LOCUS       NM_178034               4266 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens phospholipase A2 group IVD (PLA2G4D), mRNA.
ACCESSION   NM_178034
VERSION     NM_178034.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   Liu,G.J., He,J.R., Kuang,Y.S., Fan,X.J., Li,W.D., Lu,J.H.,
            Xia,X.Y., Liu,X.D., Chen,N.N., Mai,W.B., Xia,H.M. and Qiu,X.
  TITLE     Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the
            risk of spontaneous preterm birth in a Chinese population
  JOURNAL   Mol Med Rep 15 (6), 3607-3614 (2017)
   PUBMED   28440406
  REMARK    GeneRIF: These findings suggested that the polymorphism of PLA2G4D
            rs4924618 may have a protective influence on the SPTB
            susceptibility in a Chinese population, supporting a role for
            genetics in the association between PG synthesis and preterm birth.
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Cheung,K.L., Jarrett,R., Subramaniam,S., Salimi,M.,
            Gutowska-Owsiak,D., Chen,Y.L., Hardman,C., Xue,L., Cerundolo,V. and
            Ogg,G.
  TITLE     Psoriatic T cells recognize neolipid antigens generated by mast
            cell phospholipase delivered by exosomes and presented by CD1a
  JOURNAL   J Exp Med 213 (11), 2399-2412 (2016)
   PUBMED   27670592
  REMARK    GeneRIF: The findings suggest that PLA2 inhibition or CD1a blockade
            may have therapeutic potential for psoriasis.
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Parry,M., Rose-Zerilli,M.J., Gibson,J., Ennis,S., Walewska,R.,
            Forster,J., Parker,H., Davis,Z., Gardiner,A., Collins,A.,
            Oscier,D.G. and Strefford,J.C.
  TITLE     Whole exome sequencing identifies novel recurrently mutated genes
            in patients with splenic marginal zone lymphoma
  JOURNAL   PLoS One 8 (12), e83244 (2013)
   PUBMED   24349473
  REMARK    GeneRIF: study defined eight additional recurrently mutated genes
            in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11,
            PLA2G4D, TRRAP and USH2A.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   Yu,Q., Shi,J.P., Kou,C.G., Meng,X.F. and Yu,Y.Q.
  TITLE     [Study on the genetic association between the polymorphism of
            cytosolic phospholipase A2 family genes and schizophrenia]
  JOURNAL   Zhonghua Liu Xing Bing Xue Za Zhi 29 (2), 173-176 (2008)
   PUBMED   18686860
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Tao,R., Yu,Y., Zhang,X., Shi,J., Guo,Y., Wang,C., Han,B., Xu,Q.,
            Shang,H., Zhang,X., Xie,L., Liu,S., Ju,G., Shen,Y. and Wei,J.
  TITLE     A family based study of the genetic association between the PLA2G4D
            gene and schizophrenia
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 73 (6), 419-422 (2005)
   PUBMED   16213696
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Chiba,H., Michibata,H., Wakimoto,K., Seishima,M., Kawasaki,S.,
            Okubo,K., Mitsui,H., Torii,H. and Imai,Y.
  TITLE     Cloning of a gene for a novel epithelium-specific cytosolic
            phospholipase A2, cPLA2delta, induced in psoriatic skin
  JOURNAL   J Biol Chem 279 (13), 12890-12897 (2004)
   PUBMED   14709560
  REMARK    GeneRIF: cPLA(2)delta exhibits a unique distribution pattern
            compared with that of known cPLA(2) subtypes and may play a
            critical role in inflammation in psoriatic lesions
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084693.2 and AB090876.1.
            
            On May 17, 2019 this sequence version replaced NM_178034.3.
