LOCUS       NM_001395463             846 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens phospholipase A2 group IIA (PLA2G2A), transcript
            variant 5, mRNA.
ACCESSION   NM_001395463
VERSION     NM_001395463.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 846)
  AUTHORS   Wang,X., Li,S., Liu,C., Zhao,J., Ren,G., Zhang,F., Liu,X., Cao,S.,
            Xu,Y. and Xia,Z.
  TITLE     High expression of PLA2G2A in fibroblasts plays a crucial role in
            the early progression of carotid atherosclerosis
  JOURNAL   J Transl Med 22 (1), 967 (2024)
   PUBMED   39449149
  REMARK    GeneRIF: High expression of PLA2G2A in fibroblasts plays a crucial
            role in the early progression of carotid atherosclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 846)
  AUTHORS   Lv,W., Mao,H., Ruan,Y., Li,S., Shimizu,K., Zhang,L. and Zhang,C.
  TITLE     Identification and immunological characterization of PLA2G2A and
            cell death-associated molecular clusters in idiopathic pulmonary
            fibrosis
  JOURNAL   Life Sci 331, 122071 (2023)
   PUBMED   37673297
  REMARK    GeneRIF: Identification and immunological characterization of
            PLA2G2A and cell death-associated molecular clusters in idiopathic
            pulmonary fibrosis.
REFERENCE   3  (bases 1 to 846)
  AUTHORS   Zhang,H.L., Xiang,Y.K., Hu,H., Zhang,C., Kong,X.Y., Tian,F.Z.,
            Da,X.B., Qiu,C., Lyu,B.N., Wang,Y.B. and Yang,Y.L.
  TITLE     [Diagnostic value of lipoprotein-associated phospholipase A2 in
            OPBR combined with gallbladder cholesterol deposition]
  JOURNAL   Zhonghua Yi Xue Za Zhi 103 (16), 1225-1229 (2023)
   PUBMED   37087406
  REMARK    GeneRIF: [Diagnostic value of lipoprotein-associated phospholipase
            A2 in OPBR combined with gallbladder cholesterol deposition].
REFERENCE   4  (bases 1 to 846)
  AUTHORS   Urazov,S., Chernov,A., Popov,O., Klenkova,N., Sushentseva,N.,
            Polkovnikova,I., Apalko,S., Kislyuk,K., Pavlovich,D., Ivanov,A. and
            Shcherbak,S.
  TITLE     Secretory Phospholipase A2 and Interleukin-6 Levels as Predictive
            Markers of the Severity and Outcome of Patients with COVID-19
            Infections
  JOURNAL   Int J Mol Sci 24 (6), 5540 (2023)
   PUBMED   36982611
  REMARK    GeneRIF: Secretory Phospholipase A2 and Interleukin-6 Levels as
            Predictive Markers of the Severity and Outcome of Patients with
            COVID-19 Infections.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 846)
  AUTHORS   Ferrara,A.L., Bova,M., Petraroli,A., Marasco,D., Payre,C.,
            Fortuna,S., Palestra,F., Ciardi,R., Marone,G., Spadaro,G.,
            Lambeau,G. and Loffredo,S.
  TITLE     Interplay between C1-inhibitor and group IIA secreted phospholipase
            A2 impairs their respective function
  JOURNAL   Immunol Res 71 (1), 70-82 (2023)
   PUBMED   36385678
  REMARK    GeneRIF: Interplay between C1-inhibitor and group IIA secreted
            phospholipase A2 impairs their respective function.
REFERENCE   6  (bases 1 to 846)
  AUTHORS   Scott,D.L., White,S.P., Browning,J.L., Rosa,J.J., Gelb,M.H. and
            Sigler,P.B.
  TITLE     Structures of free and inhibited human secretory phospholipase A2
            from inflammatory exudate
  JOURNAL   Science 254 (5034), 1007-1010 (1991)
   PUBMED   1948070
REFERENCE   7  (bases 1 to 846)
  AUTHORS   Wery,J.P., Schevitz,R.W., Clawson,D.K., Bobbitt,J.L., Dow,E.R.,
            Gamboa,G., Goodson,T. Jr., Hermann,R.B., Kramer,R.M., McClure,D.B.
            et al.
  TITLE     Structure of recombinant human rheumatoid arthritic synovial fluid
            phospholipase A2 at 2.2 A resolution
  JOURNAL   Nature 352 (6330), 79-82 (1991)
   PUBMED   2062381
REFERENCE   8  (bases 1 to 846)
  AUTHORS   Pruzanski,W., Bogoch,E., Stefanski,E., Wloch,M. and Vadas,P.
