LOCUS       NM_001031689            4724 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phospholipase A2 activating protein (PLAA), transcript
            variant 1, mRNA.
ACCESSION   NM_001031689
VERSION     NM_001031689.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Shen,Z., Gu,L., Liu,Y., Wang,L., Zhu,J., Tang,S., Wei,X., Wang,J.,
            Zhang,S., Wang,X., Cheng,X., Xie,X. and Lu,W.
  TITLE     PLAA suppresses ovarian cancer metastasis via METTL3-mediated m6A
            modification of TRPC3 mRNA
  JOURNAL   Oncogene 41 (35), 4145-4158 (2022)
   PUBMED   35869392
  REMARK    GeneRIF: PLAA suppresses ovarian cancer metastasis via
            METTL3-mediated m(6)A modification of TRPC3 mRNA.
REFERENCE   2  (bases 1 to 4724)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4724)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4724)
  AUTHORS   Hall,E.A., Nahorski,M.S., Murray,L.M., Shaheen,R., Perkins,E.,
            Dissanayake,K.N., Kristaryanto,Y., Jones,R.A., Vogt,J.,
            Rivagorda,M., Handley,M.T., Mali,G.R., Quidwai,T., Soares,D.C.,
            Keighren,M.A., McKie,L., Mort,R.L., Gammoh,N., Garcia-Munoz,A.,
            Davey,T., Vermeren,M., Walsh,D., Budd,P., Aligianis,I.A.,
            Faqeih,E., Quigley,A.J., Jackson,I.J., Kulathu,Y., Jackson,M.,
            Ribchester,R.R., von Kriegsheim,A., Alkuraya,F.S., Woods,C.G.,
            Maher,E.R. and Mill,P.
  TITLE     PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by
            Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic
            Proteins
  JOURNAL   Am J Hum Genet 100 (5), 706-724 (2017)
   PUBMED   28413018
  REMARK    GeneRIF: In both human and mouse, hypomorphic mutations in the
            ubiquitin adaptor protein PLAA cause an infantile-lethal
            neurodysfunction syndrome with seizures.
REFERENCE   5  (bases 1 to 4724)
  AUTHORS   Falik Zaccai,T.C., Savitzki,D., Zivony-Elboum,Y., Vilboux,T.,
            Fitts,E.C., Shoval,Y., Kalfon,L., Samra,N., Keren,Z., Gross,B.,
            Chasnyk,N., Straussberg,R., Mullikin,J.C., Teer,J.K., Geiger,D.,
            Kornitzer,D., Bitterman-Deutsch,O., Samson,A.O., Wakamiya,M.,
            Peterson,J.W., Kirtley,M.L., Pinchuk,I.V., Baze,W.B., Gahl,W.A.,
            Kleta,R., Anikster,Y. and Chopra,A.K.
  TITLE     Phospholipase A2-activating protein is associated with a novel form
            of leukoencephalopathy
  JOURNAL   Brain 140 (2), 370-386 (2017)
   PUBMED   28007986
  REMARK    GeneRIF: This study presented that Phospholipase A2-activating
            protein is associated with a novel form of leukoencephalopathy.
REFERENCE   6  (bases 1 to 4724)
  AUTHORS   Seigneurin-Berny,D., Verdel,A., Curtet,S., Lemercier,C., Garin,J.,
            Rousseaux,S. and Khochbin,S.
  TITLE     Identification of components of the murine histone deacetylase 6
            complex: link between acetylation and ubiquitination signaling
            pathways
  JOURNAL   Mol Cell Biol 21 (23), 8035-8044 (2001)
   PUBMED   11689694
REFERENCE   7  (bases 1 to 4724)
  AUTHORS   Beatty,B.G., Qi,S., Pienkowska,M., Herbrick,J.A., Scheidl,T.,
            Zhang,Z.M., Kola,I., Scherer,S.W. and Seth,A.
