LOCUS       NM_024420               2879 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens phospholipase A2 group IVA (PLA2G4A), transcript
            variant 1, mRNA.
ACCESSION   NM_024420
VERSION     NM_024420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Chen,M., Zhang,C., Li,H., Zheng,S., Li,Y., Yuan,M., Chen,Y., Wu,J.
            and Sun,Q.
  TITLE     PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid
            metabolism in platinum-resistant gastric cancer
  JOURNAL   J Transl Med 22 (1), 249 (2024)
   PUBMED   38454407
  REMARK    GeneRIF: PLA2G4A and ACHE modulate lipid profiles via
            glycerophospholipid metabolism in platinum-resistant gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Ye,Y., Liu,L., Feng,Z., Liu,Y., Miao,J., Wei,X., Li,H., Yang,J.,
            Cao,X. and Zhao,J.
  TITLE     The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis
            impedes mucosal healing in ulcerative colitis
  JOURNAL   Free Radic Biol Med 214, 219-235 (2024)
   PUBMED   38367927
  REMARK    GeneRIF: The ERK-cPLA2-ACSL4 axis mediating M2 macrophages
            ferroptosis impedes mucosal healing in ulcerative colitis.
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Dessen,A., Tang,J., Schmidt,H., Stahl,M., Clark,J.D., Seehra,J. and
            Somers,W.S.
  TITLE     Crystal structure of human cytosolic phospholipase A2 reveals a
            novel topology and catalytic mechanism
  JOURNAL   Cell 97 (3), 349-360 (1999)
   PUBMED   10319815
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Tay,A., Simon,J.S., Squire,J., Hamel,K., Jacob,H.J. and Skorecki,K.
  TITLE     Cytosolic phospholipase A2 gene in human and rat: chromosomal
            localization and polymorphic markers
  JOURNAL   Genomics 26 (1), 138-141 (1995)
   PUBMED   7782073
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Miyashita,A., Crystal,R.G. and Hay,J.G.
  TITLE     Identification of a 27 bp 5'-flanking region element responsible
            for the low level constitutive expression of the human cytosolic
            phospholipase A2 gene
  JOURNAL   Nucleic Acids Res 23 (2), 293-301 (1995)
   PUBMED   7862535
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Wu,T., Ikezono,T., Angus,C.W. and Shelhamer,J.H.
  TITLE     Characterization of the promoter for the human 85 kDa cytosolic
            phospholipase A2 gene
  JOURNAL   Nucleic Acids Res 22 (23), 5093-5098 (1994)
   PUBMED   7800505
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Sharp,J.D., Pickard,R.T., Chiou,X.G., Manetta,J.V., Kovacevic,S.,
            Miller,J.R., Varshavsky,A.D., Roberts,E.F., Strifler,B.A.,
            Brems,D.N. et al.
  TITLE     Serine 228 is essential for catalytic activities of 85-kDa
            cytosolic phospholipase A2
  JOURNAL   J Biol Chem 269 (37), 23250-23254 (1994)
   PUBMED   8083230
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Lin,L.L., Wartmann,M., Lin,A.Y., Knopf,J.L., Seth,A. and Davis,R.J.
  TITLE     cPLA2 is phosphorylated and activated by MAP kinase
  JOURNAL   Cell 72 (2), 269-278 (1993)
   PUBMED   8381049
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   Sharp,J.D., White,D.L., Chiou,X.G., Goodson,T., Gamboa,G.C.,
            McClure,D., Burgett,S., Hoskins,J., Skatrud,P.L., Sportsman,J.R. et
            al.
  TITLE     Molecular cloning and expression of human Ca(2+)-sensitive
            cytosolic phospholipase A2
  JOURNAL   J Biol Chem 266 (23), 14850-14853 (1991)
   PUBMED   1869522
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Clark,J.D., Lin,L.L., Kriz,R.W., Ramesha,C.S., Sultzman,L.A.,
            Lin,A.Y., Milona,N. and Knopf,J.L.