  TITLE     Enzymatic activity and distribution of phospholipase A2 in human
            cartilage
  JOURNAL   Life Sci 48 (25), 2457-2462 (1991)
   PUBMED   2046470
REFERENCE   9  (bases 1 to 846)
  AUTHORS   Kramer,R.M., Johansen,B., Hession,C. and Pepinsky,R.B.
  TITLE     Structure and properties of a secretable phospholipase A2 from
            human platelets
  JOURNAL   Adv Exp Med Biol 275, 35-53 (1990)
   PUBMED   2239446
  REMARK    Review article
REFERENCE   10 (bases 1 to 846)
  AUTHORS   Seilhamer,J.J., Randall,T.L., Johnson,L.K., Heinzmann,C.,
            Klisak,I., Sparkes,R.S. and Lusis,A.J.
  TITLE     Novel gene exon homologous to pancreatic phospholipase A2: sequence
            and chromosomal mapping of both human genes
  JOURNAL   J Cell Biochem 39 (3), 327-337 (1989)
   PUBMED   2708461
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358253.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a member of the
            phospholipase A2 family (PLA2). PLA2s constitute a diverse family
            of enzymes with respect to sequence, function, localization, and
            divalent cation requirements. This gene product belongs to group
            II, which contains secreted form of PLA2, an extracellular enzyme
            that has a low molecular mass and requires calcium ions for
            catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl
            ester bond of phosphoglycerides, releasing free fatty acids and
            lysophospholipids, and thought to participate in the regulation of
            the phospholipid metabolism in biomembranes. Several alternatively
            spliced transcript variants with different 5' UTRs have been found
            for this gene.[provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291302.1, BX358510.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000482011.3/ ENSP00000504762.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL358253.16        73032-73070         c
            40-185              AL358253.16        72186-72331         c
            186-330             AL358253.16        71832-71976         c
            331-437             AL358253.16        71467-71573         c
            438-846             AL358253.16        68887-69295         c
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..846
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /note="phospholipase A2 group IIA"
                     /db_xref="GeneID:5320"
                     /db_xref="HGNC:HGNC:9031"
                     /db_xref="MIM:172411"
     exon            1..39
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            40..185
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..580
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2, membrane associated; NPS-PLA2;
                     GIIC sPLA2; group IIA phospholipase A2;
                     phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic
                     secretory phospholipase A2; phospholipase A2, group IIA
                     (platelets, synovial fluid)"
                     /codon_start=1
                     /product="phospholipase A2, membrane associated precursor"
                     /protein_id="NP_001382392.1"
                     /db_xref="CCDS:CCDS201.1"
                     /db_xref="GeneID:5320"
                     /db_xref="HGNC:HGNC:9031"
                     /db_xref="MIM:172411"
                     /translation="MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFY
                     GCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDS
                     CRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC"
     exon            186..330
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..437
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..846
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      826..831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /note="hexamer: AATAAA"
     polyA_site      846
                     /gene="PLA2G2A"
                     /gene_synonym="MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1;
                     sPLA2"
                     /note="major polyA site"
ORIGIN      
        1 aagacggcct ggggatacaa ctctggagtc ctctgagaga gccaccaagg aggagcaggg
       61 gagcgacggc cggggcagaa gttgagacca cccagcagag gagctaggcc agtccatctg
      121 catttgtcac ccaagaactc ttaccatgaa gaccctccta ctgttggcag tgatcatgat
      181 ctttggccta ctgcaggccc atgggaattt ggtgaatttc cacagaatga tcaagttgac
      241 gacaggaaag gaagccgcac tcagttatgg cttctacggc tgccactgtg gcgtgggtgg
      301 cagaggatcc cccaaggatg caacggatcg ctgctgtgtc actcatgact gttgctacaa
      361 acgtctggag aaacgtggat gtggcaccaa atttctgagc tacaagttta gcaactcggg
      421 gagcagaatc acctgtgcaa aacaggactc ctgcagaagt caactgtgtg agtgtgataa
      481 ggctgctgcc acctgttttg ctagaaacaa gacgacctac aataaaaagt accagtacta
      541 ttccaataaa cactgcagag ggagcacccc tcgttgctga gtcccctctt ccctggaaac
      601 cttccaccca gtgctgaatt tccctctctc ataccctccc tccctaccct aaccaagttc
      661 cttggccatg cagaaagcat ccctcaccca tcctagaggc caggcaggag cccttctata
      721 cccacccaga atgagacatc cagcagattt ccagccttct actgctctcc tccacctcaa
      781 ctccgtgctt aaccaaagaa gctgtactcc ggggggtctc ttctgaataa agcaattagc
      841 aaatca
//
