LOCUS       NM_014589                785 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.
ACCESSION   NM_014589
VERSION     NM_014589.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 785)
  AUTHORS   Bu,H., Zhang,S., Li,P., Liu,Z., Liu,Y., Li,Z., Liu,X., Wang,Z.,
            Feng,L., Chen,L. and Qu,L.
  TITLE     Secreted phospholipase PLA2G2E contributes to regulation of T cell
            immune response against influenza virus infection
  JOURNAL   J Virol 98 (5), e0019824 (2024)
   PUBMED   38591879
  REMARK    GeneRIF: Secreted phospholipase PLA2G2E contributes to regulation
            of T cell immune response against influenza virus infection.
REFERENCE   2  (bases 1 to 785)
  AUTHORS   Nakamura,A., Sakai,S., Taketomi,Y., Tsuyama,J., Miki,Y., Hara,Y.,
            Arai,N., Sugiura,Y., Kawaji,H., Murakami,M. and Shichita,T.
  TITLE     PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural
            repair after ischemic stroke
  JOURNAL   Neuron 111 (19), 2995-3010 (2023)
   PUBMED   37490917
  REMARK    GeneRIF: PLA2G2E-mediated lipid metabolism triggers
            brain-autonomous neural repair after ischemic stroke.
REFERENCE   3  (bases 1 to 785)
  AUTHORS   Hou,S., Bai,J., Lu,X., Zhang,Y., Xu,T. and Xie,J.
  TITLE     [Effect of E54 mutation of human secreted phospholipase A2 GIIE on
            substrate selectivity]
  JOURNAL   Sheng Wu Gong Cheng Xue Bao 37 (7), 2513-2521 (2021)
   PUBMED   34327916
  REMARK    GeneRIF: [Effect of E54 mutation of human secreted phospholipase A2
            GIIE on substrate selectivity].
REFERENCE   4  (bases 1 to 785)
  AUTHORS   Hou,S., Bai,J., Chen,C., Zhang,X., Chang,F., Cao,Z., Xu,T. and
            Xie,J.
  TITLE     The atypical binding mechanism of second calcium on phospholipase
            A2 group IIE
  JOURNAL   Biochem Biophys Res Commun 557, 267-272 (2021)
   PUBMED   33894413
  REMARK    GeneRIF: The atypical binding mechanism of second calcium on
            phospholipase A2 group IIE.
REFERENCE   5  (bases 1 to 785)
  AUTHORS   Hou,S., Zhang,Y., Xu,J., Bai,J., Liu,J., Xie,J. and Xu,T.
  TITLE     Residue Asn21 acts as a switch for calcium binding to modulate the
            enzymatic activity of human phospholipase A2 group IIE
  JOURNAL   Biochimie 176, 117-121 (2020)
   PUBMED   32659444
  REMARK    GeneRIF: Residue Asn21 acts as a switch for calcium binding to
            modulate the enzymatic activity of human phospholipase A2 group
            IIE.
REFERENCE   6  (bases 1 to 785)
  AUTHORS   Segat,L., Brandao,L.A.C., Guimaraes,R.L., Pontillo,A.,
            Athanasakis,E., de Oliveira,R.M., Arraes,L.C., de Lima Filho,J.L.
            and Crovella,S.
  TITLE     Polymorphisms in innate immunity genes and patients response to
            dendritic cell-based HIV immuno-treatment
  JOURNAL   Vaccine 28 (10), 2201-2206 (2010)
   PUBMED   20056178
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 785)
  AUTHORS   Barrett,J.C., Lee,J.C., Lees,C.W., Prescott,N.J., Anderson,C.A.,
            Phillips,A., Wesley,E., Parnell,K., Zhang,H., Drummond,H.,
            Nimmo,E.R., Massey,D., Blaszczyk,K., Elliott,T., Cotterill,L.,
            Dallal,H., Lobo,A.J., Mowat,C., Sanderson,J.D., Jewell,D.P.,
            Newman,W.G., Edwards,C., Ahmad,T., Mansfield,J.C., Satsangi,J.,
            Parkes,M., Mathew,C.G., Donnelly,P., Peltonen,L., Blackwell,J.M.,
            Bramon,E., Brown,M.A., Casas,J.P., Corvin,A., Craddock,N.,
            Deloukas,P., Duncanson,A., Jankowski,J., Markus,H.S., Mathew,C.G.,
            McCarthy,M.I., Palmer,C.N., Plomin,R., Rautanen,A., Sawcer,S.J.,
            Samani,N., Trembath,R.C., Viswanathan,A.C., Wood,N., Spencer,C.C.,
            Barrett,J.C., Bellenguez,C., Davison,D., Freeman,C., Strange,A.,
            Donnelly,P., Langford,C., Hunt,S.E., Edkins,S., Gwilliam,R.,
            Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M., Gray,E.,
            Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J., Perez,M.L.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M., Waller,M., Weston,P.,
            Widaa,S., Whittaker,P., Deloukas,P., Peltonen,L., Mathew,C.G.,
            Blackwell,J.M., Brown,M.A., Corvin,A., McCarthy,M.I., Spencer,C.C.,
            Attwood,A.P., Stephens,J., Sambrook,J., Ouwehand,W.H.,
            McArdle,W.L., Ring,S.M. and Strachan,D.P.
