LOCUS       NM_017878                738 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens phospholipase A and acyltransferase 2 (PLAAT2), mRNA.
ACCESSION   NM_017878
VERSION     NM_017878.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Uyama,T., Ikematsu,N., Inoue,M., Shinohara,N., Jin,X.H., Tsuboi,K.,
            Tonai,T., Tokumura,A. and Ueda,N.
  TITLE     Generation of N-acylphosphatidylethanolamine by members of the
            phospholipase A/acyltransferase (PLA/AT) family
  JOURNAL   J Biol Chem 287 (38), 31905-31919 (2012)
   PUBMED   22825852
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Golczak,M., Kiser,P.D., Sears,A.E., Lodowski,D.T., Blaner,W.S. and
            Palczewski,K.
  TITLE     Structural basis for the acyltransferase activity of
            lecithin:retinol acyltransferase-like proteins
  JOURNAL   J Biol Chem 287 (28), 23790-23807 (2012)
   PUBMED   22605381
  REMARK    GeneRIF: Data show that acyl-modified forms of HRAS-like tumor
            suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of
            lecithin retinol acyltransferase LRAT.
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Uyama,T., Jin,X.H., Tsuboi,K., Tonai,T. and Ueda,N.
  TITLE     Characterization of the human tumor suppressors TIG3 and HRASLS2 as
            phospholipid-metabolizing enzymes
  JOURNAL   Biochim Biophys Acta 1791 (12), 1114-1124 (2009)
   PUBMED   19615464
  REMARK    GeneRIF: The tumor suppressors TIG3, HRASLS2 and H-rev107 are
            involved in the phospholipid metabolism with different
            physiological roles.
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Shyu,R.Y., Hsieh,Y.C., Tsai,F.M., Wu,C.C. and Jiang,S.Y.
  TITLE     Cloning and functional characterization of the HRASLS2 gene
  JOURNAL   Amino Acids 35 (1), 129-137 (2008)
   PUBMED   18163183
  REMARK    GeneRIF: HRASLS2 protein suppressed growth and RAS activities of
            cancer cells, and the C-terminal hydrophobic domain appeared to be
            indispensable for both activities.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000563.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017878.1.
            
            Summary: The protein encoded by this gene has both phospholipase
            and acyltransferase activities and acts as a tumor suppressor. The
            encoded protein can hydrolyze dipalmitoylated phosphatidylcholine
            (PC) to palmitic acid and lyso-PC. In addition, this protein can
            catalyze the N-acylation of phosphatidylethanolamine and can
            catalyze the O-acylation of lyso-PC to form PC. [provided by
            RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000563.1, ERR279873.2047.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255695.2/ ENSP00000255695.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               AK000563.1         5-742
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..738
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /note="phospholipase A and acyltransferase 2"
                     /db_xref="GeneID:54979"
                     /db_xref="HGNC:HGNC:17824"
                     /db_xref="MIM:613866"
     exon            1..64
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..544
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="phospholipase A/acyltransferase-2; HRAS like
                     suppressor 2"
                     /codon_start=1
                     /product="phospholipase A and acyltransferase 2"
                     /protein_id="NP_060348.1"
                     /db_xref="CCDS:CCDS8046.1"
                     /db_xref="GeneID:54979"
                     /db_xref="HGNC:HGNC:17824"
                     /db_xref="MIM:613866"
                     /translation="MALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAG
                     AGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQ
                     ELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRE
                     RQ"
     exon            65..173
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            174..442
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..738
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      715..720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /note="hexamer: ATTAAA"
     polyA_site      738
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /note="major polyA site"
ORIGIN      
        1 aatttaaggc tggacacaga gtcagcaaca cacaagacat catcttgaag gaaggatggc
       61 tttggccaga ccaagaccga gacttggaga cctgattgag atttctcgct ttggctatgc
      121 acactgggcc atctacgtgg gagatggcta tgtggtccat ctggctccgg caagtgaaat
      181 tgctggagct ggtgcggcca gtgtcctgtc tgccctgacc aacaaagcca tagtgaagaa
      241 ggaactgctg tctgtggtgg ctgggggaga caactacagg gtcaataaca agcacgatga
      301 cagatacaca ccactgcctt ccaacaaaat cgtcaagcgg gcagaggagt tggtggggca
      361 ggagttgcct tattcgctga ccagtgacaa ctgcgagcac ttcgtgaacc atctgcgcta
      421 tggcgtctcc cgcagtgacc aggtcactgg tgcagtcacg acagtaggtg tggcagcagg
      481 cctgctggct gccgcaagcc ttgtggggat cctgctggcc agaagcaagc gggaaaggca
      541 ataaatccaa gaaattgtcc caacaaccac caattcttac ggaggaatat tatttagcca
      601 gcaggagtgg agtttggttt actgatttta ctgttttgtg ttcatgaatc tttattttaa
      661 tggagttaaa agcacaggaa aatgtatttg gaaatgcagc ttagtatgaa ttctattaaa
      721 gacacaattg ggctctgc
//
