Pt 3), S18-S24 (1997)
   PUBMED   9270552
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA973023.1, BC009678.1 and KF455398.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004585.4.
            
            Summary: Retinoids exert biologic effects such as potent growth
            inhibitory and cell differentiation activities and are used in the
            treatment of hyperproliferative dermatological diseases. These
            effects are mediated by specific nuclear receptor proteins that are
            members of the steroid and thyroid hormone receptor superfamily of
            transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes
            whose expression is upregulated by the synthetic retinoid
            tazarotene. RARRES3 is thought act as a tumor suppressor or growth
            regulator. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF092922.1, BU598144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255688.8/ ENSP00000255688.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA973023.1         10-22
            14-471              BC009678.1         1-458
            472-472             KF455398.1         187-187
            473-758             BC009678.1         460-745
FEATURES             Location/Qualifiers
     source          1..758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..758
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /note="phospholipase A and acyltransferase 4"
                     /db_xref="GeneID:5920"
                     /db_xref="HGNC:HGNC:9869"
                     /db_xref="MIM:605092"
     exon            1..70
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..556
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="retinoic acid receptor responder protein 3;
                     HRAS-like suppressor 4; retinoic acid-inducible gene 1;
                     RAR-responsive protein TIG3; retinoid-inducible gene 1
                     protein; tazarotene-induced gene 3 protein; retinoic acid
                     receptor responder (tazarotene induced) 3; phospholipase
                     A/acyltransferase-4; retinoic acid receptor responder 3"
                     /codon_start=1
                     /product="phospholipase A and acyltransferase 4"
                     /protein_id="NP_004576.2"
                     /db_xref="CCDS:CCDS41662.1"
                     /db_xref="GeneID:5920"
                     /db_xref="HGNC:HGNC:9869"
                     /db_xref="MIM:605092"
                     /translation="MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPG
                     AGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQ
                     KMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQK
                     KATA"
     exon            71..179
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            180..448
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..758
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      735..740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /note="hexamer: AATAAA"
     polyA_site      758
                     /gene="PLAAT4"
                     /gene_synonym="HRASLS4; HRSL4; PLA1/2-3; PLAAT-4; RARRES3;
                     RIG1; TIG3"
                     /note="major polyA site"
ORIGIN      
        1 ccttcagcat aaaagctgat ccacaaacaa gaggagcacc agacctcctc ttggcttcga
       61 gatggcttcg ccacaccaag agcccaaacc tggagacctg attgagattt tccgccttgg
      121 ctatgagcac tgggccctgt atataggaga tggctacgtg atccatctgg ctcctccaag
      181 tgagtacccc ggggctggct cctccagtgt cttctcagtc ctgagcaaca gtgcagaggt
      241 gaaacgggag cgcctggaag atgtggtggg aggctgttgc tatcgggtca acaacagctt
      301 ggaccatgag taccaaccac ggcccgtgga ggtgatcatc agttctgcga aggagatggt
      361 tggtcagaag atgaagtaca gtattgtgag caggaactgt gagcactttg tcacccagct
      421 gagatatggc aagtcccgct gtaaacaggt ggaaaaggcc aaggttgaag tcggtgtggc
      481 cacggcgctt ggaatcctgg ttgttgctgg atgctctttt gcgattagga gataccaaaa
      541 aaaagcgaca gcctgaagca gccacaaaat cctgtgttag aagcagctgt gggggtccca
      601 gtggagatga gcctccccca tgcctccagc agcctgaccc tcgtgccctg tctcaggcgt
      661 tctctagatc ctttcctctg tttccctctc tcgctggcaa aagtatgatc taattgaaac
      721 aagactgaag gatcaataaa cagccatctg ccccttca
//