  CONSRTM   UK IBD Genetics Consortium; Wellcome Trust Case Control Consortium
            2
  TITLE     Genome-wide association study of ulcerative colitis identifies
            three new susceptibility loci, including the HNF4A region
  JOURNAL   Nat Genet 41 (12), 1330-1334 (2009)
   PUBMED   19915572
REFERENCE   8  (bases 1 to 785)
  AUTHORS   Silverberg,M.S., Cho,J.H., Rioux,J.D., McGovern,D.P., Wu,J.,
            Annese,V., Achkar,J.P., Goyette,P., Scott,R., Xu,W., Barmada,M.M.,
            Klei,L., Daly,M.J., Abraham,C., Bayless,T.M., Bossa,F.,
            Griffiths,A.M., Ippoliti,A.F., Lahaie,R.G., Latiano,A., Pare,P.,
            Proctor,D.D., Regueiro,M.D., Steinhart,A.H., Targan,S.R.,
            Schumm,L.P., Kistner,E.O., Lee,A.T., Gregersen,P.K., Rotter,J.I.,
            Brant,S.R., Taylor,K.D., Roeder,K. and Duerr,R.H.
  TITLE     Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by
            genome-wide association study
  JOURNAL   Nat Genet 41 (2), 216-220 (2009)
   PUBMED   19122664
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   9  (bases 1 to 785)
  AUTHORS   Murakami,M., Yoshihara,K., Shimbara,S., Lambeau,G., Singer,A.,
            Gelb,M.H., Sawada,M., Inagaki,N., Nagai,H. and Kudo,I.
  TITLE     Arachidonate release and eicosanoid generation by group IIE
            phospholipase A(2)
  JOURNAL   Biochem Biophys Res Commun 292 (3), 689-696 (2002)
   PUBMED   11922621
  REMARK    GeneRIF: promotes stimulus-induced arachidonic acid release and
            prostaglandin (PG) production similar to those elicited by
            HSPG-dependent sPLA(2)s, suggesting that this enzyme plays a role
            in the inflammatory process.
REFERENCE   10 (bases 1 to 785)
  AUTHORS   Suzuki,N., Ishizaki,J., Yokota,Y., Higashino,K., Ono,T., Ikeda,M.,
            Fujii,N., Kawamoto,K. and Hanasaki,K.
  TITLE     Structures, enzymatic properties, and expression of novel human and
            mouse secretory phospholipase A(2)s
  JOURNAL   J Biol Chem 275 (8), 5785-5793 (2000)
   PUBMED   10681567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF189279.1 and AL358253.16.
            
            On May 17, 2019 this sequence version replaced NM_014589.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An in-frame
            AUG is located 12 codons upstream of the annotated translation
            start site but is not being annotated as a start site since it is
            poorly conserved and is in a weak Kozak sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189279.1, BC069116.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000375116.3/
                                                ENSP00000364257.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AF189279.1         1-48
            49-49               AL358253.16        17021-17021         c
            50-487              AF189279.1         50-487
            488-785             AL358253.16        13461-13758         c
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..785
                     /gene="PLA2G2E"
                     /gene_synonym="GIIE sPLA2; sPLA2-IIE"
                     /note="phospholipase A2 group IIE"
                     /db_xref="GeneID:30814"
                     /db_xref="HGNC:HGNC:13414"
                     /db_xref="MIM:618320"
     exon            1..98
                     /gene="PLA2G2E"
                     /gene_synonym="GIIE sPLA2; sPLA2-IIE"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..487
                     /gene="PLA2G2E"
                     /gene_synonym="GIIE sPLA2; sPLA2-IIE"
                     /EC_number="3.1.1.4"
                     /note="group IIE secretory phospholipase A2;
                     phosphatidylcholine 2-acylhydrolase 2E"
                     /codon_start=1
                     /product="group IIE secretory phospholipase A2 precursor"
                     /protein_id="NP_055404.1"
                     /db_xref="CCDS:CCDS200.1"
                     /db_xref="GeneID:30814"
                     /db_xref="HGNC:HGNC:13414"
                     /db_xref="MIM:618320"
                     /translation="MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGC
                     YCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQ
                     RLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC"
     exon            99..237
                     /gene="PLA2G2E"
                     /gene_synonym="GIIE sPLA2; sPLA2-IIE"
                     /inference="alignment:Splign:2.1.0"
     exon            238..344
                     /gene="PLA2G2E"
                     /gene_synonym="GIIE sPLA2; sPLA2-IIE"
                     /inference="alignment:Splign:2.1.0"
     exon            345..785
                     /gene="PLA2G2E"
                     /gene_synonym="GIIE sPLA2; sPLA2-IIE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctttctt ctgctgcctt ttatgctcct tgtgcacctc ccttcccccc aacctgggat
       61 gaaatctccc cacgtgctgg tgttcctttg cctcctggtg gctctggtca ccgggaacct
      121 ggttcagttt ggggtgatga tcgagaagat gacaggcaag tccgccctgc agtacaacga
      181 ctatggctgt tactgcggca tcggtggctc ccactggccg gtggaccaga ctgactggtg
      241 ctgccacgcc cacgactgct gctacgggcg tctggagaag ctgggctgtg agcccaaact
      301 ggaaaagtat cttttctctg tcagcgaacg tggcattttc tgcgccggca ggaccacctg
      361 ccagcggctg acctgcgagt gtgacaagag ggctgccctc tgctttcgcc gcaacctggg
      421 cacctacaac cgcaaatatg cccattatcc caacaagctg tgcaccgggc ccaccccgcc
      481 ctgctgaggc tatgctcggc ctcccccccg tccctggagg tcccgcctcg ggctgctgta
      541 gtcccaggcc tggggaacat tggcaccaaa ggccctccct ttggaaaatt cctttcctgc
      601 aaactcatcc ctccttgaga gctcagagat atgtcctgga ccatcactag cctcccaggc
      661 taccccttct ctgtagaaag aaccctgccc caggagccat ggacccttca gcacccagaa
      721 gactgtcact agcttctggg atctcagctc cctcttctga ataagtgaat aatgttttcc
      781 cataa
//
