LOCUS       NM_005084               1915 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens phospholipase A2 group VII (PLA2G7), transcript
            variant 1, mRNA.
ACCESSION   NM_005084
VERSION     NM_005084.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   Chen,Y., Wang,S., Li,J., Fu,Y., Chen,P., Liu,X., Zhang,J., Sun,L.,
            Zhang,R., Li,X. and Liu,L.
  TITLE     The relationships between biological novel biomarkers Lp-PLA2 and
            CTRP-3 and CVD in patients with type 2 diabetes mellitus
  JOURNAL   J Diabetes 16 (7), e13574 (2024)
   PUBMED   38924255
  REMARK    GeneRIF: The relationships between biological novel biomarkers
            Lp-PLA2 and CTRP-3 and CVD in patients with type 2 diabetes
            mellitus.
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Zhang,Q., Zhang,Q.Q., He,J.J., Dong,S.Q. and Lu,Y.
  TITLE     Association of 25-hydroxyvitamin D, lipoprotein-associated
            phospholipase A2 and asymptomatic coronary artery disease in
            patients with type 2 diabetes mellitus
  JOURNAL   Diabetes Res Clin Pract 212, 111681 (2024)
   PUBMED   38677367
  REMARK    GeneRIF: Association of 25-hydroxyvitamin D, lipoprotein-associated
            phospholipase A2 and asymptomatic coronary artery disease in
            patients with type 2 diabetes mellitus.
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Guo,S. and Yang,Q.
  TITLE     Bioinformatics Analysis Identifies PLA2G7 as a Key
            Antigen-Presenting Prognostic Related Gene Promoting Hepatocellular
            Carcinoma through the STAT1/PD-L1 Axis
  JOURNAL   Front Biosci (Landmark Ed) 29 (1), 39 (2024)
   PUBMED   38287833
  REMARK    GeneRIF: Bioinformatics Analysis Identifies PLA2G7 as a Key
            Antigen-Presenting Prognostic Related Gene Promoting Hepatocellular
            Carcinoma through the STAT1/PD-L1 Axis.
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Lin,L., Teng,J., Shi,Y., Xie,Q., Shen,B., Xiang,F., Cao,X.,
            Ding,X., Xu,X. and Zhang,Z.
  TITLE     Lipoprotein-associated phospholipase A2 predicts cardiovascular
            death in patients on maintenance hemodialysis: a 7-year prospective
            cohort study
  JOURNAL   Lipids Health Dis 23 (1), 15 (2024)
   PUBMED   38216940
  REMARK    GeneRIF: Lipoprotein-associated phospholipase A2 predicts
            cardiovascular death in patients on maintenance hemodialysis: a
            7-year prospective cohort study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1915)
  AUTHORS   Zhang,Y., Jiang,M., Gao,Y., Xu,Y., Zhou,Y., Wu,D., Zhou,C., Liu,G.,
            Li,M. and Ji,X.
  TITLE     Causal Effect of Lipoprotein-Associated Phospholipase A2 Activity
            on Ischemic Stroke: A Mendelian Randomization Study
  JOURNAL   Cerebrovasc Dis 53 (5), 579-587 (2024)
   PUBMED   38113871
  REMARK    GeneRIF: Causal Effect of Lipoprotein-Associated Phospholipase A2
            Activity on Ischemic Stroke: A Mendelian Randomization Study.
REFERENCE   6  (bases 1 to 1915)
  AUTHORS   Stafforini,D.M., Satoh,K., Atkinson,D.L., Tjoelker,L.W.,
            Eberhardt,C., Yoshida,H., Imaizumi,T., Takamatsu,S.,
            Zimmerman,G.A., McIntyre,T.M., Gray,P.W. and Prescott,S.M.
  TITLE     Platelet-activating factor acetylhydrolase deficiency. A missense
            mutation near the active site of an anti-inflammatory phospholipase
  JOURNAL   J Clin Invest 97 (12), 2784-2791 (1996)
   PUBMED   8675689
REFERENCE   7  (bases 1 to 1915)
  AUTHORS   Tew,D.G., Southan,C., Rice,S.Q., Lawrence,M.P., Li,H., Boyd,H.F.,
            Moores,K., Gloger,I.S. and Macphee,C.H.