  TITLE     A novel arachidonic acid-selective cytosolic PLA2 contains a
            Ca(2+)-dependent translocation domain with homology to PKC and GAP
  JOURNAL   Cell 65 (6), 1043-1051 (1991)
   PUBMED   1904318
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA451491.1, BC114340.2,
            AL049797.8, M72393.1 and BX118890.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 25, 2020 this sequence version replaced NM_024420.2.
            
            Summary: This gene encodes a member of the cytosolic phospholipase
            A2 group IV family. The enzyme catalyzes the hydrolysis of membrane
            phospholipids to release arachidonic acid which is subsequently
            metabolized into eicosanoids. Eicosanoids, including prostaglandins
            and leukotrienes, are lipid-based cellular hormones that regulate
            hemodynamics, inflammatory responses, and other intracellular
            pathways. The hydrolysis reaction also produces lysophospholipids
            that are converted into platelet-activating factor. The enzyme is
            activated by increased intracellular Ca(2+) levels and
            phosphorylation, resulting in its translocation from the cytosol
            and nucleus to perinuclear membrane vesicles. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290336.1, M68874.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367466.4/ ENSP00000356436.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DA451491.1         1-54
            55-2107             BC114340.2         1-2053
            2108-2108           AL049797.8         48342-48342
            2109-2534           BC114340.2         2055-2480
            2535-2877           M72393.1           2504-2846
            2878-2879           BX118890.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.1"
     gene            1..2879
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /note="phospholipase A2 group IVA"
                     /db_xref="GeneID:5321"
                     /db_xref="HGNC:HGNC:9035"
                     /db_xref="MIM:600522"
     exon            1..87
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            88..189
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2406
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium-dependent phospholipid-binding protein;
                     phosphatidylcholine 2-acylhydrolase; lysophospholipase;
                     cytosolic phospholipase A2; phospholipase A2, group IVA
                     (cytosolic, calcium-dependent)"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 isoform 1"
                     /protein_id="NP_077734.2"
                     /db_xref="CCDS:CCDS1372.1"
                     /db_xref="GeneID:5321"
                     /db_xref="HGNC:HGNC:9035"
                     /db_xref="MIM:600522"
                     /translation="MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDP
                     YVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETL
                     GTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQ
                     RKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGIL
                     DCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYV
                     ESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHV
                     KPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGV
                     WGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENE
                     DAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLS
                     DFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQR
                     GVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFK
                     PKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEEEKEIADFDIFDDPESPFSTFN
                     FQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFN
                     KEFLSKPKA"
     exon            190..271
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            272..420
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            421..534
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..572
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            573..714
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            715..851
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1074
