LOCUS       NM_213600               5587 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phospholipase A2 group IVF (PLA2G4F), transcript
            variant 1, mRNA.
ACCESSION   NM_213600
VERSION     NM_213600.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5587)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5587)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 5587)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 5587)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
REFERENCE   5  (bases 1 to 5587)
  AUTHORS   Ohto,T., Uozumi,N., Hirabayashi,T. and Shimizu,T.
  TITLE     Identification of novel cytosolic phospholipase A(2)s, murine
            cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster
            with cPLA(2){beta}
  JOURNAL   J Biol Chem 280 (26), 24576-24583 (2005)
   PUBMED   15866882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK172836.1, BC142682.1 and AC036103.8.
            
            On May 17, 2019 this sequence version replaced NM_213600.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK304368.1, BC142682.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397272.7/ ENSP00000380442.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK172836.1         6-29
            25-840              BC142682.1         1-816
            841-841             AC036103.8         74122-74122         c
            842-1451            BC142682.1         818-1427
            1452-1452           AC036103.8         70675-70675         c
            1453-2304           BC142682.1         1429-2280
            2305-2305           AC036103.8         66136-66136         c
            2306-3016           BC142682.1         2282-2992
            3017-5587           AC036103.8         62531-65101         c
FEATURES             Location/Qualifiers
     source          1..5587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..5587
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /note="phospholipase A2 group IVF"
                     /db_xref="GeneID:255189"
                     /db_xref="HGNC:HGNC:27396"
     exon            1..198
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2637
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /EC_number="3.1.1.4"
                     /note="cPLA2-zeta"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 zeta"
                     /protein_id="NP_998765.3"
                     /db_xref="CCDS:CCDS32204.1"
                     /db_xref="GeneID:255189"
                     /db_xref="HGNC:HGNC:27396"
                     /translation="MLWALWPRWLADKMLPLLGAVLLQKREKRGPLWRHWRRETYPYY
                     DLQVKVLRATNIRGTDLLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQI
                     HGAVKNVLELTLYDKDILGSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFV
                     LEKSQVPASEVITNGVLVAHPCLRIQGTLRGDGTAPREEYGSRQLQLAVPGAYEKPQL
                     LPLQPPTEPGLPPTFTFHVNPVLSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGI
                     LLSSLPLGQEEQCSVALGEGQEVALSMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQV
                     VSKALQQVLGLSEALDSGQVPVVAVLGSGGGTRAMSSLYGSLAGLQELGLLDTVTYLS
                     GVSGSTWCISTLYRDPAWSQVALQGPIERAQVHVCSSKMGALSTERLQYYTQELGVRE
                     RSGHSVSLIDLWGLLVEYLLYQEENPAKLSDQQEAVRQGQNPYPIYTSVNVRTNLSGE
                     DFAEWCEFTPYEVGFPKYGAYVPTELFGSELFMGRLLQLQPEPRICYLQGMWGSAFAT
                     SLDEIFLKTAGSGLSFLEWYRGSVNITDDCQKPQLHNPSRLRTRLLTPQGPFSQAVLD
                     IFTSRFTSAQSFNFTRGLCLHKDYVAGREFVAWKDTHPDAFPNQLTPMRDCLYLVDGG
                     FAINSPFPLALLPQRAVDLILSFDYSLEAPFEVLKMTEKYCLDRGIPFPSIEVGPEDM
                     EEARECYLFAKAEDPRSPIVLHFPLVNRTFRTHLAPGVERQTAEEKAFGDFVINRPDT
                     PYGMMNFTYEPQDFYRLVALSRYNVLNNVETLKCALQLALDRHQARERAGA"
     exon            199..271
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            272..408
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            409..537
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            538..578
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            579..621
