LOCUS       NM_001395548            4704 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens phospholipase A2 group IVE (PLA2G4E), transcript
            variant 2, mRNA.
ACCESSION   NM_001395548 XM_011521237
VERSION     NM_001395548.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4704)
  AUTHORS   Perez-Gonzalez,M., Mendioroz,M., Badesso,S., Sucunza,D., Roldan,M.,
            Espelosin,M., Ursua,S., Lujan,R., Cuadrado-Tejedor,M. and
            Garcia-Osta,A.
  TITLE     PLA2G4E, a candidate gene for resilience in Alzheimer s disease and
            a new target for dementia treatment
  JOURNAL   Prog Neurobiol 191, 101818 (2020)
   PUBMED   32380223
  REMARK    GeneRIF: PLA2G4E, a candidate gene for resilience in Alzheimer s
            disease and a new target for dementia treatment.
REFERENCE   2  (bases 1 to 4704)
  AUTHORS   Binte Mustafiz,S.S., Uyama,T., Morito,K., Takahashi,N., Kawai,K.,
            Hussain,Z., Tsuboi,K., Araki,N., Yamamoto,K., Tanaka,T. and Ueda,N.
  TITLE     Intracellular Ca2+-dependent formation of
            N-acyl-phosphatidylethanolamines by human cytosolic phospholipase
            A2epsilon
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (12), 158515 (2019)
   PUBMED   31473348
  REMARK    GeneRIF: Cytosolic phospholipase A2 epsilon (cPLA2-epsilon)
            Ca2+-dependently produces N-acyl-phosphatidylethanolamine.
REFERENCE   3  (bases 1 to 4704)
  AUTHORS   Binte Mustafiz,S.S., Uyama,T., Hussain,Z., Kawai,K., Tsuboi,K.,
            Araki,N. and Ueda,N.
  TITLE     The role of intracellular anionic phospholipids in the production
            of N-acyl-phosphatidylethanolamines by cytosolic phospholipase
            A2varepsilon
  JOURNAL   J Biochem 165 (4), 343-352 (2019)
   PUBMED   30517655
  REMARK    GeneRIF: The role of intracellular anionic phospholipids in the
            production of N-acyl-phosphatidylethanolamines by cytosolic
            phospholipase A2varepsilon.
REFERENCE   4  (bases 1 to 4704)
  AUTHORS   Hussain,Z., Uyama,T., Kawai,K., Binte Mustafiz,S.S., Tsuboi,K.,
            Araki,N. and Ueda,N.
  TITLE     Phosphatidylserine-stimulated production of
            N-acyl-phosphatidylethanolamines by Ca2+-dependent
            N-acyltransferase
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (5), 493-502 (2018)
   PUBMED   29447909
REFERENCE   5  (bases 1 to 4704)
  AUTHORS   Morimoto,Y., Shimada-Sugimoto,M., Otowa,T., Yoshida,S.,
            Kinoshita,A., Mishima,H., Yamaguchi,N., Mori,T., Imamura,A.,
            Ozawa,H., Kurotaki,N., Ziegler,C., Domschke,K., Deckert,J.,
            Umekage,T., Tochigi,M., Kaiya,H., Okazaki,Y., Tokunaga,K.,
            Sasaki,T., Yoshiura,K.I. and Ono,S.
  TITLE     Whole-exome sequencing and gene-based rare variant association
            tests suggest that PLA2G4E might be a risk gene for panic disorder
  JOURNAL   Transl Psychiatry 8 (1), 41 (2018)
   PUBMED   29391400
  REMARK    GeneRIF: PLA2G4E may be be a risk gene for panic disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4704)
  AUTHORS   Capestrano,M., Mariggio,S., Perinetti,G., Egorova,A.V.,
            Iacobacci,S., Santoro,M., Di Pentima,A., Iurisci,C., Egorov,M.V.,
            Di Tullio,G., Buccione,R., Luini,A. and Polishchuk,R.S.
  TITLE     Cytosolic phospholipase Aepsilon drives recycling through the
            clathrin-independent endocytic route
  JOURNAL   J Cell Sci 127 (Pt 5), 977-993 (2014)
   PUBMED   24413173
  REMARK    GeneRIF: Cytoplasmic PLA2 epsilonepsilon is a new important
            regulator of trafficking processes within the clathrin-independent
            endocytic and recycling route.
REFERENCE   7  (bases 1 to 4704)
  AUTHORS   Ohto,T., Uozumi,N., Hirabayashi,T. and Shimizu,T.