  TITLE     Chromosomal localization of phospholipase A2 activating protein, an
            Ets2 target gene, to 9p21
  JOURNAL   Genomics 62 (3), 529-532 (1999)
   PUBMED   10644453
REFERENCE   8  (bases 1 to 4724)
  AUTHORS   Ruiz,A., Nadal,M., Puig,S. and Estivill,X.
  TITLE     Cloning of the human phospholipase A2 activating protein (hPLAP)
            gene on the chromosome 9p21 melanoma deleted region
  JOURNAL   Gene 239 (1), 155-161 (1999)
   PUBMED   10571045
REFERENCE   9  (bases 1 to 4724)
  AUTHORS   Chopra,A.K., Ribardo,D.A., Wood,T.G., Prusak,D.J., Xu,X.J. and
            Peterson,J.W.
  TITLE     Molecular characterization of cDNA for phospholipase A2-activating
            protein
  JOURNAL   Biochim Biophys Acta 1444 (1), 125-130 (1999)
   PUBMED   9931468
REFERENCE   10 (bases 1 to 4724)
  AUTHORS   Clark,M.A., Ozgur,L.E., Conway,T.M., Dispoto,J., Crooke,S.T. and
            Bomalaski,J.S.
  TITLE     Cloning of a phospholipase A2-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5418-5422 (1991)
   PUBMED   2052621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA591576.1, BC032551.1 and AL356133.17.
            
            On Nov 22, 2018 this sequence version replaced NM_001031689.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.133481.1,
                                           SRR1803615.56293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397292.8/ ENSP00000380460.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DA591576.1         229-330
            103-2755            BC032551.1         13-2665
            2756-4724           AL356133.17        106846-108814       c
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..4724
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /note="phospholipase A2 activating protein"
                     /db_xref="GeneID:9373"
                     /db_xref="HGNC:HGNC:9043"
                     /db_xref="MIM:603873"
     exon            1..346
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2585
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /note="isoform 1 is encoded by transcript variant 1; DOA1
                     homolog; phospholipase A-2-activating protein"
                     /codon_start=1
                     /product="phospholipase A-2-activating protein isoform 1"
                     /protein_id="NP_001026859.1"
                     /db_xref="CCDS:CCDS35000.1"
                     /db_xref="GeneID:9373"
                     /db_xref="HGNC:HGNC:9043"
                     /db_xref="MIM:603873"
                     /translation="MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTR
                     LWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSP
                     MPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKIL
                     PEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQ
                     ITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWC
                     CCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINA
                     EQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSG
                     KVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKF
                     IIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMG
                     TTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEK
                     KLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHP
                     SVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRES
                     LMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLE
                     ATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL"
     exon            347..540