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            622..688
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            689..858
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            859..972
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1010
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1146
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1283
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1506
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1621
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1759
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1867
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2062
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2229
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2416
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..5587
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /note="hexamer: AATATA"
     polyA_site      3417
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /note="major polyA site"
     regulatory      5447..5452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /note="hexamer: AATAAA"
     polyA_site      5467
                     /gene="PLA2G4F"
                     /gene_synonym="PLA2G4FZ"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgcct gtcacacctg agccagcagt ttgtgcaacc agaggagcgc aggcagggtt
       61 ccctgctggg gcccgggctg cccagccatg ctttgggcac tctggccaag gtggctggca
      121 gacaagatgc tgcccctcct gggggcagtg ctgcttcaga agagagagaa gaggggccct
      181 ctgtggaggc actggcggcg ggaaacctac ccatactatg acctccaggt gaaggtgctg
      241 agggccacaa acatccgggg cacagacctg ctgtccaaag ccgactgcta tgtgcaactg
      301 tggctgccca cggcgtcccc aagccctgcc cagactagga tagtggccaa ctgcagtgac
      361 cccgagtgga atgagacctt ccactaccag atccatggtg ctgtgaagaa cgtcctggag
      421 ctcaccctct atgacaagga catcctgggc agcgaccagc tctctctgct cctgtttgac
      481 ctgagaagcc tcaagtgtgg ccaacctcac aaacacacct tcccactcaa ccaccaggat
      541 tcacaagagc tgcaggtgga atttgttctg gagaagagcc aggtgcctgc atctgaagtc
      601 atcaccaacg gggttctggt ggctcacccc tgtctgagaa tccagggcac gctccgggga
      661 gatgggacag ccccacggga agagtacggc tctaggcagc tccagctggc agtgcctgga
      721 gcctacgaga agccacagct cttgcccctg cagcctccca cagagccagg cctcccaccc
      781 acctttacct tccacgtgaa cccagtgctg agctccaggc tacacgtgga gctgatggag
      841 ctgctggcag ctgtgcagag tggccccagc gcagagttgg aggctcagac cagcaagctg
      901 ggcgaggggg gcatcctgct ctcctctctg cccctaggcc aggaggaaca gtgttctgtg
      961 gccctggggg agggccagga ggtggctctg agcatgaagg tggaaatgag ctccggggac
     1021 ctagacctac gccttggctt tgacctctct gacggggagc aggagtttct ggacaggagg
     1081 aagcaggtcg tgtccaaggc cctgcagcaa gtgctgggat tgagtgaggc tctggacagt
     1141 ggccaggtgc ctgtagtggc tgtgttgggt tccgggggtg gaacccgagc catgtcttct
     1201 ctgtacggca gcctggcagg gttgcaggag ctcggccttc tagacactgt gacctacctg
     1261 agtggggtct ctgggtctac ctggtgcatc tccacactct acagggaccc agcctggtcc
     1321 caggtggcct tgcagggccc cattgagcgt gcccaggttc acgtctgcag cagtaagatg
     1381 ggagctttgt ccacggagcg gctacagtac tacactcagg aactgggggt ccgggagcgc
     1441 agtggccaca gcgtgtccct catcgacctc tggggcctcc ttgttgagta tctcctgtac
     1501 caggaggaga accctgccaa gctgtctgac caacaggagg cggtccgcca gggtcagaac
     1561 ccttacccca tttacaccag tgtcaacgtc cgcaccaact tgagtgggga agattttgca
     1621 gagtggtgcg agttcacgcc ctatgaggtt ggcttcccca agtacggggc ttatgttccc
     1681 accgagctct tcggctcaga actcttcatg ggacgattgc tgcagctcca gcctgaaccc
     1741 cggatctgtt acctgcaagg tatgtggggc agcgcctttg ccaccagcct ggatgagatc
     1801 ttcctaaaga ccgccggctc gggcctcagc ttcctggagt ggtacagagg cagtgtgaat
     1861 atcacagacg actgccagaa gcctcagctg cacaacccct cgaggctgcg aacgaggctc
     1921 ctcaccccac aggggccctt ctcccaggct gtgctggaca tattcacctc ccgcttcact
     1981 tccgcccaga gctttaactt cacccggggt ctctgcttgc acaaggacta tgtggctggc
     2041 agggagttcg tggcctggaa agacacacac ccggacgcct tccccaacca gctcaccccc
     2101 atgcgggact gcctgtacct ggtggacgga ggctttgcca tcaactctcc gttcccactg
     2161 gctctgctgc ctcagagagc agtggacctc attctgtcct ttgactattc cttggaagcc
     2221 ccttttgagg tcttgaagat gacagagaag tactgcctgg accgaggaat ccccttccct