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1189
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1327
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1420
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1492
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1735
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1920
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2116
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2274
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2879
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /note="hexamer: AATACA"
     polyA_site      2879
                     /gene="PLA2G4A"
                     /gene_synonym="cPLA2; cPLA2-alpha; GURDP; PLA2G4"
                     /note="major polyA site"
ORIGIN      
        1 actcaggata agactttctc taagtccgga gctgaaaaag gatcctgact gaaagctaga
       61 ggcattgagg agcctgaaga ttctcaggtt ttaaagacgc tagagtgcca aagaagactt
      121 tgaagtgtga aaacatttcc tgtaattgaa accaaaatgt catttataga tccttaccag
      181 cacattatag tggagcacca gtattcccac aagtttacgg tagtggtgtt acgtgccacc
      241 aaagtgacaa agggggcctt tggtgacatg cttgatactc cagatcccta tgtggaactt
      301 tttatctcta caacccctga cagcaggaag agaacaagac atttcaataa tgacataaac
      361 cctgtgtgga atgagacctt tgaatttatt ttggatccta atcaggaaaa tgttttggag
      421 attacgttaa tggatgccaa ttatgtcatg gatgaaactc tagggacagc aacatttact
      481 gtatcttcta tgaaggtggg agaaaagaaa gaagttcctt ttattttcaa ccaagtcact
      541 gaaatggttc tagaaatgtc tcttgaagtt tgctcatgcc cagacctacg atttagtatg
      601 gctctgtgtg atcaggagaa gactttcaga caacagagaa aagaacacat aagggagagc
      661 atgaagaaac tcttgggtcc aaagaatagt gaaggattgc attctgcacg tgatgtgcct
      721 gtggtagcca tattgggttc aggtgggggt ttccgagcca tggtgggatt ctctggtgtg
      781 atgaaggcat tatacgaatc aggaattctg gattgtgcta cctacgttgc tggtctttct
      841 ggctccacct ggtatatgtc aaccttgtat tctcaccctg attttccaga gaaagggcca
      901 gaggagatta atgaagaact aatgaaaaat gttagccaca atcccctttt acttctcaca
      961 ccacagaaag ttaaaagata tgttgagtct ttatggaaga agaaaagctc tggacaacct
     1021 gtcaccttta ctgatatctt tgggatgtta ataggagaaa cactaattca taatagaatg
     1081 aatactactc tgagcagttt gaaggaaaaa gttaatactg cacaatgccc tttacctctt
     1141 ttcacctgtc ttcatgtcaa acctgacgtt tcagagctga tgtttgcaga ttgggttgaa
     1201 tttagtccat acgaaattgg catggctaaa tatggtactt ttatggctcc cgacttattt
     1261 ggaagcaaat tttttatggg aacagtcgtt aagaagtatg aagaaaaccc cttgcatttc
     1321 ttaatgggtg tctggggcag tgccttttcc atattgttca acagagtttt gggcgtttct
     1381 ggttcacaaa gcagaggctc cacaatggag gaagaattag aaaatattac cacaaagcat
     1441 attgtgagta atgatagctc ggacagtgat gatgaatcac acgaacccaa aggcactgaa
     1501 aatgaagatg ctggaagtga ctatcaaagt gataatcaag caagttggat tcatcgtatg
     1561 ataatggcct tggtgagtga ttcagcttta ttcaatacca gagaaggacg tgctgggaag
     1621 gtacacaact tcatgctggg cttgaatctc aatacatctt atccactgtc tcctttgagt
     1681 gactttgcca cacaggactc ctttgatgat gatgaactgg atgcagctgt agcagatcct
     1741 gatgaatttg agcgaatata tgagcctctg gatgtcaaaa gtaaaaagat tcatgtagtg
     1801 gacagtgggc tcacatttaa cctgccgtat cccttgatac tgagacctca gagaggggtt
     1861 gatctcataa tctcctttga cttttctgca aggccaagtg actctagtcc tccgttcaag
     1921 gaacttctac ttgcagaaaa gtgggctaaa atgaacaagc tcccctttcc aaagattgat
     1981 ccttatgtgt ttgatcggga agggctgaag gagtgctatg tctttaaacc caagaatcct
     2041 gatatggaga aagattgccc aaccatcatc cactttgttc tggccaacat caacttcaga
     2101 aagtacaggg ctccaggtgt tccaagggaa actgaggaag agaaagaaat cgctgacttt
     2161 gatatttttg atgacccaga atcaccattt tcaaccttca attttcaata tccaaatcaa
     2221 gcattcaaaa gactacatga tcttatgcac ttcaatactc tgaacaacat tgatgtgata
     2281 aaagaagcca tggttgaaag cattgaatat agaagacaga atccatctcg ttgctctgtt
     2341 tcccttagta atgttgaggc aagaagattt ttcaacaagg agtttctaag taaacccaaa
     2401 gcatagttca tgtactggaa atggcagcag tttctgatgc tgaggcagtt tgcaatccca
     2461 tgacaactgg atttaaaagt acagtacaga tagtcgtact gatcatgaga gactggctga
     2521 tactcaaagt tgcagttact tagctgcatg agaataatac tattataagt taggttgaca
     2581 aatgatgttg attatgtaag gatatactta gctacatttt cagtcagtat gaacttcctg
     2641 atacaaatgt agggatatat actgtatttt taaacatttc tcaccaactt tcttatgtgt
     2701 gttcttttta aaaatttttt ttcttttaaa atatttaaca gttcaatctc aataagacct
     2761 cgcattatgt atgaatgtta ttcactgact agatttattc ataccatgag acaacactat
     2821 ttttatttat atatgcatat atatacatac atgaaataaa tacatcaata taaaaataa
//
