LOCUS       NM_012400               2651 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens phospholipase A2 group IID (PLA2G2D), transcript
            variant 1, mRNA.
ACCESSION   NM_012400
VERSION     NM_012400.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Vijay,R., Hua,X., Meyerholz,D.K., Miki,Y., Yamamoto,K., Gelb,M.,
            Murakami,M. and Perlman,S.
  TITLE     Critical role of phospholipase A2 group IID in age-related
            susceptibility to severe acute respiratory syndrome-CoV infection
  JOURNAL   J Exp Med 212 (11), 1851-1868 (2015)
   PUBMED   26392224
  REMARK    GeneRIF: found to induce PLA2G2D expression in mice and in human
            monocyte-derived macrophages
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Hsu,Y.H., Dumlao,D.S., Cao,J. and Dennis,E.A.
  TITLE     Assessing phospholipase A2 activity toward cardiolipin by mass
            spectrometry
  JOURNAL   PLoS One 8 (3), e59267 (2013)
   PUBMED   23533611
  REMARK    Erratum:[PLoS One. 2013;8(6).
            doi:10.1371/annotation/47607b18-ed69-4a08-8619-60c39bd83a13]
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Li,K., Jin,J.Y., Chen,W.Y., Shi,Q.X., Ni,Y. and Roldan,E.R.
  TITLE     Secretory phospholipase A2 group IID Is involved in
            progesterone-induced acrosomal exocytosis of human spermatozoa
  JOURNAL   J Androl 33 (5), 975-983 (2012)
   PUBMED   22240557
  REMARK    GeneRIF: sPLA(2)-IID is present at the head and midpiece in the
            human sperm, and its activation seems to be involved in acrosomal
            exocytosis.
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Fonseca-Maldonado,R., Ferreira,T.L. and Ward,R.J.
  TITLE     The bactericidal effect of human secreted group IID phospholipase
            A2 results from both hydrolytic and non-hydrolytic activities
  JOURNAL   Biochimie 94 (6), 1437-1440 (2012)
   PUBMED   22490726
  REMARK    GeneRIF: phospholipid bilayer permeabilization by the hsPLA2GIID is
            independent of catalytic activity.
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Leslie,C.C.
  TITLE     Regulation of arachidonic acid availability for eicosanoid
            production
  JOURNAL   Biochem Cell Biol 82 (1), 1-17 (2004)
   PUBMED   15052324
  REMARK    GeneRIF: The GIID sPLA2 is clustered on human chromosome 1 and is
            differentially expressed in tissues, suggesting it has unique
            function.
            Review article
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Meira-Lima,I., Jardim,D., Junqueira,R., Ikenaga,E. and Vallada,H.
  TITLE     Allelic association study between phospholipase A2 genes and
            bipolar affective disorder
  JOURNAL   Bipolar Disord 5 (4), 295-299 (2003)
   PUBMED   12895207
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Lindbom,J., Ljungman,A.G., Lindahl,M. and Tagesson,C.
  TITLE     Increased gene expression of novel cytosolic and secretory
            phospholipase A(2) types in human airway epithelial cells induced
            by tumor necrosis factor-alpha and IFN-gamma
  JOURNAL   J Interferon Cytokine Res 22 (9), 947-955 (2002)
   PUBMED   12396716
  REMARK    GeneRIF: TNF-alpha & IFN-gamma induce gene expression of a novel
            secretory PLA(2)IIDin human airway epithelial cells. The
            possibility that it is involved in cytokine-mediated inflammation
            in the respiratory tract is inferred.
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Suzuki,N., Ishizaki,J., Yokota,Y., Higashino,K., Ono,T., Ikeda,M.,
            Fujii,N., Kawamoto,K. and Hanasaki,K.
  TITLE     Structures, enzymatic properties, and expression of novel human and
            mouse secretory phospholipase A(2)s
  JOURNAL   J Biol Chem 275 (8), 5785-5793 (2000)
   PUBMED   10681567
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Ishizaki,J., Suzuki,N., Higashino,K., Yokota,Y., Ono,T.,
            Kawamoto,K., Fujii,N., Arita,H. and Hanasaki,K.
  TITLE     Cloning and characterization of novel mouse and human secretory
            phospholipase A(2)s
  JOURNAL   J Biol Chem 274 (35), 24973-24979 (1999)
   PUBMED   10455175
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC295429.1, BC025706.1,
            AK026347.1 and AL158172.5.
            
            On May 17, 2019 this sequence version replaced NM_012400.3.
