LOCUS       NM_001367969            1621 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens phospholipase A2 group IIC (PLA2G2C), transcript
            variant 2, mRNA.
ACCESSION   NM_001367969
VERSION     NM_001367969.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Tang,Y., Cai,J. and Lv,B.
  TITLE     LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1
            inhibits colon adenocarcinoma progression via the miR-515-5p/slit
            guidance ligand 3 axis
  JOURNAL   Bioengineered 13 (2), 2308-2320 (2022)
   PUBMED   35034539
  REMARK    GeneRIF: LncRNA ubiquitin-binding protein domain protein 10
            antisense RNA 1 inhibits colon adenocarcinoma progression via the
            miR-515-5p/slit guidance ligand 3 axis.
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Tischfield,J.A., Xia,Y.R., Shih,D.M., Klisak,I., Chen,J.,
            Engle,S.J., Siakotos,A.N., Winstead,M.V., Seilhamer,J.J.,
            Allamand,V., Gyapay,G. and Lusis,A.J.
  TITLE     Low-molecular-weight, calcium-dependent phospholipase A2 genes are
            linked and map to homologous chromosome regions in mouse and human
  JOURNAL   Genomics 32 (3), 328-333 (1996)
   PUBMED   8838795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z98257.1.
            
            On May 20, 2020 this sequence version replaced NM_001367969.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2154405 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000679259.1/ ENSP00000504292.1
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               Z98257.1           40859-41017         c
            160-275             Z98257.1           31823-31938         c
            276-414             Z98257.1           29506-29644         c
            415-518             Z98257.1           27293-27396         c
            519-1621            Z98257.1           17554-18656         c
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..1621
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /note="phospholipase A2 group IIC"
                     /db_xref="GeneID:391013"
                     /db_xref="HGNC:HGNC:9032"
     exon            1..159
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..275
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..685
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /EC_number="3.1.1.4"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; phospholipase A2, group IIC (possible
                     pseudogene); putative inactive group IIC secretory
                     phospholipase A2; phosphatidylcholine 2-acylhydrolase-like
                     protein GIIC; UBXN10 antisense RNA 1"
                     /codon_start=1
                     /product="putative inactive group IIC secretory
                     phospholipase A2 isoform 2 precursor"
                     /protein_id="NP_001354898.1"
                     /db_xref="CCDS:CCDS90872.1"
                     /db_xref="GeneID:391013"
                     /db_xref="HGNC:HGNC:9032"
                     /translation="MKVIAILTLLLFCSPTHSSFWQFQRRVKHITGRSAFFSYYGYGC
                     YCGLGDKGIPVDDTDRHSPSSPSPYEKLKEFSCQPVLNSYQFHIVNGAVVCGCTLGPG
                     ASCHCRLKACECDKQSVHCFKESLPTYEKNFKQFSSQPRCGRHKPWC"
     exon            276..414
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..518
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..1621
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="PLA2G2C"
                     /gene_synonym="UBXN10-AS1"
                     /note="major polyA site"
ORIGIN      
        1 ctctggttct cgtctctgcc ctgccggaga ctgggacatc cttttctctc cctgggtctg
       61 tgtccccgtc gctacatccc agcctggagg gcatggccca gcggttgcat aggtccctcg
      121 gtttctgcag agcccgggag tcaccctatt ttggtaaaga ggttcagctg ggagacccct
      181 cacacacagg tgaaggcgtg gctgtagaac ctcagacccc ctggtctcct caggaatgaa
      241 ggtcattgcc atcctcaccc tcctcctctt ctgctccccc acccacagca gtttctggca
      301 gtttcagagg agggtcaaac acatcacggg gcgaagtgcc ttcttctcat attacggata
      361 tggctgctac tgtgggcttg gggataaagg gatccccgtg gatgacactg acaggcacag
      421 cccctcatct ccctctccct acgagaagct gaaggagttc agctgccagc ctgtgttgaa
      481 cagctaccag ttccacatcg tcaatggcgc agtggtttgt ggatgcaccc ttggtcctgg
      541 tgccagctgc cactgcaggc tgaaggcctg tgagtgtgac aagcaatccg tgcactgctt
      601 caaagagagc ctgcccacct atgagaaaaa cttcaagcag ttctccagcc agcccaggtg
      661 tggcagacat aagccctggt gctagggaca ccacagggtc cctctcatca tccagcatcc
      721 gctctagtgt tgctcttcca ggaagccttc tcagatcatc cccaacaggc ccctgttctt
      781 ccactgggag ggaggacaaa atgtctcccg cagggcagct cacccttcag cattctgacc
      841 aaggggactc cctgtcgttc agcatcagag ggctggagag cagaaatggg aaagatgaga
      901 tgcctgccct gcaggagctg gcattctgtg gagtggggag gactacaaat gcatggatat
      961 agaagtaaga gacacattag actgtagtaa gtgctatgat gcagtaaaac aaagggacgg
     1021 gatagagatg cacccaaccc cacatcccag ggtttccagg aggggagaag ccccaggatc
     1081 taccccaaac tctctcttca cccccactgc aaaccgggac acagagcaga cttgagcgcc
     1141 aggcccatgc ccagctctag ctggcaacaa agccaccact ttccttgccc ctctgcgtcc
     1201 tcagttttta tgatgtcatt cttagctttt cttatcaaga ggcagaatct gttttcccca
     1261 tcccatgaat ctgaactggt cttgtggctt agtttggtca atagaatgtt gtgggaggga
     1321 tggtttacca gttttgagct aggcctcagg aggtctaggg catgtctact ctctcttagg
     1381 acagctgccc ccaccctgca aaaaagcctg ggctagcctg ctggaggatg agagcccacc
     1441 tggatcagtt gtctcagctg atttcagaca cgtgagagag agctcagcga gactcagctt
     1501 gtagctgact acagatgtgt gagggaacct ggctgagacc aaaacaactg tccagctgag
     1561 cccaggctaa actgccaaca tgcagaattg tgagctaaat aaaggctgct gttctaagtc
     1621 a
//
