LOCUS       NM_020386                969 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens phospholipase A and acyltransferase 1 (PLAAT1),
            transcript variant 1, mRNA.
ACCESSION   NM_020386
VERSION     NM_020386.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Lei,K., Liang,R., Tan,B., Li,L., Lyu,Y., Wang,K., Wang,W., Wang,K.,
            Hu,X., Wu,D., Lin,H. and Wang,M.
  TITLE     Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on
            Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell
            Carcinoma
  JOURNAL   Oxid Med Cell Longev 2023, 6811625 (2023)
   PUBMED   36703911
  REMARK    GeneRIF: Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS
            on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell
            Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Han,C.W., Jeong,M.S. and Jang,S.B.
  TITLE     Molecular interaction between K-Ras and H-REV107 in the Ras
            signaling pathway
  JOURNAL   Biochem Biophys Res Commun 491 (2), 257-264 (2017)
   PUBMED   28743497
  REMARK    GeneRIF: A novel molecular mechanism describing K-Ras and H-REV107
            binding is suggested and insights into new K-Ras effector target
            drugs are provided.
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Hussain,Z., Uyama,T., Kawai,K., Rahman,I.A., Tsuboi,K., Araki,N.
            and Ueda,N.
  TITLE     Comparative analyses of isoforms of the calcium-independent
            phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and
            mice
  JOURNAL   J Lipid Res 57 (11), 2051-2060 (2016)
   PUBMED   27623847
REFERENCE   5  (bases 1 to 969)
  AUTHORS   Mardian,E.B., Bradley,R.M. and Duncan,R.E.
  TITLE     The HRASLS (PLA/AT) subfamily of enzymes
  JOURNAL   J Biomed Sci 22, 99 (2015)
   PUBMED   26503625
  REMARK    GeneRIF: The HRASLS (PLA/AT) subfamily of enzymes.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 969)
  AUTHORS   Shinohara,N., Uyama,T., Jin,X.H., Tsuboi,K., Tonai,T., Houchi,H.
            and Ueda,N.
  TITLE     Enzymological analysis of the tumor suppressor A-C1 reveals a novel
            group of phospholipid-metabolizing enzymes
  JOURNAL   J Lipid Res 52 (11), 1927-1935 (2011)
   PUBMED   21880860
  REMARK    GeneRIF: a possible enzyme activity of A-C1
REFERENCE   7  (bases 1 to 969)
  AUTHORS   Ren,X., Lin,J., Jin,C. and Xia,B.
  TITLE     Solution structure of the N-terminal catalytic domain of human
            H-REV107--a novel circular permutated NlpC/P60 domain
  JOURNAL   FEBS Lett 584 (19), 4222-4226 (2010)
   PUBMED   20837014
  REMARK    GeneRIF: The phospholipase active site possesses a structurally
            conserved Cys-His-His triad as found in NlpC/P60 peptidases,
            indicating H-REV107 should adopt a similar catalytic mechanism
            towards phospholipid substrates to that of NlpC/P60 peptidases.
REFERENCE   8  (bases 1 to 969)
  AUTHORS   Ito,H., Akiyama,H., Shigeno,C. and Nakamura,T.
  TITLE     Isolation, characterization, and chromosome mapping of a human A-C1
            Ha-Ras suppressor gene (HRASLS)
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 36-39 (2001)
   PUBMED   11474175
REFERENCE   9  (bases 1 to 969)
  AUTHORS   Akiyama,H., Hiraki,Y., Noda,M., Shigeno,C., Ito,H. and Nakamura,T.
  TITLE     Molecular cloning and biological activity of a novel Ha-Ras
            suppressor gene predominantly expressed in skeletal muscle, heart,
            brain, and bone marrow by differential display using clonal mouse
            EC cells, ATDC5
  JOURNAL   J Biol Chem 274 (45), 32192-32197 (1999)
   PUBMED   10542256
REFERENCE   10 (bases 1 to 969)
  AUTHORS   Husmann,K., Sers,C., Fietze,E., Mincheva,A., Lichter,P. and
            Schafer,R.
  TITLE     Transcriptional and translational downregulation of H-REV107, a
            class II tumour suppressor gene located on human chromosome
            11q11-12
  JOURNAL   Oncogene 17 (10), 1305-1312 (1998)
   PUBMED   9771974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048095.1 and BX098792.1.
            
            On Sep 22, 2018 this sequence version replaced NM_020386.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048095.1, DRR138525.285776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264735.4/ ENSP00000264735.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               BC048095.1         98-760
            664-969             BX098792.1         14-319              c
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..969
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /note="phospholipase A and acyltransferase 1"
                     /db_xref="GeneID:57110"
                     /db_xref="HGNC:HGNC:14922"
                     /db_xref="MIM:606487"
     exon            1..312
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..819
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="H-REV107 protein-related protein;
                     phospholipid-metabolizing enzyme A-C1; HRAS-like
                     suppressor 1; phospholipase A/acyltransferase 1; HRAS like
                     suppressor"
                     /codon_start=1
                     /product="phospholipase A and acyltransferase 1"
                     /protein_id="NP_065119.3"
                     /db_xref="CCDS:CCDS3303.3"
                     /db_xref="GeneID:57110"
                     /db_xref="HGNC:HGNC:14922"
                     /db_xref="MIM:606487"
                     /translation="MAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIA
                     PVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRS
                     EFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFP
                     KGQRAKYY"
     exon            313..451
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..717
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..969
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      943..948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /note="hexamer: AATAAA"
     polyA_site      969
                     /gene="PLAAT1"
                     /gene_synonym="A-C1; H-REV107; HRASLS; HRASLS1; HRSL1;
                     HSD28; PLA/AT1; PLAAT-1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagagcct cgtgccggct cggcagcgcc cggacgccga gcccagcgcg tcggcccccc
       61 ggcgtgcggg cgtctcagag ccgcggaggg gccgccggga ccgtttcagc gtggcggcgc
      121 tggtgctggc gttggccctg gaggacggcc ccgagtgatg gctggcgcct gcctcccggg
      181 tgtctcccgg gtacagatgg agtcgtcccg cggccgccgg cggcaaggtc ggcagctgcg
      241 aggccaagag agaccccagg acacacacag ctgcctcccg gtgcgagaag aagaccccgg
      301 cttgagagtg agatggcgtt taatgattgc ttcagtttga actaccctgg caacccctgc
      361 ccaggggact tgatcgaagt gttccgtcct ggctatcagc actgggccct gtacttgggt
      421 gatggttacg ttatcaacat agcacctgta gatggcattc ctgcgtcctt tacaagcgcc
      481 aagtctgtat tcagcagtaa ggccctggtg aaaatgcagc tcttgaagga tgttgtggga
      541 aatgacacat acagaataaa caataaatac gatgaaacgt acccccctct ccctgtggaa
      601 gaaatcataa agcggtcaga gtttgtaatt ggacaggagg tggcctataa cttacttgtc
      661 aacaactgtg aacattttgt gacattgctt cgctatggag aaggagtttc agagcaggcc
      721 aaccgagcga taagtaccgt tgagtttgtg acagctgctg ttggtgtctt ctcattcctg
      781 ggcttgtttc caaaaggaca aagagcaaaa tactattaac aatttaccaa agagatattg
      841 atattgaagg aatttgggag gaggaaaaga aacctggggt gaatacttat tttcagtgca
      901 tcattactgt tccagattcc tatgatggat ggcagactct ttaataaatt gcttactgat
      961 attatctta
//
