LOCUS       NM_000928                551 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens phospholipase A2 group IB (PLA2G1B), mRNA.
ACCESSION   NM_000928
VERSION     NM_000928.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 551)
  AUTHORS   Pothlichet,J., Meola,A., Bugault,F., Jeammet,L., Savitt,A.G.,
            Ghebrehiwet,B., Touqui,L., Pouletty,P., Fiore,F., Sauvanet,A. and
            Theze,J.
  TITLE     Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4
            T-Cell Anergy
  JOURNAL   Front Immunol 13, 824746 (2022)
   PUBMED   35392090
  REMARK    GeneRIF: Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced
            CD4 T-Cell Anergy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 551)
  AUTHORS   Ewers,M., Epple,D., Bugert,P., Rosendahl,J. and Witt,H.
  TITLE     Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in
            patients with chronic pancreatitis
  JOURNAL   Pancreatology 22 (2), 244-247 (2022)
   PUBMED   35031208
  REMARK    GeneRIF: Genetic analysis of pancreatic phospholipase A2 (PLA2G1B)
            in patients with chronic pancreatitis.
REFERENCE   3  (bases 1 to 551)
  AUTHORS   Yang,L., Wu,Y., Lin,S., Dai,B., Chen,H., Tao,X., Li,G., Wan,J. and
            Pan,Y.
  TITLE     sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to
            podocyte injury in idiopathic membranous nephropathy by activation
            of the p38MAPK/mTOR/ULK1ser757 signaling pathway
  JOURNAL   FASEB J 35 (2), e21170 (2021)
   PUBMED   33184968
  REMARK    GeneRIF: sPLA2-IB and PLA2R mediate insufficient autophagy and
            contribute to podocyte injury in idiopathic membranous nephropathy
            by activation of the p38MAPK/mTOR/ULK1(ser757) signaling pathway.
REFERENCE   4  (bases 1 to 551)
  AUTHORS   Yang,L.Y., Wu,Y.S., Dai,B.B., Lin,S.H., Chen,H., Li,G.P., Tao,X.,
            Wan,J.X. and Pan,Y.B.
  TITLE     sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of
            Idiopathic Membranous Nephropathy
  JOURNAL   Curr Med Sci 40 (4), 683-690 (2020)
   PUBMED   32862379
  REMARK    GeneRIF: sPLA2-IB Level Correlates with Hyperlipidemia and the
            Prognosis of Idiopathic Membranous Nephropathy.
REFERENCE   5  (bases 1 to 551)
  AUTHORS   Pothlichet,J., Rose,T., Bugault,F., Jeammet,L., Meola,A., Haouz,A.,
            Saul,F., Geny,D., Alcami,J., Ruiz-Mateos,E., Teyton,L., Lambeau,G.
            and Theze,J.
  TITLE     PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in
            HIV-infected patients
  JOURNAL   J Clin Invest 130 (6), 2872-2887 (2020)
   PUBMED   32436864
  REMARK    GeneRIF: PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in
            HIV-infected patients.
REFERENCE   6  (bases 1 to 551)
  AUTHORS   Kanda,A., Tamaki,M., Nakamura,E., Teraoka,H. and Yoshida,N.
  TITLE     Characterization of recombinant human and rat pancreatic
            phospholipases A2 secreted from Saccharomyces cerevisiae:
            difference in proteolytic processing
  JOURNAL   Biochim Biophys Acta 1171 (1), 1-10 (1992)
   PUBMED   1420353
REFERENCE   7  (bases 1 to 551)
  AUTHORS   Arita,H., Hanasaki,K., Nakano,T., Oka,S., Teraoka,H. and
            Matsumoto,K.
  TITLE     Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells
            via specific binding site
  JOURNAL   J Biol Chem 266 (29), 19139-19141 (1991)
   PUBMED   1918029
REFERENCE   8  (bases 1 to 551)
  AUTHORS   Clark,M.A., Ozgur,L.E., Conway,T.M., Dispoto,J., Crooke,S.T. and
            Bomalaski,J.S.