            
            Summary: The phospholipase A2 enzyme family, including PLA2G4D,
            catalyze the hydrolysis of glycerophospholipids at the sn-2
            position and then liberate free fatty acids and lysophospholipids
            (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB090876.1, SRR14038197.2085660.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290472.4/ ENSP00000290472.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC084693.2         140381-140388       c
            9-148               AC084693.2         140241-140380       c
            149-3592            AB090876.1         144-3587
            3593-4266           AC084693.2         112835-113508       c
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4266
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /note="phospholipase A2 group IVD"
                     /db_xref="GeneID:283748"
                     /db_xref="HGNC:HGNC:30038"
                     /db_xref="MIM:612864"
     exon            1..148
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2560
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2 delta, cytosolic; cPLA2-delta;
                     phospholipase A2, group IVD (cytosolic)"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 delta"
                     /protein_id="NP_828848.3"
                     /db_xref="CCDS:CCDS32203.1"
                     /db_xref="GeneID:283748"
                     /db_xref="HGNC:HGNC:30038"
                     /db_xref="MIM:612864"
                     /translation="MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEAD
                     PYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDD
                     ICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARE
                     LSCLDVHLDSTGSTAVVADQDKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETE
                     LSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPE
                     ELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARA
                     MTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHL
                     AKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRA
                     ALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFM
                     GRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIKDKTRSLEKEPLT
                     TSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDYCSHKDFSTW
                     ADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFEA
                     LQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPLVNASFKDH
                     SAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQ
                     ALRTALKHRTLEARPPRAQT"
     exon            149..221
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            222..358
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            359..490
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            491..531
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            532..574
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            575..638
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            639..775
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            776..886
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            887..924
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1060
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1197
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1420
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1538
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1676
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1784
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1979
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2146
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2333
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..4266
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3620..3625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /note="hexamer: ATTAAA"
     polyA_site      3640
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /note="major polyA site"
ORIGIN      
        1 agattcatgc tggtcctatc ccactgggac cgtcgctgcc actcagccag agagccagca
       61 tcttggcaag ggctgggcct ggagtgaagc tggaagggct agcatggaga gcctgtcacc
      121 tgggggacca cctggccacc cttaccaggg ggaggcctct acctgctggc agctcacagt
      181 gagggtcctg gaggcgcgga acctgcgctg ggctgacctg ttgagtgagg ccgaccctta
      241 cgtgatccta cagctgtcga ccgcacctgg aatgaagttt aagaccaaga cgctcaccga
      301 caccagtcat cctgtgtgga atgaggcctt ccgtttcctt atccaaagtc aggtcaagaa
      361 tgttctggag cttagcatct atgatgagga ctcagtcacg gaggatgaca tctgcttcaa
      421 ggttctctat gacatctcag aagtcctccc tggcaagctg ctccggaaaa ccttctccca