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            541..641
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            642..762
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            763..930
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1066
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1236
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1394
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1614
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1683
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1752
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1854
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2019
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..4724
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2733..2738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /note="hexamer: AATAAA"
     polyA_site      2755
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /note="major polyA site"
     regulatory      4625..4630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /note="hexamer: ATTAAA"
     polyA_site      4646
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
     regulatory      4704..4709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
                     /note="hexamer: AATAAA"
     polyA_site      4724
                     /gene="PLAA"
                     /gene_synonym="DOA1; NDMSBA; PLA2P; PLAP"
ORIGIN      
        1 aggcttgctg tgtcactcgg cccgctcggc gcgccccttc ccagccgccc ttccgtaccg
       61 gctctcgggc tcttccggtc tccggccgcc ccttacctgc aggctcttct cccgccgcgg
      121 cccggcgctc tccgagtcgc ccctgcggac tggtctcgca cagtgcctgg gcaccgggcg
      181 ccagacagac actggccatg acgagcggcg caaccaggta ccggctgagc tgctcgctcc
      241 ggggccacga gctggacgta cggggcctgg tgtgctgcgc ctatccgccg ggagcctttg
      301 tgtccgtgtc ccgagaccgc accacccgcc tctgggcccc agacagtcca aacaggagct
      361 ttacagaaat gcactgtatg agtggccatt ccaattttgt atcttgtgta tgcatcatac
      421 cctcaagtga catctaccct catggcctaa ttgccaccgg tggaaatgac cacaatatat
      481 gcattttctc actggacagt ccaatgccac tttatattct aaaaggccac aaaaatactg
      541 tttgtagtct atcatctgga aaatttggga cattacttag tggttcatgg gacaccactg
      601 ctaaagtctg gctgaatgac aagtgcatga tgaccttgca gggtcataca gctgcagtgt
      661 gggcggtaaa gatcttacct gaacagggct taatgttgac tggatcagca gacaagactg
      721 ttaaactgtg gaaggctgga agatgtgaga ggactttttc agggcatgaa gactgtgtaa
      781 gaggtttggc aattttgagt gaaacagaat ttctttcctg tgcaaatgat gctagtatta
      841 gaaggtggca aatcactggc gagtgtcttg aagtatatta tggacataca aattatattt
      901 atagcatatc cgtttttcca aattgtagag actttgtgac aacagcagag gacagatctc
      961 tgagaatctg gaaacatggg gaatgtgctc aaactatccg acttccagct cagtctatat
     1021 ggtgctgctg tgtgctcgac aatggtgaca ttgtggttgg tgcgagtgat ggcattatta
     1081 gagtgtttac agaatcagaa gatcgaacag caagtgctga agaaatcaag gcttttgaaa
     1141 aagaactgtc tcacgcaacc attgattcta aaactggcga tttaggggac atcaatgctg
     1201 agcagcttcc tgggagggaa catcttaatg aacctggtac tagagaagga cagactcgtc
     1261 taatcagaga tggggagaaa gtcgaagcct atcagtggag tgttagtgaa gggaggtgga
     1321 taaaaattgg tgatgttgtt ggctcatctg gtgctaatca gcaaacatct ggaaaagttt
     1381 tatatgaagg gaaagaattt gattatgttt tctcaattga tgtcaatgaa ggtggaccat
     1441 catataaatt gccatataat accagtgatg acccttggtt aactgcatac aacttcttac
     1501 agaagaatga tttgaatcct atgtttctgg atcaagtagc taaatttatt attgataaca
     1561 caaaaggtca aatgttggga cttgggaatc ccagcttttc agatccattt acaggtggtg
     1621 gtcggtatgt tccgggctct tcgggatctt ctaacacact acccacagca gatcctttta
     1681 caggtgctgg tcgttatgta ccaggttctg caagtatggg aactaccatg gccggagttg
     1741 atccatttac agggaatagt gcctaccgat cagctgcatc taaaacaatg aatatttatt