     2281 agcatcgagg tgggccctga ggacatggag gaggcccgtg agtgctatct gtttgccaag
     2341 gctgaggacc cccgctcccc cattgtgctg cacttccccc tggttaaccg taccttccgc
     2401 acacacctgg ccccaggtgt ggagcgacaa acagctgagg agaaggcctt tggggacttt
     2461 gtcatcaaca ggccagacac cccctatggc atgatgaact tcacctatga gccccaggac
     2521 ttttatcggc tggtggccct cagtcgatac aacgtcctga acaacgtgga gaccttgaag
     2581 tgcgccctcc agctggctct ggaccggcac caggctcggg agagggcagg ggcctgacca
     2641 aggcaggaag cggaggactg tgacagagag gagacacact gctcatggtc agggcttgta
     2701 gagggaggag cgatggggac tctgtgcagg atctgcttcc cttctctcca ggacctgcct
     2761 cgaggtgccc caggccccgg aaagctcttg cagaattgca gcttggactg gggcagggct
     2821 ctccttgtgt gtttttggag aagatgggca gtagatcgct ccagggactc ttggggatgt
     2881 agggcagaag agaacagcac tcatttcaca gcggggtgtg gagagaatca ggtgagccac
     2941 agagcccacc ccagacacag aaggacctca gagggcccaa gtcctcagac ccacacagaa
     3001 caggggctga gggcactgag aagccagctg tcctccttac actgagatgg aaagcagaga
     3061 tgcatccatc cacacttcct gcagagcggc ccaagcccca accccacctc gagctcctgg
     3121 atgcactgct atcaagaaca atgaggggct gaggggatgg ccagcctatg ttgctgactc
     3181 catcatccta accctccttc tgccttctgg tctcctcgtg cctcctccca gatcaccctt
     3241 ctcttcccag cgccctaaag cctgtggggt gatgtcccat tctggctgct ccaggtggga
     3301 gatgtgcgcg tgtctccctg ccagttaccc aggcttcact cttcgaacct ggaccacagt
     3361 ctctggtgat gtgtgtagtg gccacatcat gcaaatatag tctcaccatt cctaggagct
     3421 aaatgggtgt gtctagtagg ggcatcagtt catcggggga gaggtgtgca cctgtatgtg
     3481 gggcaggagg gtgtgcaagt tcctggaggt gggttactcc aaggcatggg cagtgcagag
     3541 ggagcctcgc ctgggctctt gcctctttcc cagatgcatc caatgggtct tggcaagttt
     3601 tgtttctcac tctccctctt ctccatttcc cctgacccgc cagggactct ccaaatacct
     3661 agaacctctc tagtgtgggc agccctcaga ttcgtgaaga ggagatcccg ttctggccag
     3721 gccctctcca tctggccacg gcctctgcag catatgcctc cagtgctgag ctgcctagga
     3781 gcctgcagca gcacttgaga ccttgttcct tctgccccct gtcccagggg ctccctcttg
     3841 gctgcacccc ctgctccatg ctctctcaca cagacacgct gtcaggaaca cctgtgctgg
     3901 gaagccttac ctgtcctgag tctggaaaga agactagttc tggtttccag gttggggaag
     3961 ggtgactgga gcccagcctg tgtcttggcc tggcctggga tctgcagccc tccagctggc
     4021 atgagttgcg agggctgggg gagccagtta tttgggctgg catggggtgg ggacacctca
     4081 gttctcctct gcctcctcac catggctgcc tgtcacaggc cacggcccct ccccttggtt
     4141 cagcagtgag aggtttatct gggagtttat ctggctcctg ctgtggccat tgtcatcaac
     4201 actgctgtgc ctgccgtcat caataacttg ttagtaaaac cttcataggg ttcacagctc
     4261 agaactgcac agcgttcaca acttagaatc tgtggtgttt cttcagtgcc cattagagcc
     4321 tcaggctgtc tctggctcct agaaagtcat tctaccatct gttttgttca ctgctgtatc
     4381 ctcagtgcct agagcagcag ttgatacatg gtaggtgctc agtaaatatt tgataaatga
     4441 atgggaacct acattctaag aaatggatcg tcacccacca accacaaaaa agcatgcaat
     4501 gctttcatga ttcctaaccc atgtggactt tttgaagagc tgatataaac cacagaccct
     4561 ctcccaagaa aaaggcatac acacacacat gaaaagttgc ttacaataag gtctctgctt
     4621 cagctatgtg atcagcagcc ccagggttgc agaggccagc gtctgtcccc gcaggccagc
     4681 aaggcttgtg aaggaggcaa acgtgggctt gtgcagagtg ggcggggacc ttctcacaca
     4741 gaagtgtagg caatgccact tgtgctcaga taaggtttgg gaggagactg ggacaagatc
     4801 aagggcaggg ggcagggggc aggaggctgg gctagtgctg tggcccagat attggccaga
     4861 agtacaggga ggatctcagc cagggatggg gaggctccaa caagactgaa tctgggagcc
     4921 acgcagagca agaagccagg ggaggggccg aaggtaaccc agccagttta atgtctgctc
     4981 ctcaggagag atctgagtct ttacctcatt cccaaccctt atctgagatg gctggaaata
     5041 agcttcaggg tcctgaaggt gacagagttg gagggatttg tctagaagag caagcatggt
     5101 ttcccttgaa gctgggtaga aacacaggag cagggacatc attcatcaac ttgtcagagc
     5161 tcctcatgag gcaagggaag aaaaaggggg ccacaagtgt aggagattgg tcagagtggt
     5221 gggagaagct atagggaaag gagcaggcct tctgaaaggt tggaaggctc tgcatagctt
     5281 tggaggagaa tagctaaaga cagctgttct ataaccctga ggcagagggc aaggagtagg
     5341 tacgagggag tgtgggggaa tttatcttaa acaggcttgt ttacttctgt tgaccaggaa
     5401 ctgacctttg atcatctacg cccatgacct tccctgaaag gggaacaata aatgttaatt
     5461 acctccagtg tttgctccag gcttttggca ttgtgcctgc actgaataaa agcaagcagc
     5521 tccagcttct cagggctgca ctttggccac ttgagctggg cagtccccta gctgctctta
     5581 cactgca
//