      481 gagtccccag ggagaggagg agctggatgt ggagttcctg atggaagaaa cgtcagatcg
      541 cccagaaaac ctcatcacca acaaagtcat tgtggcccga gagctgtcat gcctggatgt
      601 gcatctggac agcacaggga gcaccgctgt ggttgcagat caggacaagc tggagctgga
      661 gctggtgctg aaggggtcct atgaggacac acagacatcc ttcctgggca cagcctctgc
      721 cttccgcttc cactacatgg cagccctaga gacagagctg agcgggcgcc tgaggagctc
      781 cagaagcaat ggctggaatg gggacaactc agctgggtac ctcactgtgc ccctgaggcc
      841 cttgaccatt gggaaggagg tgactatgga tgttcctgct ccaaatgccc caggagtgag
      901 gctgcagctc aaggcagagg gctgccctga ggagctggcc gtgcacctgg gcttcaatct
      961 ctgtgcagag gagcaggcct tcctgagcag gaggaagcag gtggtggcca aggccctgaa
     1021 gcaggccctg cagctggaca gagacctgca ggaggatgag gtacccgttg tgggcatcat
     1081 ggccacagga ggaggtgccc gggccatgac ctcactctac ggccacctat tggccttgca
     1141 gaagctgggc ctcctagact gtgtgaccta cttcagtggc atctctggct ctacgtggac
     1201 aatggcccac ctgtacgggg accctgagtg gtcgcagagg gacctggagg gacctatcag
     1261 atacgcccgg gagcacctgg ccaagagcaa gctggaggtc ttttccccag agcgcctggc
     1321 gagctaccgc cgggagctgg agctgcgggc tgagcagggc caccccacga cctttgtgga
     1381 cctgtgggcg ctagtgctgg agtccatgct gcacggccag gtgatggatc agaagctgtc
     1441 aggacagaga gccgccctgg aacggggtca gaaccctctg cccctctact tgagcctcaa
     1501 tgtcaaagag aacaatctgg agacactgga cttcaaggag tgggttgagt tctcccccta
     1561 tgaggtcggt ttcctgaagt acggggcctt cgtccctcct gagctcttcg gctccgagtt
     1621 cttcatggga cggctgatga ggaggatccc ggagccccgg atctgctttc tggaagccat
     1681 ctggagcaac attttctccc tgaacctgct ggatgcctgg tatgacctca ccagttctgg
     1741 ggagtcctgg aaacagcaca tcaaggacaa gaccaggagc ttagagaagg agcccctgac
     1801 cacctcgggg acctcctcgc ggctggaggc ctcgtggctg cagccaggca cggcgctggc
     1861 ccaggcattt aaaggcttcc tgacaggcag gcccctccac cagcgcagcc ccaacttcct
     1921 ccagggcctc cagctgcacc aggactactg tagccacaaa gacttctcca cctgggcaga
     1981 ctaccagctt gactccatgc ccagccagct gacccccaag gagccccggc tctgcctggt
     2041 ggacgccgcc tacttcatca acaccagctc tccctccatg ttccggccag gccgcaggct
     2101 ggacctcatc ctctccttcg actactccct atctgcgccc ttcgaggcac tgcagcagac
     2161 ggagctgtac tgccgggccc gggggctgcc cttcccccgg gtggaaccca gccctcagga
     2221 ccagcaccag ccaagggaat gccacctctt ctcagacccc gcctgccccg aggccccgat
     2281 cctgctgcac ttcccgctgg tcaatgcctc cttcaaggac cactcagccc ccggtgtcca
     2341 gcgcagcccc gcagagctcc agggtggcca agtggatctc accggggcca cctgccccta
     2401 caccctgtcc aacatgacct acaaggagga agacttcgag cgcctgctgc ggctcagtga
     2461 ctacaacgtg cagaccagcc agggtgccat cctgcaggcc ctgaggaccg cgctgaagca
     2521 ccggactcta gaggcgaggc ctccaagggc acagacctga ggttgctcag aggctgcagg
     2581 accctccagg gcctgcgggc ataacctgat ctgtagctgg gctcagccac aggccttcct
     2641 ggttggagtt ctgggctctc ccaggcctgg gtggcctctg tagctggtct cactgcccag
     2701 agggaactgc acacacagac ttctctctta cgttcatggc tggcttgaga tgagttgaaa
     2761 ataacttcgc caggccagtg tgtagaacag ctggtccaac cagacagact ttcacaccac
     2821 aattacttcc atgcctgagc aggatagatt tgaagtgcaa gccggaggca gcagatcagg
     2881 agtagggaca ggaaggacag gggatgcctg acctgacagg tggcttcagg cctcgggaat
     2941 cacaagacat cctgaacaca ttgcctcctc atcttcttcc tgctcctcca cctcctcctc
     3001 tccttgtcct tctcctcttt gtcctcctgc tttccgtatc caagtcttgt acttgtttaa
     3061 atttattcct aaatatttta ttctttttga taagtggagt tactttctta atttcattta
     3121 gattattcat tgctatttta tagaaataca atggattttt aaatgttgat cttgtattcc
     3181 gcaatcttgc tgaagttgtt taccggctct aatacttttg cggatttctt agaattttct
     3241 gtagacagat catgccatct ccaaatagag atggttttac ttcttcctgt ctgatctgaa
     3301 tgccttttat ttatttttcc caattgccct gagcagtaca atgatgaaca cacgtttcaa
     3361 gagcagacat cttgtcttgt tcctgactct gacaagaaag cataagtctc tcaccattta
     3421 gtgtgatttt agctgtgggt ttttcttgga catccttatc aggttgagaa agttctcttt
     3481 tatttctagt ttattgagtg ttttatgatg aaacggtgtt aggttttgtc aagtgatttt
     3541 tctgtgtcta tgggcatgat catgtggttt tgtcgtgtat tttattaatg tactctattg
     3601 cattaattgg tttttggata ttaaaccaac tttgcattcc tggggcagtt tccatttgat
     3661 tatggtatat aaaccttttt gtttattgct ggcacatttc tttttctttt tctttctttt
     3721 tttttttttt tgagacagaa tctcatcaca ctctgtcacc caggccaagt tcaatggtgc
     3781 aatctggctc actgcatcct caacttcctg ggctcaagtg atccttccac ttcagcctcc
     3841 caagtagctg ggactacagg catgtaacac catacttggc taaattaaaa aaatggtttt
     3901 ttgtagagat gaggtctcac catgttgccc aggctggtct tgaactcctg aactcaagca
     3961 atcctcctgc ctcagcctcc caaagtgctg ggattactgg tgtgagccac cacggccagc
     4021 tgctagcaca tttcttacct ccctcatgca agggtgcgtg tacacataca cacacacaca
     4081 cacctggccc caggtggggg ttgtagtgag agcttcggga cagaccttgg ctcagggact
     4141 gccctcatct gatgtcctct ctcagcttcc ttccctgtgc ctcttctgca tttggcttta
     4201 ttttgattct tcactttttc cctttatcat ggactcttat ttttttaaca gtgatatggg
     4261 aattga
//
