LOCUS       NM_000929               1918 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipase A2 group V (PLA2G5), mRNA.
ACCESSION   NM_000929
VERSION     NM_000929.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Koganesawa,M., Yamaguchi,M., Samuchiwal,S.K. and Balestrieri,B.
  TITLE     Lipid Profile of Activated Macrophages and Contribution of Group V
            Phospholipase A2
  JOURNAL   Biomolecules 11 (1), 25 (2020)
   PUBMED   33383652
  REMARK    GeneRIF: Lipid Profile of Activated Macrophages and Contribution of
            Group V Phospholipase A2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Meliton,L.N., Zhu,X., Brown,M., Epshtein,Y., Kawasaki,T.,
            Letsiou,E. and Dudek,S.M.
  TITLE     Degradation of group V secretory phospholipase A2 in lung
            endothelium is mediated by autophagy
  JOURNAL   Microvasc Res 129, 103954 (2020)
   PUBMED   31730773
  REMARK    GeneRIF: Lysosome-mediated autophagy pathway contributes to gVPLA2
            clearance from lung endothelial cells.
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Kuksis,A. and Pruzanski,W.
  TITLE     Hydrolysis of Phosphatidylcholine-Isoprostanes (PtdCho-IP) by
            Peripheral Human Group IIA, V and X Secretory Phospholipases A2
            (sPLA2)
  JOURNAL   Lipids 52 (6), 477-488 (2017)
   PUBMED   28528433
  REMARK    GeneRIF: This report provides the first demonstration that
            Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group
            IIA, V and X Secretory Phospholipases A2.
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   Menschikowski,M., Hagelgans,A., Nacke,B., Jandeck,C.,
            Mareninova,O.A., Asatryan,L. and Siegert,G.
  TITLE     Epigenetic control of group V phospholipase A2 expression in human
            malignant cells
  JOURNAL   Tumour Biol 37 (6), 8097-8105 (2016)
   PUBMED   26715269
  REMARK    GeneRIF: Low GV-PLA2 expression is associated with cancer.
REFERENCE   5  (bases 1 to 1918)
  AUTHORS   Pruzanski,W., Kopilov,J. and Kuksis,A.
  TITLE     Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and
            eicosanoid release from vascular smooth muscle cells: Diverse
            activity of sPLA2's IIA, V and X
  JOURNAL   Prostaglandins Other Lipid Mediat 122, 64-68 (2016)
   PUBMED   26711221
  REMARK    GeneRIF: Data show that phospholipase A2 group IIA, V and X have
            different target/function related activity.
REFERENCE   6  (bases 1 to 1918)
  AUTHORS   Johansen,B., Rakkestad,K., Balboa,M.A. and Dennis,E.A.
  TITLE     Expression of cytosolic and secreted forms of phospholipase A(2)
            and cyclooxygenases in human placenta, fetal membranes, and
            chorionic cell lines
  JOURNAL   Prostaglandins Other Lipid Mediat 60 (4-6), 119-125 (2000)
   PUBMED   10751642
REFERENCE   7  (bases 1 to 1918)
  AUTHORS   Bingham,C.O. 3rd, Fijneman,R.J., Friend,D.S., Goddeau,R.P.,
            Rogers,R.A., Austen,K.F. and Arm,J.P.
  TITLE     Low molecular weight group IIA and group V phospholipase A(2)
            enzymes have different intracellular locations in mouse bone
            marrow-derived mast cells
  JOURNAL   J Biol Chem 274 (44), 31476-31484 (1999)
   PUBMED   10531350
REFERENCE   8  (bases 1 to 1918)
  AUTHORS   Chen,Y. and Dennis,E.A.
  TITLE     Expression and characterization of human group V phospholipase A2
  JOURNAL   Biochim Biophys Acta 1394 (1), 57-64 (1998)
   PUBMED   9767110
  REMARK    Erratum:[Biochim Biophys Acta 1999 Jan 4;1436(3):629]
REFERENCE   9  (bases 1 to 1918)
  AUTHORS   Tischfield,J.A., Xia,Y.R., Shih,D.M., Klisak,I., Chen,J.,
            Engle,S.J., Siakotos,A.N., Winstead,M.V., Seilhamer,J.J.,
            Allamand,V., Gyapay,G. and Lusis,A.J.
  TITLE     Low-molecular-weight, calcium-dependent phospholipase A2 genes are
            linked and map to homologous chromosome regions in mouse and human
  JOURNAL   Genomics 32 (3), 328-333 (1996)
   PUBMED   8838795
REFERENCE   10 (bases 1 to 1918)
  AUTHORS   Chen,J., Engle,S.J., Seilhamer,J.J. and Tischfield,J.A.
  TITLE     Cloning and recombinant expression of a novel human low molecular
            weight Ca(2+)-dependent phospholipase A2
  JOURNAL   J Biol Chem 269 (4), 2365-2368 (1994)
   PUBMED   8300559
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158172.5, AV709457.1,
            BM705479.1, BC036792.1 and BM684907.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000929.2.
            
            Summary: This gene is a member of the secretory phospholipase A2
            family. It is located in a tightly-linked cluster of secretory
            phospholipase A2 genes on chromosome 1. The encoded enzyme
            catalyzes the hydrolysis of membrane phospholipids to generate
            lysophospholipids and free fatty acids including arachidonic acid.
            It preferentially hydrolyzes linoleoyl-containing
            phosphatidylcholine substrates. Secretion of this enzyme is thought
            to induce inflammatory responses in neighboring cells.
