LOCUS       NM_003706               2486 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipase A2 group IVC (PLA2G4C), transcript
            variant 1, mRNA.
ACCESSION   NM_003706
VERSION     NM_003706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Nadalin,S., Zatkovic,L., Peitl,V., Karlovic,D., Vidrih,B.,
            Puljic,A., Pavlic,S.D. and Buretic-Tomljanovic,A.
  TITLE     Association between PLA2 gene polymorphisms and treatment response
            to antipsychotic medications: A study of antipsychotic-naive
            first-episode psychosis patients and nonadherent chronic psychosis
            patients
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 194, 102578 (2023)
   PUBMED   37290257
  REMARK    GeneRIF: Association between PLA2 gene polymorphisms and treatment
            response to antipsychotic medications: A study of
            antipsychotic-naive first-episode psychosis patients and
            nonadherent chronic psychosis patients.
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Su,X., Liu,S., Zhang,X., Lam,S.M., Hu,X., Zhou,Y., Chen,J.,
            Wang,Y., Wu,C., Shui,G., Lu,M., Pei,R. and Chen,X.
  TITLE     Requirement of cytosolic phospholipase A2 gamma in lipid droplet
            formation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1862 (7), 692-705 (2017)
   PUBMED   28336330
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Nadalin,S. and Buretic-Tomljanovic,A.
  TITLE     An association between PLA2G6 and PLA2G4C gene polymorphisms and
            schizophrenia risk and illness severity in a Croatian population
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 121, 57-59 (2017)
   PUBMED   28651698
  REMARK    GeneRIF: We found no significant influence of the PLA2G6 and
            PLA2G4C polymorphisms on mean age at first hospital admission (P >
            0.05) and that the investigated polymorphisms significantly
            influenced the clinical psychopathology only in male patients. The
            PLA2G4C polymorphism accounted for approximately 12% of negative
            symptom severity.
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Liu,S., Qiu,S., Lu,Y., Kanu,J.S., Li,R., Bai,Y., Zhu,X., Lei,J.,
            Xu,N., Yu,Y., Liu,Y. and Jiang,H.
  TITLE     The rs251684 Variant of PLA2G4C Is Associated with Autism Spectrum
            Disorder in the Northeast Han Chinese Population
  JOURNAL   Genet Test Mol Biomarkers 20 (12), 747-752 (2016)
   PUBMED   27611910
  REMARK    GeneRIF: Five single-nucleotide polymorphisms (SNPs) (rs9226,
            rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four
            SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A
            were selected and genotyped. Our results showed a significant
            association between ASD and the rs251684 variant of PLA2G4C. The
            rs251684 polymorphism of PLA2G4C may be associated with Autism
            Spectrum Disorder risk.
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Hartmann,C., Johnk,L., Sasaki,H., Jenkins,R.B. and Louis,D.N.
  TITLE     Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q
            loss in human gliomas
  JOURNAL   Brain Pathol 12 (2), 178-182 (2002)
   PUBMED   11958371
  REMARK    GeneRIF: Novel PLA2G4C polymorphism as a molecular diagnostic A
            minisatellite polymorphism in the untranslated region of exon 1,
            with allelic variants that have one, two or three 27-bp repeats
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Smith,J.S., Tachibana,I., Pohl,U., Lee,H.K., Thanarajasingam,U.,
            Portier,B.P., Ueki,K., Ramaswamy,S., Billings,S.J.,
            Mohrenweiser,H.W., Louis,D.N. and Jenkins,R.B.
  TITLE     A transcript map of the chromosome 19q-arm glioma tumor suppressor
            region
  JOURNAL   Genomics 64 (1), 44-50 (2000)
   PUBMED   10708517
REFERENCE   8  (bases 1 to 2486)
  AUTHORS   Pickard,R.T., Strifler,B.A., Kramer,R.M. and Sharp,J.D.