  TITLE     Purification, properties, sequencing, and cloning of a
            lipoprotein-associated, serine-dependent phospholipase involved in
            the oxidative modification of low-density lipoproteins
  JOURNAL   Arterioscler Thromb Vasc Biol 16 (4), 591-599 (1996)
   PUBMED   8624782
REFERENCE   8  (bases 1 to 1915)
  AUTHORS   Tjoelker,L.W., Eberhardt,C., Unger,J., Trong,H.L., Zimmerman,G.A.,
            McIntyre,T.M., Stafforini,D.M., Prescott,S.M. and Gray,P.W.
  TITLE     Plasma platelet-activating factor acetylhydrolase is a secreted
            phospholipase A2 with a catalytic triad
  JOURNAL   J Biol Chem 270 (43), 25481-25487 (1995)
   PUBMED   7592717
REFERENCE   9  (bases 1 to 1915)
  AUTHORS   Tjoelker,L.W., Wilder,C., Eberhardt,C., Stafforini,D.M.,
            Dietsch,G., Schimpf,B., Hooper,S., Le Trong,H., Cousens,L.S.,
            Zimmerman,G.A., Yamada,Y., McIntyre,T.M., Prescott,S.M. and
            Gray,P.W.
  TITLE     Anti-inflammatory properties of a platelet-activating factor
            acetylhydrolase
  JOURNAL   Nature 374 (6522), 549-553 (1995)
   PUBMED   7700381
REFERENCE   10 (bases 1 to 1915)
  AUTHORS   Stremler,K.E., Stafforini,D.M., Prescott,S.M. and McIntyre,T.M.
  TITLE     Human plasma platelet-activating factor acetylhydrolase.
            Oxidatively fragmented phospholipids as substrates
  JOURNAL   J Biol Chem 266 (17), 11095-11103 (1991)
   PUBMED   2040620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP326231.1, U20157.1,
            AL591242.4 and BC025674.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005084.3.
            
            Summary: The protein encoded by this gene is a secreted enzyme that
            catalyzes the degradation of platelet-activating factor to
            biologically inactive products. Defects in this gene are a cause of
            platelet-activating factor acetylhydrolase deficiency. Two
            transcript variants encoding the same protein have been found for
            this gene.[provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.121520.1, BC025674.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274793.12/ ENSP00000274793.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BP326231.1         44-112
            70-1574             U20157.1           1-1505
            1575-1648           AL591242.4         65131-65204         c
            1649-1800           BC025674.1         1601-1752
            1801-1915           AL591242.4         64864-64978         c
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..1915
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /note="phospholipase A2 group VII"
                     /db_xref="GeneID:7941"
                     /db_xref="HGNC:HGNC:9040"
                     /db_xref="MIM:601690"
     exon            1..196
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            197..339
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1556
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /EC_number="3.1.1.47"
                     /note="lipoprotein-associated phospholipase A2; PAF
                     2-acylhydrolase; 2-acetyl-1-alkylglycerophosphocholine
                     esterase; 1-alkyl-2-acetylglycerophosphocholine esterase;
                     LDL-PLA(2); gVIIA-PLA2; PAF acetylhydrolase; group-VIIA
                     phospholipase A2; LDL-associated phospholipase A2;
                     phospholipase A2, group VII (platelet-activating factor
                     acetylhydrolase, plasma)"
                     /codon_start=1
                     /product="platelet-activating factor acetylhydrolase
                     precursor"
                     /protein_id="NP_005075.3"
                     /db_xref="CCDS:CCDS4917.1"
                     /db_xref="GeneID:7941"
                     /db_xref="HGNC:HGNC:9040"
                     /db_xref="MIM:601690"
                     /translation="MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQV
                     LMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKE
                     YFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLY
                     SAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIR
                     NEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGG
                     ATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKC
                     YSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFL
                     QKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN"
     exon            340..461
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            462..606
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            607..700
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            701..769
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            770..893
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1007
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1099
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1270
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1419
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1915
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1558..1563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /note="hexamer: ATTAAA"
     polyA_site      1578
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /note="major polyA site"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /note="hexamer: AATACA"
     polyA_site      1800
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
     regulatory      1888..1893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
                     /note="hexamer: ATTAAA"
     polyA_site      1915
                     /gene="PLA2G7"
                     /gene_synonym="LDL-PLA2; LP-PLA2; PAFAD; PAFAH"
ORIGIN      
        1 acagcccgcg cgcagcccac ccgcccgccg cctgccagag ctgctcggcc cgcagccagg
       61 gggacagcgg ctggtcggag gctcgcagtg ctgtcggcga gaagcagtcg ggtttggagc
      121 gcttgggtcg cgttggtgcg cggtggaacg cgcccaggga ccccagttcc cgcgagcagc
      181 tccgcgccgc gcctgagaga ctaagctgaa actgctgctc agctcccaag atggtgccac
      241 ccaaattgca tgtgcttttc tgcctctgcg gctgcctggc tgtggtttat ccttttgact
      301 ggcaatacat aaatcctgtt gcccatatga aatcatcagc atgggtcaac aaaatacaag
      361 tactgatggc tgctgcaagc tttggccaaa ctaaaatccc ccggggaaat gggccttatt
      421 ccgttggttg tacagactta atgtttgatc acactaataa gggcaccttc ttgcgtttat
      481 attatccatc ccaagataat gatcgccttg acaccctttg gatcccaaat aaagaatatt
      541 tttggggtct tagcaaattt cttggaacac actggcttat gggcaacatt ttgaggttac
      601 tctttggttc aatgacaact cctgcaaact ggaattcccc tctgaggcct ggtgaaaaat
      661 atccacttgt tgttttttct catggtcttg gggcattcag gacactttat tctgctattg
      721 gcattgacct ggcatctcat gggtttatag ttgctgctgt agaacacaga gatagatctg
      781 catctgcaac ttactatttc aaggaccaat ctgctgcaga aataggggac aagtcttggc
      841 tctaccttag aaccctgaaa caagaggagg agacacatat acgaaatgag caggtacggc
      901 aaagagcaaa agaatgttcc caagctctca gtctgattct tgacattgat catggaaagc
      961 cagtgaagaa tgcattagat ttaaagtttg atatggaaca actgaaggac tctattgata
     1021 gggaaaaaat agcagtaatt ggacattctt ttggtggagc aacggttatt cagactctta
     1081 gtgaagatca gagattcaga tgtggtattg ccctggatgc atggatgttt ccactgggtg
     1141 atgaagtata ttccagaatt cctcagcccc tcttttttat caactctgaa tatttccaat
     1201 atcctgctaa tatcataaaa atgaaaaaat gctactcacc tgataaagaa agaaagatga
     1261 ttacaatcag gggttcagtc caccagaatt ttgctgactt cacttttgca actggcaaaa
     1321 taattggaca catgctcaaa ttaaagggag acatagattc aaatgtagct attgatctta
     1381 gcaacaaagc ttcattagca ttcttacaaa agcatttagg acttcataaa gattttgatc
     1441 agtgggactg cttgattgaa ggagatgatg agaatcttat tccagggacc aacattaaca
     1501 caaccaatca acacatcatg ttacagaact cttcaggaat agagaaatac aattaggatt
     1561 aaaataggtt ttttaaaagt cttgtttcaa aactgtctaa aattatgtgt gtgtgtgtgt
     1621 gtgtgtgtgt gtgtgtgaga gagagagaga gagagagaga gagagagaga gagaatttta
     1681 atgtattttc ccaaaggact catattttaa aatgtaggct atactgtaat cgtgattgaa
     1741 gcttggacta agaatttttt ccctttagat gtaaagaaag aatacagtat acaatattca
     1801 tatcagccta aattttaatt ttaaagatga ttccttttca gtgtcgaagt taaaaactgt
     1861 ttttacatta ctttgacaga caagtagatt aaaacaggca aaatcccagt gaaaa
//