            Alternatively spliced transcript variants have been found, but
            their full-length nature has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036792.1, U03090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375108.4/ ENSP00000364249.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL158172.5         23336-23349
            15-46               AV709457.1         1-32
            47-105              BM705479.1         22-80
            106-135             AV709457.1         92-121
            136-1175            BC036792.1         1-1040
            1176-1296           AL158172.5         44311-44431
            1297-1908           BM684907.1         18-629              c
            1909-1918           AL158172.5         45044-45053
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1918
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /note="phospholipase A2 group V"
                     /db_xref="GeneID:5322"
                     /db_xref="HGNC:HGNC:9038"
                     /db_xref="MIM:601192"
     exon            1..272
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /inference="alignment:Splign:2.1.0"
     exon            273..322
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..699
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /EC_number="3.1.1.4"
                     /note="Ca2+-dependent phospholipase A2; calcium-dependent
                     phospholipase A2; phosphatidylcholine 2-acylhydrolase 5"
                     /codon_start=1
                     /product="phospholipase A2 group V precursor"
                     /protein_id="NP_000920.1"
                     /db_xref="CCDS:CCDS202.1"
                     /db_xref="GeneID:5322"
                     /db_xref="HGNC:HGNC:9038"
                     /db_xref="MIM:601192"
                     /translation="MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFY
                     GCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPF
                     CHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS"
     exon            323..467
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /inference="alignment:Splign:2.1.0"
     exon            468..574
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /inference="alignment:Splign:2.1.0"
     exon            575..1918
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1146..1151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /note="hexamer: AATAAA"
     regulatory      1168..1173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /note="hexamer: AATAAA"
     polyA_site      1175
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /note="major polyA site"
     polyA_site      1197
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
                     /note="hexamer: AATAAA"
     polyA_site      1911
                     /gene="PLA2G5"
                     /gene_synonym="FRFB; GV-PLA2; hVPLA(2); PLA2-10"
ORIGIN      
        1 agtcgggggc tgagcagggt tctacccggc tgggtccagg cagaagtttt tcctccccac
       61 ctccgggttt gtcctcatca tcggtcactc ccattcacag ctttaagatt ctggaggcca
      121 agaatttgac tccccccgga tccatggtct gtggatacca atgttccgac tggagacggg
      181 gagcccgcga gacccgggtc tccagggtct gcccaaggaa gttgctcatg ggagcagacc
      241 tctagagcag gatttgaggc caggccaaag agaaccccag agatgaaagg cctcctccca
      301 ctggcttggt tcctggcttg tagtgtgcct gctgtgcaag gaggcttgct ggacctaaaa
      361 tcaatgatcg agaaggtgac agggaagaac gccctgacaa actacggctt ctacggctgt
      421 tactgcggct ggggcggccg aggaaccccc aaggatggca ccgattggtg ctgttgggcg
      481 catgaccact gctatgggcg gctggaggag aagggctgca acattcgcac acagtcctac
      541 aaatacagat tcgcgtgggg cgtggtcacc tgcgagcccg ggcccttctg ccatgtgaac
      601 ctctgtgcct gtgaccggaa gctcgtctac tgcctcaaga gaaacctacg gagctacaac
      661 ccacagtacc aatactttcc caacatcctc tgctcctagg cctccccagc gagctcctcc
      721 cagaccaaga cttttgttct gtttttctac aacacagagt actgactctg cctggttcct
      781 gagagaggct cctaagtcac agacctcagt ctttctcgaa gcttggcgga cccccagggc
      841 cacactgtac cctccagcga gtcccaggag agtgactctg gtcataggac ttggtagggt
      901 cccagggtcc ctaggcctcc acttctgagg gcagcccctc tggtgccaag agctctcctc
      961 caactcaggg ttggctgtgt ctcttttctt ctctgaagac agcgtcctgg ctccagttgg
     1021 aacactttcc tgagatgcac ttacttctca gcttctgcga tcagattatc atcaccacca
     1081 ccctccagag aatttttacg caagaagagc caaattgact ctctaaatct ggtgtatggg
     1141 tattaaataa aattcattct caaggctaat aaaaaccaca ttggcatttt cctctgctgt
     1201 gggggatcgc tggtgcctct ttctctgcca ctggggcaat aaacccaaag atgtctacat
     1261 tatctccgaa acagaaggga agattagtaa atgcagggtt ttctgggatg agcttcaggc
     1321 tttctcttgg gctaattttc ttacaccttg gggtcctctc cagtattggg tctcattctt
     1381 cctcgatggg gtcagggaaa gataactggt gattatgcca gcttcagctt ccaggccaga
     1441 gagggtggca ttcaaatccc agtgctggct tcttcagctg tgtggtcttg gacccgttac
     1501 tgaacctctt tgactttcag tctctttgag aaataaactg tcttgttcct tgcaatgtaa
     1561 aatgagactt ctaaagccca ccttgatgct gatatggaga atgctgaggt tctaggattt
     1621 cacacagcag gaattttttt ttaataggtg tcagctgtgg ggtttatttt ttacaaagta
     1681 aggacattaa aaaaaccaac ccgtctatca attcataaaa gaaaggatgt tctgatacca
     1741 agactgaaag aagaaaggat gtattccaaa acaaaggaac atccttccaa gaaaggacct
     1801 atggcttctt tattccgaca taccccaaaa taactgcatg ataaataggt ctatatttaa
     1861 aaagctctag tgtcgaatgt tttcaaaata aaatttaatt ttatgagatt accctgaa
//
