LOCUS       NM_001114633            2696 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens phospholipase A2 group IVB (PLA2G4B), mRNA.
ACCESSION   NM_001114633
VERSION     NM_001114633.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Cheng,Y., Wang,Y., Li,J., Chang,I. and Wang,C.Y.
  TITLE     A novel read-through transcript JMJD7-PLA2G4B regulates head and
            neck squamous cell carcinoma cell proliferation and survival
  JOURNAL   Oncotarget 8 (2), 1972-1982 (2017)
   PUBMED   28030848
  REMARK    GeneRIF: JMJD7-PLA2G4B may serve as an important therapeutic target
            and prognostic marker for head and neck squamous cell carcinoma
            development and progression.
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Lee,I.T., Lee,C.W., Tung,W.H., Wang,S.W., Lin,C.C., Shu,J.C. and
            Yang,C.M.
  TITLE     Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic
            acid-induced cPLA2/COX-2-dependent airway inflammatory responses
  JOURNAL   Am J Pathol 176 (4), 1671-1684 (2010)
   PUBMED   20167866
  REMARK    GeneRIF: TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic
            acid-induced cPLA2/COX-2-dependent airway inflammatory responses
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Segat,L., Brandao,L.A.C., Guimaraes,R.L., Pontillo,A.,
            Athanasakis,E., de Oliveira,R.M., Arraes,L.C., de Lima Filho,J.L.
            and Crovella,S.
  TITLE     Polymorphisms in innate immunity genes and patients response to
            dendritic cell-based HIV immuno-treatment
  JOURNAL   Vaccine 28 (10), 2201-2206 (2010)
   PUBMED   20056178
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Ghosh,M., Loper,R., Gelb,M.H. and Leslie,C.C.
  TITLE     Identification of the expressed form of human cytosolic
            phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant
            localized to mitochondria and early endosomes
  JOURNAL   J Biol Chem 281 (24), 16615-16624 (2006)
   PUBMED   16617059
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Degousee,N., Ghomashchi,F., Stefanski,E., Singer,A., Smart,B.P.,
            Borregaard,N., Reithmeier,R., Lindsay,T.F., Lichtenberger,C.,
            Reinisch,W., Lambeau,G., Arm,J., Tischfield,J., Gelb,M.H. and
            Rubin,B.B.
  TITLE     Groups IV, V, and X phospholipases A2s in human neutrophils: role
            in eicosanoid production and gram-negative bacterial phospholipid
            hydrolysis
  JOURNAL   J Biol Chem 277 (7), 5061-5073 (2002)
   PUBMED   11741884
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Song,C., Chang,X.J., Bean,K.M., Proia,M.S., Knopf,J.L. and
            Kriz,R.W.
  TITLE     Molecular characterization of cytosolic phospholipase A2-beta
  JOURNAL   J Biol Chem 274 (24), 17063-17067 (1999)
   PUBMED   10358058
REFERENCE   9  (bases 1 to 2696)
  AUTHORS   Pickard,R.T., Strifler,B.A., Kramer,R.M. and Sharp,J.D.
  TITLE     Molecular cloning of two new human paralogs of 85-kDa cytosolic
            phospholipase A2
  JOURNAL   J Biol Chem 274 (13), 8823-8831 (1999)
   PUBMED   10085124
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Underwood,K.W., Song,C., Kriz,R.W., Chang,X.J., Knopf,J.L. and
            Lin,L.L.
  TITLE     A novel calcium-independent phospholipase A2, cPLA2-gamma, that is
            prenylated and contains homology to cPLA2
  JOURNAL   J Biol Chem 273 (34), 21926-21932 (1998)
   PUBMED   9705332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK310651.1, DA250544.1, CA488226.1, BF372565.1, CU447449.1 and
            BM982475.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001114633.1.
            
            Summary: This gene encodes a member of the cytosolic phospholipase
            A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond
            of phospholipids, releasing lysophospholipids and fatty acids. This
            enzyme may be associated with mitochondria and early endosomes.