  TITLE     Cloning of a phospholipase A2-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5418-5422 (1991)
   PUBMED   2052621
REFERENCE   9  (bases 1 to 551)
  AUTHORS   Seilhamer,J.J., Randall,T.L., Yamanaka,M. and Johnson,L.K.
  TITLE     Pancreatic phospholipase A2: isolation of the human gene and cDNAs
            from porcine pancreas and human lung
  JOURNAL   DNA 5 (6), 519-527 (1986)
   PUBMED   3028739
REFERENCE   10 (bases 1 to 551)
  AUTHORS   Verheij,H.M., Westerman,J., Sternby,B. and De Haas,G.H.
  TITLE     The complete primary structure of phospholipase A2 from human
            pancreas
  JOURNAL   Biochim Biophys Acta 747 (1-2), 93-99 (1983)
   PUBMED   6349696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M21054.1 and AA844927.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000928.2.
            
            Summary: This gene encodes a secreted member of the phospholipase
            A2 (PLA2) class of enzymes, which is produced by the pancreatic
            acinar cells. The encoded calcium-dependent enzyme catalyzes the
            hydrolysis of the sn-2 position of membrane glycerophospholipids to
            release arachidonic acid (AA) and lysophospholipids. AA is
            subsequently converted by downstream metabolic enzymes to several
            bioactive lipophilic compounds (eicosanoids), including
            prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be
            involved in several physiological processes including cell
            contraction, cell proliferation and pathological response.
            [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP322008.1, BP322424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308366.9/ ENSP00000312286.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 M21054.1           11-14
            5-550               M21054.1           16-561
            551-551             AA844927.1         11-11               c
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..551
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /note="phospholipase A2 group IB"
                     /db_xref="GeneID:5319"
                     /db_xref="HGNC:HGNC:9030"
                     /db_xref="MIM:172410"
     exon            1..60
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..473
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /EC_number="3.1.1.4"
                     /note="phosphatidylcholine 2-acylhydrolase 1B;
                     phospholipase A2, group IB (pancreas)"
                     /codon_start=1
                     /product="phospholipase A2 precursor"
                     /protein_id="NP_000919.1"
                     /db_xref="CCDS:CCDS9195.1"
                     /db_xref="GeneID:5319"
                     /db_xref="HGNC:HGNC:9030"
                     /db_xref="MIM:172410"
                     /translation="MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEY
                     NNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGS
                     AITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS"
     exon            61..220
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..348
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..551
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      529..534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /note="hexamer: AATAAA"
     polyA_site      551
                     /gene="PLA2G1B"
                     /gene_synonym="PLA2; PLA2A; PPLA2"
                     /note="major polyA site"
ORIGIN      
        1 agttcttttc tcaccttgac tgcaagatga aactccttgt gctagctgtg ctgctcacag
       61 tggccgccgc cgacagcggc atcagccctc gggccgtgtg gcagttccgc aaaatgatca
      121 agtgcgtgat cccggggagt gaccccttct tggaatacaa caactacggc tgctactgtg
      181 gcttgggggg ctcaggcacc cccgtggatg aactggacaa gtgctgccag acacatgaca
      241 actgctatga ccaggccaag aagctggaca gctgtaaatt tctgctggac aacccgtaca
      301 cccacaccta ttcatactcg tgctctggct cggcaatcac ctgtagcagc aaaaacaaag
      361 agtgtgaggc cttcatttgc aactgcgacc gcaacgctgc catctgcttt tcaaaagctc
      421 catataacaa ggcacacaag aacctggaca ccaagaagta ttgtcagagt tgaatatcac
      481 ctctcaaaag catcacctct atctgcctca tctcacactg tactctccaa taaagcacct
      541 tgttgaaaga c
//
