LOCUS       NM_022819               2721 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phospholipase A2 group IIF (PLA2G2F), transcript
            variant 1, mRNA.
ACCESSION   NM_022819
VERSION     NM_022819.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2721)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2721)
  AUTHORS   Ilic,D., Bollinger,J.M., Gelb,M. and Mauro,T.M.
  TITLE     sPLA2 and the epidermal barrier
  JOURNAL   Biochim Biophys Acta 1841 (3), 416-421 (2014)
   PUBMED   24269828
  REMARK    GeneRIF: two of these isoforms, sPLA2 IIA and sPLA2 IIF, localize
            to the upper stratum granulosum and increase in response to
            experimental barrier perturbation.
REFERENCE   3  (bases 1 to 2721)
  AUTHORS   Segat,L., Brandao,L.A.C., Guimaraes,R.L., Pontillo,A.,
            Athanasakis,E., de Oliveira,R.M., Arraes,L.C., de Lima Filho,J.L.
            and Crovella,S.
  TITLE     Polymorphisms in innate immunity genes and patients response to
            dendritic cell-based HIV immuno-treatment
  JOURNAL   Vaccine 28 (10), 2201-2206 (2010)
   PUBMED   20056178
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 2721)
  AUTHORS   Murakami,M., Yoshihara,K., Shimbara,S., Lambeau,G., Gelb,M.H.,
            Singer,A.G., Sawada,M., Inagaki,N., Nagai,H., Ishihara,M.,
            Ishikawa,Y., Ishii,T. and Kudo,I.
  TITLE     Cellular arachidonate-releasing function and
            inflammation-associated expression of group IIF secretory
            phospholipase A2
  JOURNAL   J Biol Chem 277 (21), 19145-19155 (2002)
   PUBMED   11877435
REFERENCE   5  (bases 1 to 2721)
  AUTHORS   Valentin,E., Singer,A.G., Ghomashchi,F., Lazdunski,M., Gelb,M.H.
            and Lambeau,G.
  TITLE     Cloning and recombinant expression of human group IIF-secreted
            phospholipase A(2)
  JOURNAL   Biochem Biophys Res Commun 279 (1), 223-228 (2000)
   PUBMED   11112443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158172.5, BX647458.1, AF306566.1, AK093645.1, Z98257.1 and
            BM987713.1.
            
            On Jun 2, 2019 this sequence version replaced NM_022819.3.
            
            Transcript Variant: This variant (1) encodes a longer protein
            (isoform 1), which lacks a signal peptide. With the available
            conservation data, it is not clear which start codon is most likely
            used.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1344780.1,
                                           SRR7346977.1130655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375102.4/ ENSP00000364243.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL158172.5         92465-92471
            8-274               BX647458.1         1-267
            275-741             AF306566.1         41-507
            742-2237            AK093645.1         739-2234
            2238-2238           Z98257.1           4397-4397
            2239-2719           AK093645.1         2236-2716
            2720-2721           BM987713.1         24-25               c
FEATURES             Location/Qualifiers
     source          1..2721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..2721
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /note="phospholipase A2 group IIF"
                     /db_xref="GeneID:64600"
                     /db_xref="HGNC:HGNC:30040"
                     /db_xref="MIM:616793"
     exon            1..221
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..741
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 is encoded by transcript variant 1; group
                     IIF secretory phospholipase A2; phosphatidylcholine
                     2-acylhydrolase 2F; GIIF sPLA2"
                     /codon_start=1
                     /product="group IIF secretory phospholipase A2 isoform 1"
                     /protein_id="NP_073730.3"
                     /db_xref="CCDS:CCDS204.2"
                     /db_xref="GeneID:64600"
                     /db_xref="HGNC:HGNC:30040"
                     /db_xref="MIM:616793"
                     /translation="MADGAKANPKGFKKKVLDRCFSGWRGPRFGASCPSRTSRSSLGM
                     KKFFTVAILAGSVLSTAHGSLLNLKAMVEAVTGRSAILSFVGYGCYCGLGGRGQPKDE