  TITLE     Identification of novel cytosolic phospholipase A(2)s, murine
            cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster
            with cPLA(2){beta}
  JOURNAL   J Biol Chem 280 (26), 24576-24583 (2005)
   PUBMED   15866882
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC039056.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 16, 2021 this sequence version replaced XM_011521237.2.
            
            Summary: This gene encodes a member of the cytosolic phospholipase
            A2 group IV family. Members of this family are involved in
            regulation of membrane tubule-mediated transport. The enzyme
            encoded by this member of the family plays a role in trafficking
            through the clathrin-independent endocytic pathway. The enzyme
            regulates the recycling process via formation of tubules that
            transport internalized clathrin-independent cargo proteins back to
            the cell surface. [provided by RefSeq, Jan 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.9473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696112.1/ ENSP00000512406.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC039056.7         145400-145507       c
            109-181             AC039056.7         138150-138222       c
            182-318             AC039056.7         132194-132330       c
            319-450             AC039056.7         130455-130586       c
            451-491             AC039056.7         129403-129443       c
            492-534             AC039056.7         127119-127161       c
            535-598             AC039056.7         125622-125685       c
            599-777             AC039056.7         124569-124747       c
            778-861             AC039056.7         124382-124465       c
            862-899             AC039056.7         123989-124026       c
            900-1035            AC039056.7         121589-121724       c
            1036-1172           AC039056.7         119825-119961       c
            1173-1395           AC039056.7         117202-117424       c
            1396-1510           AC039056.7         114586-114700       c
            1511-1648           AC039056.7         113880-114017       c
            1649-1756           AC039056.7         112514-112621       c
            1757-1960           AC039056.7         111637-111840       c
            1961-2127           AC039056.7         110304-110470       c
            2128-2311           AC039056.7         108901-109084       c
            2312-4704           AC039056.7         106047-108439       c
FEATURES             Location/Qualifiers
     source          1..4704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4704
                     /gene="PLA2G4E"
                     /note="phospholipase A2 group IVE"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
     exon            1..108
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2532
                     /gene="PLA2G4E"
                     /EC_number="3.1.1.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytosolic phospholipase A2 epsilon; cPLA2-epsilon;
                     calcium-dependent N-acyltransferase"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 epsilon isoform 2"
                     /protein_id="NP_001382477.1"
                     /db_xref="CCDS:CCDS91983.1"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
                     /translation="MLLRQMHARVSHSLPDPCQAEDSRPSATCALKEGLSPCHLLTVR
                     VIRMKNVRQADMLSQTDCFVSLWLPTASQKKLRTRTISNCPNPEWNESFNFQIQSRVK
                     NVLELSVCDEDTVTPDDHLLTVLYDLTKLCFRKKTHVKFPLNPQGMEELEVEFLLEES
                     PSPPETLVTNGVLVSRQVSCLEVHAQSRRRRKREKMKDLLVMVNESFENTQRVRPCLE
                     PCCPTSACFQTAACFHYPKYFQSQVHVEVPKSHWSCGLCCRSRKKGPISQPLDCLSDG
                     QVMTLPVGESYELHMKSTPCPETLDVRLGFSLCPAELEFLQKRKVVVAKALKQVLQLE
                     EDLQEDEVPLIAIMATGGGTRSMTSMYGHLLGLQKLNLLDCASYITGLSGATWTMATL