            Most tissues also express read-through transcripts from the
            upstream gene into this gene, some of which may encode fusion
            proteins combining the N-terminus of the upstream gene including
            its JmjC domain with the almost complete coding region of this
            gene, including the C2 and cytoplasmic phospholipase A2 domains.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299419.1, SRR11853565.9500.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458483.4/ ENSP00000416610.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AK310651.1         35-321
            288-799             DA250544.1         3-514
            800-1352            CA488226.1         81-633
            1353-1734           BF372565.1         46-427              c
            1735-2074           CU447449.1         16-355              c
            2075-2696           BM982475.1         14-635              c
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..2696
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /note="phospholipase A2 group IVB"
                     /db_xref="GeneID:100137049"
                     /db_xref="HGNC:HGNC:9036"
                     /db_xref="MIM:606088"
     exon            1..76
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2413
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2, group IVB (cytosolic);
                     lysophospholipase A1 group IVB"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 beta"
                     /protein_id="NP_001108105.1"
                     /db_xref="CCDS:CCDS45241.1"
                     /db_xref="GeneID:100137049"
                     /db_xref="HGNC:HGNC:9036"
                     /db_xref="MIM:606088"
                     /translation="MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACS
                     HRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTL
                     RAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETG
                     DQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPL
                     SALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVA
                     AALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGA
                     SGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARL
                     GYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFE
                     FGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAAN
                     LQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPL
                     AQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSC
                     LPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECH
                     TFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVT
                     YSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH"
     exon            77..149
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            150..286
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            287..418
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            419..459
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            460..502
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            503..557
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            558..688
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            689..772
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            773..810
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            811..946
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1083
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1306
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1424
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1562
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1667
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1847
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2014
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2201
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2696
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2696
                     /gene="PLA2G4B"
                     /gene_synonym="cPLA2-beta; HsT16992"
                     /note="major polyA site"
ORIGIN      
        1 agaaagctga cagtccttga tcctgtggcc actgccccat cattcctgct cctgaggact
       61 cagtctcatg gctgtggcag aggtgtccag gacctgcctg ctcacggttc gtgtcctgca
      121 ggcccatcgc ctaccctcta aggacctagt gaccccctct gactgctacg tgactctctg
      181 gctgcccacg gcctgcagcc acaggctcca gacacgcacg gtcaagaaca gcagtagccc
      241 tgtctggaac cagagctttc acttcaggat ccacaggcag ctcaagaatg tcatggaact
      301 gaaagtcttt gaccaggacc tggtgaccgg agatgaccct gtgttgtcag tactgtttga
      361 tgcggggact ctgcgggctg gggagttccg gcgcgagagc ttctcactga gccctcaggg
      421 tgaggggcgc ctggaagttg aatttcgcct gcagagtctg gctgaccgtg gcgagtggct
      481 cgtcagcaat ggcgttctgg tggcccggga gctctcctgc ttgcacgttc aactggagga
      541 gacaggagac cagaagtcct cagagcacag agttcagctt gtggttcctg ggtcctgtga
      601 gggtccgcag gaggcctctg tgggcactgg caccttccgc ttccactgcc cagcctgctg
      661 ggagcaggag ctgagtattc gcctgcagga tgcccccgag gagcaactaa aggcgccact
      721 gagtgccctg ccctctggtc aagtggtgag gcttgtcttc cccacgtccc aggagcccct
      781 gatgagagtg gagctgaaaa aagaagcagg actgagggag ctggccgtgc gactgggctt
      841 cgggccctgt gcagaggagc aggccttcct gagcaggagg aagcaggtgg tggccgcggc
      901 cttgaggcag gccctgcagc tggacggaga cctgcaggag gatgagatcc cagtggtagc
      961 tattatggcc actggtggtg ggatccgggc aatgacttcc ctgtatgggc agctggctgg
     1021 cctgaaggag ctgggcctct tggattgcgt ctcctacatc accggggcct cgggctccac
     1081 ctgggccttg gccaaccttt atgaggaccc agagtggtct cagaaggacc tggcagggcc
     1141 cactgagttg ctgaagaccc aggtgaccaa gaacaagctg ggtgtgctgg cccccagcca
     1201 gctgcagcgg taccggcagg agctggccga gcgtgcccgc ttgggctacc caagctgctt
     1261 caccaacctg tgggccctca tcaacgaggc gctgctgcat gatgagcccc atgatcacaa
     1321 gctctcagat caacgggagg ccctgagtca tggccagaac cctctgccca tctactgtgc
     1381 cctcaacacc aaagggcaga gcctgaccac ttttgaattt ggggagtggt gcgagttctc
     1441 tccctacgag gtcggcttcc ccaagtacgg ggccttcatc ccctctgagc tctttggctc
     1501 cgagttcttt atggggcagc tgatgaagag gcttcctgag tcccgcatct gcttcttaga
     1561 aggtatctgg agcaacctgt atgcagccaa cctccaggac agcttatact gggcctcaga
     1621 gcccagccag ttctgggacc gctgggtcag gaaccaggcc aacctggaca aggagcaggt
     1681 cccccttctg aagatagaag aaccaccctc aacagccggc aggatagctg agtttttcac
     1741 cgatcttctg acgtggcgtc cactggccca ggccacacat aatttcctgc gtggcctcca
     1801 tttccacaaa gactactttc agcatcctca cttctccaca tggaaagcta ccactctgga
     1861 tgggctcccc aaccagctga caccctcgga gccccacctg tgcctgctgg atgttggcta
     1921 cctcatcaat accagctgcc tgcccctcct gcagcccact cgggacgtgg acctcatcct
     1981 gtcattggac tacaacctcc acggagcctt ccagcagttg cagctcctgg gccggttctg
     2041 ccaggagcag gggatcccgt tcccacccat ctcgcccagc cccgaagagc agctccagcc
     2101 tcgggagtgc cacaccttct ccgaccccac ctgccccgga gcccctgcgg tgctgcactt
     2161 tcctctggtc agcgactcct tccgggagta ctcggcccct ggggtccggc ggacacccga
     2221 ggaggcggca gctggggagg tgaacctgtc ttcatcggac tctccctacc actacacgaa
     2281 ggtgacctac agccaggagg acgtggacaa gctgctgcac ctgacacatt acaatgtctg
     2341 caacaaccag gagcagctgc tggaggctct gcgccaggca gtgcagcgga ggcggcagcg
     2401 caggccccac tgatggccgg ggcccctgcc acccctaact ctcattcatt ccctggctgc
     2461 tgagttgcag gtgggaactg tcatcacgca gtgcttcaga gcctcgggct caggtggcac
     2521 ggtcccaggg tccaggctga gggctgggag ctcccttgcg cctcagcagt ttgcagtggg
     2581 gtaaggaggc caagcccatt tgtgtaatca cccaaaaccc cccggcctgt gcctgttttc
     2641 ccttctgcgc taccttgagt agttggagca cttgatacat cacagactca tacaaa
//
