LOCUS       NM_001128203            1075 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens phospholipase A and acyltransferase 3 (PLAAT3),
            transcript variant 2, mRNA.
ACCESSION   NM_001128203
VERSION     NM_001128203.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Xia,W., Bai,H., Deng,Y. and Yang,Y.
  TITLE     PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes
            glycolysis of pancreatic cancer
  JOURNAL   J Cell Mol Med 24 (21), 12642-12655 (2020)
   PUBMED   32985124
  REMARK    GeneRIF: PLA2G16 is a mutant p53/KLF5 transcriptional target and
            promotes glycolysis of pancreatic cancer.
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Parmer,C., De Sousa-Coelho,A.L., Cheng,H.S., Daher,G., Burkart,A.,
            Dreyfuss,J.M., Pan,H., Prenner,J.C., Keilson,J.M., Pande,R.,
            Henkin,S., Feinberg,M.W., Patti,M.E. and Creager,M.A.
  TITLE     Skeletal muscle expression of adipose-specific phospholipase in
            peripheral artery disease
  JOURNAL   Vasc Med 25 (5), 401-410 (2020)
   PUBMED   32853041
  REMARK    GeneRIF: Skeletal muscle expression of adipose-specific
            phospholipase in peripheral artery disease.
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Jarrard,W.E., Schultz,A., Etheridge,T., Damodaran,S., Allen,G.O.,
            Jarrard,D. and Yang,B.
  TITLE     Screening of urine identifies PLA2G16 as a field defect methylation
            biomarker for prostate cancer detection
  JOURNAL   PLoS One 14 (6), e0218950 (2019)
   PUBMED   31233548
  REMARK    GeneRIF: PLA2G16 methylation defines an extensive field defect in
            histologically normal prostate tissue associated with PC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Xie,X.N., Yu,J., Zhang,L.H., Luo,Z.Y., Ouyang,D.S., Zheng,L.J.,
            Wang,C.Y., Yang,L., Chen,L. and Tan,Z.R.
  TITLE     Relationship between polymorphisms of the lipid metabolism-related
            gene PLA2G16 and risk of colorectal cancer in the Chinese
            population
  JOURNAL   Funct Integr Genomics 19 (2), 227-236 (2019)
   PUBMED   30343388
  REMARK    GeneRIF: PLA2G16 SNPs are associated with the colorectal cancer
            risk in the Chinese population.
REFERENCE   6  (bases 1 to 1075)
  AUTHORS   Sers,C., Husmann,K., Nazarenko,I., Reich,S., Wiechen,K.,
            Zhumabayeva,B., Adhikari,P., Schroder,K., Gontarewicz,A. and
            Schafer,R.
  TITLE     The class II tumour suppressor gene H-REV107-1 is a target of
            interferon-regulatory factor-1 and is involved in IFNgamma-induced
            cell death in human ovarian carcinoma cells
  JOURNAL   Oncogene 21 (18), 2829-2839 (2002)
   PUBMED   11973642
REFERENCE   7  (bases 1 to 1075)
  AUTHORS   Siegrist,S., Feral,C., Chami,M., Solhonne,B., Mattei,M.G.,
            Rajpert-De Meyts,E., Guellaen,G. and Bulle,F.
  TITLE     hH-Rev107, a class II tumor suppressor gene, is expressed by
            post-meiotic testicular germ cells and CIS cells but not by human
            testicular germ cell tumors
  JOURNAL   Oncogene 20 (37), 5155-5163 (2001)
   PUBMED   11526504
REFERENCE   8  (bases 1 to 1075)
  AUTHORS   Suzuki,Y., Tsunoda,T., Sese,J., Taira,H., Mizushima-Sugano,J.,
            Hata,H., Ota,T., Isogai,T., Tanaka,T., Nakamura,Y., Suyama,A.,
            Sakaki,Y., Morishita,S., Okubo,K. and Sugano,S.
  TITLE     Identification and characterization of the potential promoter
            regions of 1031 kinds of human genes
  JOURNAL   Genome Res 11 (5), 677-684 (2001)
   PUBMED   11337467
REFERENCE   9  (bases 1 to 1075)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (bases 1 to 1075)
  AUTHORS   Husmann,K., Sers,C., Fietze,E., Mincheva,A., Lichter,P. and
            Schafer,R.