                     YRDPDWSSKNLEPAIFEARRHVVKDKLPSLFPDQLRKFQEELRQRSQEGYRVTFTDFW
                     GLLIETCLGDERNECKLSDQRAALSCGQNPLPIYLTINVKDDVSNQDFREWFEFSPYE
                     VGLQKYGAFIPSELFGSEFFMGRLVKRIPESRICYMLGLWSSIFSLNLLDAWNLSHTS
                     EEFFHRWTREKVQDIEDEPILPEIPKCDANILETTVVIPGSWLSNSFREILTHRSFVS
                     EFHNFLSGLQLHTNYLQNGQFSRWKDTVLDGFPNQLTESANHLCLLDTAFFVNSSYPP
                     LLRPERKADLIIHLNYCAGSQTKPLKQTCEYCTVQNIPFPKYELPDENENLKECYLME
                     NPQEPDAPIVTFFPLINDTFRKYKAPGVERSPEELEQGQVDIYGPKTPYATKELTYTE
                     ATFDKLVKLSEYNILNNKDTLLQALRLAVEKKKRLKGQCPS"
     exon            109..181
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            182..318
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            319..450
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            451..491
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            492..534
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            535..598
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            599..777
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            778..861
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            862..899
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1035
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1172
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1395
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1510
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1648
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1756
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1960
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2127
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2311
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..4704
                     /gene="PLA2G4E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4682..4687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G4E"
                     /note="hexamer: AATAAA"
     polyA_site      4704
                     /gene="PLA2G4E"
                     /note="major polyA site"
ORIGIN      
        1 agagctgccg tgatgctcct gaggcagatg cacgccaggg tctcccactc cctgccagac
       61 ccatgccaag cagaagacag caggccctcg gccacctgtg ccttgaagga ggggctgtct
      121 ccatgccacc tgttgacagt gagggtcatc cggatgaaaa atgtccggca ggctgatatg
      181 ctgagccaga cagactgttt tgtgagcctc tggctgccca ccgcctctca gaagaagctg
      241 aggacaagga ccatctccaa ctgcccaaat ccagagtgga atgaaagctt caacttccag
      301 atccagagcc gagtgaagaa cgtgctagag ttgagtgtct gtgatgaaga cacagtgaca
      361 ccagatgacc atctcctgac agttctctat gacctcacca agctctgttt ccgaaagaaa
      421 acccacgtga agtttccact caacccgcag ggcatggaag agctggaggt ggagttcctg
      481 ctggaggaga gtccctctcc acctgagacc ctcgtcacca atggcgtgct ggtgtctcga
      541 caagtctcct gcctggaggt tcatgcacaa tccaggaggc ggaggaagag ggagaaaatg
      601 aaggacctcc tggtgatggt gaacgaatcc tttgagaaca cccagcgtgt ccggccctgc
      661 ttggaaccct gctgcccaac ctctgcctgc ttccaaaccg ctgcctgctt ccactacccc
      721 aagtacttcc agtcccaggt gcacgtggaa gtgcccaaga gtcactggag ctgtgggctt
      781 tgctgccgct ctcgcaagaa gggccccatc agccagcccc tcgactgcct ttccgatggt
      841 caggtgatga ccctgcctgt gggtgagagt tatgaattac acatgaagtc tacaccctgc
      901 cctgagacac tggacgtgcg gctgggcttc agcctgtgcc cagcagagct ggagtttctg
      961 cagaagcgga aggtcgtggt ggccaaggcc ctgaagcagg tgctgcagct ggaggaagac
     1021 ctgcaggagg acgaggtgcc gctgatagcc atcatggcca ctgggggtgg aacaagatcc
     1081 atgacctcca tgtatggcca cctgctgggg ctgcagaagc tgaacctcct ggactgtgcc
     1141 agctacatca ccggtctatc aggggccacc tggaccatgg ctaccttgta ccgtgaccct
     1201 gactggtcct ccaaaaactt ggagcctgct atctttgagg ctcggagaca tgtggtaaag
     1261 gacaagctac cctccctgtt cccagaccag ctccgcaaat tccaggagga gctccggcag
     1321 cgcagccagg aaggctacag ggtcaccttt acagacttct ggggcctgct gatagagacc
     1381 tgcctggggg acgagagaaa tgaatgcaaa ctgtcagatc agcgtgctgc tttgagctgc
     1441 ggccagaacc ccctgcccat ctacctcacc atcaatgtca aggatgatgt aagcaaccag