            
            Summary: This gene encodes a secreted member of the phospholipase
            A2 family, and is found in a cluster of related family members on
            chromosome 1. Phospholipase A2 family members hydrolyze the sn-2
            fatty acid ester bond of glycerophospholipids to produce
            lysophospholipids and free fatty acid. This gene may be involved in
            inflammation and immune response, and in weight loss associated
            with chronic obstructive pulmonary disease. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF188625.1, DC389636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2155628
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375105.8/ ENSP00000364246.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DC295429.1         31-51
            22-1770             BC025706.1         1-1749
            1771-1940           AK026347.1         911-1080
            1941-2651           AL158172.5         65081-65791         c
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..2651
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /note="phospholipase A2 group IID"
                     /db_xref="GeneID:26279"
                     /db_xref="HGNC:HGNC:9033"
                     /db_xref="MIM:605630"
     exon            1..78
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..476
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; secretory phospholipase A2s; group IID
                     secretory phospholipase A2; GIID sPLA2;
                     phosphatidylcholine 2-acylhydrolase 2D; secretory-type
                     PLA, stroma-associated homolog"
                     /codon_start=1
                     /product="group IID secretory phospholipase A2 isoform 1
                     precursor"
                     /protein_id="NP_036532.1"
                     /db_xref="CCDS:CCDS203.1"
                     /db_xref="GeneID:26279"
                     /db_xref="HGNC:HGNC:9033"
                     /db_xref="MIM:605630"
                     /translation="MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPY
                     GCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGS
                     WCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC"
     exon            79..223
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            224..330
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /inference="alignment:Splign:2.1.0"
     exon            331..2651
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1920..1925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /note="hexamer: AGTAAA"
     polyA_site      1940
                     /gene="PLA2G2D"
                     /gene_synonym="PLA2IID; sPLA2-IID; sPLA2S; SPLASH"
                     /note="major polyA site"
ORIGIN      
        1 actgccagca tctgcctcca ctgctctgtg ctgggatcat ggaacttgca ctgctgtgtg
       61 ggctggtggt gatggctggt gtgattccaa tccagggcgg gatcctgaac ctgaacaaga
      121 tggtcaagca agtgactggg aaaatgccca tcctctccta ctggccctac ggctgtcact
      181 gcggactagg tggcagaggc caacccaaag atgccacgga ctggtgctgc cagacccatg
      241 actgctgcta tgaccacctg aagacccagg ggtgcagcat ctacaaggac tattacagat
      301 acaacttttc ccaggggaac atccactgct ctgacaaggg aagctggtgt gagcagcagc
      361 tgtgtgcctg tgacaaggag gtggccttct gcctgaagcg caacctggac acctaccaga
      421 agcgactgcg tttctactgg cggccccact gccgggggca gacccctggg tgctagaagc
      481 ccacaccctc taccctgttc ctcagcatgg agctctggca tccccacctc agtatctaac
      541 ctgaaccagc ctggcttttc aaacactccg gggggaggta gtcccagcct cccccggaac
      601 cctctaccaa tgccttctga ccttctgaag ctttccgaat cctcccagtt gaggcagtag
      661 ctgtgtcctc tgagggtgga tgggaatctt gggagaagcc caagcaaggg agccctcaga
      721 ggtggtgttt ggaccaaagc atcggggtgg gggaggggtc tgccgctgtc ccccacctgc
      781 tggccccctt gtccttcctc accccctcca atatagtctc ggagctacaa ccgcagcagc
      841 cactataaag ggcaatattg atctttctgt ccatgtggct ctatctttta aaacctcaag
      901 gccctccact gtcctaagat aaagcctctc ataggcactg gggaccctgc acagtctggc
      961 catgtgaccc tctccccagg caagctctga agtccctgca ggtggaggcc atgcctgtct
     1021 taaactcagt tgcatccctg gtgcccaaag caacaccaga accaagaagg agctccataa
     1081 atccttcttg ggtgaagcct agacaaagcc gccaggtctt gtggctccag gcaccagagc
     1141 cttgagtact ttctcctgcc tccaggcatt ggctcagggt gaattacaag gggctactga
     1201 atggctatta ctttcatcac gactgatccc cacctcctca gggtcaaagg gctactttct
     1261 ggaagtctcc ccaggctgac tccttctccc tgactgcaag ggctcactcc ctcctccaag
     1321 ctcccacaat gcttcatggc tctgccgctt acctagcttg gcctagagtg gcaaatggaa
     1381 cttctctgat ctcccccaac tagactggag cccccgaagg atggagacca tgtctgtgcc
     1441 atctctgttt cccctgtttt cccacatact aggtgctcaa ttcatgcctg tgaatggcgt
     1501 gagcccataa tggatacaca gaggttgcag cagatggtgt gggtacctca cccagatatc
     1561 atccaggccc aaggcccctc tccctgagtg aggccaggtg ttggcagcca actgctccaa
     1621 tctgcctcct tcccctaaat actgccctgg tctagtggga gctgccttcc ccctgcccca
     1681 cctctcccac caagaggcca cctgtcactc atggccagga gagtgacacc atggagggta
     1741 caattgccag ctcccccgtg tctgtgcagg attgtctggg ttgaatgaca ctctcaaatt
     1801 gttcctggga tcgggctgag gccaggcctc tcctggaacc acctctctgc ttggtctgac
     1861 cccttggcct atccagtttt cctggttccc tcacaggttt ctccagaaag tactccctca
     1921 gtaaagcatt tgcacaagaa tccttgtctc aggctctgct tctaaggaaa gagactgaag
     1981 agggacaact ttttcctatg aggactccca atctgccatt tgtgtgtggc tagctgtttc
     2041 cagccagggg gctgaggcac ctgcagtcac ccacactctg ggcctgtggc accatctgtg
     2101 cctcagctga ctgagcagtt ctgagatgtg gtgactcatg tgaagtggtg tcataggaat
     2161 gaaggactgt gggcgctggg ttcaaattcc agttctatgc accactccag gtagggatac
     2221 ccatgggggc agctgtgcct gtgtggggga acagggtagg gaaatctcca taccttctca
     2281 attttgctgt gaacctaaaa ctgccatata aagataaagt ctaggccagg catggtggct
     2341 catgcctgta atcccaacac ttagggtggc tgaggcaggc agatcacctg gggtcaggag
     2401 ttcaagacca gcctgcccaa catggcaaaa cctcgtctct actaaaaata caaaaattag
     2461 ccaggcatcg tggtgggtgc ctgtaatccc agctattcag gaggctgagg caggagaatc
     2521 acttggacct gggaggcaga ggtttcagtg agcccagatc gcgacactgc actccagcct
     2581 gggcaacaga gtgacactct gtctcaaaaa ataaaataaa ataaaataaa ataaaataaa
     2641 ataaaataaa a
//