  TITLE     Molecular cloning of two new human paralogs of 85-kDa cytosolic
            phospholipase A2
  JOURNAL   J Biol Chem 274 (13), 8823-8831 (1999)
   PUBMED   10085124
REFERENCE   9  (bases 1 to 2486)
  AUTHORS   Underwood,K.W., Song,C., Kriz,R.W., Chang,X.J., Knopf,J.L. and
            Lin,L.L.
  TITLE     A novel calcium-independent phospholipase A2, cPLA2-gamma, that is
            prenylated and contains homology to cPLA2
  JOURNAL   J Biol Chem 273 (34), 21926-21932 (1998)
   PUBMED   9705332
REFERENCE   10 (bases 1 to 2486)
  AUTHORS   Wu,T., Angus,C.W., Yao,X.L., Logun,C. and Shelhamer,J.H.
  TITLE     P11, a unique member of the S100 family of calcium-binding
            proteins, interacts with and inhibits the activity of the 85-kDa
            cytosolic phospholipase A2
  JOURNAL   J Biol Chem 272 (27), 17145-17153 (1997)
   PUBMED   9202034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011466.6, BC063416.1 and
            AC010458.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003706.2.
            
            Summary: This gene encodes a protein which is a member of the
            phospholipase A2 enzyme family which hydrolyzes
            glycerophospholipids to produce free fatty acids and
            lysophospholipids, both of which serve as precursors in the
            production of signaling molecules. The encoded protein has been
            shown to be a calcium-independent and membrane bound enzyme.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.189744.1,
                                           SRR1660805.227856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599921.6/ ENSP00000469473.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC011466.6         28121-28407         c
            288-872             BC063416.1         306-890
            873-873             AC011466.6         15787-15787         c
            874-2042            BC063416.1         892-2060
            2043-2043           AC010458.6         82541-82541
            2044-2486           BC063416.1         2062-2504
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2486
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /note="phospholipase A2 group IVC"
                     /db_xref="GeneID:8605"
                     /db_xref="HGNC:HGNC:9037"
                     /db_xref="MIM:603602"
     exon            1..331
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            332..371
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1989
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytosolic phospholipase A2 gamma; phospholipase
                     A2, group IVC (cytosolic, calcium-independent); cytosolic
                     lysophospholipase; cytosolic lysophospholipid
                     O-acyltransferase"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 gamma isoform 1
                     precursor"
                     /protein_id="NP_003697.2"
                     /db_xref="CCDS:CCDS12710.1"
                     /db_xref="GeneID:8605"
                     /db_xref="HGNC:HGNC:9037"
                     /db_xref="MIM:603602"
                     /translation="MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVV
                     AVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALE
                     ADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKK
                     PVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKF
                     KKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSI
                     GHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPER
                     KGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINT
                     PFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAP
                     ASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAK
                     KNVRENKKKILRELMNVAGLYYPKDSARSCCLA"
     exon            372..483
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            484..620
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            621..810