  TITLE     Transcriptional and translational downregulation of H-REV107, a
            class II tumour suppressor gene located on human chromosome
            11q11-12
  JOURNAL   Oncogene 17 (10), 1305-1312 (1998)
   PUBMED   9771974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK003948.1, BG719903.1, AI590735.1 and AI374456.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001128203.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA166673.1, DA623957.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415826.3/ ENSP00000389124.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CK003948.1         38-65
            29-604              BG719903.1         60-635
            605-765             AI590735.1         1-161               c
            766-1075            AI374456.1         45-354
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3-q13.1"
     gene            1..1075
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /note="phospholipase A and acyltransferase 3"
                     /db_xref="GeneID:11145"
                     /db_xref="HGNC:HGNC:17825"
                     /db_xref="MIM:613867"
     exon            1..49
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            50..118
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..592
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="adipose-specific PLA2; HRAS-like suppressor 3;
                     group XVI phospholipase A2; phospholipase
                     A/acyltransferase-3; Ca-independent phospholipase A1/2;
                     HRAS-like suppressor 1; phospholipase A2 group XVI; H-rev
                     107 protein homolog; adipose-specific phospholipase A2;
                     renal carcinoma antigen NY-REN-65; group XVI phospholipase
                     A1/A2"
                     /codon_start=1
                     /product="phospholipase A and acyltransferase 3"
                     /protein_id="NP_001121675.1"
                     /db_xref="CCDS:CCDS8047.1"
                     /db_xref="GeneID:11145"
                     /db_xref="HGNC:HGNC:17825"
                     /db_xref="MIM:613867"
                     /translation="MRAPIPEPKPGDLIEIFRPFYRHWAIYVGDGYVVHLAPPSEVAG
                     AGAASVMSALTDKAIVKKELLYDVAGSDKYQVNNKHDDKYSPLPCSKIIQRAEELVGQ
                     EVLYKLTSENCEHFVNELRYGVARSDQVRDVIIAASVAGMGLAAMSLIGVMFSRNKRQ
                     KQ"
     exon            119..221
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            222..490
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..1075
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      718..723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /note="hexamer: AATAAA"
     polyA_site      762
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
                     /note="major polyA site"
     polyA_site      765
                     /gene="PLAAT3"
                     /gene_synonym="AdPLA; FPLD9; H-REV107; H-REV107-1;
                     HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3; PLA2G16;
                     PLAAT-3"
ORIGIN      
        1 agacccggtc caattgctgg ggctgcagcg ctgcctccga gaccgcgaga catctacgca
       61 gcgaaatcga gcctggcctt gagggtccac accgcgaggg aagatgcgtg cgcccattcc
      121 agagcctaag cctggagacc tgattgagat ttttcgccct ttctacagac actgggccat
      181 ctatgttggc gatggatatg tggttcatct ggcccctcca agtgaggtcg caggagctgg
      241 tgcagccagt gtcatgtccg ccctgactga caaggccatc gtgaagaagg aattgctgta
      301 tgatgtggcc gggagtgaca agtaccaggt caacaacaaa catgatgaca agtactcgcc
      361 gctgccctgc agcaaaatca tccagcgggc ggaggagctg gtggggcagg aggtgctcta
      421 caagctgacc agtgagaact gcgagcactt tgtgaatgag ctgcgctatg gagtcgcccg
      481 cagtgaccag gtcagagatg tcatcatcgc tgcaagcgtt gcaggaatgg gcttggcagc
      541 catgagcctt attggagtca tgttctcaag aaacaagcga caaaagcaat aactgaaaaa
      601 gactgtcctg tcagcgatga ctttatacat caagggggtc ttgttttgct agagagtttg
      661 gggtttggtt tgtggatttc attgtgattt ataataaggc ttattttcac agaataaaat
      721 aaagcaaaac gagggaggat tttattgggg gaagtgcagc aagaactgcc tggtgtgaag
      781 tctgttcagg gaacagccgg gctgtcttcc tggtcaggga ttgtctttca ctttcttttt
      841 gcgtgctgtg ttctttgcat tgcaggaggc agagtccagc tccagttatc tcaagtagag
      901 ggcgtttctg gtcgtcagga tacatgcggg gcggaaggga gacagaaaga cataatacac
      961 aagaacagaa agcagcagac agccaggacc cttggcccgg aactagatct aggatggcct
     1021 ctgagactca gcagctggag tctgtagatg ttcagctgag ttgaaaaaaa aaaag
//