     1801 tccctaaaaa agaggctgtc acatttgacc aagcaaaccc tacacaaata ttaggtaaac
     1861 tgaaggaact taatggaact gcacctgaag agaagaagtt aactgaggat gacttgatac
     1921 ttcttgagaa gatactgtct ctaatatgta atagttcttc agaaaaaccc acagtccagc
     1981 aacttcagat tttgtggaaa gctattaact gtcctgaaga tattgtcttt cctgcacttg
     2041 acattcttcg gttgtcaatt aaacacccca gtgtgaatga gaacttctgc aatgaaaagg
     2101 aaggggctca gttcagcagt catcttatca atcttctgaa ccctaaagga aagccagcaa
     2161 accagctgct tgctctcagg actttttgca attgttttgt tggccaggca ggacaaaaac
     2221 tcatgatgtc ccagagggaa tcactgatgt cccatgcaat agaactgaaa tcagggagca
     2281 ataagaacat tcacattgct ctggctacat tggccctgaa ctattctgtt tgttttcata
     2341 aagaccataa cattgaaggg aaagcccaat gtttgtcact aattagcaca atcttggaag
     2401 tagtacaaga cctagaagcc acttttagac ttcttgtggc tcttggaaca cttatcagtg
     2461 atgattcaaa tgctgtacaa ttagccaagt ctttaggtgt tgattctcaa ataaaaaagt
     2521 attcctcagt atcagaacca gctaaagtaa gtgaatgctg tagatttatc ctaaatttgc
     2581 tgtagcagtg gggaagaggg acggatattt ttaattgatt agtgtttttt tcctcacatt
     2641 tgacatgact gataacagat aattaaaaaa agagaatacg gtggattaag taaaatttta
     2701 catcttgtaa agtggtgggg aggggaaaca gaaataaaat ttttgcactg ctgaactgtg
     2761 agattttcct gtgtaatttg ggtagatttt caagagtgtg aacacaaatt taaaataagc
     2821 tataatcagc aacaacacaa tgacaatgac atcttcccct taccttagcc actaagaaga
     2881 caagggctgt tactcatata acttgctttt attacttaat gtacaccaaa ctgttgttgt
     2941 caattatctt ttatttaact tctccacctt cattgctaga tccttcgaac agcactgata
     3001 catttcaagg tcttgtttta ggataactac tttaaaattt tttaaattat attaaattta
     3061 taaaataatt tataaattca tatattaaaa caatataaga taatttcttg atttgtcatt
     3121 tataaatcct aaagtatatt tgtttaatgg cctattttta gatgaagaaa aagccagttg
     3181 gtaagctgtg ttagtcatgt atcagttcag acagacgagg tctcaattta actccaggct
     3241 tagatccagt ttcttttgcc cttcactatt tgaggtaact tcatttttca ttctagtttt
     3301 gatatttggc tgtttatttt tgtcattttc cattatttca aagggaattt ggaacatgtt
     3361 gaattttatc aggtggttac ataagcaaga gtacatcaaa ctgtattatt tgaaagtcta
     3421 gaacctgtca tgtgaaatta ctatttttga gccctctatg tggtccaggc agaatagtag
     3481 acacactgat atttaatcct taaaacccct ttaaatgagg gccagtatta tctctgcttt
     3541 cagaagtaga cataatagga tgaatcatat aacagaaaaa aaaaagtgaa gccaagaggg
     3601 agttaactac ttaaagtaca tgctatgcta tactttctag agagatcaca gatgtgtgtg
     3661 aacatcctag caattaacac aaagaaggaa ccatcacatt aattacacaa tttattgtgt
     3721 ctgaggtaac ccagtttctt gagagaagcg taactatttt caaaagtggg aaagatcttt
     3781 tcataaagac gttgccagaa atagcaacat tctcaatact cgtggtgtaa aaaccatgaa
     3841 tcccctggct taatgccaaa ttatagcctt agaagaataa ttgttcccca aatgggcaag
     3901 aaaggttcta attgtcaaga gtaacccaag taagaacttt tggaatatca aaaggaaatg
     3961 agcaaaatgt aaatagaggg gatatgtact ttgctgagta ttaaattgga actacctggt
     4021 gtgtacctgg actaaatatt ctgttcactg gctcagttga gtacctatac ttttcgtttt
     4081 ttgattgggt ttaggtggtt atgtcaaagt taaatggcaa aattaggaat ttaacccagg
     4141 tctggctggt tcctttacaa tacactgctt tcttaagtac aaataattta attgcaatat
     4201 ttaggaaaag taggtacctt tgaataatga taagaaacag tcttggttaa gaatatgagt
     4261 tccctcttca aaatgtaagg ggtggcaaaa tgtaaacact gcttcctatt actgtgcaag
     4321 tttttttatg tcaactttac tatttcatgt ttgttgtgga gattacaaaa tatagcttag
     4381 caaaaggaaa caatctcact tgaaggatat gttaaataat ttaatgatat tttaaagatt
     4441 ttctttttta gttaaacttt cctatgattc tcttaatgtt ttttctgaat acaaaagtaa
     4501 taaatattta ttgagtaaaa cacacacacc ccaaataaaa attgcctgta aggccactat
     4561 ctagagaaaa ctattcttaa catcttgtgg catagtgact atgtatgtaa atgtatttta
     4621 ttttattaaa aaagcgttgt atcatacata ctctttgata acctgatttt taaacttata
     4681 tttggtacaa agagctccac attaataaat acaatattct atca
//