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1072
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1126
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1153
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1207
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1261
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1369
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1465
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1620
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1792
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1943
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2486
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /note="hexamer: AATAAA"
     polyA_site      2486
                     /gene="PLA2G4C"
                     /gene_synonym="CPLA2-gamma"
                     /note="major polyA site"
ORIGIN      
        1 agctgaaaaa gctggagcaa ccaagcaggg cctacaagcc gaggagggct gtttaaaggc
       61 gcaggggcca ttttacctcc aggttggccc tgctcaggac caggaggaaa cacctccagc
      121 ccgcgacctc ctcccacagg gggaaaagga aagcaggagg accacagaag ctttggcacc
      181 gaggatcccc gcagtcttca cccgcggaga ttccggctga aggagctgtc cagcgactac
      241 accgctaagc gcagggagcc caagcctccg caccggattc cggagcacaa gctccaccgc
      301 gcatgcgcac acgccccaga cccaggctca ggaggactga gaattttctg accgcagtgc
      361 accatgggaa gctctgaagt ttccataatt cctgggctcc agaaagaaga aaaggcggcc
      421 gtggagagac gaagacttca tgtgctgaaa gctctgaaga agctaaggat tgaggctgat
      481 gaggccccag ttgttgctgt gctgggctca ggcggaggac tgcgggctca cattgcctgc
      541 cttggggtcc tgagtgagat gaaagaacag ggcctgttgg atgccgtcac gtacctcgca
      601 ggggtctctg gatccacttg ggcaatatct tctctctaca ccaatgatgg tgacatggaa
      661 gctctcgagg ctgacctgaa acatcgattt acccgacagg agtgggactt ggctaagagc
      721 ctacagaaaa ccatccaagc agcgaggtct gagaattact ctctgaccga cttctgggcc
      781 tacatggtta tctctaagca aaccagagaa ctgccggagt ctcatttgtc caatatgaag
      841 aagcccgtgg aagaagggac actaccctac ccaatatttg cagccattga caatgacctg
      901 caaccttcct ggcaggaggc aagagcacca gagacctggt tcgagttcac ccctcaccac
      961 gctggcttct ctgcactggg ggcctttgtt tccataaccc acttcggaag caaattcaag
     1021 aagggaagac tggtcagaac tcaccctgag agagacctga ctttcctgag aggtttatgg
     1081 ggaagtgctc ttggtaacac tgaagtcatt agggaataca tttttgacca gttaaggaat
     1141 ctgaccctga aaggtttatg gagaagggct gttgctaatg ctaaaagcat tggacacctt
     1201 atttttgccc gattactgag gctgcaagaa agttcacaag gggaacatcc tcccccagaa
     1261 gatgaaggcg gtgagcctga acacacctgg ctgactgaga tgctcgagaa ttggaccagg
     1321 acctccctgg aaaagcagga gcagccccat gaggaccccg aaaggaaagg ctcactcagt
     1381 aacttgatgg attttgtgaa gaaaacaggc atttgcgctt caaagtggga atgggggacc
     1441 actcacaact tcctgtacaa acacggtggc atccgggaca agataatgag cagccggaag
     1501 cacctccacc tggtggatgc tggtttagcc atcaacactc ccttcccact cgtgctgccc
     1561 ccgacgcggg aggttcacct catcctctcc ttcgacttca gtgccggaga tcctttcgag
     1621 accatccggg ctaccactga ctactgccgc cgccacaaga tcccctttcc ccaagtagaa
     1681 gaggctgagc tggatttgtg gtccaaggcc cccgccagct gctacatcct gaaaggagaa
     1741 actggaccag tggtgatgca ttttcccctg ttcaacatag atgcctgtgg aggtgatatt
     1801 gaggcatgga gtgacacata cgacacattc aagcttgctg acacctacac tctagatgtg
     1861 gtggtgctac tcttggcatt agccaagaag aatgtcaggg aaaacaagaa gaagatcctt
     1921 agagagttga tgaacgtggc cgggctctac tacccgaagg atagtgcccg aagttgctgc
     1981 ttggcataga tgagcctcag cttccagggc actgtgggcc tgttggtcta ctagggccct
     2041 gatgtccacc tggccttcct gttcttcact cccttcagcc acacgcttca tggccttgag
     2101 ttcaccttgg ctgtcctaac agggccaatc accagtgacc agctagactg tgattttgat
     2161 agcgtcattc agaagaaggc gtccaaggag ctgaaggtgg tgaaatttgt cctgcaggtc
     2221 cctcgggaga tcctggagct ggagcatgag tgtctgacaa tcagaagcat catgtccaat
     2281 gtccagatgg ccagaatgaa tgtgatagtt cagaccaatg ccttccactg ctcctttatg
     2341 actgcacttc tagccagtag ctctgcacaa gttagctctg tagaagtaag aacttgggct
     2401 taaatcatgg gctatctctc cacagccaag tggagctctg agaatacaac aagtgctcaa
     2461 taaatgcttg ctgattgact gatgga
//