                     VDWCCHAHDCCYQELFDQGCHPYVDHYDHTIENNTEIVCSDLNKTECDKQTCMCDKNM
                     VLCLMNQTYREEYRGFLNVYCQGPTPNCSIYEPPPEEVTCSHQSPAPPAPP"
     exon            222..274
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            275..419
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            420..529
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            530..2721
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2701..2706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /note="hexamer: AATAAA"
     polyA_site      2721
                     /gene="PLA2G2F"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /note="major polyA site"
ORIGIN      
        1 gccagtgtgc gaggcagcgt gaagctgggg cctgctcccc gcagcctctg gagcgcatct
       61 cagaccttct gagacctatg ttgctggccc cccagaaccc gcaacatggc agatggggca
      121 aaggccaacc ccaaagggtt caaaaagaag gtgctggata gatgcttctc tgggtggagg
      181 ggcccacgct tcggggcctc ctgtccttca agaacctcca ggtctagcct gggtatgaag
      241 aagttcttca ccgtggccat ccttgctggc agcgttctgt ccacagctca cggcagcctg
      301 ctcaacctga aggccatggt ggaggccgtc acagggagga gcgccatcct gtccttcgtg
      361 ggctacggtt gctactgtgg gctggggggc cgtggccagc ccaaggatga ggtggactgg
      421 tgctgccacg cccacgactg ctgctaccag gaactctttg accaaggctg tcacccctat
      481 gtggaccact atgatcacac catcgagaac aacactgaga tagtctgcag tgacctcaac
      541 aagacagagt gtgacaagca gacatgcatg tgtgacaaga acatggttct gtgcctcatg
      601 aaccagacgt accgagagga gtaccgtggc ttcctcaatg tctactgcca gggccccacg
      661 cccaactgca gcatctatga accgccccct gaggaggtca cctgcagtca ccaatcccca
      721 gcgccccccg cccctcccta gagcctctga ggtttgagag agagagcggg aggagggtct
      781 ggcttgggga ccagacgagg tgcagggagg gtaggagcca ggccaggagc ctgagggttg
      841 ctggttgcct cctccctgga gctctccagt gagggctcag ctctcagagg actcaggaag
      901 gcctgggtcc tgactccccc agcccagccc caggcatggg tgcctcctgc tgctggttct
      961 ggactgggtg ggaggcacgg agcttatagg ggtctctcct gagggtggcc ggggagacct
     1021 gagagagagg aggaggggcc tctgagtggg gcctctgttg ctggcgccag tttaactccc
     1081 cggagcctta gaaagtctga gccttagaaa gtctgggcct gagcatccag gcccagagct
     1141 ggatgcatcc tcggcccaag atcacaggaa ggcagattgc tggtcacaaa gcatgggttc
     1201 cgggagcccc tcagctgatc ccacaggatg gcctggggtg gtggctactt tgggcttgaa
     1261 gctctctaga gccccattca cagagcaggt gccccacccc agccctcact gaggtggcca
     1321 tgagtccagg ttcagaccct aggggatgtg cagtgctgag tgtcccagcc ctgaagtcta
     1381 gcctcagagc aggctcctgg gcactgacag agccacacac ccaggtacac cccccaggct
     1441 aatatgggga cacacaaaaa tatggccttc aacacctaca agtcttctct gtgtccccca
     1501 tcgacccatg cacatcaccc caaccctgct ctgccacacc acgtgggtct gaggagcact
     1561 cctacccccc ggctccgggt ccctgacaga cactgccctc ctggcctgca cctggaatgg
     1621 cagccagaac actggagggg gacccacacc ctctctccct gggctgtgga tgggtgttgc
     1681 aagtcccatc cctcctggcc tgcacctgga acagcagcca gaacaccgga gggggaccca
     1741 caccctctct ccctgggctg tgggcaggcg tcacaagtcc cattggtggg gaagaggctg
     1801 agggctgaga cccacctcag tgaagaggga aacgtaagca gggagagcat caaggcggga
     1861 ggcagcctgg aaacttctag aagagggtca aggtaggagg ctacatggaa gcttctagaa
     1921 ggcagtaagg aacagggtgg tgaaggagag gggagaagat gggagcatgg agagacgagg
     1981 tgagtgacag ccaccagcag ggacgggcct ccaggcaaca cagaggagct gggggccagg
     2041 gccttacggg gctgggttcc tgtgtggggc gtggagctgg ggctgaagtg gaggggacgg
     2101 ccctgcggcc cccagcactg ttgtttctcc aggtgcacct taccttcctc cttacctgcc
     2161 cgagcctcaa ctcagggtca gcagcctcca cggagccagc cccacctgcc cgaaaaccac
     2221 tgaagccacc ctccgcccgg actcaacagc cgccagcaag ctcgcctggc agtgcccctg
     2281 gagcaccatt gtcgctgggg agggagagcc gggaagggtg gagaaggagg cagaagggac
     2341 atgtatgaaa aaaggacagg aaacctgacc agaggcggtt tccagagccc cagccttgga
     2401 gacaaggaca ctgccaccca gcgccacagt cagtctggga ggggcccacg ccccccaccc
     2461 cccatgccac actgccgcct cttgctggcc atggttctcc ggcttggggg aacgcaggtt
     2521 cccagctgcg cccctccccc gcgcacacac accctcccct gtccctcgga aagactaggc
     2581 cagggtctgg ggatgggatt ctgctgccag gggtcctgcc tgcccccact caccccagac
     2641 gcttcggatg ctgcagctcc tggataatct ccacaggact cggcttcctc tcctcaaatg
     2701 aataaaggcc tcctacctca a
//