     1501 gacttcagag agtggttcga gttctccccc tacgaggtgg gcctgcagaa gtatggggcc
     1561 ttcatcccct ccgagctctt cggctccgag ttcttcatgg ggcggctggt gaagaggatc
     1621 ccggagtctc gaatctgcta catgctaggc ctgtggagca gcatcttctc cctgaacctg
     1681 ctggatgcct ggaacctgtc acacacctcg gaggagtttt tccacaggtg gacaagggag
     1741 aaagtgcagg acatcgaaga cgagccgatc ctgcctgaaa tccccaaatg tgatgctaac
     1801 atcctggaga ccacggtagt gatcccaggg tcatggctgt ccaattcttt ccgagaaatc
     1861 cttacccatc ggtccttcgt gtctgagttt cacaacttcc tgtctgggct gcagctgcac
     1921 accaactacc tccagaatgg ccagttctct aggtggaaag acacagtgct agatggtttc
     1981 ccaaaccagc tgaccgagtc cgcgaaccac ctgtgcctgc tggacactgc gttctttgtc
     2041 aactccagct acccgcccct cctcaggcca gagcgaaaag ccgacctcat catccacctc
     2101 aactactgtg ctgggtccca gacaaagccc ctgaaacaaa cctgtgagta ctgcactgtg
     2161 cagaacatcc ccttccccaa atacgagctg ccagatgaga atgaaaatct caaggaatgc
     2221 tacctgatgg agaaccccca ggaacccgat gcccccatcg tgactttctt cccactcatc
     2281 aatgacactt tccgaaaata caaggcacca ggtgtagagc gaagccctga ggagctggag
     2341 cagggccagg tggacattta tggtcccaaa actccctatg ccaccaagga gctgacatac
     2401 acagaggcca cctttgacaa gctggtgaaa ctctcagagt ataacatcct gaataataag
     2461 gacactctcc tccaggctct gcggctcgca gtggagaaga agaagcgcct gaagggccag
     2521 tgtccctcct aggccccagg gagcctcccc tgttctgtgt cagcttctac catcagaggt
     2581 gcaggacccc tcagggctga ccaggttact acgcagccag ctctgctctc cggcaatggg
     2641 tgtgagcagg ttggcctggg ctttctaacg aaaagtaaaa aattttaaaa agttgagaaa
     2701 gtcagaaaga gagagagagg agctctgttg gggttttata cccactagag tttcttcaag
     2761 tgcttcccta tagagaaggt ggtctcatag ccacaggctc ccacacatct gtggagagga
     2821 aaagcctggg gaagaggctg ggcccccaga aacctcgact cagaggcaga gcccagggct
     2881 ggcagccctc ctctctctgt cctctacctc gtgtggcggg cctagggaaa tgcacagaag
     2941 gacctgagag gcactcggcg tttcactgga aaaacacttc aaaatttaag gcaattctag
     3001 tcttgtgatt tttgggtttt tttagacgga gtctcactct gttgcccagg ctggagtgca
     3061 atggcgcgat ctcggctcac tgcaacctct gcctcccagg ttcaagcaat tctcttgcct
     3121 cagcctccca agtggccggg attagaggca cccgccacca tgcccagcta attttttgta
     3181 tttttagtac aggctggtct ggaactcctg acctcaggtg atccacctgc ctcggcctcc
     3241 caaagtgctg ggattacagg catgagccaa cgcacccggc cctagtctca ttatttttat
     3301 aggcaattat atttcatgat ttttattttt atgaatcgga gtattaatag gaagcatgaa
     3361 gctagaagat ctagatggag ccctagaaat aagccagtct ctgccacaac aaagccaaat
     3421 aggtggccgg tttcagtggc tctctccagc tacccagagc tccagggctg gtgatccatg
     3481 tcatcatgac cagacagcca tgcccaagca tccagctcca aacaaatgcc aggcaaagcc
     3541 taagtctata gcccaggttc accaaatgag gatctgggat ggagttcagc aaggtcaggc
     3601 aggctgtggg taaatgaggt tgggggccag gcaggcgatg catccagcgc tgcccactcc
     3661 agctgtcggt gctcactgac gaccctgctc caagagcatc tctcagcctc ttactgccca
     3721 tctctctggc tgcctcatgg gattacttat ttctaaatgt gattcctctt atctgtgttg
     3781 tcaacaccgt gaccagtgca ttccaactct tggagagtca cccacagaga ctgaaactgg
     3841 gaagaattag tgaaaaagga ctaggttagc cgtcagagga agaagcccgc cctttaagat
     3901 tgcttcctaa tgaatctctg ggaaaaccct gggacacaga gaaacccaaa gtcagcaggt
     3961 ctcccttcag gctgggaaca taaccaagga aatgtataac cggagccact gacaggccca
     4021 ggctgataga aggtgaaagc agaaaggcag gaagacatga ggtctgcagg aaacccagca
     4081 accctggaag gcggagtccc ctttctgggc caccatgctc cctaagcagt ctttgggttg
     4141 tgaggaaacc agtggtgaca ggtaccaaaa gtttagaaaa attggcctcc gatgtacatc
     4201 cttgctactc aaagtgcagt ggggagctgg ttggaaatgc ggaatctcag gccttagccc
     4261 agctgtacta aattagaagc tgcatttttc aggagattcc catccccagg cgccccccgt
     4321 gattcctgtg catattgaag tttgagaggc ctggatttac gccactccct cccatgagct
     4381 tggaacgtat gaatcagtgc tcccttgagc cactgataaa ctgagctctg gacctgcaaa
     4441 actggtcccc atccaggtaa tgctaacctg ggacaccagc cctcccctcc accagagcaa
     4501 ctggctgcct ccactttgac atcttttctt tctgactgca acagactctc cttccagtat
     4561 caaagagtga gccaagcaac agacaggact tgtttatcgt aaggcgaagg cagccatgcc
     4621 ttggattcat caaaagtttg tgaaacgagg tttataaaat catcatatta tttgtgcatg
     4681 gaataaaatg gccatgtggg tgaa
//
